Details of the Target

General Information of Target

Target ID LDTP15644
Target Name Caskin-1 (CASKIN1)
Gene Name CASKIN1
Gene ID 57524
Synonyms
KIAA1306; Caskin-1; CASK-interacting protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAINPWASWGALTDQSWGMTAVDPWASWALCPQYPAWHVEGSLEEGRRATGLPAAQVQE
PVTFKDVAVDFTQEEWGQLDLVQRTLYRDVMLETYGHLLSVGNQIAKPEVISLLEQGEEP
WSVEQACPQRTCPEWVRNLESKALIPAQSIFEEEQSHGMKLERYIWDDPWFSRLEVLGCK
DQLEMYHMNQSTAMRQMVFMQKQVLSQRSSEFCGLGAEFSQNLNFVPSQRVSQIEHFYKP
DTHAQSWRCDSAIMYADKVTCENNDYDKTVYQSIQPIYPARIQTGDNLFKCTDAVKSFNH
IIHFGDHKGIHTGEKLYEYKECHQIFNQSPSFNEHPRLHVGENQYNYKEYENIFYFSSFM
EHQKIGTVEKAYKYNEWEKVFGYDSFLTQHTSTYTAEKPYDYNECGTSFIWSSYLIQHKK
THTGEKPYECDKCGKVFRNRSALTKHERTHTGIKPYECNKCGKAFSWNSHLIVHKRIHTG
EKPYVCNECGKSFNWNSHLIGHQRTHTGEKPFECTECGKSFSWSSHLIAHMRMHTGEKPF
KCDECEKAFRDYSALSKHERTHSGAKPYKCTECGKSFSWSSHLIAHQRTHTGEKPYNCQE
CGKAFRERSALTKHEIIHSGIKPYECNKCGKSCSQMAHLVRHQRTHTGEKPYECNKCGKS
FSQSCHLVAHRRIHTGEKPYKCNQCERSFNCSSHLIAHRRTHTGEKPYRCNECGKAFNES
SSLIVHLRNHTGEKPYKCNHCEKAFCKNSSLIIHQRMHSGEKRFICSECGKAFSGHSALL
QHQRNHSEEKLN
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May link the scaffolding protein CASK to downstream intracellular effectors.
Uniprot ID
Q8WXD9
Ensemble ID
ENST00000343516.8
HGNC ID
HGNC:20879

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C156(1.12)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C156(1.12)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C156(0.73)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C156(0.42)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C156(0.41)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C156(0.43)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C156(0.45)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C156(0.43)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C156(0.47)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C156(0.45)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C156(0.61)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C156(0.49)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C156(0.46)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C156(0.79)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C156(0.41)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C156(0.52)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C156(0.57)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C156(1.00)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C156(0.85)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C156(0.82)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C156(0.89)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C156(0.85)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C156(0.89)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C156(0.94)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C156(0.82)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C156(0.79)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C156(0.89)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C156(0.88)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C156(0.86)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C156(0.93)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C156(0.83)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C156(0.94)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C156(0.95)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C156(1.25)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C156(1.12)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C156(1.05)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C156(1.24)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C156(1.10)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C156(1.14)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C156(1.34)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C156(1.22)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C156(1.11)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C156(1.15)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C156(1.05)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C156(1.19)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C156(0.93)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C156(1.14)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C156(1.20)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C156(1.22)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C156(0.89)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C156(0.64)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C156(0.70)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C156(0.70)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C156(0.69)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C156(0.87)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C156(0.86)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C156(0.82)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C156(0.67)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C156(0.66)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C156(0.76)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C156(0.91)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C156(0.67)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C156(0.63)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C156(0.68)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C156(0.62)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C156(0.78)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C156(0.70)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C156(0.78)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C156(1.02)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C156(0.80)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C156(0.75)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C156(0.84)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C156(0.90)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C156(0.85)  LDD0601  [1]
 LDCM0290  AC3 HCT 116 C156(1.11)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C156(1.24)  LDD0618  [1]
 LDCM0308  AC46 HCT 116 C156(1.11)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C156(1.00)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C156(1.14)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C156(1.39)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C156(1.28)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C156(1.25)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C156(1.14)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C156(1.16)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C156(1.09)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C156(1.13)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C156(1.22)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C156(1.66)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C156(0.86)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C156(0.84)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C156(0.85)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C156(0.82)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C156(0.90)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C156(0.98)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C156(0.92)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C156(0.85)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C156(0.96)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C156(1.15)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C156(1.02)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C156(1.22)  LDD0648  [1]
 LDCM0334  AC7 HCT 116 C156(0.76)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C156(0.84)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C156(0.96)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C156(0.85)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C156(0.81)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C156(0.72)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C156(0.89)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C156(0.71)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C156(0.74)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C156(0.90)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C156(0.95)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C156(0.88)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C156(0.75)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C156(0.67)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C156(0.92)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C156(0.79)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C156(0.77)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C156(0.58)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C156(0.46)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C156(1.03)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C156(0.83)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C156(1.02)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C156(1.13)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C156(1.46)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C156(0.96)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C156(0.74)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C156(0.73)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C156(0.97)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C156(0.92)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C156(0.76)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C156(0.80)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C156(0.84)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C156(0.83)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C156(0.76)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C156(1.25)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C156(0.73)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C156(0.75)  LDD0698  [1]
 LDCM0385  CL115 HEK-293T C323(1.08); C156(1.11)  LDD1589  [2]
 LDCM0389  CL119 HEK-293T C323(1.16); C156(1.12)  LDD1593  [2]
 LDCM0390  CL12 HCT 116 C156(2.31)  LDD0707  [1]
 LDCM0392  CL121 HCT 116 C156(0.90)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C156(1.24)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C156(1.19)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C156(1.17)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C156(0.84)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C156(0.76)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C156(0.85)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C156(0.80)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C156(0.84)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C156(1.37)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C156(1.06)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C156(0.93)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C156(0.94)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C156(0.98)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C156(1.02)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C156(1.35)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C156(0.97)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C156(1.03)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C156(1.36)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C156(0.96)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C156(1.04)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C156(0.98)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C156(1.00)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C156(1.11)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C156(0.91)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C156(1.08)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C156(1.31)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C156(0.89)  LDD0736  [1]
 LDCM0428  CL39 HEK-293T C323(0.92); C156(0.98)  LDD1632  [2]
 LDCM0429  CL4 HCT 116 C156(1.27)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C156(1.07)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C156(1.35)  LDD0768  [1]
 LDCM0455  CL63 HEK-293T C323(1.21); C156(1.07)  LDD1658  [2]
 LDCM0462  CL7 HCT 116 C156(0.96)  LDD0779  [1]
 LDCM0469  CL76 HCT 116 C156(0.96)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C156(0.79)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C156(0.75)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C156(1.04)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C156(1.15)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C156(1.02)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C156(0.87)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C156(1.14)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C156(1.42)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C156(1.17)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C156(0.88)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C156(0.85)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C156(0.94)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C156(1.03)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C156(1.53)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C156(1.06)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C156(1.27)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C156(1.02)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C156(1.14)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C156(0.97)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C156(0.85)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C156(1.08)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C156(1.15)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C156(0.96)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C156(1.38)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C156(1.03)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C323(0.97); C156(1.04)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C323(1.19); C156(1.04)  LDD1671  [2]
 LDCM0022  KB02 HEK-293T C156(0.88)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C156(0.89)  LDD1497  [2]
 LDCM0024  KB05 ZR-75-1 C323(1.54)  LDD3493  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peripheral plasma membrane protein CASK (CASK) CAMK Ser/Thr protein kinase family O14936
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caskin-1 (CASKIN1) . Q8WXD9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840