Details of the Target

General Information of Target

Target ID LDTP16561
Target Name BCLAF1 and THRAP3 family member 3 (BCLAF3)
Gene Name BCLAF3
Gene ID 256643
Synonyms
CXorf23; BCLAF1 and THRAP3 family member 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASEVPYASGMPIKKIGHRSVDSSGGTTSSALKGAIQLGITHTVGSLSTKPESDVLMQDF
HMVESIFFPSEGSNLTPAHHYNAFRFKTYAPVAFRYFWELFGIRPDDYLYSLCSEPLIEL
CSSGASGSLFYVSSDDEFIVKTVRHKEAEFLQKLLPGYYINLNQNPRTLLPKFYGLYCVQ
TGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYRRRASQKEREKPLPTFKDLDFLQDIPDG
LFLDADVHNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRP
APQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVK
KLEHSWKALIHDGDTVSVHRPGFYAEWFQRFMCNTVFKKIPLKPSPSKKLRSGSSFSQRA
GSSGNSCITYQPLVSGEHKAQVTTKAEVEPGVHLGCPDVLPQTPPLEEISEGSPTPDPSF
SPLVEETLQMLTTSVDNSEYMGNGDFLPTRLQAQQDAVNTVCHSKTRSNPENNVGLITLD
NDCEVLTTLTPDTGRILSKLHTVQPKGKITFCMGIHVAHLALKHRQGNNHKIRIIAFVGN
PVEDNEKNLVKLAKCLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPP
GPSLADALISFPILAGEGGAMMGLGASDFEFGVDPSADPELALVLRVFMEEQRQRQEEEA
RQAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGHTGLPDLSSMTEEEKIVCAMQMSL
QGAEFGLAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNA
VGSLASQATKDSKKDKKEEDKK
Target Bioclass
Other
Family
BCLAF1/THRAP3 family
Subcellular location
Mitochondrion
Uniprot ID
A2AJT9
Ensemble ID
ENST00000379682.9
HGNC ID
HGNC:27413

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.G316AfsTer3 .
JURKAT SNV: p.Q625Ter .
MCC26 SNV: p.G152E .
MFE319 SNV: p.Q334R .
OVKATE SNV: p.T333A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C304(1.00)  LDD2227  [1]
AHL-Pu-1
 Probe Info  		C379(3.70)  LDD0170  [2]
DBIA
 Probe Info  		C324(2.17)  LDD0080  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C379(3.70)  LDD0170  [2]
 LDCM0214  AC1 HCT 116 C324(1.43)  LDD0531  [3]
 LDCM0216  AC100 HCT 116 C324(0.72)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C324(0.66)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C324(0.64)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C324(0.69)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C324(0.73)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C324(0.81)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C324(0.70)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C324(0.65)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C324(0.89)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C324(0.72)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C352(1.16)  LDD1509  [5]
 LDCM0227  AC110 HCT 116 C324(0.73)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C324(0.74)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C324(0.68)  LDD0546  [3]
 LDCM0237  AC12 HEK-293T C352(1.05)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C352(1.01)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C352(1.06)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C352(0.99)  LDD1515  [5]
 LDCM0278  AC19 HEK-293T C352(1.53)  LDD1517  [5]
 LDCM0279  AC2 HCT 116 C324(1.10)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C352(1.04)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C352(1.09)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C352(1.01)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C352(1.06)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C352(0.92)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C352(1.06)  LDD1524  [5]
 LDCM0287  AC27 HEK-293T C352(0.84)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C352(1.04)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C352(0.99)  LDD1528  [5]
 LDCM0290  AC3 HCT 116 C324(1.38)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C352(1.00)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C352(0.92)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C352(1.03)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C352(1.03)  LDD1533  [5]
 LDCM0296  AC35 HEK-293T C352(1.07)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C352(1.05)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C352(0.98)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C352(1.01)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C352(0.95)  LDD1539  [5]
 LDCM0301  AC4 HCT 116 C324(1.27)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C352(1.05)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C352(1.03)  LDD1542  [5]
 LDCM0305  AC43 HEK-293T C352(0.97)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C352(1.11)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C352(1.04)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C352(0.96)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C352(0.95)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C352(0.97)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C352(0.97)  LDD1550  [5]
 LDCM0312  AC5 HCT 116 C324(1.27)  LDD0629  [3]
 LDCM0314  AC51 HEK-293T C352(0.96)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C352(1.09)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C352(0.98)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C352(1.00)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C352(1.04)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C352(1.05)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C352(1.18)  LDD1559  [5]
 LDCM0322  AC59 HEK-293T C352(1.14)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C352(1.01)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C352(1.07)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C352(0.98)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C352(0.99)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C352(0.94)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C352(0.99)  LDD1567  [5]
 LDCM0332  AC68 HCT 116 C324(0.83)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C324(1.12)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C352(0.91)  LDD1568  [5]
 LDCM0335  AC70 HCT 116 C324(0.82)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C324(0.96)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C324(1.26)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C324(1.30)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C324(1.15)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C324(1.56)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C324(1.10)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C324(1.06)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C324(0.87)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C324(1.19)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C352(1.08)  LDD1569  [5]
 LDCM0346  AC80 HCT 116 C324(0.97)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C324(0.96)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C324(1.26)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C324(0.81)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C324(0.55)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C352(1.02)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C352(1.07)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C352(1.07)  LDD1514  [5]
 LDCM0632  CL-Sc Hep-G2 C304(1.00)  LDD2227  [1]
 LDCM0367  CL1 HCT 116 C324(1.00)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C324(2.39)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C324(1.34)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C352(1.14)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C352(0.98)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C352(1.05)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C352(1.01)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C352(0.99)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C352(1.03)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C352(0.95)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C352(1.01)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C352(1.02)  LDD1582  [5]
 LDCM0379  CL11 HCT 116 C324(1.68)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C352(0.92)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C352(0.93)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C352(1.09)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C352(1.05)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C352(0.88)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C352(0.95)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C352(0.98)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C352(1.14)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C352(1.04)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C352(1.07)  LDD1593  [5]
 LDCM0390  CL12 HCT 116 C324(2.07)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C352(1.03)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C352(1.15)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C352(0.97)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C352(0.93)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C352(0.99)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C352(1.03)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C352(0.91)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C352(1.06)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C352(0.88)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C324(1.48)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C324(1.16)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C324(1.83)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C352(1.11)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C352(1.19)  LDD1608  [5]
 LDCM0406  CL19 HEK-293T C352(1.49)  LDD1610  [5]
 LDCM0407  CL2 HCT 116 C324(1.05)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C352(1.13)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C352(1.12)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C352(1.16)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C352(1.09)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C352(0.99)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C352(0.80)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C352(0.96)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C352(0.93)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C352(1.03)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C352(0.95)  LDD1621  [5]
 LDCM0418  CL3 HCT 116 C324(1.25)  LDD0735  [3]
 LDCM0420  CL31 HEK-293T C352(1.43)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C352(0.99)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C352(0.96)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C352(1.04)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C352(0.97)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C352(1.12)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C352(0.87)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C352(1.05)  LDD1632  [5]
 LDCM0429  CL4 HCT 116 C324(1.05)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C352(1.06)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C352(1.07)  LDD1635  [5]
 LDCM0433  CL43 HEK-293T C352(1.20)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C352(1.09)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C352(1.11)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C352(0.99)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C352(1.00)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C352(0.95)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C352(0.96)  LDD1643  [5]
 LDCM0440  CL5 HCT 116 C324(1.23)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C352(1.02)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C352(1.01)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C352(1.17)  LDD1647  [5]
 LDCM0446  CL55 HEK-293T C352(1.40)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C352(1.10)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C352(1.07)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C352(1.01)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C352(1.05)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C324(1.35)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C352(0.90)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C352(0.94)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C352(0.89)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C352(0.84)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C352(0.98)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C352(1.13)  LDD1660  [5]
 LDCM0459  CL67 HEK-293T C352(1.72)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C352(1.02)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C352(1.04)  LDD1664  [5]
 LDCM0462  CL7 HCT 116 C324(2.26)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C352(1.11)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C352(0.92)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C352(1.31)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C352(0.89)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C352(0.98)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C352(0.96)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C352(0.99)  LDD1673  [5]
 LDCM0472  CL79 HEK-293T C352(1.24)  LDD1675  [5]
 LDCM0473  CL8 HCT 116 C324(0.61)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C352(1.01)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C352(1.01)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C352(1.04)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C352(0.89)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C352(1.03)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C352(0.96)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C352(0.82)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C352(0.90)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C352(0.96)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C352(1.05)  LDD1686  [5]
 LDCM0484  CL9 HCT 116 C324(1.27)  LDD0801  [3]
 LDCM0486  CL91 HCT 116 C324(1.30)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C324(1.26)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C324(1.21)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C324(1.18)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C324(1.43)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C324(1.28)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C324(1.36)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C324(1.02)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C324(1.18)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C352(0.95)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C352(1.03)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C352(1.08)  LDD1631  [5]
 LDCM0022  KB02 HCT 116 C324(2.17)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C324(1.39)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C324(1.70)  LDD0082  [3]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402