Details of the Target

General Information of Target

Target ID LDTP03317
Target Name Nuclear transcription factor Y subunit beta (NFYB)
Gene Name NFYB
Gene ID 4801
Synonyms
HAP3; Nuclear transcription factor Y subunit beta; CAAT box DNA-binding protein subunit B; Nuclear transcription factor Y subunit B; NF-YB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLP
IANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILF
AMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLIT
TDGQQQNVMVYTTSYQQISGVQQIQFS
Target Bioclass
Transcription factor
Family
NFYB/HAP3 subunit family
Subcellular location
Nucleus
Function
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Uniprot ID
P25208
Ensemble ID
ENST00000240055.8
HGNC ID
HGNC:7805

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K69(1.21)  LDD0277  [1]
DBIA
 Probe Info  		C85(1.02); C89(1.02)  LDD1093  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]
AOyne
 Probe Info  		12.50  LDD0443  [5]
NAIA_5
 Probe Info  		C89(0.00); C85(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C85(1.02); C89(1.02)  LDD1093  [2]
 LDCM0215  AC10 PaTu 8988t C85(1.40); C89(1.40)  LDD1094  [2]
 LDCM0216  AC100 PaTu 8988t C85(0.95); C89(0.95)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C85(1.06); C89(1.06)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C85(1.05); C89(1.05)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C85(0.87); C89(0.87)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C85(1.00); C89(1.00)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C85(1.44); C89(1.44)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C85(0.82); C89(0.82)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C85(1.12); C89(1.12)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C85(0.96); C89(0.96)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C85(1.30); C89(1.30)  LDD1104  [2]
 LDCM0226  AC11 PaTu 8988t C85(1.19); C89(1.19)  LDD1105  [2]
 LDCM0227  AC110 PaTu 8988t C85(1.14); C89(1.14)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C85(0.89); C89(0.89)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C85(0.98); C89(0.98)  LDD1108  [2]
 LDCM0237  AC12 PaTu 8988t C85(1.38); C89(1.38)  LDD1116  [2]
 LDCM0246  AC128 PaTu 8988t C85(1.01); C89(1.01)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C85(0.84); C89(0.84)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C85(1.03); C89(1.03)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C85(1.13); C89(1.13)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C85(0.99); C89(0.99)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C85(1.00); C89(1.00)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C85(0.94); C89(0.94)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C85(1.00); C89(1.00)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C85(0.97); C89(0.97)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C85(1.03); C89(1.03)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C85(0.88); C89(0.88)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C85(1.21); C89(1.21)  LDD1137  [2]
 LDCM0259  AC14 PaTu 8988t C85(1.08); C89(1.08)  LDD1138  [2]
 LDCM0260  AC140 PaTu 8988t C85(0.90); C89(0.90)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C85(0.95); C89(0.95)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C85(0.94); C89(0.94)  LDD1141  [2]
 LDCM0263  AC143 PaTu 8988t C85(1.48); C89(1.48)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C85(1.29); C89(1.29)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C85(1.08); C89(1.08)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C85(1.56); C89(1.56)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C85(0.95); C89(0.95)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C85(1.19); C89(1.19)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C85(1.57); C89(1.57)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C85(1.28); C89(1.28)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C85(1.08); C89(1.08)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C85(1.19); C89(1.19)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C85(2.04); C89(2.04)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C85(1.39); C89(1.39)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C85(1.27); C89(1.27)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C85(1.39); C89(1.39)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C85(1.32); C89(1.32)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C85(1.55); C89(1.55)  LDD2169  [2]
 LDCM0276  AC17 PaTu 8988t C85(1.18); C89(1.18)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C85(1.27); C89(1.27)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C85(0.98); C89(0.98)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C85(0.80); C89(0.80)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C85(1.05); C89(1.05)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C85(1.25); C89(1.25)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C85(1.32); C89(1.32)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C85(1.46); C89(1.46)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C85(1.23); C89(1.23)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C85(1.02); C89(1.02)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C85(1.09); C89(1.09)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C85(1.12); C89(1.12)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C85(1.26); C89(1.26)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C85(1.18); C89(1.18)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C85(1.00); C89(1.00)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C85(1.09); C89(1.09)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C85(0.99); C89(0.99)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C85(1.44); C89(1.44)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C85(1.18); C89(1.18)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C85(1.73); C89(1.73)  LDD1174  [2]
 LDCM0296  AC35 PaTu 8988t C85(0.91); C89(0.91)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C85(0.81); C89(0.81)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C85(0.81); C89(0.81)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C85(0.80); C89(0.80)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C85(0.88); C89(0.88)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C85(0.84); C89(0.84)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C85(1.08); C89(1.08)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C85(0.70); C89(0.70)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C85(0.88); C89(0.88)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C85(1.02); C89(1.02)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C85(1.32); C89(1.32)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C85(0.84); C89(0.84)  LDD1186  [2]
 LDCM0308  AC46 HEK-293T C85(1.01)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C85(1.23)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C85(0.93)  LDD1549  [7]
 LDCM0312  AC5 PaTu 8988t C85(0.99); C89(0.99)  LDD1191  [2]
 LDCM0313  AC50 HEK-293T C85(0.92); C89(1.21)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C85(1.24)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C85(1.07)  LDD1554  [7]
 LDCM0317  AC54 HEK-293T C85(1.28)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C85(1.13)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C85(0.98)  LDD1558  [7]
 LDCM0320  AC57 PaTu 8988t C85(0.89); C89(0.89)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C85(1.13); C89(1.13)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C85(1.28); C89(1.28)  LDD1201  [2]
 LDCM0323  AC6 PaTu 8988t C85(1.14); C89(1.14)  LDD1202  [2]
 LDCM0324  AC60 PaTu 8988t C85(0.88); C89(0.88)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C85(1.00); C89(1.00)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C85(1.04); C89(1.04)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C85(1.15); C89(1.15)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C85(1.09); C89(1.09)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C85(1.11); C89(1.11)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C85(1.35); C89(1.35)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C85(1.33); C89(1.33)  LDD1210  [2]
 LDCM0332  AC68 PaTu 8988t C85(0.95); C89(0.95)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C85(0.96); C89(0.96)  LDD1212  [2]
 LDCM0334  AC7 PaTu 8988t C85(1.04); C89(1.04)  LDD1213  [2]
 LDCM0335  AC70 PaTu 8988t C85(0.93); C89(0.93)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C85(1.02); C89(1.02)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C85(1.13); C89(1.13)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C85(0.88); C89(0.88)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C85(1.01); C89(1.01)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C85(1.07); C89(1.07)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C85(1.10); C89(1.10)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C85(0.81); C89(0.81)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C85(1.13); C89(1.13)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C85(0.85); C89(0.85)  LDD1223  [2]
 LDCM0345  AC8 PaTu 8988t C85(1.04); C89(1.04)  LDD1224  [2]
 LDCM0346  AC80 PaTu 8988t C85(0.95); C89(0.95)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C85(1.12); C89(1.12)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C85(1.05); C89(1.05)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C85(0.84); C89(0.84)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C85(1.10); C89(1.10)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C85(0.96); C89(0.96)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C85(1.09); C89(1.09)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C85(0.94); C89(0.94)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C85(1.01); C89(1.01)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C85(0.92); C89(0.92)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C85(1.01); C89(1.01)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C85(0.83); C89(0.83)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C85(0.91); C89(0.91)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C85(0.93); C89(0.93)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C85(0.99); C89(0.99)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C85(1.01); C89(1.01)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C85(0.91); C89(0.91)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C85(0.91); C89(0.91)  LDD1243  [2]
 LDCM0365  AC98 PaTu 8988t C85(1.00); C89(1.00)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C85(1.24); C89(1.24)  LDD1245  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C85(1.34); C89(1.34)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C85(1.28); C89(1.28)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C85(1.35); C89(1.35)  LDD1154  [2]
 LDCM0367  CL1 HEK-293T C85(0.97)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C85(0.96)  LDD1572  [7]
 LDCM0369  CL100 PaTu 8988t C85(0.72); C89(0.72)  LDD1248  [2]
 LDCM0370  CL101 PaTu 8988t C85(0.88); C89(0.88)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C85(1.28); C89(1.28)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C85(1.78); C89(1.78)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C85(1.30); C89(1.30)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C85(0.80); C89(0.80)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C85(1.11); C89(1.11)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C85(0.79); C89(0.79)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C85(1.02); C89(1.02)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C85(1.28); C89(1.28)  LDD1257  [2]
 LDCM0379  CL11 HEK-293T C85(0.99)  LDD1583  [7]
 LDCM0380  CL110 PaTu 8988t C85(0.94); C89(0.94)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C85(1.49); C89(1.49)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C85(1.07); C89(1.07)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C85(1.01); C89(1.01)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C85(1.13); C89(1.13)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C85(1.10); C89(1.10)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C85(1.16); C89(1.16)  LDD1265  [2]
 LDCM0387  CL117 PaTu 8988t C85(0.78); C89(0.78)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C85(0.89); C89(0.89)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C85(1.24); C89(1.24)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C85(0.87)  LDD1594  [7]
 LDCM0391  CL120 PaTu 8988t C85(1.00); C89(1.00)  LDD1270  [2]
 LDCM0392  CL121 HEK-293T C85(0.92)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C85(1.05); C89(1.18)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C85(1.54)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C85(1.28); C89(0.95)  LDD1599  [7]
 LDCM0396  CL125 PaTu 8988t C85(1.28); C89(1.28)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C85(1.41); C89(1.41)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C85(1.35); C89(1.35)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C85(1.04); C89(1.04)  LDD1278  [2]
 LDCM0400  CL13 HEK-293T C85(0.94)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C85(0.99); C89(1.24)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C85(1.70)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C85(1.19); C89(1.05)  LDD1607  [7]
 LDCM0405  CL18 HEK-293T C85(1.10); C89(1.28)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C85(1.33)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C85(1.04); C89(1.21)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C85(0.92)  LDD1612  [7]
 LDCM0410  CL22 HEK-293T C85(0.86)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C85(1.11)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C85(0.90)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C85(0.93)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C85(1.03); C89(0.90)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C85(1.06)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C85(1.13); C89(0.82)  LDD1620  [7]
 LDCM0418  CL3 HEK-293T C85(1.16)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C85(0.83); C89(0.97)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C85(1.15)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C85(1.02)  LDD1625  [7]
 LDCM0423  CL34 HEK-293T C85(0.78)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C85(0.93)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C85(0.84)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C85(0.84)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C85(1.16)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C85(0.97); C89(1.01)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C85(0.91); C89(0.88)  LDD1634  [7]
 LDCM0432  CL42 HEK-293T C85(1.02); C89(1.12)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C85(0.83)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C85(0.96)  LDD1638  [7]
 LDCM0436  CL46 PaTu 8988t C85(0.78); C89(0.78)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C85(0.71); C89(0.71)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C85(1.03); C89(1.03)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C85(0.84); C89(0.84)  LDD1318  [2]
 LDCM0441  CL50 PaTu 8988t C85(0.81); C89(0.81)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C85(0.76); C89(0.76)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C85(0.82); C89(0.82)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C85(1.28); C89(1.28)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C85(0.73); C89(0.73)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C85(0.82); C89(0.82)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C85(0.74); C89(0.74)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C85(1.07); C89(1.07)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C85(0.80); C89(0.80)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C85(0.75); C89(0.75)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C85(0.92); C89(0.97)  LDD1654  [7]
 LDCM0452  CL60 PaTu 8988t C85(0.67); C89(0.67)  LDD1331  [2]
 LDCM0453  CL61 HEK-293T C85(0.98)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C85(1.37); C89(1.17)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C85(1.20)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C85(1.14); C89(1.06)  LDD1659  [7]
 LDCM0458  CL66 HEK-293T C85(0.98); C89(1.05)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C85(1.41)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C85(1.08)  LDD1663  [7]
 LDCM0462  CL7 HEK-293T C85(1.13)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C85(0.99)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C85(1.04)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C85(1.11)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C85(0.82)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C85(1.16); C89(1.55)  LDD1670  [7]
 LDCM0469  CL76 PaTu 8988t C85(0.98); C89(0.98)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C85(0.79); C89(0.79)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C85(0.91); C89(0.91)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C85(1.09); C89(1.09)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C85(1.12)  LDD1676  [7]
 LDCM0474  CL80 PaTu 8988t C85(0.97); C89(0.97)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C85(1.10); C89(1.10)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C85(0.99); C89(0.99)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C85(1.15); C89(1.15)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C85(0.91); C89(0.91)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C85(0.93); C89(0.93)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C85(1.10); C89(1.10)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C85(1.18); C89(1.18)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C85(1.18); C89(1.18)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C85(1.06); C89(1.06)  LDD1362  [2]
 LDCM0485  CL90 PaTu 8988t C85(1.27); C89(1.27)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C85(0.65); C89(0.65)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C85(0.70); C89(0.70)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C85(0.72); C89(0.72)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C85(0.83); C89(0.83)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C85(0.94); C89(0.94)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C85(1.00); C89(1.00)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C85(0.81); C89(0.81)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C85(1.06); C89(1.06)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C85(0.91); C89(0.91)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C85(1.24)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C85(0.86)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C85(0.97); C89(0.91)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C85(0.96)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C85(0.94)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C85(0.96)  LDD1502  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dr1-associated corepressor (DRAP1) NC2 alpha/DRAP1 family Q14919
Nuclear transcription factor Y subunit alpha (NFYA) NFYA/HAP2 subunit family P23511
Nuclear transcription factor Y subunit gamma (NFYC) NFYC/HAP5 subunit family Q13952
DNA polymerase epsilon subunit 4 (POLE4) . Q9NR33
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402