Details of the Target

General Information of Target

Target ID LDTP01780
Target Name Coagulation factor XIII A chain (F13A1)
Gene Name F13A1
Gene ID 2162
Synonyms
F13A; Coagulation factor XIII A chain; Coagulation factor XIIIa; EC 2.3.2.13; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Transglutaminase superfamily, Transglutaminase family
Subcellular location
Cytoplasm
Function
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
TTD ID
T66925
Uniprot ID
P00488
DrugMap ID
TTXI2RA
Ensemble ID
ENST00000264870.8
HGNC ID
HGNC:3531
ChEMBL ID
CHEMBL4530

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K258(1.15)  LDD3494  [1]
IPM
 Probe Info  		C328(2.01)  LDD1702  [2]
DBIA
 Probe Info  		C410(0.86)  LDD0531  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C410(0.86)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C410(1.26)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C410(0.94)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C410(1.10)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C410(1.26)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C410(1.37)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C410(0.91)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C410(0.72)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C410(0.34)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C410(1.00)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C410(0.04)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C410(0.07)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C410(0.08)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C410(0.18)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C410(0.32)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C410(0.72)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C410(4.42)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C410(2.70)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C410(2.72)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C410(2.56)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C410(1.14)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C410(3.18)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C410(2.91)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C410(3.72)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C410(1.87)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C410(1.10)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C410(1.28)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C410(3.40)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C410(4.53)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C410(0.49)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C410(3.35)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C410(0.08)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C410(0.26)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C410(2.80)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C410(3.16)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C410(3.04)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C410(0.30)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C410(2.39)  LDD0624  [3]
 LDCM0312  AC5 HCT 116 C410(0.29)  LDD0629  [3]
 LDCM0323  AC6 HCT 116 C410(0.11)  LDD0640  [3]
 LDCM0334  AC7 HCT 116 C410(0.31)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C410(0.12)  LDD0662  [3]
 LDCM0248  AKOS034007472 HCT 116 C410(1.49)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C410(1.18)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C410(1.34)  LDD0592  [3]
 LDCM0369  CL100 HCT 116 C410(1.20)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C410(0.24)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C410(1.56)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C410(0.11)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C410(1.17)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C410(0.56)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C410(0.03)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C410(0.54)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C410(13.64)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C410(0.16)  LDD0695  [3]
 LDCM0380  CL110 HCT 116 C410(0.97)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C410(0.78)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C410(2.99)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C410(1.16)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C410(3.09)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C410(1.51)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C410(2.86)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C410(4.37)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C410(2.89)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C410(1.77)  LDD0706  [3]
 LDCM0391  CL120 HCT 116 C410(6.28)  LDD0708  [3]
 LDCM0420  CL31 HCT 116 C410(1.45)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C410(2.91)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C410(1.35)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C410(1.03)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C410(2.30)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C410(2.16)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C410(4.01)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C410(2.32)  LDD0745  [3]
 LDCM0430  CL40 HCT 116 C410(1.71)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C410(1.37)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C410(2.40)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C410(3.43)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C410(1.95)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C410(0.99)  LDD0752  [3]
 LDCM0453  CL61 HCT 116 C410(1.56)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C410(1.46)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C410(2.33)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C410(0.42)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C410(1.91)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C410(1.53)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C410(1.94)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C410(2.19)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C410(2.53)  LDD0778  [3]
 LDCM0463  CL70 HCT 116 C410(0.35)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C410(1.80)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C410(1.54)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C410(1.66)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C410(1.65)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C410(1.04)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C410(1.08)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C410(1.18)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C410(1.37)  LDD0789  [3]
 LDCM0474  CL80 HCT 116 C410(1.04)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C410(1.16)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C410(0.47)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C410(1.71)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C410(0.20)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C410(1.31)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C410(0.30)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C410(0.72)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C410(0.37)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C410(0.26)  LDD0800  [3]
 LDCM0485  CL90 HCT 116 C410(0.80)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C410(1.22)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C410(0.90)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C410(0.93)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C410(0.44)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C410(1.39)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C410(1.14)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C410(1.03)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C410(0.96)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C410(0.89)  LDD0811  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C328(2.01)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C410(1.63)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C410(3.10)  LDD0744  [3]
 LDCM0022  KB02 697 C410(1.54)  LDD2245  [4]
 LDCM0023  KB03 786-O C410(3.12)  LDD2664  [4]
 LDCM0024  KB05 MOLM-16 C410(2.64); C328(1.71)  LDD3334  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) Archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family P19388
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) Tim17/Tim22/Tim23 family O60830
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76) . Q96EF9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epithelial splicing regulatory protein 1 (ESRP1) ESRP family Q6NXG1
Protein FAM163A (FAM163A) FAM163 family Q96GL9
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Cell division cycle-associated protein 4 (CDCA4) . Q9BXL8
Epidermal growth factor-like protein 8 (EGFL8) . Q99944
Galectin-9C (LGALS9C) . Q6DKI2
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Telethonin (TCAP) . O15273

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-glutamine Small molecular drug DB00130
Anti-inhibitor Coagulant Complex . DB13151
Human Thrombin . DB11571
Prothrombin . DB11311
Thrombin . DB11300
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-acetyl-serine . DB02340
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid26560530-compound-13 Small molecular drug D0KK6L

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840