Details of the Target

General Information of Target

Target ID LDTP16061
Target Name Transmembrane protein 9B (TMEM9B)
Gene Name TMEM9B
Gene ID 56674
Synonyms
C11orf15; Transmembrane protein 9B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MMDNRGNSSLPDKLPIFPDSARLPLTRSFYLEPMVTFHVHPEAPVSSPYSEELPRLPFPS
DSLILGNYSEPCPFSFPMPYPNYRGCEYSYGPAFTRKRNERERQRVKCVNEGYAQLRHHL
PEEYLEKRLSKVETLRAAIKYINYLQSLLYPDKAETKNNPGKVSSMIATTSHHADPMFRI
V
Target Bioclass
Other
Family
TMEM9 family
Subcellular location
Lysosome membrane
Function Enhances production of pro-inflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.
Uniprot ID
Q9NQ34
Ensemble ID
ENST00000309134.9
HGNC ID
HGNC:1168

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 SNV: p.C46Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K171(4.64)  LDD0277  [1]
DBIA
 Probe Info  		C66(0.93); C68(0.93)  LDD0531  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C66(0.93); C68(0.93)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C66(1.13); C68(1.13)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C66(0.87); C68(0.87)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C66(1.08); C68(1.08)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C66(1.14); C68(1.14)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C66(1.01); C68(1.01)  LDD0587  [2]
 LDCM0279  AC2 HCT 116 C66(1.27); C68(1.27)  LDD0596  [2]
 LDCM0285  AC25 HCT 116 C66(1.16); C68(1.16)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C66(1.23); C68(1.23)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C66(1.23); C68(1.23)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C66(1.21); C68(1.21)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C66(1.46); C68(1.46)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C66(1.15); C68(1.15)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C66(1.21); C68(1.21)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C66(1.23); C68(1.23)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C66(1.26); C68(1.26)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C66(1.21); C68(1.21)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C66(1.20); C68(1.20)  LDD0612  [2]
 LDCM0301  AC4 HCT 116 C66(1.12); C68(1.12)  LDD0618  [2]
 LDCM0308  AC46 HCT 116 C66(0.96); C68(0.96)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C66(1.11); C68(1.11)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C66(1.24); C68(1.24)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C66(0.99); C68(0.99)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C66(1.44); C68(1.44)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C66(1.04); C68(1.04)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C66(1.33); C68(1.33)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C66(1.12); C68(1.12)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C66(1.22); C68(1.22)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C66(0.96); C68(0.96)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C66(1.20); C68(1.20)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C66(0.91); C68(0.91)  LDD0636  [2]
 LDCM0323  AC6 HCT 116 C66(0.92); C68(0.92)  LDD0640  [2]
 LDCM0334  AC7 HCT 116 C66(1.20); C68(1.20)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C66(0.87); C68(0.87)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C66(1.41); C68(1.41)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C66(1.27); C68(1.27)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C66(1.23); C68(1.23)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C66(1.24); C68(1.24)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C66(1.06); C68(1.06)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C66(1.03); C68(1.03)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C66(1.18); C68(1.18)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C66(0.96); C68(0.96)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C66(1.33); C68(1.33)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C66(1.32); C68(1.32)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C66(0.97); C68(0.97)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C66(1.13); C68(1.13)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C66(0.90); C68(0.90)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C66(1.14); C68(1.14)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C66(1.14); C68(1.14)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C66(0.99); C68(0.99)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C66(1.08); C68(1.08)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C66(1.17); C68(1.17)  LDD0592  [2]
 LDCM0369  CL100 HCT 116 C66(1.11); C68(1.11)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C66(1.13); C68(1.13)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C66(1.09); C68(1.09)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C66(1.16); C68(1.16)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C66(0.93); C68(0.93)  LDD0690  [2]
 LDCM0382  CL112 HCT 116 C66(1.00); C68(1.00)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C66(1.00); C68(1.00)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C66(0.90); C68(0.90)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C66(1.06); C68(1.06)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C66(1.04); C68(1.04)  LDD0703  [2]
 LDCM0392  CL121 HCT 116 C66(1.86); C68(1.86)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C66(1.16); C68(1.16)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C66(1.25); C68(1.25)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C66(0.92); C68(0.92)  LDD0712  [2]
 LDCM0420  CL31 HCT 116 C66(0.74); C68(0.74)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C66(0.83); C68(0.83)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C66(0.74); C68(0.74)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C66(0.80); C68(0.80)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C66(0.94); C68(0.94)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C66(1.23); C68(1.23)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C66(1.36); C68(1.36)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C66(0.71); C68(0.71)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C66(0.78); C68(0.78)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C66(0.87); C68(0.87)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C66(0.85); C68(0.85)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C66(0.78); C68(0.78)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C66(1.03); C68(1.03)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C66(0.85); C68(0.85)  LDD0752  [2]
 LDCM0469  CL76 HCT 116 C66(1.11); C68(1.11)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C66(0.96); C68(0.96)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C66(0.91); C68(0.91)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C66(0.82); C68(0.82)  LDD0789  [2]
 LDCM0474  CL80 HCT 116 C66(1.39); C68(1.39)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C66(1.03); C68(1.03)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C66(0.95); C68(0.95)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C66(0.74); C68(0.74)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C66(0.93); C68(0.93)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C66(0.74); C68(0.74)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C66(1.25); C68(1.25)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C66(1.30); C68(1.30)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C66(0.82); C68(0.82)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C66(0.72); C68(0.72)  LDD0800  [2]
 LDCM0485  CL90 HCT 116 C66(0.80); C68(0.80)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C66(1.46); C68(1.46)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C66(1.27); C68(1.27)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C66(1.30); C68(1.30)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C66(1.03); C68(1.03)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C66(1.14); C68(1.14)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C66(1.51); C68(1.51)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C66(1.29); C68(1.29)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C66(1.94); C68(1.94)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C66(1.65); C68(1.65)  LDD0811  [2]
 LDCM0427  Fragment51 HCT 116 C66(0.82); C68(0.82)  LDD0744  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853