Details of the Target

General Information of Target

Target ID LDTP02504
Target Name Cytochrome c oxidase subunit 5B, mitochondrial (COX5B)
Gene Name COX5B
Gene ID 1329
Synonyms
Cytochrome c oxidase subunit 5B, mitochondrial; Cytochrome c oxidase polypeptide Vb
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLD
PYNVLAPKGASGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHY
KLVPQQLAH
Target Bioclass
Transporter and channel
Family
Cytochrome c oxidase subunit 5B family
Subcellular location
Mitochondrion inner membrane
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Uniprot ID
P10606
Ensemble ID
ENST00000258424.3
HGNC ID
HGNC:2269

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y62(11.45)  LDD0260  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
ONAyne
 Probe Info  		K56(0.00); K86(0.00); K57(0.00)  LDD0273  [3]
Probe 1
 Probe Info  		Y62(71.40)  LDD3495  [4]
DBIA
 Probe Info  		C116(0.73)  LDD3314  [5]
BTD
 Probe Info  		C113(1.39)  LDD1700  [6]
HHS-475
 Probe Info  		Y62(0.90)  LDD0264  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		K57(0.00); K86(0.00)  LDD0199  [9]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0176  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
SF
 Probe Info  		Y62(0.00); K57(0.00)  LDD0028  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
Phosphinate-6
 Probe Info  		C113(0.00); C93(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
HHS-465
 Probe Info  		N.A.  LDD2240  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C116(0.67)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C116(0.69)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C116(1.01)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C116(1.09); C113(0.51)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C116(1.48); C113(1.21)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C116(0.50)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C116(0.69)  LDD2131  [6]
 LDCM0214  AC1 HEK-293T C91(1.12)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C93(1.01)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C91(0.98)  LDD1509  [17]
 LDCM0259  AC14 HEK-293T C93(1.05)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C91(1.14)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C91(1.21)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C93(1.20)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C91(0.98)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C93(1.06)  LDD1518  [17]
 LDCM0281  AC21 HEK-293T C93(1.24)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C93(1.28)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C91(1.13)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C93(1.14)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C91(1.09)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C93(0.94)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C91(0.98)  LDD1526  [17]
 LDCM0289  AC29 HEK-293T C93(0.96)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C91(0.99)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C93(0.92)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C91(1.02)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C93(1.23)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C91(1.17)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C93(1.16)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C91(1.08)  LDD1535  [17]
 LDCM0298  AC37 HEK-293T C93(1.11)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C93(0.99)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C91(1.34)  LDD1539  [17]
 LDCM0302  AC40 HEK-293T C93(1.18)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C91(1.30)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C93(1.02)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C91(1.20)  LDD1544  [17]
 LDCM0307  AC45 HEK-293T C93(0.88)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C93(1.06)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C91(1.03)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C93(1.09)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C91(1.10)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C93(0.97)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C93(0.95)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C91(1.01)  LDD1553  [17]
 LDCM0316  AC53 HEK-293T C93(1.14)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C93(0.82)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C91(1.17)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C93(1.09)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C91(1.24)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C93(0.97)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C91(0.99)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C93(1.00)  LDD1562  [17]
 LDCM0325  AC61 HEK-293T C93(1.21)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C93(0.98)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C91(1.17)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C93(1.25)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C91(1.07)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C93(0.87)  LDD1569  [17]
 LDCM0545  Acetamide MDA-MB-231 C116(0.68); C113(0.17)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C116(1.24)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C93(1.02)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C91(1.25)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C93(0.94)  LDD1514  [17]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0367  CL1 HEK-293T C91(0.91)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C93(0.64)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C91(0.97); C93(1.32)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C91(1.08)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C93(1.03)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C91(1.12); C93(1.12)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C91(0.83); C93(1.07)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C91(1.23)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C93(1.14)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C91(1.11); C93(1.25)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C91(1.04); C93(1.08)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C91(1.21)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C91(0.96)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C93(0.92)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C91(1.13); C93(1.12)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C91(0.90); C93(0.96)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C91(1.06)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C93(0.81)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C91(1.22); C93(1.05)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C91(1.15); C93(1.19)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C91(1.39)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C93(0.97)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C91(1.11); C93(1.02)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C93(0.88)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C91(1.00); C93(1.17)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C91(1.31)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C93(0.93)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C91(0.89); C93(0.95)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C91(0.87); C93(1.08)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C91(1.10)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C93(1.00)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C91(0.92); C93(0.95)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C91(0.96); C93(1.27)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C91(1.08)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C93(1.06)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C91(0.78); C93(1.08)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C91(0.97); C93(1.34)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C91(0.93)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C93(1.05)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C91(1.09)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C93(1.02)  LDD1611  [17]
 LDCM0409  CL21 HEK-293T C93(0.95)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C93(1.01)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C91(1.16)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C93(1.14)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C91(1.44)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C93(1.05)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C91(1.03); C93(1.09)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C91(0.96); C93(1.06)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C91(1.26)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C91(0.75); C93(0.92)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C93(1.14)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C91(0.93)  LDD1624  [17]
 LDCM0422  CL33 HEK-293T C93(0.80)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C93(0.74)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C91(1.02)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C93(0.98)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C91(1.21)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C91(1.37); C93(1.07)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C91(0.88); C93(1.14)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C91(1.01); C93(1.17)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C91(1.13)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C93(1.20)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C91(1.00)  LDD1637  [17]
 LDCM0435  CL45 HEK-293T C93(0.97)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C93(0.99)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C91(1.04)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C93(1.12)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C91(1.00)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C91(1.11)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C93(1.02)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C91(1.02); C93(1.11)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C91(0.97)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C93(0.98)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C91(1.05)  LDD1649  [17]
 LDCM0448  CL57 HEK-293T C93(0.94)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C93(0.96)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C91(1.13)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C93(0.96)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C93(1.08)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C91(1.42)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C93(1.12)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C91(1.15); C93(1.08)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C91(0.96); C93(1.10)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C91(1.20)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C93(1.08)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C91(1.06)  LDD1662  [17]
 LDCM0461  CL69 HEK-293T C93(1.22)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C91(1.04)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C93(1.00)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C91(1.26)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C93(1.25)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C91(1.19)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C93(1.06)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C91(1.00); C93(1.15)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C91(1.01)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C93(0.94)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C91(0.80)  LDD1675  [17]
 LDCM0475  CL81 HEK-293T C93(0.97)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C93(0.94)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C91(1.00)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C93(0.88)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C91(1.43)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C93(1.02)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C91(1.11); C93(0.93)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C91(1.11); C93(1.27)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C91(1.07)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C93(0.79)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C93(1.14)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C91(1.19)  LDD1689  [17]
 LDCM0488  CL93 HEK-293T C93(1.04)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C93(1.33)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C91(1.08)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C93(0.87)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C91(1.18)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C93(0.87)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C91(1.10); C93(1.25)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C91(1.30); C93(1.03)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C91(0.99); C93(1.14)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C93(1.08)  LDD1631  [17]
 LDCM0116  HHS-0101 DM93 Y62(0.90)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y62(1.52)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y62(1.00)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y62(1.28)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y62(0.97)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0022  KB02 A101D C116(1.25)  LDD2250  [5]
 LDCM0023  KB03 A101D C116(1.53)  LDD2667  [5]
 LDCM0024  KB05 IGR37 C116(0.73)  LDD3314  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C116(1.09)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [14]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C116(1.09)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C113(1.11)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C116(1.40); C113(0.74)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C113(1.84)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C116(1.74); C113(0.88)  LDD2097  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C116(1.37); C113(0.66)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C116(0.25)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C116(0.36)  LDD2104  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C116(0.34)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C116(0.81); C113(0.80)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C116(0.81)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C116(1.48); C113(0.53)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C116(0.42)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C116(0.72); C113(0.62)  LDD2111  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C113(1.13)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C116(1.98); C113(2.45)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C113(0.63)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C116(1.08); C113(0.74)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C113(0.75)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C116(1.11); C113(0.44)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C116(0.98); C113(0.69)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C116(1.29); C113(1.05)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C116(0.72)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C116(1.00); C113(0.62)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C116(1.03); C113(0.82)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C116(1.52); C113(0.55)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C116(1.08); C113(0.73)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C113(1.39)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C116(1.12); C113(0.44)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C116(0.37); C113(0.26)  LDD2141  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C116(2.51); C113(3.31)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C116(1.70)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C113(0.58)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C116(0.50)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C113(1.01)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C116(0.75); C113(0.33)  LDD2150  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
ADP-sugar pyrophosphatase (NUDT5) Nudix hydrolase family Q9UKK9
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Flotillin-1 (FLOT1) Band 7/mec-2 family O75955
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cdc42 effector protein 2 (CDC42EP2) BORG/CEP family O14613
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Protein FAM228A (FAM228A) FAM228 family Q86W67
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Protein Mis18-beta (OIP5) Mis18 family O43482
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
RNA-binding protein 48 (RBM48) RBM48 family Q5RL73
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
Mitochondrial coiled-coil domain protein 1 (MCCD1) . P59942
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Testis-expressed protein 12 (TEX12) . Q9BXU0
TNF receptor-associated factor 1 (TRAF1) . Q13077

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cholic Acid Small molecular drug DB02659
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-formylmethionine Small molecular drug DB04464

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402