Details of the Target

General Information of Target

Target ID LDTP15342
Target Name Testis-expressed protein 2 (TEX2)
Gene Name TEX2
Gene ID 55852
Synonyms
KIAA1738; TMEM96; Testis-expressed protein 2; Transmembrane protein 96
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDCGPPATLQPHLTGPPGTAHHPVAVCQQESLSFAELPALKPPSPVCLDLFPVAPEELRA
PGSRWSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPR
HTQPQRRASHGSEKKSAWRKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVEL
SGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKASGMEAR
SVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSD
VASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPD
VRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWL
FSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTY
QRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE
DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV
ELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKL
QGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQV
QCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSAR
LRNLRENKRVTSATSKLGEAPV
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation.
Uniprot ID
Q8IWB9
Ensemble ID
ENST00000258991.7
HGNC ID
HGNC:30884

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CMK SNV: p.H522Y DBIA    Probe Info 
COLO320 SNV: p.G314A .
COLO800 SNV: p.M862V DBIA    Probe Info 
HEC1 SNV: p.R625Q DBIA    Probe Info 
HEC1B SNV: p.R625Q; p.P885H .
HLF SNV: p.L943V .
HUH1 SNV: p.P725L DBIA    Probe Info 
KNS42 SNV: p.H1055Y .
LNCaP clone FGC SNV: p.V199A DBIA    Probe Info 
MELHO SNV: p.G314A .
MEWO SNV: p.P791L DBIA    Probe Info 
MFE280 SNV: p.D1125Y DBIA    Probe Info 
MOLT4 SNV: p.P131S .
NCIH2170 SNV: p.G694C DBIA    Probe Info 
NCIH2286 SNV: p.V401F .
SKMEL2 Deletion: p.G967EfsTer22 DBIA    Probe Info 
VMRCRCW SNV: p.K857M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		7.07  LDD0066  [1]
STPyne
 Probe Info  		K215(10.00)  LDD0277  [2]
DBIA
 Probe Info  		C790(3.18)  LDD3311  [3]
BTD
 Probe Info  		C1114(1.13)  LDD2134  [4]
AHL-Pu-1
 Probe Info  		C419(2.01)  LDD0171  [5]
IPM
 Probe Info  		C936(5.29)  LDD1702  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C419(2.01)  LDD0171  [5]
 LDCM0215  AC10 HEK-293T C783(1.07)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C783(1.03)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C783(1.07)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C783(1.09); C1114(1.06)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C783(0.97); C1114(1.11)  LDD1513  [7]
 LDCM0277  AC18 HEK-293T C783(0.95)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C783(1.29)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C783(1.02)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C783(1.03)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C783(1.06); C1114(0.96)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C783(1.04); C1114(0.97)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C783(1.00); C1114(1.08)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C783(0.96); C1114(0.94)  LDD1523  [7]
 LDCM0286  AC26 HEK-293T C783(1.00)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C783(1.10)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C783(1.05)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C783(1.05); C1114(1.00)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C783(0.92)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C783(0.91); C1114(0.96)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C783(1.00); C1114(1.03)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C783(1.15); C1114(1.03)  LDD1532  [7]
 LDCM0295  AC34 HEK-293T C783(0.88)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C783(1.06)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C783(1.00)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C783(1.18); C1114(1.01)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C783(0.91); C1114(0.96)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C783(1.09); C1114(1.11)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C783(0.94)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C783(0.94); C1114(1.11)  LDD1541  [7]
 LDCM0304  AC42 HEK-293T C783(1.04)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C783(1.12)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C783(1.01)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C783(1.09); C1114(1.02)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C783(0.87); C1114(1.02)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C783(1.07); C1114(1.08)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C783(1.07); C1114(1.05)  LDD1549  [7]
 LDCM0312  AC5 HEK-293T C783(0.99); C1114(1.01)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C783(1.04)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C783(1.11)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C783(1.16)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C783(1.00); C1114(0.99)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C783(1.06); C1114(0.99)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C783(0.98); C1114(1.11)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C783(1.19); C1114(1.09)  LDD1558  [7]
 LDCM0321  AC58 HEK-293T C783(0.95)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C783(0.98)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C783(0.95); C1114(0.93)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C783(1.00)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C783(1.17); C1114(1.05)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C783(0.93); C1114(0.96)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C783(1.00); C1114(1.08)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C783(1.05); C1114(1.04)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C783(1.01); C1114(1.04)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C783(0.98); C1114(1.12)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C783(1.14); C1114(1.02)  LDD1511  [7]
 LDCM0275  AKOS034007705 HEK-293T C783(1.06); C1114(1.03)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C783(0.97); C1114(1.01)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C783(1.30); C1114(1.43)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C783(1.06)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C783(1.04); C1114(1.02)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C783(1.20); C1114(1.13)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C1114(1.06)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C783(0.99)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C783(0.96); C1114(1.07)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C783(1.22); C1114(1.01)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C1114(0.99)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C783(1.00)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C783(0.95); C1114(0.98)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C783(1.12); C1114(1.31)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C783(1.14); C1114(1.02)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C1114(1.08)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C783(1.04)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C783(0.97); C1114(1.02)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C783(1.35); C1114(1.20)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C1114(1.12)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C783(1.01)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C783(0.99); C1114(1.14)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C783(1.66); C1114(1.16)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C1114(1.05)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C783(1.25); C1114(1.15)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C783(1.02)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C783(0.94); C1114(1.04)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C783(1.04); C1114(1.08)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C1114(1.23)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C783(1.11)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C783(0.95); C1114(1.13)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C783(0.97); C1114(1.06)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C1114(1.06)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C783(1.06)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C783(1.03); C1114(1.14)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C783(1.06); C1114(1.11)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C1114(1.14)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C783(0.99)  LDD1607  [7]
 LDCM0405  CL18 HEK-293T C783(1.28)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C783(1.17)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C783(1.09); C1114(1.08)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C783(1.16)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C783(1.22); C1114(1.29)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C783(1.28); C1114(1.14)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C783(1.20); C1114(1.17)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C783(1.22); C1114(1.15)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C783(0.98); C1114(0.96)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C783(1.37); C1114(1.06)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C1114(1.04)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C783(1.02)  LDD1620  [7]
 LDCM0418  CL3 HEK-293T C1114(1.04)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C783(1.05)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C783(1.18)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C783(1.27)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C783(1.20); C1114(1.26)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C783(1.10); C1114(1.16)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C783(1.20); C1114(1.12)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C783(1.29); C1114(1.21)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C783(0.94); C1114(0.91)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C1114(1.06)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C783(0.91)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C783(1.09)  LDD1634  [7]
 LDCM0432  CL42 HEK-293T C783(1.00)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C783(1.09)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C783(1.10)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C783(1.08); C1114(1.16)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C783(1.14); C1114(1.11)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C783(1.12); C1114(1.26)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C783(1.05); C1114(1.17)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C783(1.03); C1114(0.99)  LDD1643  [7]
 LDCM0441  CL50 HEK-293T C783(1.20); C1114(1.05)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C783(1.02)  LDD1646  [7]
 LDCM0445  CL54 HEK-293T C783(0.93)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C783(1.22)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C783(1.26)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C783(1.29); C1114(1.26)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C783(1.19); C1114(1.25)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C783(1.18); C1114(1.28)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C783(1.01)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C783(1.07); C1114(1.24)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C783(0.95); C1114(1.07)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C783(1.22); C1114(0.98)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C1114(1.14)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C783(0.98)  LDD1659  [7]
 LDCM0458  CL66 HEK-293T C783(1.07)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C783(1.09)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C783(1.11)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C783(1.09); C1114(1.13)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C783(0.98)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C783(1.14); C1114(1.15)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C783(1.18); C1114(1.21)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C783(1.17); C1114(1.10)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C783(0.96); C1114(1.04)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C783(1.15); C1114(0.97)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C783(1.05)  LDD1672  [7]
 LDCM0471  CL78 HEK-293T C783(1.11)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C783(1.08)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C783(1.23)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C783(1.01)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C783(1.14); C1114(1.12)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C783(1.04); C1114(1.14)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C783(1.21); C1114(1.30)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C783(1.14); C1114(1.22)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C783(0.90); C1114(1.01)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C783(0.96); C1114(1.04)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C1114(1.13)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C783(1.01)  LDD1685  [7]
 LDCM0484  CL9 HEK-293T C783(0.99); C1114(1.19)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C783(0.98)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C783(0.98)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C783(1.18)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C783(1.09); C1114(1.11)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C783(1.04); C1114(1.13)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C783(1.34); C1114(1.46)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C783(0.96); C1114(1.19)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C783(0.97); C1114(1.02)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C783(1.10); C1114(1.10)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C1114(1.07)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C1114(1.11)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C936(5.29)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C1114(1.05)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C783(1.21); C1114(0.95)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C405(0.91); C783(0.87)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C405(0.91); C783(1.07)  LDD1497  [7]
 LDCM0024  KB05 G361 C790(3.18)  LDD3311  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1114(1.13)  LDD2134  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1114(1.04)  LDD2143  [4]

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402