Details of the Target

General Information of Target

Target ID LDTP19409
Target Name Tetratricopeptide repeat protein 22 (TTC22)
Gene Name TTC22
Gene ID 55001
Synonyms
Tetratricopeptide repeat protein 22; TPR repeat protein 22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILKGCLLYPLCSPRNKQRCARLWKIAYGGLLKIVTGSLLTFYVVLCLDGGMVLMRKQVP
SRFMYPKEWQHLTMFILLTLNGCVDFMSKNVLPQRCVGLEKGTLVLIIYELLLLMVSHVK
DSEGVELHVYSLLILVVFLLLLVLTAELWAPNMCHLQLMETFLILMMGSWLMQAGFILYR
PVSGYPWQDDDISDIMFVTTFFCWHVMINASFLLGIYGFSSFWYHCFRPSLKLTGPKEAP
YYASTPGPLYKLLQEVEQSEKEDQALLLPKSSP
Target Bioclass
Other
Uniprot ID
Q5TAA0
Ensemble ID
ENST00000371274.8
HGNC ID
HGNC:26067

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.C474R .
C32 SNV: p.F548L .
DU145 SNV: p.G557V .
G361 SNV: p.S466P .
HCT15 SNV: p.L82M .
HEC1 SNV: p.Q402Ter .
HEC1B SNV: p.Q402Ter .
MELJUSO SNV: p.A334T .
NCIH23 SNV: p.G131V .
REH SNV: p.Q482Ter .
SKMEL2 SNV: p.P432L .
SKNSH SNV: p.G390C .
SW756 SNV: p.L11V .
T24 SNV: p.S276Ter .
TE4 SNV: p.A339S .
THP1 SNV: p.K292R .
TOV21G SNV: p.E135D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C368(0.73)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C368(0.73)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C368(0.78)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C368(0.91)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C368(0.69)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C368(0.79)  LDD0587  [1]
 LDCM0285  AC25 HCT 116 C368(1.22)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C368(0.73)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C368(0.73)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C368(0.44)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C368(0.88)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C368(0.85)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C368(0.54)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C368(0.52)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C368(0.93)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C368(1.49)  LDD0612  [1]
 LDCM0323  AC6 HCT 116 C368(0.90)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C368(0.82)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C368(0.93)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C368(0.94)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C368(1.20)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C368(0.63)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C368(0.66)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C368(0.84)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C368(0.80)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C368(0.65)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C368(0.47)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C368(0.69)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C368(0.82)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C368(1.22)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C368(1.10)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C368(1.20)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C368(1.42)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C368(0.72)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C368(0.90)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C368(0.91)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C368(0.87)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C368(0.82)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C368(0.96)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C368(0.70)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C368(0.83)  LDD0690  [1]
 LDCM0382  CL112 HCT 116 C368(1.17)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C368(1.61)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C368(2.16)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C368(1.31)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C368(1.16)  LDD0703  [1]
 LDCM0420  CL31 HCT 116 C368(1.33)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C368(1.32)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C368(0.92)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C368(0.82)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C368(0.90)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C368(0.75)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C368(1.00)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C368(0.93)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C368(1.31)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C368(0.86)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C368(0.98)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C368(1.02)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C368(1.01)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C368(1.15)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C368(0.78)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C368(1.21)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C368(0.82)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C368(0.70)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C368(0.97)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C368(0.62)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C368(0.94)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C368(1.14)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C368(0.88)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C368(1.21)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C368(0.96)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C368(0.89)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C368(0.75)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C368(0.92)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C368(0.81)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C368(0.86)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C368(1.48)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C368(0.89)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C368(0.62)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C368(1.23)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C368(0.63)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C368(1.19)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C368(2.26)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C368(0.81)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C368(1.96)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C368(1.01)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C368(0.76)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C368(0.94)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C368(0.98)  LDD0784  [1]
 LDCM0468  Fragment33 HCT 116 C368(0.97)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C368(1.48)  LDD0744  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.