Details of the Target

General Information of Target

Target ID LDTP17437
Target Name Protein ABHD15 (ABHD15)
Gene Name ABHD15
Gene ID 116236
Synonyms
Protein ABHD15; Alpha/beta hydrolase domain-containing protein 15; Abhydrolase domain-containing protein 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSVRSLLRLLAAAAACGAFAFLGYCIYLNRKRRGDPAFKRRLRDKRRAEPQKAEEQGTQ
LWDPTKNKKLQELFLQEVRMGELWLSRGEHRMGIQHLGNALLVCEQPRELLKVFKHTLPP
KVFEMLLHKIPLICQQFEADMNEQDCLEDDPD
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, AB hydrolase 4 family
Subcellular location
Secreted
Function May regulate adipocyte lipolysis and liver lipid accumulation.
Uniprot ID
Q6UXT9
Ensemble ID
ENST00000307201.5
HGNC ID
HGNC:26971

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C199(0.70)  LDD2109  [1]
IPM
 Probe Info  		C199(0.87)  LDD1702  [1]
DBIA
 Probe Info  		C392(1.10)  LDD0532  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C199(0.89)  LDD2152  [1]
 LDCM0215  AC10 HCT 116 C392(1.10)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C392(0.99)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C392(1.08)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C392(1.14)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C392(0.95)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C392(1.08)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C392(1.22)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C392(1.00)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C392(0.98)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C392(0.91)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C392(1.21)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C392(0.96)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C392(1.02)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C392(0.87)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C392(0.95)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C392(0.97)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C392(0.96)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C392(1.19)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C392(0.90)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C392(0.95)  LDD0587  [2]
 LDCM0323  AC6 HCT 116 C392(1.06)  LDD0640  [2]
 LDCM0332  AC68 HCT 116 C392(0.74)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C392(0.76)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C392(0.84)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C392(0.83)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C392(1.03)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C392(0.69)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C392(0.93)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C392(0.90)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C392(0.69)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C392(0.73)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C392(0.68)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C392(0.85)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C392(0.78)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C392(0.99)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C392(0.69)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C392(0.77)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C392(0.84)  LDD0665  [2]
 LDCM0248  AKOS034007472 HCT 116 C392(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C392(0.97)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C392(1.11)  LDD0592  [2]
 LDCM0370  CL101 HCT 116 C392(0.96)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C392(0.98)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C392(0.85)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C392(0.80)  LDD0690  [2]
 LDCM0420  CL31 HCT 116 C392(1.02)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C392(1.28)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C392(1.25)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C392(1.18)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C392(0.95)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C392(1.03)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C392(1.05)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C392(1.25)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C392(1.03)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C392(0.99)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C392(0.91)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C392(1.05)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C392(1.16)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C392(1.20)  LDD0752  [2]
 LDCM0469  CL76 HCT 116 C392(0.76)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C392(0.52)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C392(0.66)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C392(0.78)  LDD0789  [2]
 LDCM0474  CL80 HCT 116 C392(1.00)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C392(0.82)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C392(1.02)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C392(0.80)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C392(0.78)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C392(0.78)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C392(0.58)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C392(0.68)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C392(0.59)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C392(0.57)  LDD0800  [2]
 LDCM0485  CL90 HCT 116 C392(0.57)  LDD0802  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C199(0.87)  LDD1702  [1]
 LDCM0427  Fragment51 HCT 116 C392(1.05)  LDD0744  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C199(0.70)  LDD2109  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.