Details of the Target

General Information of Target

Target ID LDTP02253
Target Name Complement decay-accelerating factor (CD55)
Gene Name CD55
Gene ID 1604
Synonyms
CR; DAF; Complement decay-accelerating factor; CD antigen CD55
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTV
ITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFP
VGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGER
DHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT
TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLS
GHTCFTLTGLLGTLVTMGLLT
Target Type
Clinical trial
Target Bioclass
Other
Family
Receptors of complement activation (RCA) family
Subcellular location
Secreted; Lipid-anchor, GPI-anchor; Cell membrane
Function
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.; (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5.; (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable).; (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21.
TTD ID
T78114
Uniprot ID
P08174
DrugMap ID
TT5Z9WY
Ensemble ID
ENST00000314754.12
HGNC ID
HGNC:2665
ChEMBL ID
CHEMBL4879428

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.V304I DBIA    Probe Info 
G361 SNV: p.E156K .
JHH1 SNV: p.T320A DBIA    Probe Info 
JHH4 SNV: p.S7I .
KMS11 SNV: p.T336I DBIA    Probe Info 
LN229 SNV: p.C65S .
MOLT4 SNV: p.P166S .
NCIH1155 SNV: p.Y133Ter DBIA    Probe Info 
OCUG1 SNV: p.V32G .
REH SNV: p.E156K .
SJSA1 SNV: p.N95K
Substitution: p.G74E		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K161(0.83); K160(1.09); K110(2.89)  LDD3494  [1]
DBIA
 Probe Info  		C98(1.45); C163(3.42)  LDD3310  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C158(0.00); C253(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C81(0.00); C145(0.00); C163(0.00); C158(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C81(0.00); C145(0.00); C98(0.00); C158(0.00)  LDD0037  [3]
BTD
 Probe Info  		N.A.  LDD0004  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Acrolein
 Probe Info  		C225(0.00); C158(0.00); C163(0.00); C253(0.00)  LDD0217  [6]
Crotonaldehyde
 Probe Info  		C158(0.00); C145(0.00); H242(0.00); C163(0.00)  LDD0219  [6]
Methacrolein
 Probe Info  		C145(0.00); C81(0.00); C163(0.00); C158(0.00)  LDD0218  [6]
NAIA_5
 Probe Info  		C65(0.00); C225(0.00); C145(0.00); C158(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C145(1.26)  LDD2117  [8]
 LDCM0214  AC1 HEK-293T C145(0.83)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C145(0.80)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C145(0.75)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C145(0.84)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C145(0.89)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C145(0.87)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C145(0.79)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C145(0.87)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C145(0.95)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C145(0.91)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C145(0.88)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C145(0.96); C81(0.99)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C145(0.90)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C145(0.93)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C145(1.11)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C145(0.85)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C145(0.92)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C145(0.88)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C145(0.90)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C145(0.98); C81(0.93)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C145(0.85)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C145(0.93)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C145(0.81)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C145(1.01)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C145(0.76)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C145(0.95)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C145(0.86)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C145(0.86)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C145(1.01); C81(0.97)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C145(0.85)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C145(0.91)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C145(0.93)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C145(1.00)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C145(0.73)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C145(0.78)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C145(0.82)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C145(0.91)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C145(0.98); C81(0.99)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C145(0.92)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C145(0.85)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C145(1.04)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C145(0.77)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C145(1.01); C81(1.12)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C145(0.97)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C145(0.99)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C145(0.93)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C145(0.87); C81(0.99)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C145(0.89)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C145(0.82)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C145(0.97)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C145(0.74)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C145(0.81)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C145(0.87)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C145(0.96)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C145(0.86)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C145(0.87); C81(0.95)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C145(0.88)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C145(0.91)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C145(0.96)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C145(0.97)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C145(0.97)  LDD1569  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C98(0.96)  LDD2113  [8]
 LDCM0248  AKOS034007472 HEK-293T C145(0.94); C81(1.02)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C145(0.77)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C145(1.07)  LDD1514  [9]
 LDCM0108  Chloroacetamide HeLa C225(0.00); C81(0.00); C163(0.00); C158(0.00)  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C145(0.78)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C145(0.74)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C98(1.13)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C145(0.77)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C145(0.82)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C145(0.87)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C98(0.93)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C145(0.81)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C145(0.92)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C145(0.79)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C98(1.13)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C145(0.89)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C145(0.87)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C145(0.75)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C145(0.99)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C98(1.41)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C145(0.81)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C145(0.88)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C145(0.89)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C98(1.30)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C145(0.80)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C145(0.92)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C145(0.97)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C145(0.92)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C98(1.14)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C145(0.79)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C145(0.87)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C145(0.83)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C98(1.33)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C145(0.88)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C145(0.90)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C145(0.93)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C98(1.09)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C145(0.76)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C145(0.82)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C145(0.77)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C98(0.99)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C145(0.83)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C145(0.85)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C145(0.79)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C145(0.94)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C145(0.83)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C145(0.78); C81(1.14)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C145(0.82)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C145(0.82)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C145(0.93)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C145(0.78)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C145(0.75)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C145(0.88)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C98(0.92)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C145(0.85)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C145(0.88)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C145(0.86)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C145(0.78)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C145(0.88)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C145(0.86); C81(0.88)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C145(0.90)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C145(0.83)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C145(0.94)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C145(0.82)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C145(0.79)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C98(1.16)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C98(0.93)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C145(0.71)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C145(0.65)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C145(0.74)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C145(0.86)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C145(0.89); C81(0.97)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C145(0.86)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C145(0.81)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C145(0.92)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C145(0.86)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C145(0.89)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C145(0.76)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C98(1.35)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C145(0.75)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C145(0.79)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C145(0.80)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C145(0.73)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C145(0.91); C81(0.47)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C145(0.79)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C145(0.76)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C145(0.81)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C145(0.93)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C145(0.80)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C145(0.79)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C145(0.83)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C98(1.04)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C145(0.79)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C145(0.81)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C145(0.79)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C145(0.76)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C145(0.89); C81(1.04)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C145(0.87)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C145(0.78)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C145(0.89)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C145(0.94)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C145(0.90)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C145(0.99)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C98(1.12)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C145(0.71)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C145(0.92)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C145(0.76)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C145(0.59)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C145(0.90)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C145(1.00); C81(0.99)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C145(0.92)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C145(0.93)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C145(1.18)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C145(0.79)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C145(0.84)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C145(0.83)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C98(1.02)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C145(0.74)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C145(0.98); C81(1.33)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C145(0.68)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C145(0.72)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C145(0.73)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C145(0.98); C81(1.03)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C145(0.83)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C145(0.76)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C145(1.00)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C145(0.77)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C145(0.92)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C145(0.86)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C145(0.75)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C145(0.98)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C145(0.99)  LDD1631  [9]
 LDCM0107  IAA HeLa C158(0.00); C145(0.00); C163(0.00); H242(0.00)  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C81(1.07)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C81(0.97)  LDD1497  [9]
 LDCM0024  KB05 COLO792 C98(1.45); C163(3.42)  LDD3310  [2]
 LDCM0109  NEM HeLa C158(0.00); C145(0.00); C163(0.00); H242(0.00)  LDD0223  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C145(1.72); C98(0.99)  LDD2093  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C98(1.02)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C98(1.16)  LDD2100  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C81(0.93)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C98(0.45)  LDD2109  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C98(0.98)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C145(0.51); C98(0.55)  LDD2115  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C145(0.41)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C145(0.86); C98(0.57); C81(0.68)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C98(0.84)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C145(0.89); C81(0.76); C253(0.59)  LDD2127  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C98(0.77)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C98(1.10)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C98(0.89); C81(0.50)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C145(2.08); C98(0.73)  LDD2136  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C98(0.88)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C98(0.80); C81(1.35)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C98(0.84)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C145(0.44)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C145(2.50); C81(1.38)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C98(1.08)  LDD2145  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C145(0.58)  LDD2147  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adhesion G protein-coupled receptor E5 (ADGRE5) G-protein coupled receptor 2 family P48960

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Chloramphenicol Small molecular drug DB00446
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pat-sc1 Antibody D00UOQ
Onyvax-105 Vaccine D02WLS
Coxsackievirus A21 . D0C4BL

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402