Details of the Target

General Information of Target

Target ID LDTP17607
Target Name Copine-8 (CPNE8)
Gene Name CPNE8
Gene ID 144402
Synonyms
Copine-8; Copine VIII
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLNVSGLFVLLCGLLVSSSAQEVLAGVSSQLLNDLTQGLLRADFLPSLQTTGLQKPLSSA
FDGVSGLLDIFGPPLTNEINTVSIQVKNPQLLHVSIESTPQRKEATVQVPFTSELIVQLL
TMKPFTANMQSDIKVQIRLEKNVGGRYELAFGNCRLLPEAIWIQTGVQLAPAQNLLWQT
Target Bioclass
Other
Family
Copine family
Function Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
Uniprot ID
Q86YQ8
Ensemble ID
ENST00000331366.10
HGNC ID
HGNC:23498

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.G121R .
HT115 SNV: p.E59Ter; p.R186Ter .
L428 SNV: p.Q408R .
RKO SNV: p.V26A .
SNU1079 SNV: p.S490Y .
SUPT1 SNV: p.Y234H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C32(1.07)  LDD2117  [2]
Acrolein
 Probe Info  		N.A.  LDD0223  [3]
DBIA
 Probe Info  		C155(0.86); C156(0.86)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
1c-yne
 Probe Info  		K405(0.00); K525(0.00)  LDD0228  [6]
1d-yne
 Probe Info  		N.A.  LDD0357  [6]
AOyne
 Probe Info  		8.50  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C32(1.07)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C155(0.86)  LDD1507  [8]
 LDCM0216  AC100 HCT 116 C155(1.19); C156(1.19)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C155(1.36); C156(1.36)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C155(0.98); C156(0.98)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C155(1.16); C156(1.16)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C155(0.83); C156(0.83)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C155(1.30); C156(1.30)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C155(1.20); C156(1.20)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C155(1.23); C156(1.23)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C155(1.36); C156(1.36)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C155(1.00); C156(1.00)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C32(0.98); C155(1.00)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C155(1.14); C156(1.14)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C155(1.04); C156(1.04)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C155(1.09); C156(1.09)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C155(0.81); C156(0.81)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C155(1.09); C156(0.96)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C155(1.07); C156(0.85)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C155(1.07); C156(1.36)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C155(1.00); C156(0.87)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C155(1.15); C156(0.99)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C155(1.24); C156(0.91)  LDD0553  [4]
 LDCM0238  AC120 HCT 116 C155(0.98); C156(1.02)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C155(1.14); C156(0.88)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C155(0.99); C156(0.98)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C155(1.52); C156(0.82)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C155(1.08); C156(0.97)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C155(1.08); C156(1.05)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C155(1.07); C156(1.15)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C155(1.36); C156(1.10)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C155(1.07); C156(1.07)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C155(1.18); C156(1.18)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C155(1.41); C156(1.41)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C155(1.42); C156(1.42)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C155(1.40); C156(1.40)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C155(1.15); C156(1.15)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C155(1.70); C156(1.70)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C155(2.15); C156(2.15)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C155(1.44); C156(1.44)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C155(1.37); C156(1.37)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C155(2.03); C156(2.03)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C155(1.98); C156(1.98)  LDD0575  [4]
 LDCM0260  AC140 HCT 116 C155(2.33); C156(2.33)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C155(2.06); C156(2.06)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C155(1.81); C156(1.81)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C155(0.94); C156(0.94)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C156(0.84); C155(1.42)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C156(0.95); C155(1.38)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C155(1.21); C156(1.31)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C156(0.98); C155(1.16)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C156(1.18); C155(1.27)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C155(1.15); C156(1.42)  LDD0586  [4]
 LDCM0271  AC150 HCT 116 C156(0.91); C155(1.15)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C156(1.14); C155(1.22)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C155(1.19); C156(1.21)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C156(1.21); C155(1.92)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C155(1.09); C156(1.06)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C155(1.28); C156(1.12)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C155(1.34); C156(1.22)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C155(1.32); C156(0.92)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C155(1.21); C156(1.21)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C155(1.46); C156(1.46)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C155(1.79); C156(1.79)  LDD0595  [4]
 LDCM0280  AC20 HCT 116 C155(0.92); C156(0.92)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C155(1.32); C156(1.32)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C155(1.06); C156(1.06)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C155(1.04); C156(1.04)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C155(1.49); C156(1.49)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C155(0.96)  LDD1524  [8]
 LDCM0287  AC27 HEK-293T C32(0.99); C155(1.20)  LDD1526  [8]
 LDCM0290  AC3 HEK-293T C32(0.89); C155(0.94)  LDD1529  [8]
 LDCM0294  AC33 HEK-293T C155(1.05)  LDD1533  [8]
 LDCM0296  AC35 HCT 116 C155(1.06); C156(1.06)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C155(0.96); C156(0.96)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C155(1.11); C156(1.11)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C155(0.96); C156(0.96)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C155(0.87); C156(0.87)  LDD0617  [4]
 LDCM0302  AC40 HCT 116 C155(0.82); C156(0.82)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C155(1.14); C156(1.14)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C155(1.09); C156(1.09)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C155(1.03); C156(1.03)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C155(0.89); C156(0.89)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C155(0.79); C156(0.79)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C155(0.97); C156(0.97)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C155(1.10); C156(1.10)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C155(0.65); C156(0.65)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C155(1.28); C156(1.28)  LDD0628  [4]
 LDCM0313  AC50 HCT 116 C155(1.08); C156(1.08)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C155(0.98); C156(0.98)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C155(0.71); C156(0.71)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C155(0.82); C156(0.82)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C155(0.72); C156(0.72)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C155(0.89); C156(0.89)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C155(0.76); C156(0.76)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C155(0.93)  LDD1559  [8]
 LDCM0322  AC59 HEK-293T C32(0.92); C155(1.02)  LDD1561  [8]
 LDCM0349  AC83 HCT 116 C155(1.36); C156(1.36)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C155(1.21); C156(1.21)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C155(1.27); C156(1.27)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C155(1.28); C156(1.28)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C155(1.23); C156(1.23)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C155(1.48); C156(1.48)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C155(1.09); C156(1.09)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C155(1.29); C156(1.29)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C155(0.74); C156(0.74)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C155(1.22); C156(1.22)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C155(1.12); C156(1.12)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C155(0.93); C156(0.93)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C155(1.33); C156(1.33)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C155(0.99); C156(0.99)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C155(1.27); C156(1.27)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C155(1.19); C156(1.19)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C155(1.29); C156(1.29)  LDD0683  [4]
 LDCM0356  AKOS034007680 HEK-293T C155(0.82)  LDD1570  [8]
 LDCM0156  Aniline NCI-H1299 11.60  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C155(0.86); C156(0.86)  LDD0078  [4]
 LDCM0369  CL100 HEK-293T C118(0.78)  LDD1573  [8]
 LDCM0371  CL102 HEK-293T C32(0.97)  LDD1575  [8]
 LDCM0373  CL104 HEK-293T C118(1.04)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C155(0.98); C156(0.98)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C155(0.91); C156(0.91)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C155(1.26); C156(1.26)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C155(1.05); C156(1.05)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C155(1.11); C156(1.11)  LDD0695  [4]
 LDCM0380  CL110 HCT 116 C155(1.83); C156(1.83)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C155(1.26); C156(1.26)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C118(0.86)  LDD1586  [8]
 LDCM0384  CL114 HEK-293T C32(1.08)  LDD1588  [8]
 LDCM0386  CL116 HEK-293T C118(0.88)  LDD1590  [8]
 LDCM0387  CL117 HCT 116 C155(0.79); C156(0.79)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C155(1.00); C156(1.00)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C155(1.23); C156(1.23)  LDD0706  [4]
 LDCM0391  CL120 HCT 116 C155(1.12); C156(1.12)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C155(1.08); C156(1.08)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C155(0.74); C156(0.74)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C155(0.57); C156(0.57)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C155(0.75); C156(0.75)  LDD0712  [4]
 LDCM0397  CL126 HEK-293T C32(1.03)  LDD1601  [8]
 LDCM0399  CL128 HEK-293T C118(0.90)  LDD1603  [8]
 LDCM0401  CL14 HEK-293T C32(1.07)  LDD1605  [8]
 LDCM0403  CL16 HEK-293T C118(1.13)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C155(0.94)  LDD1608  [8]
 LDCM0406  CL19 HEK-293T C32(1.45); C155(1.11)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C32(1.18)  LDD1611  [8]
 LDCM0414  CL26 HEK-293T C32(0.99)  LDD1618  [8]
 LDCM0416  CL28 HEK-293T C118(0.58)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C155(0.78)  LDD1621  [8]
 LDCM0420  CL31 HEK-293T C32(1.50); C155(1.16)  LDD1624  [8]
 LDCM0429  CL4 HEK-293T C118(1.01)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C118(1.03)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C155(0.67)  LDD1635  [8]
 LDCM0433  CL43 HEK-293T C32(1.36); C155(1.00)  LDD1637  [8]
 LDCM0440  CL5 HEK-293T C155(1.03)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C32(1.25)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C118(0.89)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C155(1.35)  LDD1647  [8]
 LDCM0446  CL55 HEK-293T C32(1.32); C155(0.97)  LDD1649  [8]
 LDCM0453  CL61 HCT 116 C155(0.74); C156(0.74)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C155(0.74); C156(0.74)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C155(0.84); C156(0.84)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C155(0.72); C156(0.72)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C155(0.75); C156(0.75)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C155(0.68); C156(0.68)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C155(0.70); C156(0.70)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C155(0.88); C156(0.88)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C155(1.02); C156(1.02)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C32(1.35); C155(1.23)  LDD1665  [8]
 LDCM0463  CL70 HCT 116 C155(0.69); C156(0.69)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C155(0.73); C156(0.73)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C155(0.74); C156(0.74)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C155(0.78); C156(0.78)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C155(0.82); C156(0.82)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C155(1.00); C156(1.00)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C155(1.10); C156(1.10)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C155(0.99); C156(0.99)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C155(1.24); C156(1.24)  LDD0789  [4]
 LDCM0474  CL80 HCT 116 C155(0.97); C156(0.97)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C155(1.00); C156(1.00)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C155(1.15); C156(1.15)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C155(0.88); C156(0.88)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C155(0.85); C156(0.85)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C155(0.85); C156(0.85)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C155(0.99); C156(0.99)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C155(0.77); C156(0.77)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C155(0.77); C156(0.77)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C155(0.96); C156(0.96)  LDD0800  [4]
 LDCM0485  CL90 HCT 116 C155(0.89); C156(0.89)  LDD0802  [4]
 LDCM0486  CL91 HEK-293T C32(1.19); C155(0.98)  LDD1689  [8]
 LDCM0493  CL98 HEK-293T C32(1.32)  LDD1696  [8]
 LDCM0468  Fragment33 HCT 116 C155(0.95); C156(0.95)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C32(1.04)  LDD1631  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C32(0.88)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C32(1.32)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C32(1.34)  LDD2127  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C196(0.69)  LDD2145  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein S100-B (S100B) S-100 family P04271
N-terminal EF-hand calcium-binding protein 1 (NECAB1) . Q8N987
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vinexin (SORBS3) . O60504

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD044402