Details of the Target

General Information of Target

Target ID LDTP01669
Target Name Polypyrimidine tract-binding protein 3 (PTBP3)
Gene Name PTBP3
Gene ID 9991
Synonyms
ROD1; Polypyrimidine tract-binding protein 3; Regulator of differentiation 1; Rod1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTANGNDSKKFKRDRPPCSPSRV
LHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPH
LRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSP
VLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALD
GQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGI
ISSPYAGAAGFAPAIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVL
LVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRL
YGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLS
NIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGEN
HHLRVSFSKSTI
Target Bioclass
Other
Function
RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).
Uniprot ID
O95758
Ensemble ID
ENST00000334318.10
HGNC ID
HGNC:10253

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K431(10.00); K506(8.75)  LDD0277  [1]
BTD
 Probe Info  		C55(1.04)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C68(3.63)  LDD0168  [3]
DBIA
 Probe Info  		C248(53.33); C55(195.45)  LDD0209  [4]
HHS-465
 Probe Info  		Y265(10.00)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0233  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		C500(0.00); C68(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C68(0.00); C500(0.00); C55(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
SF
 Probe Info  		K269(0.00); K461(0.00); Y127(0.00); K257(0.00)  LDD0028  [13]
VSF
 Probe Info  		N.A.  LDD0007  [11]
W1
 Probe Info  		N.A.  LDD0236  [14]
NAIA_5
 Probe Info  		C55(0.00); C68(0.00); C500(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.75  LDD0476  [15]
FFF probe2
 Probe Info  		5.89  LDD0463  [15]
STS-1
 Probe Info  		N.A.  LDD0136  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C55(0.97)  LDD2112  [2]
 LDCM0025  4SU-RNA HEK-293T C68(3.63)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C68(4.74)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C68(1.14); C55(0.82); C500(0.93); C248(0.95)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C68(1.25); C55(0.91); C248(0.90)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C68(1.08); C55(0.90); C500(0.98); C248(1.07)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C68(1.09); C55(0.92); C248(0.92)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C68(0.93); C55(0.94); C500(1.04); C248(0.88)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C68(1.03); C55(0.93); C500(0.92)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C68(1.08); C55(0.91); C500(1.04); C248(0.95)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C68(1.10); C55(0.94); C248(1.01)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C68(0.92); C55(0.88); C500(0.83); C248(0.77)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C68(1.14); C55(0.90); C248(0.91)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C68(1.05); C55(0.93); C248(0.94)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C68(1.06); C55(1.02); C248(0.96)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C68(1.02); C55(0.97); C500(1.11); C248(0.93)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C68(0.98); C55(0.98); C500(0.92)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C68(1.03); C55(1.05); C500(0.96); C248(1.00)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C68(1.13); C55(0.85); C500(0.96); C248(1.00)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C68(1.08); C55(0.95); C248(1.07)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C68(1.04); C55(0.88); C500(1.12); C248(1.06)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C68(1.07); C55(0.88); C248(0.95)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C68(1.13); C55(0.97); C248(0.96)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C68(1.07); C55(0.88); C500(0.95); C248(1.04)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C68(0.96); C55(0.99); C500(1.05); C248(0.88)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C68(0.99); C55(0.97); C500(0.88)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C68(1.04); C55(0.92); C500(0.84); C248(0.99)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C68(0.97); C55(0.87); C500(0.98); C248(1.03)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C68(1.10); C55(1.01); C248(0.94)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C68(1.03); C55(0.88); C500(0.96); C248(1.05)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C68(1.06); C55(0.94); C248(0.90)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C68(0.99); C55(1.02); C248(0.99)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C68(0.90); C55(0.97); C500(0.97); C248(1.03)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C68(1.05); C55(1.00); C500(0.96)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C68(1.06); C55(0.92); C248(0.96)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C68(0.96); C55(0.95); C500(1.02); C248(0.94)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C68(1.04); C55(0.92); C500(0.94); C248(1.02)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C68(1.23); C55(0.91); C248(0.80)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C68(1.00); C55(0.89); C500(1.01); C248(1.12)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C68(0.95); C55(0.90); C248(0.91)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C68(1.10); C55(0.99); C248(0.89)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C68(0.99); C55(1.01); C500(1.12); C248(0.95)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C68(1.13); C55(0.97); C500(0.98)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C68(1.04); C55(0.93); C500(0.94); C248(1.07)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C68(1.10); C55(0.87); C500(1.00); C248(0.96)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C68(0.98); C55(1.04); C248(1.08)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C68(1.17); C55(0.97); C248(0.99)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C68(1.01); C55(0.94); C500(1.05); C248(0.99)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C68(0.97); C55(0.86); C248(0.88)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C68(1.06); C55(0.98); C248(1.04)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C68(0.97); C55(0.96); C500(1.10); C248(0.88)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C68(0.99); C55(0.98); C500(0.97)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C68(1.01); C55(0.99); C500(0.89); C248(1.01)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C68(1.11); C55(0.85); C500(0.94); C248(1.00)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C68(1.14); C55(0.94); C248(0.82)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C68(1.06); C55(0.88); C500(0.93); C248(1.02)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C68(0.89); C55(0.92); C500(1.10); C248(1.01)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C68(1.05); C55(0.86); C248(0.90)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C68(1.04); C55(0.96); C248(0.99)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C68(0.96); C55(0.99); C500(1.10); C248(1.13)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C68(1.10); C55(1.01); C500(0.88)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C68(1.04); C55(0.98); C500(1.05); C248(1.06)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C68(0.99); C55(1.02); C500(0.97)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C68(0.96); C55(1.09); C500(0.98); C248(0.99)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C68(1.05); C55(1.02); C248(0.90)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C68(1.05); C55(0.85); C500(1.02); C248(1.04)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C68(0.99); C55(0.97); C500(0.96); C248(0.93)  LDD1514  [17]
 LDCM0630  CCW28-3 231MFP C68(1.57)  LDD2214  [18]
 LDCM0632  CL-Sc Hep-G2 C68(1.06); C55(0.87)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C68(1.01); C55(0.80); C500(0.98); C248(1.16)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C68(0.84); C55(0.85); C500(1.08); C248(0.98)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C68(1.20); C55(1.03); C500(1.02); C248(0.86)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C68(1.03); C55(0.91); C500(0.98); C248(0.95)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C68(1.10); C55(0.77); C248(0.83)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C68(1.00); C55(0.93); C500(0.97); C248(0.86)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C68(1.12); C55(1.02); C500(1.17); C248(0.99)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C68(0.98); C55(0.88); C500(0.98); C248(0.97)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C68(0.97); C55(0.82); C248(0.98)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C68(0.90); C55(0.95); C500(1.01); C248(0.91)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C68(1.07); C55(0.96); C500(1.18); C248(0.90)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C68(1.10); C55(0.88); C500(1.01); C248(1.04)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C68(0.83); C55(0.98); C500(1.01)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C68(0.86); C55(0.86); C248(0.83)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C68(1.00); C55(0.92); C500(0.96); C248(0.85)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C68(1.10); C55(1.01); C500(0.99); C248(0.95)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C68(1.12); C55(0.89); C500(1.06); C248(0.97)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C68(1.00); C55(1.26); C248(0.88)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C68(1.01); C55(0.96); C500(1.02); C248(1.00)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C68(1.09); C55(0.98); C500(1.16); C248(0.91)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C68(1.05); C55(0.89); C500(1.05); C248(0.97)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C68(1.03); C55(0.82); C248(0.99)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C68(0.97); C55(0.96); C500(1.06); C248(1.02)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C68(0.92); C55(1.00); C500(1.32); C248(0.98)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C68(1.02); C55(0.98); C500(1.05); C248(0.90)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C68(1.02); C55(0.92); C500(1.05); C248(0.95)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C68(1.05); C55(0.81); C248(0.85)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C68(1.00); C55(0.89); C500(1.03); C248(0.89)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C68(1.17); C55(0.97); C500(1.07); C248(0.86)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C68(0.97); C55(0.94); C500(1.00); C248(1.04)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C68(1.10); C55(0.87); C248(0.82)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C68(1.02); C55(0.93); C500(1.04); C248(0.98)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C68(1.23); C55(1.01); C500(1.13); C248(0.91)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C68(1.02); C55(0.86); C500(0.86); C248(0.98)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C68(0.98); C55(0.73); C248(0.96)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C68(0.97); C55(0.81); C500(0.84); C248(1.11)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C68(1.04); C55(1.02); C500(1.28); C248(1.01)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C68(0.94); C55(0.83); C500(0.88); C248(1.01)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C68(0.89); C55(0.99); C248(0.93)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C68(0.84); C55(0.97); C500(1.04); C248(1.14)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C68(1.06); C55(0.78); C248(0.88)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C68(0.72); C55(1.09); C248(0.98)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C68(0.85); C55(0.95); C248(1.01)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C68(0.90); C55(1.04); C500(1.15); C248(0.97)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C68(0.78); C55(1.09); C500(1.28)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C68(0.83); C55(1.11); C500(0.84); C248(0.89)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C68(0.87); C55(0.88); C500(0.87); C248(1.00)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C68(1.05); C55(1.04); C248(0.91)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C68(0.99); C55(0.98); C500(0.99); C248(0.92)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C68(1.13); C55(1.05); C500(1.01); C248(0.89)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C68(0.96); C55(0.89); C500(1.03); C248(1.08)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C68(1.02); C55(0.84); C500(0.91); C248(0.99)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C68(0.93); C55(1.00); C248(1.00)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C68(0.89); C55(1.03); C500(1.04); C248(1.09)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C68(0.87); C55(1.15); C248(0.88)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C68(0.78); C55(0.86); C248(0.81)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C68(0.95); C55(1.01); C500(1.18); C248(1.04)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C68(0.84); C55(1.06); C500(1.01)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C68(0.85); C55(1.05); C500(1.07); C248(0.89)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C68(0.94); C55(0.95); C500(0.93); C248(1.05)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C68(1.01); C55(0.93); C500(0.94); C248(0.92)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C68(1.02); C55(0.95); C500(1.03); C248(0.95)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C68(1.02); C55(1.10); C500(1.03); C248(0.89)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C68(1.01); C55(0.90); C500(1.10); C248(1.08)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C68(0.94); C55(0.99); C248(1.02)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C68(0.82); C55(0.96); C500(1.22); C248(1.00)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C68(0.83); C55(1.07); C248(0.99)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C68(0.81); C55(0.96); C248(0.99)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C68(0.98); C55(1.14); C500(1.17); C248(0.98)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C68(0.80); C55(1.08); C500(1.02)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C68(0.93); C55(1.02); C500(1.00); C248(1.08)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C68(0.90); C55(0.91); C500(0.98); C248(1.05)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C68(1.06); C55(0.93); C500(0.92); C248(1.08)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C68(0.95); C55(0.83); C248(0.93)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C68(1.04); C55(0.97); C500(1.06); C248(0.96)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C68(0.93); C55(0.90); C500(0.88); C248(0.99)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C68(0.82); C55(0.82); C248(0.91)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C68(0.87); C55(1.05); C500(0.95); C248(1.04)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C68(0.86); C55(1.06); C248(1.05)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C68(0.82); C55(0.95); C248(1.00)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C68(0.87); C55(1.04); C500(1.28); C248(1.00)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C68(0.73); C55(1.04); C500(1.26)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C68(0.94); C55(0.93); C248(1.07)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C68(0.88); C55(1.00); C500(0.88); C248(0.95)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C68(0.97); C55(0.90); C500(0.97); C248(1.05)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C68(1.10); C55(0.83); C248(0.93)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C68(0.98); C55(0.99); C500(0.98); C248(1.07)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C68(0.98); C55(0.99); C500(1.00); C248(0.91)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C68(1.04); C55(0.92); C500(0.89); C248(1.04)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C68(0.98); C55(0.94); C248(1.05)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C68(0.92); C55(1.00); C500(1.02); C248(1.16)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C68(0.78); C55(1.08); C248(0.99)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C68(0.92); C55(0.99); C248(0.98)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C68(0.90); C55(0.98); C500(0.91); C248(0.98)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C68(0.92); C55(1.09); C500(1.15); C248(0.92)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C68(0.77); C55(1.13); C500(1.11)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C68(0.97); C55(0.97); C500(1.15); C248(0.93)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C68(0.96); C55(0.83); C500(1.00); C248(0.99)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C68(1.09); C55(1.28); C248(0.87)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C68(1.10); C55(1.01); C500(1.08); C248(1.06)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C68(1.05); C55(0.89); C500(1.06); C248(0.99)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C68(0.97); C55(0.92); C248(1.03)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C68(0.88); C55(1.02); C500(1.13); C248(1.26)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C68(0.75); C55(0.80); C248(0.85)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C68(0.86); C55(1.11); C248(1.04)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C68(0.90); C55(1.04); C248(0.98)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C68(0.95); C55(1.09); C500(1.09); C248(1.05)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C68(0.86); C55(1.05); C500(1.04)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C68(0.89); C55(1.01); C500(1.03); C248(0.93)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C68(0.91); C55(0.89); C500(0.96); C248(0.96)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C68(1.20); C55(0.87); C248(0.82)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C68(1.10); C55(0.94); C500(0.94); C248(0.90)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C68(1.19); C55(1.07); C500(1.08); C248(0.92)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C68(1.10); C55(0.83); C500(1.02); C248(0.95)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C68(0.89); C55(1.03); C248(1.07)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C68(0.95); C55(0.77); C248(0.84)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C68(0.95); C55(0.99); C500(1.01); C248(1.12)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C68(0.93); C55(0.97); C248(0.89)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C68(0.88); C55(0.98); C248(0.92)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C68(1.03); C55(1.06); C500(1.10); C248(0.98)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C68(0.84); C55(0.95); C500(0.84)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C68(1.03); C55(0.91); C500(0.80); C248(1.08)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C68(1.04); C55(0.88); C500(0.90); C248(1.04)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C68(1.08); C55(0.92); C248(0.86)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C68(0.98); C55(0.94); C500(0.94); C248(0.97)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C68(0.90); C55(0.96); C500(1.00); C248(1.05)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C55(1.80); C500(1.74)  LDD1702  [2]
 LDCM0625  F8 Ramos C55(1.11); C68(1.08)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C55(0.82)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C55(0.48); C68(1.08)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C55(0.58); C68(0.34)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C55(0.94); C68(0.68)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C55(0.84); C68(1.06)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C55(0.71); C68(0.37)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C55(0.97); C68(1.51)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C55(0.71)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C55(1.01)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C55(0.47); C68(0.55)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C55(1.22); C68(0.30)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C55(0.83); C68(0.38)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C55(0.77); C68(0.47)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C68(1.02); C55(0.96); C500(1.02); C248(0.99)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C55(0.89); C68(0.46)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C55(0.80); C68(1.02)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C68(1.10); C55(0.89); C248(0.97)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C55(1.38); C68(0.22)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C55(1.47); C68(0.79)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C55(0.63); C68(1.18)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C55(0.71); C68(0.45)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C55(1.08); C68(1.15); C248(0.99)  LDD1492  [17]
 LDCM0023  KB03 Jurkat C248(53.33); C55(195.45)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C506(1.57)  LDD3310  [20]
 LDCM0109  NEM HeLa N.A.  LDD0233  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C55(0.91)  LDD2098  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C55(0.99)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C55(1.11)  LDD2105  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C55(0.84)  LDD2108  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C55(1.40)  LDD2110  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C55(0.78)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C55(0.87)  LDD2114  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C55(0.85)  LDD2129  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C55(1.04)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C500(0.56)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C55(0.79)  LDD2141  [2]

References

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Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD044402
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840