Details of the Target

General Information of Target

Target ID LDTP00582
Target Name Protein CASC3 (CASC3)
Gene Name CASC3
Gene ID 22794
Synonyms
MLN51; Protein CASC3; Cancer susceptibility candidate gene 3 protein; Metastatic lymph node gene 51 protein; MLN 51; Protein barentsz; Btz
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALH
LRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEAN
DAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPA
YIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALY
GYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRN
AAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVR
DPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKL
AEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQ
PSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHI
SIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLY
PPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQV
YGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS
Target Bioclass
Transporter and channel
Family
CASC3 family
Subcellular location
Cytoplasm
Function
Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer.
Uniprot ID
O15234
Ensemble ID
ENST00000264645.12
HGNC ID
HGNC:17040

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C36(9.16)  LDD2157  [1]
m-APA
 Probe Info  		11.91  LDD0403  [2]
DBIA
 Probe Info  		C36(1.73)  LDD0532  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C36(1.70)  LDD1507  [7]
 LDCM0215  AC10 HCT 116 C36(1.73)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C36(1.09)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C36(1.09)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C36(0.87)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C36(0.90)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C36(0.99)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C36(1.00)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C36(0.75)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C36(0.86)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C36(1.00)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C36(1.21)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C36(1.89)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C36(0.40)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C36(0.39)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C36(0.53)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C36(20.00)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C36(0.70)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C36(0.95)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C36(0.74)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C36(0.75)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C36(0.87)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C36(2.56)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C36(1.95)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C36(1.13)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C36(1.24)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C36(0.63)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C36(0.68)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C36(1.52)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C36(0.76)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C36(0.31)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C36(0.35)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C36(0.87)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C36(1.09)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C36(1.14)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C36(1.27)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C36(1.43)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C36(1.74)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C36(1.61)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C36(1.10)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C36(1.46)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C36(1.04)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C36(0.91)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C36(1.69)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C36(1.43)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C36(1.47)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C36(1.94)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C36(1.41)  LDD0579  [3]
 LDCM0270  AC15 HCT 116 C36(2.35)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C36(1.13)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C36(1.04)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C36(0.98)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C36(0.78)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C36(0.79)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C36(1.00)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C36(0.92)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C36(1.42)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C36(1.88)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C36(0.76)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C36(1.06)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C36(1.05)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C36(0.88)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C36(1.15)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C36(1.01)  LDD1529  [7]
 LDCM0291  AC30 HCT 116 C36(1.02)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C36(1.24)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C36(2.13)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C36(1.15)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C36(1.02)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C36(1.09)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C36(1.38)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C36(0.98)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C36(0.93)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C36(1.36)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C36(1.19)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C36(0.95)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C36(1.09)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C36(1.14)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C36(0.97)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C36(1.23)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C36(1.21)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C36(1.24)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C36(1.08)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C36(0.95)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C36(1.22)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C36(0.99)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C36(1.08)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C36(0.92)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C36(1.27)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C36(0.88)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C36(1.04)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C36(1.06)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C36(0.98)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C36(1.38)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C36(1.06)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C36(0.96)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C36(0.91)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C36(1.11)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C36(1.03)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C36(1.07)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C36(1.13)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C36(0.90)  LDD1567  [7]
 LDCM0334  AC7 HCT 116 C36(0.84)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C36(0.80)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C36(1.73)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C36(1.34)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C36(1.13)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C36(1.22)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C36(1.04)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C36(1.33)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C36(1.13)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C36(1.74)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C36(0.87)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C36(1.12)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C36(1.09)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C36(0.87)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C36(1.15)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C36(0.69)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C36(1.19)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C36(1.24)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C36(1.03)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C36(2.46)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C36(1.56)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C36(2.36)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.91  LDD0403  [2]
 LDCM0367  CL1 HEK-293T C36(1.18)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C36(1.34)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C36(1.00)  LDD1573  [7]
 LDCM0370  CL101 HCT 116 C36(1.77)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C36(1.74)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C36(0.87)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C36(1.98)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C36(1.36)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C36(1.10)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C36(1.61)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C36(3.21)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C36(1.19)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C36(1.25)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C36(2.04)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C36(3.33)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C36(0.99)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C36(1.57)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C36(1.16)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C36(1.26)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C36(1.32)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C36(1.09)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C36(1.01)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C36(0.92)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C36(1.12)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C36(1.03)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C36(0.89)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C36(1.04)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C36(0.81)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C36(0.89)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C36(0.97)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C36(1.20)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C36(1.18)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C36(1.14)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C36(1.34)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C36(1.18)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C36(0.92)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C36(0.84)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C36(1.05)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C36(1.16)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C36(0.81)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C36(1.00)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C36(1.56)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C36(1.05)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C36(1.27)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C36(1.57)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C36(1.59)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C36(0.90)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C36(1.39)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C36(1.96)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C36(2.02)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C36(1.78)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C36(0.88)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C36(0.98)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C36(0.63)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C36(0.76)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C36(0.63)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C36(0.76)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C36(0.62)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C36(0.68)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C36(0.87)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C36(0.36)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C36(1.23)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C36(0.87)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C36(0.62)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C36(0.52)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C36(0.60)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C36(0.71)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C36(0.76)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C36(1.42)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C36(0.93)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C36(1.16)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C36(1.11)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C36(1.02)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C36(1.04)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C36(1.59)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C36(1.13)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C36(1.26)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C36(0.98)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C36(1.04)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C36(0.94)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C36(0.85)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C36(0.98)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C36(1.24)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C36(0.96)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C36(1.67)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C36(1.00)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C36(1.27)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C36(0.89)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C36(0.83)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C36(1.12)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C36(1.11)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C36(1.10)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C36(1.10)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C36(1.37)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C36(1.23)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C36(1.20)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C36(1.17)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C36(1.14)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C36(0.99)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C36(1.12)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C36(1.21)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C36(1.03)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C36(1.03)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C36(1.00)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C36(1.16)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C36(1.53)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C36(1.09)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C36(0.82)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C36(1.18)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C36(0.98)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C36(1.10)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C36(0.89)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C36(1.01)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C36(1.05)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C36(1.10)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C36(1.12)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C36(0.78)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C36(0.99)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C36(1.14)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C36(1.12)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C36(0.98)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C36(1.23)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C36(1.08)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C36(0.86)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C36(1.23)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C36(0.75)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C36(1.01)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C36(1.15)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C36(1.09)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C36(0.90)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C36(1.02)  LDD1497  [7]
 LDCM0024  KB05 HMCB C36(1.46)  LDD3312  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein mago nashi homolog (MAGOH) Mago nashi family P61326
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840