Details of the Target

General Information of Target

Target ID LDTP02033
Target Name von Willebrand factor (VWF)
Gene Name VWF
Gene ID 7450
Synonyms
F8VWF; von Willebrand factor; vWF) [Cleaved into: von Willebrand antigen 2; von Willebrand antigen II)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYL
LAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYL
ETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTL
TSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPL
VDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGME
YRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPG
TSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQD
HSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDL
RIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSG
LAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVS
PLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQ
CGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPED
IFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADN
LRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGE
TVKIGCNTCVCQDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGS
NPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGR
YIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVD
FGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPY
LDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGY
ECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCE
VAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVE
DISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVE
YHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRI
TLLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVL
SSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVA
FVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGD
ILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLP
GDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTL
SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT
IDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILV
TDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTM
VTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCHTVTCQPDGQTLLKSHRVNCD
RGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNK
EQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEV
NVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRD
GTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHKVLAPATFY
AICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCPRHC
DGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQI
CTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHC
ERGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVN
STVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAV
MGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQ
WASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERME
ACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGEC
CGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHK
CLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMY
SIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK
Target Type
Successful
Target Bioclass
Other
Subcellular location
Secreted
Function
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
TTD ID
T23348
Uniprot ID
P04275
DrugMap ID
TT3SZBT
Ensemble ID
ENST00000261405.10
HGNC ID
HGNC:12726
ChEMBL ID
CHEMBL2021748

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.G618C .
CAL72 SNV: p.C889Y .
CHL1 SNV: p.W191Ter .
DAOY SNV: p.S1756R .
DETROIT562 SNV: p.C200R .
DU145 SNV: p.D2669N .
HCT116 SNV: p.R1308C .
HCT15 SNV: p.L884M .
HS578T SNV: p.Y1570C .
HT SNV: p.N1574S .
HT115 SNV: p.D437N; p.A1474T; p.N1847D; p.D2106Y; p.Y2760H .
ICC10 Substitution: p.P1162L DBIA    Probe Info 
ICC106 Substitution: p.P1162L DBIA    Probe Info 
IGROV1 SNV: p.P645S .
Ishikawa (Heraklio) 02 ER Deletion: p.K1491RfsTer34 .
K562 SNV: p.G713S .
KMCH1 SNV: p.M299I .
LN18 SNV: p.G1674E .
LNCaP clone FGC SNV: p.D1529E; p.A2703T .
MCC13 SNV: p.P359L; p.G635E; p.T1547I .
MELJUSO SNV: p.N573D; p.N1929T .
MEWO SNV: p.G1579R .
NALM6 SNV: p.T577A .
NB1 SNV: p.P1480T .
NB4 SNV: p.N2725D .
OCIAML2 SNV: p.N2546Y .
ONS76 SNV: p.T2623S .
PC14 SNV: p.G142S .
PC9 SNV: p.G142S .
RL952 SNV: p.M50I .
RVH421 SNV: p.G1415S .
SH4 SNV: p.E2633K .
SNU1079 SNV: p.F735L .
SW480 SNV: p.G1324V .
SW620 SNV: p.C2431Y .
TOV21G SNV: p.R606L; p.R1641M .
YSCCC SNV: p.F735L; p.G1479D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C372(1.45)  LDD0812  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [2]
NAIA_4
 Probe Info  		C2641(0.00); C2640(0.00)  LDD2226  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C372(1.45)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C372(1.36)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C372(1.02)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C372(0.88)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C372(0.94)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C372(1.03)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C372(1.11)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C372(0.92)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C372(0.68)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C372(0.94)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C372(0.86)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C372(0.83)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C372(1.16)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C372(1.26)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C372(1.67)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C372(1.28)  LDD0827  [1]
 LDCM0237  AC12 HEK-293T C372(1.15)  LDD0835  [1]
 LDCM0246  AC128 HEK-293T C372(0.98)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C372(1.21)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C372(1.20)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C372(1.08)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C372(1.10)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C372(1.31)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C372(1.23)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C372(1.32)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C372(1.32)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C372(1.52)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C372(1.77)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C372(1.54)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C372(1.28)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C372(1.31)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C372(1.62)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C372(1.27)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C372(0.82)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C372(1.23)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C372(1.15)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C372(1.25)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C372(1.18)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C372(0.85)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C372(0.86)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C372(1.38)  LDD0868  [1]
 LDCM0271  AC150 HEK-293T C372(1.03)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C372(1.27)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C372(1.22)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C372(1.07)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C372(1.16)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C372(1.11)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C372(1.21)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C372(1.40)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C372(1.53)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C372(1.23)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C372(1.01)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C372(1.08)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C372(1.35)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C372(1.61)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C372(1.29)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C372(1.49)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C372(1.09)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C372(1.18)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C372(0.99)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C372(1.10)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C372(1.59)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C372(1.26)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C372(0.87)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C372(1.13)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C372(0.92)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C372(1.16)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C372(1.42)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C372(1.00)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C372(0.87)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C372(1.05)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C372(1.09)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C372(0.89)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C372(1.14)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C372(1.01)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C372(1.26)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C372(1.17)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C372(1.20)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C372(1.26)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C372(1.22)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C372(1.15)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C372(0.99)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C372(1.21)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C372(1.14)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C372(1.14)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C372(1.06)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C372(1.07)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C372(1.23)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C372(1.19)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C372(1.10)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C372(1.15)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C372(1.08)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C372(1.03)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C372(0.87)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C372(0.81)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C372(0.84)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C372(1.05)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C372(1.24)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C372(0.74)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C372(1.10)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C372(1.06)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C372(0.83)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C372(1.23)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C372(0.70)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C372(1.13)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C372(1.17)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C372(1.14)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C372(1.19)  LDD0932  [1]
 LDCM0335  AC70 HEK-293T C372(1.29)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C372(1.40)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C372(1.36)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C372(1.32)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C372(1.74)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C372(1.34)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C372(1.26)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C372(1.28)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C372(1.36)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C372(1.31)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C372(1.28)  LDD0943  [1]
 LDCM0346  AC80 HEK-293T C372(1.54)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C372(1.50)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C372(1.97)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C372(1.05)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C372(1.33)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C372(1.21)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C372(1.10)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C372(1.12)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C372(1.14)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C372(1.34)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C372(1.18)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C372(1.18)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C372(1.20)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C372(1.32)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C372(1.36)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C372(1.24)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C372(1.31)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C372(2.01)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C372(0.80)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C372(0.88)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C372(1.16)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C372(1.73)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C372(1.23)  LDD0873  [1]
 LDCM0367  CL1 HEK-293T C372(1.76)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C372(2.06)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C372(1.20)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C372(1.29)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C372(1.63)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C372(1.28)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C372(1.39)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C372(1.12)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C372(1.12)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C372(1.22)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C372(1.36)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C372(1.30)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C372(2.22)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C372(1.27)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C372(1.29)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C372(1.46)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C372(1.11)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C372(1.40)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C372(1.27)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C372(1.65)  LDD0984  [1]
 LDCM0387  CL117 HEK-293T C372(0.97)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C372(1.09)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C372(1.35)  LDD0987  [1]
 LDCM0390  CL12 HEK-293T C372(1.33)  LDD0988  [1]
 LDCM0391  CL120 HEK-293T C372(1.30)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C372(1.25)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C372(1.13)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C372(1.63)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C372(1.15)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C372(1.31)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C372(0.65)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C372(0.85)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C372(1.05)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C372(1.29)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C372(2.20)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C372(2.34)  LDD1000  [1]
 LDCM0407  CL2 HEK-293T C372(1.13)  LDD1005  [1]
 LDCM0418  CL3 HEK-293T C372(1.25)  LDD1016  [1]
 LDCM0420  CL31 HEK-293T C372(1.29)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C372(1.19)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C372(2.11)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C372(1.14)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C372(1.16)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C372(1.31)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C372(1.10)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C372(2.35)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C372(1.31)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C372(1.36)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C372(2.04)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C372(1.52)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C372(1.70)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C372(1.11)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C372(1.98)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C372(1.23)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C372(1.12)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C372(1.13)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C372(1.20)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C372(1.50)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C372(1.54)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C372(1.35)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C372(0.86)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C372(1.10)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C372(1.55)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C372(1.23)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C372(1.04)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C372(1.47)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C372(1.14)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C372(1.27)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C372(1.48)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C372(1.58)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C372(1.41)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C372(1.29)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C372(1.35)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C372(1.44)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C372(1.13)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C372(1.33)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C372(1.12)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C372(1.37)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C372(1.28)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C372(1.73)  LDD1060  [1]
 LDCM0463  CL70 HEK-293T C372(1.19)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C372(1.32)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C372(1.06)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C372(1.67)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C372(1.65)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C372(0.86)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C372(1.13)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C372(0.76)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C372(0.83)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C372(1.15)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C372(0.81)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C372(0.97)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C372(0.96)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C372(1.15)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C372(0.96)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C372(0.84)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C372(0.86)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C372(0.87)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C372(1.04)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C372(0.87)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C372(1.14)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C372(1.30)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C372(0.94)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C372(1.34)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C372(1.15)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C372(1.47)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C372(1.55)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C372(0.99)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C372(1.10)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C372(1.13)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C372(1.11)  LDD1092  [1]
 LDCM0468  Fragment33 HEK-293T C372(1.75)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C372(1.07)  LDD1025  [1]
 LDCM0022  KB02 ICC10 C2190(2.25)  LDD2379  [4]
 LDCM0023  KB03 ICC10 C2190(3.28)  LDD2796  [4]
 LDCM0024  KB05 ICC10 C2190(2.89)  LDD3213  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coagulation factor VIII (F8) Multicopper oxidase family P00451
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) . Q76LX8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Achaete-scute homolog 4 (ASCL4) . Q6XD76
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor-like protein 8 (EGFL8) . Q99944
Platelet glycoprotein Ib alpha chain (GP1BA) . P07359
TP53-binding protein 1 (TP53BP1) . Q12888
von Willebrand factor (VWF) . P04275

The Drug(s) Related To This Target

Approved
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Caplacizumab Antibody DUCA08
Antihemophilic Factor Human Recombinant BiotechDrug DB00025
Vonvendi Recombinant protein D4Y0SB
Antihemophilic Factor (Recombinant) Pegylated . DB09329
Efmoroctocog Alfa . DB11607
Lonoctocog Alfa . DB13998
Moroctocog Alfa . DB13999
Rurioctocog Alfa Pegol . DB16007
Simoctocog Alfa . DB09108
Susoctocog Alfa . DB11606
Turoctocog Alfa Pegol . DB14738
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alx-0081 . D08POF
Recombinant Von Willebrand Factor/Recombinant Factor Viii Complex . D0B3XG
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Arc1779 Small molecular drug DH8FY6
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Da-697b . D0HX1T
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Auryntricarboxylic Acid (Ata) Small molecular drug D0F1EF
Egaptivon Pegol . DB05202
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mitoflaxone Small molecular drug D0KN7H

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840