Details of the Target

General Information of Target

Target ID LDTP02810
Target Name N-chimaerin (CHN1)
Gene Name CHN1
Gene ID 1123
Synonyms
ARHGAP2; CHN; N-chimaerin; A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD
QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG
LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS
EKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCG
LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE
GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY
PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI
VFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
Target Bioclass
Other
Function GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Uniprot ID
P15882
Ensemble ID
ENST00000295497.13
HGNC ID
HGNC:1943

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.E38K .
HCC44 SNV: p.G52C .
IGR1 SNV: p.P216S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C35(1.52); C37(1.52)  LDD0580  [1]
IA-alkyne
 Probe Info  		C35(0.00); C37(0.00)  LDD2241  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C37(0.98)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C37(0.89)  LDD1508  [4]
 LDCM0216  AC100 PaTu 8988t C35(1.16); C37(1.16)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C35(1.04); C37(1.04)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C35(0.96); C37(0.96)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C35(0.99); C37(0.99)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C35(1.25); C37(1.25)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C35(1.78); C37(1.78)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C35(0.94); C37(0.94)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C35(0.47); C37(0.47)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C35(0.78); C37(0.78)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C35(1.03); C37(1.03)  LDD1104  [1]
 LDCM0226  AC11 HEK-293T C37(0.98)  LDD1509  [4]
 LDCM0227  AC110 PaTu 8988t C35(0.77); C37(0.77)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C35(1.07); C37(1.07)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C35(0.76); C37(0.76)  LDD1108  [1]
 LDCM0230  AC113 PaTu 8988t C236(1.19); C239(1.19); C35(1.38); C37(1.38)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C236(1.07); C239(1.07); C35(1.31); C37(1.31)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C236(1.20); C239(1.20); C35(1.15); C37(1.15)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C236(1.37); C239(1.37); C35(1.03); C37(1.03)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C236(1.47); C239(1.47); C35(1.13); C37(1.13)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C236(0.81); C239(0.81); C35(0.88); C37(0.88)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C236(0.98); C239(0.98); C35(1.33); C37(1.33)  LDD1115  [1]
 LDCM0237  AC12 HEK-293T C37(1.02)  LDD1510  [4]
 LDCM0238  AC120 PaTu 8988t C236(0.99); C239(0.99); C35(1.20); C37(1.20)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C236(1.07); C239(1.07); C35(1.22); C37(1.22)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C236(1.00); C239(1.00); C35(1.05); C37(1.05)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C236(1.05); C239(1.05); C35(1.08); C37(1.08)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C236(0.95); C239(0.95); C35(1.02); C37(1.02)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C236(0.86); C239(0.86); C35(0.96); C37(0.96)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C236(1.19); C239(1.19); C35(1.05); C37(1.05)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C236(0.95); C239(0.95); C35(1.29); C37(1.29)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C236(0.76); C239(0.76); C35(0.73); C37(0.73)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C236(0.77); C239(0.77); C35(0.80); C37(0.80)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C236(0.90); C239(0.90); C35(0.90); C37(0.90)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C236(0.69); C239(0.69); C35(0.97); C37(0.97)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C236(0.82); C239(0.82); C35(0.90); C37(0.90)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C236(0.60); C239(0.60); C35(0.80); C37(0.80)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C236(0.70); C239(0.70); C35(0.71); C37(0.71)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C236(0.52); C239(0.52); C35(0.80); C37(0.80)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C236(0.84); C239(0.84); C35(0.85); C37(0.85)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C236(0.62); C239(0.62); C35(0.70); C37(0.70)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C236(0.72); C239(0.72); C35(1.03); C37(1.03)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C236(0.85); C239(0.85); C35(1.04); C37(1.04)  LDD1137  [1]
 LDCM0259  AC14 HEK-293T C37(0.96)  LDD1512  [4]
 LDCM0260  AC140 PaTu 8988t C236(0.91); C239(0.91); C35(0.55); C37(0.55)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C236(0.94); C239(0.94); C35(0.61); C37(0.61)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C236(0.83); C239(0.83); C35(0.71); C37(0.71)  LDD1141  [1]
 LDCM0263  AC143 HCT 116 C35(1.52); C37(1.52)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C35(1.14); C37(1.14)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C35(1.24); C37(1.24)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C35(1.06); C37(1.06)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C35(1.34); C37(1.34)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C35(1.34); C37(1.34)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C35(0.98); C37(0.98)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C37(0.96)  LDD1513  [4]
 LDCM0271  AC150 HCT 116 C35(1.55); C37(1.55)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C35(1.13); C37(1.13)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C35(1.36); C37(1.36)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C35(1.03); C37(1.03)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C35(1.29); C37(1.29)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C35(1.13); C37(1.13)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C35(1.12); C37(1.12)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C35(1.18); C37(1.18)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C35(0.88); C37(0.88)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C35(0.80); C37(0.80)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C35(1.14); C37(1.14)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C37(0.90)  LDD1518  [4]
 LDCM0280  AC20 HCT 116 C35(0.95); C37(0.95)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C35(0.61); C37(0.61)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C35(1.17); C37(1.17)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C35(0.63); C37(0.63)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C35(1.20); C37(1.20)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C37(0.95)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C37(0.92)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C37(0.95)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C37(0.91)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C268(0.99); C391(1.02); C37(0.97)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C37(1.00)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C37(0.93)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C37(0.96)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C37(0.94)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C37(0.94)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C37(0.93)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C37(1.01)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C37(1.06)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C268(0.95); C391(1.07); C37(0.95)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C37(0.93)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C37(0.97)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C37(0.94)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C37(0.94)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C37(0.97)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C37(0.94)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C37(0.98)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C37(1.02)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C268(0.97); C391(1.07); C37(0.93)  LDD1546  [4]
 LDCM0308  AC46 HCT 116 C35(0.88); C37(0.88)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C35(1.23); C37(1.23)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C35(2.21); C37(2.21)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C35(1.33); C37(1.33)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C268(0.91); C391(1.09); C37(0.87)  LDD1551  [4]
 LDCM0313  AC50 HCT 116 C35(1.50); C37(1.50)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C35(2.18); C37(2.18)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C35(1.43); C37(1.43)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C35(1.10); C37(1.10)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C35(1.03); C37(1.03)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C35(1.46); C37(1.46)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C35(1.24); C37(1.24)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C37(1.02)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C37(0.89)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C37(0.94)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C37(0.92)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C37(0.97)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C268(1.08); C391(0.98); C37(0.95)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C37(0.92)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C37(0.93)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C37(0.87)  LDD1567  [4]
 LDCM0332  AC68 HCT 116 C35(1.67); C37(1.67)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C35(1.18); C37(1.18)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C37(0.95)  LDD1568  [4]
 LDCM0335  AC70 HCT 116 C35(1.03); C37(1.03)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C35(1.18); C37(1.18)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C35(1.18); C37(1.18)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C35(1.36); C37(1.36)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C35(1.12); C37(1.12)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C35(1.35); C37(1.35)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C35(1.56); C37(1.56)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C35(1.02); C37(1.02)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C35(1.14); C37(1.14)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C35(1.25); C37(1.25)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C37(0.89)  LDD1569  [4]
 LDCM0346  AC80 HCT 116 C35(1.26); C37(1.26)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C35(1.52); C37(1.52)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C35(1.09); C37(1.09)  LDD0665  [1]
 LDCM0365  AC98 PaTu 8988t C35(1.03); C37(1.03)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C35(1.04); C37(1.04)  LDD1245  [1]
 LDCM0248  AKOS034007472 HEK-293T C268(0.97); C391(1.19); C37(0.94)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C37(1.05)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C37(0.93)  LDD1514  [4]
 LDCM0367  CL1 HCT 116 C35(0.95); C37(0.95)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C35(1.05); C37(1.05)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C37(0.85)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C268(1.26); C37(0.99)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C37(0.83)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C268(1.25); C37(1.01)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C37(0.89)  LDD1577  [4]
 LDCM0374  CL105 HCT 116 C35(0.91); C37(0.91)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C35(0.91); C37(0.91)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C35(0.81); C37(0.81)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C35(0.87); C37(0.87)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C35(1.05); C37(1.05)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C35(0.87); C37(0.87)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C35(0.82); C37(0.82)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C35(0.85); C37(0.85)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C37(0.95)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C268(1.18); C37(0.92)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C37(0.78)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C268(1.24); C37(1.03)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C37(0.92)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C268(1.37); C37(0.92)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C37(0.89)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C268(1.27); C37(0.97)  LDD1593  [4]
 LDCM0390  CL12 HCT 116 C35(1.07); C37(1.07)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C37(0.94)  LDD1595  [4]
 LDCM0392  CL121 HCT 116 C35(1.05); C37(1.05)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C35(0.99); C37(0.99)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C35(1.12); C37(1.12)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C35(1.94); C37(1.94)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C268(1.22); C37(0.82)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C37(0.88)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C268(1.14); C37(0.90)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C37(0.89)  LDD1603  [4]
 LDCM0400  CL13 HCT 116 C35(0.79); C37(0.79)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C35(0.99); C37(0.99)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C35(0.78); C37(0.78)  LDD0719  [1]
 LDCM0403  CL16 PaTu 8988t C236(0.91); C239(0.91); C35(0.56); C37(0.56)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C236(0.87); C239(0.87); C35(0.63); C37(0.63)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C236(0.82); C239(0.82); C35(0.69); C37(0.69)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C236(0.68); C239(0.68); C35(0.75); C37(0.75)  LDD1285  [1]
 LDCM0407  CL2 HCT 116 C35(0.77); C37(0.77)  LDD0724  [1]
 LDCM0408  CL20 PaTu 8988t C236(0.72); C239(0.72); C35(0.85); C37(0.85)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C236(0.47); C239(0.47); C35(0.71); C37(0.71)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C236(0.64); C239(0.64); C35(0.56); C37(0.56)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C236(0.61); C239(0.61); C35(0.55); C37(0.55)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C236(0.74); C239(0.74); C35(0.78); C37(0.78)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C236(0.90); C239(0.90); C35(0.67); C37(0.67)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C236(0.69); C239(0.69); C35(0.61); C37(0.61)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C236(0.78); C239(0.78); C35(0.67); C37(0.67)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C236(0.51); C239(0.51); C35(0.63); C37(0.63)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C236(0.50); C239(0.50); C35(0.68); C37(0.68)  LDD1296  [1]
 LDCM0418  CL3 HCT 116 C35(0.91); C37(0.91)  LDD0735  [1]
 LDCM0419  CL30 PaTu 8988t C236(0.69); C239(0.69); C35(0.73); C37(0.73)  LDD1298  [1]
 LDCM0420  CL31 HEK-293T C37(1.03)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C37(1.07)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C268(0.75); C391(0.99); C37(0.84)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C37(1.05)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C37(1.09)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C37(1.01)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C268(1.26); C37(0.83)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C268(1.14); C37(0.97)  LDD1632  [4]
 LDCM0429  CL4 HCT 116 C35(1.05); C37(1.05)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C37(0.97)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C37(0.92)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C37(0.90)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C37(0.99)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C37(1.10)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C268(0.84); C391(1.04); C37(0.97)  LDD1639  [4]
 LDCM0436  CL46 PaTu 8988t C236(1.05); C239(1.05); C35(1.15); C37(1.15)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C236(0.84); C239(0.84); C35(0.69); C37(0.69)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C236(0.80); C239(0.80); C35(0.78); C37(0.78)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C236(0.99); C239(0.99); C35(1.11); C37(1.11)  LDD1318  [1]
 LDCM0440  CL5 HCT 116 C35(0.83); C37(0.83)  LDD0757  [1]
 LDCM0441  CL50 PaTu 8988t C236(0.89); C239(0.89); C35(0.93); C37(0.93)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C236(0.86); C239(0.86); C35(0.79); C37(0.79)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C236(0.92); C239(0.92); C35(1.01); C37(1.01)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C236(0.84); C239(0.84); C35(0.93); C37(0.93)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C236(0.74); C239(0.74); C35(1.01); C37(1.01)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C236(0.84); C239(0.84); C35(0.94); C37(0.94)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C236(0.22); C239(0.22); C35(0.78); C37(0.78)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C236(0.46); C239(0.46); C35(0.90); C37(0.90)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C236(0.71); C239(0.71); C35(0.91); C37(0.91)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C236(0.49); C239(0.49); C35(0.93); C37(0.93)  LDD1329  [1]
 LDCM0451  CL6 HCT 116 C35(0.96); C37(0.96)  LDD0768  [1]
 LDCM0452  CL60 PaTu 8988t C236(0.66); C239(0.66); C35(0.83); C37(0.83)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C35(0.79); C37(0.79)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C35(1.18); C37(1.18)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C35(1.06); C37(1.06)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C35(1.11); C37(1.11)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C35(1.14); C37(1.14)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C35(1.09); C37(1.09)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C35(1.01); C37(1.01)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C35(0.79); C37(0.79)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C35(0.96); C37(0.96)  LDD1340  [1]
 LDCM0462  CL7 HCT 116 C35(1.03); C37(1.03)  LDD0779  [1]
 LDCM0463  CL70 PaTu 8988t C35(0.97); C37(0.97)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C35(1.05); C37(1.05)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C35(1.16); C37(1.16)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C35(0.88); C37(0.88)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C35(0.79); C37(0.79)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C35(2.19); C37(2.19)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C35(1.37); C37(1.37)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C35(1.93); C37(1.93)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C35(1.40); C37(1.40)  LDD1351  [1]
 LDCM0473  CL8 HCT 116 C35(1.08); C37(1.08)  LDD0790  [1]
 LDCM0474  CL80 PaTu 8988t C35(1.21); C37(1.21)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C35(1.38); C37(1.38)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C35(1.58); C37(1.58)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C35(0.81); C37(0.81)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C35(1.39); C37(1.39)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C35(1.03); C37(1.03)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C35(1.09); C37(1.09)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C35(0.85); C37(0.85)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C35(1.26); C37(1.26)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C35(1.52); C37(1.52)  LDD1362  [1]
 LDCM0484  CL9 HCT 116 C35(1.00); C37(1.00)  LDD0801  [1]
 LDCM0485  CL90 PaTu 8988t C35(1.18); C37(1.18)  LDD1364  [1]
 LDCM0486  CL91 HEK-293T C37(0.94)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C37(0.97)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C268(0.99); C391(1.05); C37(0.91)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C37(0.97)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C37(0.80)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C37(0.75)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C268(1.28); C37(0.89)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C37(0.88)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C268(0.97); C37(1.02)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C268(1.17); C37(0.96)  LDD1698  [4]
 LDCM0468  Fragment33 PaTu 8988t C35(0.85); C37(0.85)  LDD1347  [1]
 LDCM0427  Fragment51 HEK-293T C37(0.90)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C37(1.01)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C37(1.08)  LDD1497  [4]
 LDCM0024  KB05 MEL167 C391(1.41)  LDD3316  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
Ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1) TKL Ser/Thr protein kinase family Q8NFD2
MTRF1L release factor glutamine methyltransferase (HEMK1) Protein N5-glutamine methyltransferase family Q9Y5R4
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic protein NCK2 (NCK2) . O43639

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840