Details of the Target

General Information of Target

Target ID LDTP02630
Target Name Ski-like protein (SKIL)
Gene Name SKIL
Gene ID 6498
Synonyms
SNO; Ski-like protein; Ski-related oncogene; Ski-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEA
PVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV
FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTL
QQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP
QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAP
QTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG
KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVS
QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI
SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLK
QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ
KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA
RQKLEMMIKELKLQILKSSKTAKE
Target Bioclass
Other
Family
SKI family
Function May have regulatory role in cell division or differentiation in response to extracellular signals.
Uniprot ID
P12757
Ensemble ID
ENST00000259119.9
HGNC ID
HGNC:10897

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.P28QfsTer5 .
CCK81 SNV: p.H37P .
HCC15 SNV: p.A418S; p.Q579H DBIA    Probe Info 
LNCaP clone FGC Deletion: p.I530SfsTer5 .
MOLT4 SNV: p.P216T; p.V381F .
RKO SNV: p.V46A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K50(6.25)  LDD0277  [1]
DBIA
 Probe Info  		C615(3.22); C617(3.22)  LDD0080  [2]
N1
 Probe Info  		S484(0.00); S486(0.00)  LDD0245  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C615(1.88); C617(1.88); C316(0.53); C187(0.92)  LDD1093  [2]
 LDCM0215  AC10 PaTu 8988t C615(1.85); C617(1.85); C187(1.05); C194(1.05)  LDD1094  [2]
 LDCM0216  AC100 PaTu 8988t C187(0.97); C194(0.97)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C187(0.90); C194(0.90)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C187(0.87); C194(0.87)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C187(0.79); C194(0.79)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C187(0.90); C194(0.90)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C187(0.73); C194(0.73)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C187(0.79); C194(0.79)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C187(0.82); C194(0.82)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C187(0.82); C194(0.82)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C187(0.96); C194(0.96)  LDD1104  [2]
 LDCM0226  AC11 PaTu 8988t C615(1.50); C617(1.50); C187(1.34); C194(1.34)  LDD1105  [2]
 LDCM0227  AC110 PaTu 8988t C187(0.81); C194(0.81)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C187(0.86); C194(0.86)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C187(0.92); C194(0.92)  LDD1108  [2]
 LDCM0237  AC12 PaTu 8988t C615(1.42); C617(1.42); C187(0.89); C194(0.89)  LDD1116  [2]
 LDCM0246  AC128 PaTu 8988t C615(1.07); C617(1.07); C187(1.40); C194(1.40)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C615(1.16); C617(1.16); C187(1.37); C194(1.37)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C615(1.03); C617(1.03); C187(1.73); C194(1.73)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C615(1.07); C617(1.07); C187(1.87); C194(1.87)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C615(0.98); C617(0.98); C187(1.28); C194(1.28)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C615(1.63); C617(1.63); C187(1.82); C194(1.82)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C615(1.46); C617(1.46); C187(1.60); C194(1.60)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C615(1.62); C617(1.62); C187(1.18); C194(1.18)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C615(1.41); C617(1.41); C187(1.24); C194(1.24)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C615(1.55); C617(1.55); C187(1.80); C194(1.80)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C615(1.02); C617(1.02); C187(1.45); C194(1.45)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C615(1.28); C617(1.28); C187(1.48); C194(1.48)  LDD1137  [2]
 LDCM0259  AC14 PaTu 8988t C615(1.40); C617(1.40); C187(0.84); C194(0.84)  LDD1138  [2]
 LDCM0260  AC140 PaTu 8988t C615(1.12); C617(1.12); C187(1.77); C194(1.77)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C615(1.07); C617(1.07); C187(1.43); C194(1.43)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C615(1.04); C617(1.04); C187(1.25); C194(1.25)  LDD1141  [2]
 LDCM0263  AC143 PaTu 8988t C615(1.48); C617(1.48); C166(1.06)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C615(1.17); C617(1.17); C166(1.04)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C615(1.22); C617(1.22); C166(0.86)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C615(0.95); C617(0.95); C166(1.00)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C615(1.14); C617(1.14); C166(1.14)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C615(1.53); C617(1.53); C166(0.95)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C615(1.33); C617(1.33); C166(1.06)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C615(1.62); C617(1.62); C187(0.86); C194(0.86)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C615(1.02); C617(1.02); C166(1.12)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C615(1.36); C617(1.36); C166(1.46)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C615(1.35); C617(1.35); C166(0.96)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C615(1.27); C617(1.27); C166(1.03)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C615(1.27); C617(1.27); C166(1.14)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C615(1.14); C617(1.14); C166(0.94)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C615(1.37); C617(1.37); C166(0.94)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C615(0.94); C617(0.94); C166(1.45)  LDD2169  [2]
 LDCM0276  AC17 PaTu 8988t C615(1.06); C617(1.06)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C615(1.16); C617(1.16)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C615(1.05); C617(1.05)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C615(1.47); C617(1.47); C316(0.40); C187(1.06)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C615(1.30); C617(1.30)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C615(1.09); C617(1.09)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C615(1.12); C617(1.12)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C615(1.40); C617(1.40)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C615(1.52); C617(1.52)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C615(1.13); C617(1.13); C166(1.03)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C615(1.19); C617(1.19); C166(1.12)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C615(1.50); C617(1.50); C166(1.09)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C615(1.49); C617(1.49); C166(0.99)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C615(1.25); C617(1.25); C166(1.06)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C615(1.43); C617(1.43); C316(0.52); C187(0.95)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C615(1.13); C617(1.13); C166(1.00)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C615(1.08); C617(1.08); C166(1.43)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C615(1.04); C617(1.04); C166(0.99)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C615(1.64); C617(1.64); C166(0.93)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C615(1.19); C617(1.19); C166(0.95)  LDD1174  [2]
 LDCM0296  AC35 PaTu 8988t C615(1.05); C617(1.05); C316(1.10); C166(0.92)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C615(1.18); C617(1.18); C316(1.21); C166(0.98)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C615(1.23); C617(1.23); C316(1.01); C166(0.99)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C615(1.15); C617(1.15); C316(1.14); C166(0.81)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C615(1.36); C617(1.36); C316(1.35); C166(0.95)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C615(1.28); C617(1.28); C316(0.40); C187(1.02)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C615(1.49); C617(1.49); C316(1.37); C166(0.84)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C615(1.31); C617(1.31); C316(1.23); C166(1.10)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C615(1.27); C617(1.27); C316(1.27); C166(0.88)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C615(1.30); C617(1.30); C316(1.07); C166(0.88)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C615(1.72); C617(1.72); C316(1.22); C166(0.89)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C615(1.52); C617(1.52); C316(1.07); C166(0.96)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C187(0.66); C194(0.66)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C187(0.84); C194(0.84)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C187(0.54); C194(0.54)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C187(0.80); C194(0.80)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C615(1.89); C617(1.89); C316(0.53); C187(0.85)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C187(0.74); C194(0.74)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C187(0.29); C194(0.29)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C187(0.86); C194(0.86)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C187(0.73); C194(0.73)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C187(1.12); C194(1.12)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C187(0.71); C194(0.71)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C187(0.97); C194(0.97)  LDD1198  [2]
 LDCM0320  AC57 PaTu 8988t C615(1.45); C617(1.45)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C615(1.64); C617(1.64)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C615(1.22); C617(1.22)  LDD1201  [2]
 LDCM0323  AC6 PaTu 8988t C615(1.23); C617(1.23); C187(1.08); C194(1.08)  LDD1202  [2]
 LDCM0324  AC60 PaTu 8988t C615(1.90); C617(1.90)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C615(1.35); C617(1.35)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C615(1.17); C617(1.17)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C615(1.47); C617(1.47)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C615(1.30); C617(1.30)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C615(1.20); C617(1.20)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C615(1.40); C617(1.40)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C615(1.30); C617(1.30)  LDD1210  [2]
 LDCM0332  AC68 PaTu 8988t C615(0.99); C617(0.99); C166(1.09)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C615(1.12); C617(1.12); C166(1.13)  LDD1212  [2]
 LDCM0334  AC7 PaTu 8988t C615(1.09); C617(1.09); C187(0.87); C194(0.87)  LDD1213  [2]
 LDCM0335  AC70 PaTu 8988t C615(1.07); C617(1.07); C166(0.96)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C615(0.98); C617(0.98); C166(1.32)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C615(0.89); C617(0.89); C166(1.09)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C615(0.91); C617(0.91); C166(1.05)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C615(0.95); C617(0.95); C166(1.36)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C615(1.10); C617(1.10); C166(1.18)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C615(1.06); C617(1.06); C166(1.02)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C615(1.05); C617(1.05); C166(1.19)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C615(0.92); C617(0.92); C166(1.33)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C615(1.00); C617(1.00); C166(1.75)  LDD1223  [2]
 LDCM0345  AC8 PaTu 8988t C615(1.22); C617(1.22); C187(0.80); C194(0.80)  LDD1224  [2]
 LDCM0346  AC80 PaTu 8988t C615(0.98); C617(0.98); C166(1.42)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C615(1.05); C617(1.05); C166(1.27)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C615(1.07); C617(1.07); C166(1.17)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C615(0.92); C617(0.86); C316(0.86)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C615(1.06); C617(1.02); C316(0.92)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C615(0.88); C617(0.79); C316(0.88)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C615(0.86); C617(0.71); C316(1.01)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C615(0.98); C617(0.78); C316(0.82)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C615(0.82); C617(0.73); C316(0.85)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C615(0.83); C617(0.75); C316(0.91)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C615(1.24); C617(0.81); C316(0.69)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C615(0.98); C617(0.78); C316(0.72)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C615(0.98); C617(0.82); C316(0.94)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C615(0.82); C617(0.63); C316(0.69)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C615(1.07); C617(0.73); C316(0.78)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C615(1.05); C617(0.79); C316(0.82)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C615(0.85); C617(0.70); C316(0.69)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C615(0.80); C617(0.70); C316(0.76)  LDD1243  [2]
 LDCM0365  AC98 PaTu 8988t C187(0.94); C194(0.94)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C187(0.90); C194(0.90)  LDD1245  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C615(1.75); C617(1.75); C187(1.01); C194(1.01)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C615(1.43); C617(1.43); C187(0.88); C194(0.88)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C615(1.62); C617(1.62); C187(1.57); C194(1.57)  LDD1154  [2]
 LDCM0367  CL1 PaTu 8988t C316(1.64); C187(1.16); C194(1.16)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C316(3.74); C187(2.06); C194(2.06)  LDD1247  [2]
 LDCM0369  CL100 PaTu 8988t C615(1.35); C617(1.35); C316(0.42); C187(0.82)  LDD1248  [2]
 LDCM0370  CL101 PaTu 8988t C615(1.20); C617(1.20); C187(1.06); C194(1.06)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C615(1.31); C617(1.31); C187(0.95); C194(0.95)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C615(2.01); C617(2.01); C187(1.31); C194(1.31)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C615(1.35); C617(1.35); C187(1.20); C194(1.20)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C615(1.13); C617(1.13)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C615(1.17); C617(1.17)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C615(1.03); C617(1.03)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C615(1.20); C617(1.20)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C615(1.06); C617(1.06)  LDD1257  [2]
 LDCM0379  CL11 PaTu 8988t C316(1.22); C187(0.85); C194(0.85)  LDD1258  [2]
 LDCM0380  CL110 PaTu 8988t C615(1.48); C617(1.48)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C615(1.52); C617(1.52)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C615(1.15); C617(1.15); C166(1.00)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C615(1.24); C617(1.24); C166(1.00)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C615(1.31); C617(1.31); C166(0.99)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C615(1.31); C617(1.31); C166(0.92)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C615(1.27); C617(1.27); C166(1.01)  LDD1265  [2]
 LDCM0387  CL117 PaTu 8988t C615(1.23); C617(1.23); C316(1.26); C166(1.06)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C615(1.35); C617(1.35); C316(0.97); C166(1.19)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C615(1.44); C617(1.44); C316(1.16); C166(0.68)  LDD1268  [2]
 LDCM0390  CL12 PaTu 8988t C316(1.17); C187(1.17); C194(1.17)  LDD1269  [2]
 LDCM0391  CL120 PaTu 8988t C615(1.24); C617(1.24); C316(4.30); C166(0.73)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C187(0.68); C194(0.68)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C187(0.71); C194(0.71)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C187(1.78); C194(1.78)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C187(0.84); C194(0.84)  LDD1274  [2]
 LDCM0396  CL125 PaTu 8988t C615(1.24); C617(1.24)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C615(1.25); C617(1.25)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C615(1.18); C617(1.18)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C615(1.26); C617(1.26)  LDD1278  [2]
 LDCM0400  CL13 PaTu 8988t C316(2.13); C187(0.93); C194(0.93)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C316(2.11); C187(1.97); C194(1.97)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C316(2.29); C187(2.09); C194(2.09)  LDD1281  [2]
 LDCM0403  CL16 PaTu 8988t C615(1.09); C617(1.09)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C615(1.58); C617(1.58)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C615(1.11); C617(1.11)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C615(1.10); C617(1.10)  LDD1285  [2]
 LDCM0407  CL2 PaTu 8988t C316(1.11); C187(0.90); C194(0.90)  LDD1286  [2]
 LDCM0408  CL20 PaTu 8988t C615(1.35); C617(1.35)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C615(2.10); C617(2.10)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C615(1.28); C617(1.28)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C615(1.40); C617(1.40)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C615(1.22); C617(1.22)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C615(1.33); C617(1.33)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C615(1.25); C617(1.25)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C615(1.20); C617(1.20)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C615(1.49); C617(1.49)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C615(1.35); C617(1.35)  LDD1296  [2]
 LDCM0418  CL3 PaTu 8988t C316(1.14); C187(1.11); C194(1.11)  LDD1297  [2]
 LDCM0419  CL30 PaTu 8988t C615(1.23); C617(1.23)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C615(1.10); C617(1.10)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C615(1.34); C617(1.34)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C615(5.13); C617(5.13)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C615(1.65); C617(1.65)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C615(1.31); C617(1.31)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C615(1.08); C617(1.08)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C615(2.03); C617(2.03)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C615(1.62); C617(1.62)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C316(1.21); C187(1.13); C194(1.13)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C615(1.48); C617(1.48)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C615(1.63); C617(1.63)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C615(1.54); C617(1.54)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C615(1.92); C617(1.92)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C615(1.52); C617(1.52)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C615(2.42); C617(2.42)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C615(1.04); C617(1.04); C187(1.54); C194(1.54)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C615(1.07); C617(1.07); C187(0.88); C194(0.88)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C615(1.16); C617(1.16); C187(1.46); C194(1.46)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C615(1.10); C617(1.10); C187(1.30); C194(1.30)  LDD1318  [2]
 LDCM0440  CL5 PaTu 8988t C316(2.09); C187(1.25); C194(1.25)  LDD1319  [2]
 LDCM0441  CL50 PaTu 8988t C615(1.31); C617(1.31); C187(1.77); C194(1.77)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C615(1.40); C617(1.40); C187(1.23); C194(1.23)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C615(1.15); C617(1.15); C187(0.80); C194(0.80)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C615(1.52); C617(1.52); C187(1.15); C194(1.15)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C615(1.27); C617(1.27); C187(1.15); C194(1.15)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C615(1.17); C617(1.17); C187(1.05); C194(1.05)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C615(1.25); C617(1.25); C187(1.39); C194(1.39)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C615(1.38); C617(1.38); C187(1.89); C194(1.89)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C615(1.10); C617(1.10); C187(0.93); C194(0.93)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C615(1.02); C617(1.02); C187(1.29); C194(1.29)  LDD1329  [2]
 LDCM0451  CL6 PaTu 8988t C316(1.78); C187(1.08); C194(1.08)  LDD1330  [2]
 LDCM0452  CL60 PaTu 8988t C615(1.09); C617(1.09); C187(1.23); C194(1.23)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C615(1.09); C617(1.09); C166(1.17); C187(1.04)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C615(0.80); C617(0.80); C166(0.77); C187(1.07)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C615(0.90); C617(0.90); C166(0.77); C187(0.69)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C615(1.03); C617(1.03); C166(0.95); C187(1.12)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C615(0.94); C617(0.94); C166(0.87); C187(1.32)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C615(0.91); C617(0.91); C166(0.90); C187(0.79)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C615(1.11); C617(1.11); C166(0.93); C187(0.94)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C615(1.86); C617(1.86); C166(1.00); C187(1.44)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C615(1.78); C617(1.78); C166(0.91); C187(1.87)  LDD1340  [2]
 LDCM0462  CL7 PaTu 8988t C316(1.56); C187(1.46); C194(1.46)  LDD1341  [2]
 LDCM0463  CL70 PaTu 8988t C615(1.25); C617(1.25); C166(0.73); C187(1.23)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C615(0.97); C617(0.97); C166(0.76); C187(0.84)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C615(0.87); C617(0.87); C166(0.83); C187(0.90)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C615(1.36); C617(1.36); C166(1.16); C187(1.09)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C615(0.99); C617(0.99); C166(0.79); C187(1.13)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C615(1.39); C617(1.39); C166(1.02)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C615(0.96); C617(0.96); C166(0.93)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C615(1.18); C617(1.18); C166(0.74)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C615(1.18); C617(1.18); C166(0.80)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C316(2.19); C187(1.50); C194(1.50)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C615(1.39); C617(1.39); C166(0.82)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C615(1.32); C617(1.32); C166(0.73)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C615(1.17); C617(1.17); C166(0.74)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C615(1.77); C617(1.77); C166(0.77)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C615(1.71); C617(1.71); C166(0.87)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C615(1.04); C617(1.04); C166(0.86)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C615(1.48); C617(1.48); C166(0.68)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C615(1.79); C617(1.79); C166(0.97)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C615(1.46); C617(1.46); C166(0.77)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C615(1.54); C617(1.54); C166(0.91)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C316(1.38); C187(0.93); C194(0.93)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C615(2.45); C617(2.45); C166(1.49)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C615(1.18); C617(1.18); C316(0.41); C187(0.69)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C615(1.92); C617(1.92); C316(0.63); C187(1.27)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C615(1.68); C617(1.68); C316(0.44); C187(1.00)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C615(1.46); C617(1.46); C316(0.44); C187(1.29)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C615(5.07); C617(5.07); C316(1.51); C187(2.28)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C615(1.61); C617(1.61); C316(0.57); C187(0.86)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C615(1.53); C617(1.53); C316(0.42); C187(1.64)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C615(2.15); C617(2.15); C316(0.48); C187(1.10)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C615(1.43); C617(1.43); C316(0.44); C187(0.69)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C197(1.05)  LDD1698  [4]
 LDCM0468  Fragment33 PaTu 8988t C615(1.16); C617(1.16); C166(0.75); C187(1.08)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C615(1.91); C617(1.91)  LDD1306  [2]
 LDCM0022  KB02 HCT 116 C615(3.22); C617(3.22)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C615(1.93); C617(1.93)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C615(2.19); C617(2.19)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) Cation transport ATPase (P-type) (TC 3.A.3) family P13637
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Developmentally-regulated GTP-binding protein 1 (DRG1) OBG GTPase family Q9Y295
Single-strand selective monofunctional uracil DNA glycosylase (SMUG1) SMUG1 family Q53HV7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Vimentin (VIM) Intermediate filament family P08670
Protein Mis18-beta (OIP5) Mis18 family O43482
Nuclear RNA export factor 3 (NXF3) NXF family Q9H4D5
Vacuolar protein sorting-associated protein 28 homolog (VPS28) VPS28 family Q9UK41
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
DNA repair protein complementing XP-A cells (XPA) XPA family P23025
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402