Details of the Target

General Information of Target

Target ID LDTP18133
Target Name RUN domain-containing protein 1 (RUNDC1)
Gene Name RUNDC1
Synonyms
RUN domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAELQQLRVQEAVESMVKSLERENIRKMQGLMFRCSASCCEDSQASMKQVHQCIERCHVP
LAQAQALVTSELEKFQDRLARCTMHCNDKAKDSIDAGSKELQVKQQLDSCVTKCVDDHMH
LIPTMTKKMKEALLSIGK
Target Bioclass
Other
Function May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.
Uniprot ID
Q96C34
Ensemble ID
ENST00000361677.6
HGNC ID
HGNC:25418

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ECC2 SNV: p.D600G .
HSC3 SNV: p.D149H .
JURKAT SNV: p.A360T .
MOLT4 SNV: p.R39C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C559(0.85)  LDD0531  [1]
IA-alkyne
 Probe Info  		C262(0.00); C95(0.00)  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C559(0.85)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C559(1.05)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C559(1.23)  LDD1509  [3]
 LDCM0230  AC113 HCT 116 C559(1.00)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C559(0.99)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C559(1.00)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C559(0.98)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C559(1.03)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C559(0.97)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C559(0.90)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C559(1.46)  LDD1510  [3]
 LDCM0238  AC120 HCT 116 C559(0.93)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C559(0.97)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C559(0.90)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C559(0.93)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C559(1.01)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C559(0.93)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C559(0.91)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C559(0.96)  LDD0562  [1]
 LDCM0259  AC14 HEK-293T C559(0.89)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C559(1.03)  LDD1513  [3]
 LDCM0276  AC17 HCT 116 C559(1.09)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C559(0.79)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C559(0.96)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C559(0.95)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C559(0.97)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C559(0.87)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C559(1.00)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C559(0.83)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C559(1.17)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C559(1.11)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C559(0.96)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C559(1.08)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C559(1.03)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C559(1.07)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C559(0.91)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C559(1.04)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C559(1.03)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C559(1.01)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C559(0.98)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C559(1.06)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C559(0.93)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C559(0.88)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C559(0.95)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C559(1.19)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C559(1.07)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C559(0.82)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C559(1.03)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C559(0.96)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C559(1.13)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C559(1.16)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C559(0.99)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C559(1.04)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C559(1.03)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C559(1.00)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C559(0.90)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C559(1.17)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C559(0.83)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C559(1.07)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C559(1.04)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C559(0.96)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C559(1.07)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C559(1.03)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C559(1.12)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C559(1.43)  LDD0636  [1]
 LDCM0321  AC58 HEK-293T C559(1.21)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C559(1.32)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C559(0.97)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C559(1.36)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C559(1.27)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C559(1.07)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C559(1.17)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C299(1.10)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C559(0.96)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C299(0.94)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C559(1.23)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C299(1.02)  LDD1514  [3]
 LDCM0367  CL1 HCT 116 C559(1.20)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C559(1.02)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C559(0.88)  LDD0686  [1]
 LDCM0371  CL102 HEK-293T C559(1.61)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C559(1.08); C299(1.17)  LDD1576  [3]
 LDCM0374  CL105 HCT 116 C559(0.88)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C559(0.78)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C559(0.76)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C559(0.87)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C559(0.91)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C559(1.02)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C559(0.82)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C559(0.93)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C559(1.05)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C559(0.99)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C559(0.98)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C559(0.97)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C559(0.99)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C559(1.05)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C559(1.01)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C559(1.07)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C559(1.20)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C559(1.04)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C559(1.17)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C559(0.94)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C559(1.04)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C559(1.03)  LDD0712  [1]
 LDCM0397  CL126 HEK-293T C559(1.11)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C559(0.89); C299(1.02)  LDD1602  [3]
 LDCM0400  CL13 HCT 116 C559(1.08)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C559(1.05)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C559(1.10)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C559(0.93)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C559(0.81)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C559(0.76)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C559(0.95)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C559(1.03)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C559(0.84)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C559(0.90)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C559(1.07)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C559(0.88)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C559(0.83)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C559(0.82)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C559(0.81)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C559(0.82)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C559(0.87)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C559(0.87)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C559(0.94)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C559(0.88)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C559(0.90)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C559(1.55)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C559(1.60)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C559(1.26)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C559(1.18)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C299(0.94)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C559(0.97); C299(0.80)  LDD1632  [3]
 LDCM0429  CL4 HCT 116 C559(1.07)  LDD0746  [1]
 LDCM0432  CL42 HEK-293T C559(0.93)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C559(1.05)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C559(1.20)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C559(1.18)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C559(0.75)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C559(1.94)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C299(0.96)  LDD1642  [3]
 LDCM0440  CL5 HCT 116 C559(1.07)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C559(1.31)  LDD1645  [3]
 LDCM0445  CL54 HEK-293T C559(1.00)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C559(0.88)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C559(1.27)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C559(1.13)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C559(1.07)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C559(1.09)  LDD1653  [3]
 LDCM0451  CL6 HCT 116 C559(1.00)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C299(0.92)  LDD1655  [3]
 LDCM0453  CL61 HCT 116 C559(0.98)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C559(0.94)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C559(0.79)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C559(0.85)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C559(0.93)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C559(0.90)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C559(0.95)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C559(0.86)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C559(0.90)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C559(1.09)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C559(0.85)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C559(0.87)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C559(0.92)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C559(0.87)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C559(0.87)  LDD0784  [1]
 LDCM0471  CL78 HEK-293T C559(1.38)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C559(0.93)  LDD1675  [3]
 LDCM0473  CL8 HCT 116 C559(1.12)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C559(1.39)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C559(1.64)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C559(0.99)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C559(1.36)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C299(0.82)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C559(1.04)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C559(1.11); C299(1.07)  LDD1684  [3]
 LDCM0484  CL9 HCT 116 C559(1.05)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C559(0.89)  LDD1688  [3]
 LDCM0486  CL91 HCT 116 C559(0.80)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C559(0.92)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C559(0.95)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C559(0.85)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C559(0.81)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C559(0.84)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C559(0.97)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C559(0.87)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C559(0.87)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C559(1.16); C299(1.08)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C559(0.87)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C559(0.84)  LDD1631  [3]
 LDCM0022  KB02 22RV1 C559(1.90)  LDD2243  [4]
 LDCM0023  KB03 22RV1 C559(3.29)  LDD2660  [4]
 LDCM0024  KB05 NCI-H196 C559(2.08)  LDD3351  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840