Details of the Target

General Information of Target

Target ID LDTP16024
Target Name Ribosome production factor 1 (RPF1)
Gene Name RPF1
Gene ID 80135
Synonyms
BXDC5; Ribosome production factor 1; Brix domain-containing protein 5; Ribosome biogenesis protein RPF1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAWPCISRLCCLARRWNQLDRSDVAVPLTLHGYSDLDSEEPGTGGAASRRGQPPAGARDS
GRDVPLTQYQRDFGLWTTPAGPKDPPPGRGPGAGGRRGKSSAQSSAPPAPGARGVYVLPI
GDADAAAAVTTSYRQEFQAWTGVKPSRSTKTKPARVITTHTSGWDSSPGAGFQVPEVRKK
FTPNPSAIFQASAPRILNV
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function May be required for ribosome biogenesis.
Uniprot ID
Q9H9Y2
Ensemble ID
ENST00000370654.6
HGNC ID
HGNC:30350

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
BTD
 Probe Info  		C187(0.55)  LDD2125  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
DBIA
 Probe Info  		C187(1.08)  LDD0531  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C187(1.08)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C187(1.10)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C187(1.05)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C187(0.98)  LDD1510  [8]
 LDCM0270  AC15 HEK-293T C187(1.16)  LDD1513  [8]
 LDCM0276  AC17 HCT 116 C187(1.08)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C187(0.86)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C187(0.82)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C187(0.80)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C187(0.92)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C187(0.72)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C187(0.83)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C187(0.84)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C187(0.92)  LDD0601  [4]
 LDCM0286  AC26 HEK-293T C187(1.04)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C187(0.89)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C187(0.86)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C187(0.98)  LDD1528  [8]
 LDCM0290  AC3 HCT 116 C187(1.01)  LDD0607  [4]
 LDCM0292  AC31 HEK-293T C187(1.26)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C187(1.16)  LDD1532  [8]
 LDCM0295  AC34 HEK-293T C187(1.24)  LDD1534  [8]
 LDCM0296  AC35 HCT 116 C187(0.96)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C187(0.93)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C187(0.98)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C187(0.95)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C187(1.07)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C187(1.11)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C187(1.06)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C187(0.87)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C187(0.98)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C187(0.82)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C187(1.01)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C187(1.02)  LDD0624  [4]
 LDCM0309  AC47 HEK-293T C187(1.06)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C187(1.09)  LDD1549  [8]
 LDCM0312  AC5 HCT 116 C187(0.92)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C187(1.03)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C187(1.00)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C187(0.89)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C187(0.87)  LDD1555  [8]
 LDCM0318  AC55 HEK-293T C187(1.13)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C187(1.10)  LDD1558  [8]
 LDCM0321  AC58 HEK-293T C187(1.17)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C187(0.99)  LDD1561  [8]
 LDCM0324  AC60 HEK-293T C187(0.89)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C187(0.94)  LDD1564  [8]
 LDCM0327  AC63 HEK-293T C187(1.10)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C187(1.14)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C187(1.23)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C187(1.06)  LDD1569  [8]
 LDCM0349  AC83 HCT 116 C187(0.90)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C187(0.80)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C187(0.83)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C187(0.79)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C187(0.78)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C187(0.66)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C187(0.87)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C187(0.88)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C187(0.72)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C187(0.74)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C187(1.03)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C187(0.82)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C187(0.76)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C187(0.97)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C187(0.79)  LDD0681  [4]
 LDCM0248  AKOS034007472 HEK-293T C187(1.15)  LDD1511  [8]
 LDCM0275  AKOS034007705 HEK-293T C187(1.02)  LDD1514  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C187(1.07)  LDD1571  [8]
 LDCM0369  CL100 HCT 116 C187(1.01)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C187(1.06)  LDD1574  [8]
 LDCM0373  CL104 HEK-293T C187(1.09)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C187(0.99)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C187(0.96)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C187(0.99)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C187(1.01)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C187(0.80)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C187(1.21)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C187(0.92)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C187(1.07)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C187(1.11)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C187(1.11)  LDD1587  [8]
 LDCM0386  CL116 HEK-293T C187(1.05)  LDD1590  [8]
 LDCM0387  CL117 HCT 116 C187(0.98)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C187(0.94)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C187(0.95)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C187(1.16)  LDD1594  [8]
 LDCM0391  CL120 HCT 116 C187(0.84)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C187(1.02)  LDD1596  [8]
 LDCM0395  CL124 HEK-293T C187(1.03)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C187(1.00)  LDD1600  [8]
 LDCM0399  CL128 HEK-293T C187(1.03)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C187(1.07)  LDD1604  [8]
 LDCM0403  CL16 HEK-293T C187(0.97)  LDD1607  [8]
 LDCM0405  CL18 HEK-293T C187(1.02)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C187(0.93)  LDD1610  [8]
 LDCM0408  CL20 HEK-293T C187(1.09)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C187(1.20)  LDD1613  [8]
 LDCM0411  CL23 HEK-293T C187(1.13)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C187(1.09)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C187(0.95)  LDD1617  [8]
 LDCM0416  CL28 HEK-293T C187(0.89)  LDD1620  [8]
 LDCM0419  CL30 HEK-293T C187(1.17)  LDD1623  [8]
 LDCM0420  CL31 HCT 116 C187(1.05)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C187(0.89)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C187(0.96)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C187(1.03)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C187(1.03)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C187(0.93)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C187(0.93)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C187(0.86)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C187(1.17)  LDD1633  [8]
 LDCM0430  CL40 HCT 116 C187(0.80)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C187(0.92)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C187(0.80)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C187(1.07)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C187(0.89)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C187(1.01)  LDD0752  [4]
 LDCM0437  CL47 HEK-293T C187(1.12)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C187(1.17)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C187(0.97)  LDD1643  [8]
 LDCM0443  CL52 HEK-293T C187(1.03)  LDD1646  [8]
 LDCM0445  CL54 HEK-293T C187(0.98)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C187(0.97)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C187(0.90)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C187(1.08)  LDD1651  [8]
 LDCM0450  CL59 HEK-293T C187(1.16)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C187(0.95)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C187(1.19)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C187(1.05)  LDD1656  [8]
 LDCM0456  CL64 HEK-293T C187(1.05)  LDD1659  [8]
 LDCM0458  CL66 HEK-293T C187(1.06)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C187(0.99)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C187(0.90)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C187(0.91)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C187(0.94)  LDD1665  [8]
 LDCM0464  CL71 HEK-293T C187(1.01)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C187(1.11)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C187(1.02)  LDD1669  [8]
 LDCM0469  CL76 HEK-293T C187(1.04)  LDD1672  [8]
 LDCM0471  CL78 HEK-293T C187(1.13)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C187(1.02)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C187(0.94)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C187(0.95)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C187(1.03)  LDD1678  [8]
 LDCM0477  CL83 HEK-293T C187(0.97)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C187(0.91)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C187(1.20)  LDD1682  [8]
 LDCM0482  CL88 HEK-293T C187(1.05)  LDD1685  [8]
 LDCM0484  CL9 HEK-293T C187(1.04)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C187(1.04)  LDD1688  [8]
 LDCM0486  CL91 HCT 116 C187(0.92)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C187(0.77)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C187(1.00)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C187(0.94)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C187(0.96)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C187(0.92)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C187(1.00)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C187(0.98)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C187(0.89)  LDD0811  [4]
 LDCM0427  Fragment51 HCT 116 C187(1.05)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C187(1.06)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C187(0.98)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C187(1.07)  LDD1502  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C187(0.55)  LDD2125  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402