Details of the Target

General Information of Target

Target ID LDTP01297
Target Name Gap junction beta-3 protein (GJB3)
Gene Name GJB3
Gene ID 2707
Synonyms
CX31; Gap junction beta-3 protein; Connexin-31; Cx31
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGC
TNVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCAKLYDNA
GKKHGGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIAR
PTEKKIFTYFMVGASAVCIVLTICELCYLICHRVLRGLHKDKPRGGCSPSSSASRASTCR
CHHKLVEAGEVDPDPGNNKLQASAPNLTPI
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Connexin family, Beta-type (group I) subfamily
Subcellular location
Cell membrane
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
TTD ID
T16326
Uniprot ID
O75712
DrugMap ID
TTVRQ8L
Ensemble ID
ENST00000373362.3
HGNC ID
HGNC:4285

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C113(0.86)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C113(0.86)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C227(1.10); C113(1.14)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C227(1.11); C113(1.03)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C227(1.15); C113(0.86)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C227(1.13); C113(1.23)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C113(1.08); C227(1.24)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C227(1.64)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C227(0.93)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C227(1.44)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C113(0.98)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C227(0.99)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C227(1.41)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C227(1.51)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C227(1.57)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C227(1.00)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C227(0.48); C113(1.00)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C227(0.53); C113(1.23)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C227(0.68); C113(1.31)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C227(0.57); C113(1.12)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C227(0.70); C113(1.26)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C113(1.04)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C227(0.59); C113(1.22)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C227(0.58); C113(1.22)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C227(0.63); C113(1.42)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C227(0.92); C113(1.26)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C227(0.75); C113(1.33)  LDD0612  [1]
 LDCM0296  AC35 PaTu 8988t C113(1.17)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C113(1.34)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C113(1.23)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C113(1.25)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C113(1.36)  LDD1179  [1]
 LDCM0301  AC4 HCT 116 C113(1.05)  LDD0618  [1]
 LDCM0302  AC40 PaTu 8988t C113(1.39)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C113(1.03)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C113(1.06)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C113(1.15)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C113(1.15)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C113(1.02)  LDD1186  [1]
 LDCM0308  AC46 HCT 116 C227(0.63)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C227(1.77)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C227(1.06)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C227(1.48)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C113(1.01)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C227(1.09)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C227(0.78)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C227(0.80)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C227(1.41)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C227(1.04)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C227(1.61)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C227(2.31)  LDD0636  [1]
 LDCM0323  AC6 HCT 116 C113(1.16); C227(1.67)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C113(0.92); C227(1.38)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C113(0.96); C227(1.03)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C227(3.99)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C227(1.30)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C227(2.46)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C227(2.78)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C227(2.22)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C227(3.13)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C227(3.27)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C227(6.52)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C227(7.20)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C227(2.21)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C227(2.64)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C227(2.59)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C227(5.08)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C227(4.36)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C227(4.00)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C227(1.22); C113(1.02)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C113(0.99); C227(1.11)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C113(1.30); C227(1.39)  LDD0592  [1]
 LDCM0369  CL100 HCT 116 C113(0.89)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C227(0.88); C113(1.32)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C227(1.02); C113(1.19)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C227(0.82); C113(0.94)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C113(0.96); C227(1.33)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C227(0.86)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C227(1.37)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C227(1.21)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C227(1.29)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C227(1.66)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C227(1.31)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C227(1.44)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C227(0.74); C113(0.92)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C227(0.93); C113(1.27)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C227(0.73); C113(0.97)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C227(0.49); C113(1.21)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C227(0.85); C113(1.30)  LDD0703  [1]
 LDCM0387  CL117 PaTu 8988t C113(1.14)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C113(1.02)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C113(1.14)  LDD1268  [1]
 LDCM0391  CL120 PaTu 8988t C113(1.34)  LDD1270  [1]
 LDCM0392  CL121 HCT 116 C227(0.80)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C227(1.40)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C227(1.57)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C227(2.09)  LDD0712  [1]
 LDCM0403  CL16 HCT 116 C113(1.26); C227(1.37)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C113(1.16); C227(2.10)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C227(1.14); C113(1.21)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C113(1.23); C227(1.28)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C113(1.29); C227(1.53)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C227(1.36); C113(1.39)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C113(1.97); C227(2.50)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C113(1.21); C227(1.81)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C113(1.49); C227(2.49)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C227(1.33); C113(1.21)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C227(1.93); C113(1.23)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C227(1.63); C113(1.24)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C227(1.45); C113(1.15)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C227(1.84); C113(1.48)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C227(1.16); C113(1.10)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C227(1.56)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C227(2.37)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C227(1.22)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C227(2.16)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C227(1.92)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C227(1.63)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C227(2.13)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C227(2.28)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C227(1.49)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C227(2.01)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C227(3.73)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C227(1.87)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C227(1.49)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C227(2.31)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C113(1.18)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C113(1.20)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C113(1.17)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C113(1.22)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C113(1.15)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C113(1.20)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C113(1.18)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C113(0.99)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C113(1.04)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C113(0.99)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C113(0.95)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C113(1.03)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C113(1.00)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C113(0.92)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C113(0.99)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C227(1.86)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C227(1.82)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C227(1.77)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C227(1.72)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C227(1.49)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C227(1.07)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C227(1.45)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C227(1.03)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C227(1.84)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C227(1.15)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C227(1.48)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C227(1.36)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C227(1.30)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C227(1.25)  LDD0784  [1]
 LDCM0469  CL76 PaTu 8988t C113(1.00)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C113(0.93)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C113(1.32)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C113(1.38)  LDD1351  [1]
 LDCM0474  CL80 PaTu 8988t C113(1.23)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C113(1.50)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C113(1.63)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C113(1.58)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C113(1.17)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C113(1.14)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C113(1.19)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C113(1.38)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C113(1.38)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C113(1.03)  LDD1362  [1]
 LDCM0485  CL90 PaTu 8988t C113(1.48)  LDD1364  [1]
 LDCM0486  CL91 HCT 116 C113(1.34)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C113(1.19)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C113(0.95)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C113(1.09)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C113(1.07)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C113(1.13)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C113(1.33)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C113(1.08)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C113(0.96)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C227(1.19)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C227(2.16)  LDD0744  [1]
 LDCM0022  KB02 A431 C227(1.35)  LDD2258  [3]
 LDCM0023  KB03 A431 C227(1.45)  LDD2675  [3]
 LDCM0024  KB05 MKN-1 C227(1.68)  LDD3331  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stress-associated endoplasmic reticulum protein 1 (SERP1) RAMP4 family Q9Y6X1
Protein reprimo (RPRM) Reprimo family Q9NS64
UNC93-like protein MFSD11 (MFSD11) Unc-93 family O43934
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2) . Q71RG4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Octanol Small molecular drug D00VJY

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840