Details of the Target

General Information of Target

Target ID LDTP01632
Target Name Histidine protein methyltransferase 1 homolog (METTL18)
Gene Name METTL18
Gene ID 92342
Synonyms
ASTP2; C1orf156; Histidine protein methyltransferase 1 homolog; EC 2.1.1.85; Arsenic-transactivated protein 2; AsTP2; Methyltransferase-like protein 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHL
WEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIET
LPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFT
KAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDE
ENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPD
YYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKIIDEGLK
RFIIEITFKFPG
Target Bioclass
Enzyme
Family
Methyltransferase superfamily, METTL18 family
Subcellular location
Cytoplasm, cytosol
Function
Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins.
Uniprot ID
O95568
Ensemble ID
ENST00000303469.6
HGNC ID
HGNC:28793

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C48(1.71)  LDD3342  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C196(0.52)  LDD1093  [5]
 LDCM0215  AC10 HEK-293T C48(1.13); C196(1.12)  LDD1508  [6]
 LDCM0216  AC100 HEK-293T C274(1.07)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C274(1.01)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C274(1.07)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C274(1.20)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C274(1.08)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C274(0.99)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C274(0.90)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C274(1.03)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C274(0.95)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C274(0.97)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C48(1.02); C196(1.01)  LDD1509  [6]
 LDCM0227  AC110 HEK-293T C274(1.35)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C274(1.79)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C274(1.54)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C274(0.89)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C274(0.92)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C274(0.97)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C274(1.00)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C274(1.11)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C274(1.15)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C274(1.07)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C48(1.15); C196(1.07)  LDD1510  [6]
 LDCM0238  AC120 HEK-293T C274(1.09)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C274(1.12)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C274(1.24)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C274(1.30)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C274(0.97)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C274(1.16)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C274(1.67)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C274(1.59)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C274(0.97)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C274(1.14)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C274(1.10)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C274(0.98)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C274(1.09)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C274(1.23)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C274(1.17)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C274(1.22)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C274(1.27)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C274(1.38)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C274(1.72)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C274(1.46)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C196(1.09)  LDD1512  [6]
 LDCM0260  AC140 HEK-293T C274(1.28)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C274(1.43)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C274(1.33)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C274(1.14)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C274(1.47)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C274(1.44)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C274(1.40)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C274(1.52)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C274(1.54)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C274(1.08)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C48(1.19); C196(1.11)  LDD1513  [6]
 LDCM0271  AC150 HEK-293T C274(1.24)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C274(1.38)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C274(1.18)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C274(1.23)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C274(1.08)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C274(1.12)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C274(1.43)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C274(1.74)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C48(1.06); C196(1.06)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C48(1.09); C196(1.05)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C48(0.98); C196(0.98)  LDD1517  [6]
 LDCM0279  AC2 PaTu 8988t C196(0.57)  LDD1158  [5]
 LDCM0280  AC20 HEK-293T C48(1.03); C196(1.01)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C48(1.05); C196(1.20)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C196(1.31)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C48(1.11); C196(1.40)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C48(1.15); C196(0.95)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C274(1.16)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C274(1.18)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C274(1.06)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C274(1.32)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C274(1.16)  LDD0887  [5]
 LDCM0290  AC3 PaTu 8988t C196(0.59)  LDD1169  [5]
 LDCM0291  AC30 HEK-293T C274(1.13)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C274(0.99)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C274(1.11)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C274(1.09)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C274(1.04)  LDD0893  [5]
 LDCM0296  AC35 PaTu 8988t C196(0.65)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C196(0.55)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C196(0.74)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C196(0.63)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C196(0.59)  LDD1179  [5]
 LDCM0301  AC4 PaTu 8988t C196(0.64)  LDD1180  [5]
 LDCM0302  AC40 PaTu 8988t C196(0.68)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C196(0.97)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C196(0.89)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C196(0.83)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C196(0.81)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C196(0.95)  LDD1186  [5]
 LDCM0308  AC46 HEK-293T C274(0.95)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C274(1.02)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C274(1.01)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C274(1.02)  LDD0909  [5]
 LDCM0312  AC5 PaTu 8988t C196(0.56)  LDD1191  [5]
 LDCM0313  AC50 HEK-293T C274(1.12)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C274(1.12)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C274(1.17)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C274(0.94)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C274(1.05)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C274(0.98)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C274(1.05)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C274(1.09)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C274(1.01)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C274(1.07)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C196(1.13)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C274(1.21)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C274(1.17)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C274(1.22)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C274(1.12)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C274(1.12)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C274(1.26)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C274(1.25)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C274(1.18)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C274(1.07)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C274(1.15)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C48(1.18); C196(1.21)  LDD1568  [6]
 LDCM0335  AC70 HEK-293T C274(1.23)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C274(1.19)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C274(1.14)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C274(1.10)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C274(1.22)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C274(1.22)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C274(1.17)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C274(1.15)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C274(1.13)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C274(1.06)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C48(1.14); C196(0.98)  LDD1569  [6]
 LDCM0346  AC80 HEK-293T C274(1.20)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C274(1.06)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C274(1.36)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C274(1.31)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C274(1.35)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C274(1.19)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C274(1.16)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C274(1.07)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C274(1.18)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C274(1.33)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C274(1.12)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C274(1.07)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C274(1.20)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C274(1.36)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C274(1.40)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C274(1.30)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C274(1.48)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C274(2.12)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C274(0.98)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C274(0.97)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C48(1.15); C196(0.97)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C48(1.08); C196(0.88)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C48(1.24); C196(1.03)  LDD1514  [6]
 LDCM0632  CL-Sc Hep-G2 C48(0.97)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C274(0.97)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C274(1.64)  LDD0966  [5]
 LDCM0369  CL100 PaTu 8988t C196(0.52)  LDD1248  [5]
 LDCM0370  CL101 HEK-293T C48(1.00)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C48(0.93); C196(1.08)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C48(1.11); C196(1.22)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C48(0.99); C196(0.99)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C48(1.04)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C48(0.97); C196(0.90)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C48(1.07); C196(1.03)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C48(1.07); C196(1.11)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C48(0.96)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C274(1.66)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C48(0.99); C196(1.06)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C48(0.94); C196(0.94)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C274(1.04)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C274(1.11)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C274(1.43)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C274(1.14)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C274(1.25)  LDD0984  [5]
 LDCM0387  CL117 PaTu 8988t C196(1.03)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C196(1.08)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C196(0.86)  LDD1268  [5]
 LDCM0390  CL12 HEK-293T C274(0.98)  LDD0988  [5]
 LDCM0391  CL120 PaTu 8988t C196(0.68)  LDD1270  [5]
 LDCM0392  CL121 HEK-293T C274(1.03)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C274(1.07)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C274(1.00)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C274(0.96)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C274(1.01)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C274(0.98)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C274(1.07)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C274(1.02)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C274(1.12)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C274(1.13)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C274(1.43)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C274(1.04)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C274(1.12)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C274(1.22)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C274(1.17)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C274(1.12)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C274(1.11)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C274(1.38)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C274(1.20)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C274(1.16)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C274(1.05)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C274(1.14)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C274(1.03)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C274(1.10)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C274(1.06)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C274(1.10)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C274(0.97)  LDD1016  [5]
 LDCM0419  CL30 HEK-293T C274(1.27)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C274(0.96)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C274(1.08)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C274(1.22)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C274(0.94)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C274(0.99)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C274(1.08)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C274(1.18)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C274(1.52)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C274(1.04)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C274(1.04)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C274(1.35)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C274(1.28)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C274(1.55)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C274(1.13)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C274(1.42)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C196(1.13)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C48(1.11); C196(1.29)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C48(0.96); C196(0.88)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C48(1.01)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C274(1.13)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C48(1.08); C196(0.95)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C48(1.15); C196(0.91)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C48(0.93); C196(0.67)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C48(0.94); C196(0.93)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C48(1.03); C196(1.12)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C48(0.98); C196(1.48)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C48(1.10); C196(1.25)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C196(1.42)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C48(1.07); C196(1.32)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C274(1.17)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C48(1.11); C196(0.84)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C274(0.91)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C274(0.70)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C274(1.24)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C274(1.27)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C274(0.81)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C274(1.04)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C274(1.01)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C274(1.03)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C274(0.97)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C274(1.18)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C274(1.13)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C274(1.06)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C274(0.82)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C274(0.84)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C274(1.42)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C274(0.97)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C274(0.98)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C274(0.84)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C274(1.22)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C274(1.22)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C274(1.02)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C274(1.08)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C274(1.36)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C274(0.98)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C274(0.76)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C274(0.72)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C274(0.78)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C274(1.23)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C274(1.01)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C274(1.13)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C274(1.52)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C274(1.21)  LDD1083  [5]
 LDCM0486  CL91 PaTu 8988t C196(0.68)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C196(0.52)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C196(0.60)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C196(0.65)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C196(0.46)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C196(0.50)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C196(0.65)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C196(0.52)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C196(0.52)  LDD1373  [5]
 LDCM0495  E2913 HEK-293T C48(1.10); C196(1.31)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C274(0.81)  LDD1066  [5]
 LDCM0427  Fragment51 HEK-293T C274(1.02)  LDD1025  [5]
 LDCM0022  KB02 A-375 C48(1.71)  LDD2255  [1]
 LDCM0023  KB03 A-375 C48(1.40)  LDD2672  [1]
 LDCM0024  KB05 NCI-H1155 C48(1.71)  LDD3342  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402