Details of the Target

General Information of Target

Target ID LDTP02219
Target Name Bisphosphoglycerate mutase (BPGM)
Gene Name BPGM
Gene ID 669
Synonyms
Bisphosphoglycerate mutase; BPGM; EC 5.4.2.4; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; EC 5.4.2.11; 2,3-diphosphoglycerate mutase; DPGM; BPG-dependent PGAM
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVL
NRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYN
VTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRG
KTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEA
IQAAIKKVEDQGKVKQAKK
Target Bioclass
Enzyme
Family
Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
Function Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity.
Uniprot ID
P07738
Ensemble ID
ENST00000344924.8
HGNC ID
HGNC:1093
ChEMBL ID
CHEMBL5169112

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		Y92(10.00)  LDD2237  [1]
DBIA
 Probe Info  		C23(0.93)  LDD0078  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C145(0.00); C23(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
SF
 Probe Info  		N.A.  LDD0028  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C23(1.37)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C23(0.66)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C23(0.86)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C23(0.79)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C23(0.85)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C23(0.98)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C23(0.95)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C23(1.06)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C23(1.09)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C23(0.61)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C23(0.62)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C23(0.57)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C23(1.07)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C23(0.53)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C23(0.56)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C23(0.53)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C23(1.05)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C23(0.76)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C23(0.94)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C23(1.01)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C23(1.39)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C23(0.98)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C23(1.14)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C23(1.11)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C23(0.76)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C23(1.38)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C23(0.78)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C23(1.49)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C23(1.21)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C23(0.76)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C23(0.83)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C23(1.04)  LDD0562  [2]
 LDCM0259  AC14 HEK-293T C23(0.93)  LDD0857  [2]
 LDCM0263  AC143 HEK-293T C23(1.21)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C23(1.02)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C23(1.04)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C23(1.04)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C23(0.97)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C23(1.02)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C23(1.22)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C23(1.06)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C23(1.05)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C23(1.07)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C23(1.08)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C23(0.99)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C23(0.96)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C23(1.04)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C23(1.07)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C23(1.03)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C23(1.00)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C23(0.93)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C23(0.96)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C23(2.94)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C23(0.89)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C23(0.97)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C23(0.92)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C23(0.89)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C23(0.90)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C23(1.55)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C23(1.88)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C23(1.66)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C23(1.72)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C23(1.71)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C23(1.43)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C23(1.64)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C23(1.69)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C23(1.66)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C23(1.60)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C23(1.68)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C23(0.87)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C23(1.17)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C23(0.94)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C23(1.05)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C23(1.08)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C23(1.36)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C23(1.03)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C23(0.94)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C23(1.03)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C23(1.25)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C23(0.95)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C23(0.96)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C23(0.91)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C23(0.95)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C23(1.05)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C23(1.38)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C23(1.88)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C23(1.12)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C23(1.31)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C23(1.62)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C23(1.05)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C23(1.31)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C23(1.17)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C23(1.14)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C23(1.46)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C23(1.44)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C23(1.78)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C23(0.79)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C23(1.54)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C23(1.37)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C23(1.55)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C23(1.43)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C23(1.66)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C23(2.07)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C23(1.78)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C23(1.61)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C23(1.14)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C23(1.00)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C23(0.96)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C23(1.11)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C23(1.15)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C23(1.37)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C23(1.26)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C23(1.07)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C23(1.42)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C23(1.04)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C23(1.28)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C23(1.29)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C23(1.12)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C23(1.28)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C23(1.33)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C23(1.35)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C23(2.03)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C23(1.40)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C23(1.48)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C23(1.21)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C23(1.12)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C23(0.96)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C23(1.10)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C23(1.15)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C23(1.10)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C23(1.35)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C23(1.36)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C23(1.07)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C23(1.11)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C23(0.95)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C23(1.23)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C23(1.27)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C23(0.70)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C23(0.79)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C23(0.66)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C23(0.97)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C23(0.69)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C23(0.93)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C23(0.97)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C23(0.88)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C23(1.06)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C23(0.81)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C23(0.77)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C23(0.66)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C23(0.81)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C23(1.01)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C23(1.16)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C23(1.07)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C23(1.13)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C23(0.96)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C23(0.79)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C23(1.04)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C23(0.90)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C23(1.87)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C23(1.50)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C23(2.75)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C23(2.08)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C23(2.18)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C23(0.89)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C23(0.96)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C23(0.91)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C23(0.76)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C23(0.99)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C23(1.41)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C23(1.31)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C23(1.14)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C23(1.18)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C23(1.09)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C23(1.19)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C23(1.17)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C23(1.52)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C23(0.87)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C23(0.89)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C23(0.78)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C23(1.43)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C23(1.10)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C23(1.43)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C23(1.30)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C23(0.88)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C23(1.30)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C23(1.30)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C23(1.34)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C23(1.10)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C23(1.41)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C23(1.20)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C23(1.66)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C23(1.59)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C23(1.37)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C23(1.07)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C23(0.87)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C23(1.42)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C23(0.92)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C23(1.02); C145(1.02)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C145(0.99)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C23(0.99)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C23(0.97); C145(1.08)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C23(0.90)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C23(0.98); C145(0.85)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C23(1.03); C145(0.96)  LDD1632  [7]
 LDCM0429  CL4 HCT 116 C23(0.97)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C23(1.00)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C23(0.96); C145(0.89)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C23(0.95); C145(0.99)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C23(0.93)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C23(0.92); C145(1.06)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C145(1.05)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C23(1.01)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C23(1.03); C145(1.01)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C23(0.96)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C23(0.91); C145(0.97)  LDD1643  [7]
 LDCM0440  CL5 HCT 116 C23(0.99)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C23(0.92); C145(1.04)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C23(0.81)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C23(0.87); C145(0.95)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C23(0.86); C145(1.12)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C23(0.88)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C23(1.04); C145(1.08)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C145(1.18)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C23(0.96)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C23(0.97); C145(1.26)  LDD1653  [7]
 LDCM0451  CL6 HCT 116 C23(1.01)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C23(0.96)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C23(0.87)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C23(0.91)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C23(1.06)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C23(0.84)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C23(0.99)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C23(0.83)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C23(0.83)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C23(1.00)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C23(1.04)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C23(1.00)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C23(0.94)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C23(0.87)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C23(0.99)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C23(0.87)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C23(0.98)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C23(0.90)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C23(0.91); C145(1.01)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C23(0.90); C145(1.05)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C23(0.49)  LDD1675  [7]
 LDCM0473  CL8 HCT 116 C23(1.00)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C23(1.02); C145(1.16)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C145(1.14)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C23(1.01)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C23(0.98); C145(1.25)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C23(0.92)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C23(0.98); C145(0.95)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C23(0.98); C145(0.99)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C23(0.89); C145(1.06)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C23(0.96)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C23(0.90); C145(0.98)  LDD1686  [7]
 LDCM0484  CL9 HCT 116 C23(1.02)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C23(0.74); C145(1.06)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C23(1.54)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C23(1.26)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C23(1.68)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C23(1.23)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C23(1.42)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C23(1.53)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C23(1.41)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C23(1.31)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C23(1.00)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C23(0.98); C145(0.95)  LDD1698  [7]
 LDCM0625  F8 Ramos C23(1.26)  LDD2187  [8]
 LDCM0573  Fragment11 Ramos C23(0.10)  LDD2190  [8]
 LDCM0576  Fragment14 Ramos C23(0.18)  LDD2193  [8]
 LDCM0468  Fragment33 HEK-293T C23(1.08)  LDD1066  [2]
 LDCM0566  Fragment4 Ramos C23(1.09)  LDD2184  [8]
 LDCM0427  Fragment51 HEK-293T C23(1.00); C145(1.02)  LDD1631  [7]
 LDCM0569  Fragment7 Ramos C23(1.61)  LDD2186  [8]
 LDCM0022  KB02 HEK-293T C23(1.00)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C23(1.07)  LDD1497  [7]
 LDCM0024  KB05 Hs 936.T C145(1.30)  LDD3313  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphoglycerate mutase 2 (PGAM2) Phosphoglycerate mutase family P15259

References

1 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840