Details of the Target

General Information of Target

Target ID LDTP00787
Target Name Mediator of RNA polymerase II transcription subunit 7 (MED7)
Gene Name MED7
Gene ID 9443
Synonyms
ARC34; CRSP9; Mediator of RNA polymerase II transcription subunit 7; hMED7; Activator-recruited cofactor 34 kDa component; ARC34; Cofactor required for Sp1 transcriptional activation subunit 9; CRSP complex subunit 9; Mediator complex subunit 7; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLE
SQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVH
HLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEA
GMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP
Target Bioclass
Other
Family
Mediator complex subunit 7 family
Subcellular location
Nucleus
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Uniprot ID
O43513
Ensemble ID
ENST00000286317.6
HGNC ID
HGNC:2378

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C197(2.51)  LDD0168  [1]
DBIA
 Probe Info  		C197(0.92)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C223(0.00); C167(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C197(2.51)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C197(2.96)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C223(1.04)  LDD1507  [7]
 LDCM0215  AC10 HCT 116 C197(1.56)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C197(0.90)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C197(0.99)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C197(0.96)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C197(1.55)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C197(1.08)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C197(1.49)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C197(1.53)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C197(0.76)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C197(1.45)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C197(1.13)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C197(2.03)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C197(1.22)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C197(1.33)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C197(0.80)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C197(1.02)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C197(1.11)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C197(1.45)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C197(1.30)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C197(1.10)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C197(0.95)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C197(0.95)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C197(1.17)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C197(0.79)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C197(1.12)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C197(1.08)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C197(1.06)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C197(0.81)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C197(1.10)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C197(1.61)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C197(1.38)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C197(1.46)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C197(1.02)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C197(1.58)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C197(1.41)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C197(1.10)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C197(1.68)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C197(1.69)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C197(1.30)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C197(1.94)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C197(1.56)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C197(1.06)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C197(1.17)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C197(2.63)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C197(1.12)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C197(1.21)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C197(1.42)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C197(1.06)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C197(0.60)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C197(0.56)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C197(0.67)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C167(0.87)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C197(0.56)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C197(0.99)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C197(0.80)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C197(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C197(0.64)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C223(1.07)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C167(0.88)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C167(0.70)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C167(1.16)  LDD1527  [7]
 LDCM0290  AC3 HEK-293T C167(0.88)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C167(1.15); C223(1.13)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C167(0.95); C223(0.79)  LDD1531  [7]
 LDCM0294  AC33 HEK-293T C223(1.23)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C167(1.00)  LDD1534  [7]
 LDCM0296  AC35 HCT 116 C197(0.77)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C197(0.91)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C197(1.23)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C197(1.01)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C197(1.12)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C167(1.00)  LDD1540  [7]
 LDCM0302  AC40 HCT 116 C197(1.38)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C197(0.81)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C197(1.41)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C197(1.25)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C197(1.00)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C197(1.52)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C197(1.18)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C197(1.36)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C197(1.40)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C197(1.44)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C197(2.54)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C197(1.05)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C197(1.42)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C197(1.50)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C197(2.19)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C197(2.21)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C197(2.58)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C197(0.80)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C197(1.25)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C197(1.09)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C197(2.45)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C197(1.20)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C197(0.57)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C197(0.85)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C197(1.08)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C197(1.03)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C197(0.72)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C197(0.77)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C197(1.08)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C197(1.50)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C197(1.18)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C197(1.83)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C197(1.14)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C197(1.26)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C197(1.27)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C197(2.17)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C197(2.09)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C197(2.53)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C197(1.62)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C197(2.03)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C197(1.23)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C197(1.41)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C197(1.59)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C197(1.53)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C197(1.10)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C197(2.23)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C197(2.35)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C197(1.50)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C197(1.10)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C197(1.75)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C197(0.97)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C197(1.39)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C197(1.45)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C197(0.78)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C197(2.10)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C197(2.27)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C197(1.03)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C197(0.98)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C197(1.62)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C197(1.80)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C197(1.50)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C197(2.24)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C197(0.78)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C197(1.49)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C197(2.13)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C197(6.02)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C197(0.92)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C197(1.57)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C167(0.87); C223(0.89)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C167(0.74); C223(0.83)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C167(1.30); C223(1.04)  LDD1573  [7]
 LDCM0370  CL101 HCT 116 C197(1.33)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C197(1.22)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C197(1.51)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C197(1.97)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C197(0.64)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C197(0.86)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C197(0.90)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C197(0.70)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C197(0.66)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C167(1.00); C223(0.83)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C197(0.91)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C197(0.76)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C167(1.20); C223(0.93)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C167(0.71); C223(0.99)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C51(0.93)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C223(1.03)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C167(1.11); C223(1.04)  LDD1590  [7]
 LDCM0387  CL117 HCT 116 C197(1.75)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C197(1.15)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C197(1.33)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C197(1.19)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C197(1.18)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C197(1.32)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C197(2.18)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C197(1.89)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C197(0.97)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C197(0.89)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C197(0.92)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C197(0.82)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C167(1.15); C223(1.10)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C51(1.66)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C223(1.17)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C167(1.11); C223(1.02)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C223(1.04)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C167(1.20)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C167(0.80)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C51(1.16)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C167(0.98)  LDD1612  [7]
 LDCM0410  CL22 HEK-293T C167(0.92); C223(1.14)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C167(1.02); C223(0.94)  LDD1615  [7]
 LDCM0413  CL25 HEK-293T C167(1.02); C223(0.93)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C51(1.29)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C223(1.01)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C167(0.75); C223(0.86)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C223(0.99)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C223(1.11)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C167(1.11)  LDD1623  [7]
 LDCM0420  CL31 PaTu 8988t C197(1.12)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C197(1.17)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C197(0.86)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C197(1.17)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C197(1.36)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C197(1.11)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C197(1.34)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C197(1.32)  LDD1307  [2]
 LDCM0429  CL4 HEK-293T C167(0.57); C223(0.92)  LDD1633  [7]
 LDCM0430  CL40 PaTu 8988t C197(1.57)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C197(1.07)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C197(1.30)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C197(1.58)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C197(1.71)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C197(1.45)  LDD1314  [2]
 LDCM0436  CL46 HEK-293T C167(0.54); C223(0.85)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C167(0.98); C223(0.92)  LDD1641  [7]
 LDCM0439  CL49 HEK-293T C167(1.49); C223(0.97)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C223(1.10)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C51(1.21)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C167(1.00); C223(0.98)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C223(1.18)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C167(0.96)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C167(0.66)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C167(1.03)  LDD1650  [7]
 LDCM0449  CL58 HEK-293T C167(0.76); C223(1.27)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C167(0.96); C223(0.97)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C167(0.96)  LDD1654  [7]
 LDCM0453  CL61 HEK-293T C167(1.19); C223(1.07)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C51(1.19)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C223(1.22)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C167(1.62); C223(1.02)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C223(1.15)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C167(1.07)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C167(0.73)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C167(1.08)  LDD1663  [7]
 LDCM0462  CL7 HEK-293T C167(0.97)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C167(0.47); C223(1.57)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C167(0.91); C223(0.83)  LDD1667  [7]
 LDCM0466  CL73 HEK-293T C167(0.86); C223(0.99)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C51(1.20)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C167(1.21); C223(1.06)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C223(0.88)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C167(0.91)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C167(0.76)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C167(1.59)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C167(0.73)  LDD1677  [7]
 LDCM0476  CL82 HEK-293T C167(0.54); C223(1.01)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C167(0.58); C223(0.85)  LDD1680  [7]
 LDCM0479  CL85 HEK-293T C167(1.08); C223(0.96)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C51(0.97)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C223(1.05)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C167(1.32); C223(1.03)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C223(1.16)  LDD1686  [7]
 LDCM0485  CL90 HEK-293T C167(1.28)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C167(1.00)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C167(1.35)  LDD1690  [7]
 LDCM0489  CL94 HEK-293T C167(0.95); C223(1.34)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C167(0.08); C223(0.84)  LDD1693  [7]
 LDCM0492  CL97 HEK-293T C167(1.22); C223(0.95)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C51(1.09)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C223(1.05)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C223(1.07)  LDD1698  [7]
 LDCM0576  Fragment14 Ramos C197(1.02)  LDD2193  [8]
 LDCM0586  Fragment28 Ramos C197(0.27)  LDD2198  [8]
 LDCM0468  Fragment33 HEK-293T C223(0.97)  LDD1671  [7]
 LDCM0566  Fragment4 Ramos C197(0.70)  LDD2184  [8]
 LDCM0427  Fragment51 PaTu 8988t C197(1.62)  LDD1306  [2]
 LDCM0569  Fragment7 Ramos C197(0.65)  LDD2186  [8]
 LDCM0022  KB02 HCT 116 C197(1.29)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C197(1.00)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C197(1.07)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 21 (MED21) Mediator complex subunit 21 family Q13503
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 1 (MED1) Mediator complex subunit 1 family Q15648
Mediator of RNA polymerase II transcription subunit 10 (MED10) Mediator complex subunit 10 family Q9BTT4
Mediator of RNA polymerase II transcription subunit 26 (MED26) Mediator complex subunit 26 family O95402
Mediator of RNA polymerase II transcription subunit 31 (MED31) Mediator complex subunit 31 family Q9Y3C7
Calcium-binding protein 39 (CAB39) Mo25 family Q9Y376
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578