Details of the Target

General Information of Target

Target ID LDTP15286
Target Name Transmembrane protein 135 (TMEM135)
Gene Name TMEM135
Gene ID 65084
Synonyms
Transmembrane protein 135; Peroxisomal membrane protein 52; PMP52
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPNVAETERSNDSGNGEHKSERKSPEENLQGAVKSFCTSASGAPLGPKGDGHYPWSCPVT
HTREKIYAICSDYAFLNQATSIYKTPNPSRSPCLPDSTSLSAGNNSSRYIGIPTSTSEII
YNEENSLENLSNSLGKLPLAWEIDKSEFDGVTTNSKHKSGNAKKQVSKRKTSDKKGRYQK
ECPQHSPLEDIKQRKVLDLRRWYCISRPQYKTSCGISSLISCWNFLYSTMGAGNLPPITQ
EEALHILGFQPPFEDIRFGPFTGNTTLMRWFRQINDHFHVKGCSYVLYKPHGKNKTAGET
ASGALSKLTRGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAFSRGPLSPQEVEYWILI
GESSRKHPAIHCKKWADIVTDLNTQNPEYLDIRHLERGLQYRKTKKVGGNLHCIIAFQRL
NWQRFGLWNFPFGTIRQESQPPTHAQGIAKSESEDNISKKQHGRLGRSFSASFHQDSAWK
KMSSIHERRNSGYQGYSDYDGND
Target Bioclass
Other
Family
TMEM135 family
Subcellular location
Mitochondrion membrane
Function
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.
Uniprot ID
Q86UB9
Ensemble ID
ENST00000305494.6
HGNC ID
HGNC:26167

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.A106V .
MDAMB231 SNV: p.L304V .
MFE319 SNV: p.A50T .
NCIH2172 SNV: p.G224V .
SW1573 SNV: p.M220V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C234(2.78)  LDD3427  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C316(0.97)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C316(0.99); C234(0.87)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C316(1.02); C234(0.91)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C316(0.95); C234(1.00)  LDD1510  [7]
 LDCM0246  AC128 HEK-293T C316(0.96)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C316(0.94)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C316(0.73)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C316(0.61)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C316(0.83)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C316(0.62)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C316(0.80)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C316(0.75)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C316(1.09)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C316(1.05)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C316(1.10)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C316(1.20)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C316(1.05); C234(0.94)  LDD1512  [7]
 LDCM0260  AC140 HEK-293T C316(0.94)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C316(0.99)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C316(0.97)  LDD0860  [6]
 LDCM0270  AC15 HEK-293T C316(1.08); C234(0.99); C250(1.22)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C316(0.97); C234(0.90)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C316(1.02); C234(0.95)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C316(0.97); C234(1.48)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C316(1.26)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C316(0.92); C234(0.96)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C316(1.04); C234(0.99)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C316(0.95); C234(0.92)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C316(0.98); C234(0.99); C250(1.01)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C316(1.03); C234(0.97)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C316(0.94); C234(0.88)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C316(1.03); C234(0.98)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C316(1.04); C234(0.96)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C316(1.01); C234(0.99)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C316(0.92); C234(0.95)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C316(0.95)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C316(1.05); C234(0.97)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C316(1.01); C234(0.99); C250(1.14)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C316(0.92); C234(0.93)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C316(0.92); C234(0.90)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C316(1.00); C234(0.93)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C316(0.57)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C316(2.81)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C316(0.97)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C316(1.12)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C316(0.91)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C316(0.92)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C316(1.11)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C316(1.16)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C316(1.43)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C316(1.29)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C316(1.44)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C316(1.30)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C316(1.00); C234(0.90)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C316(0.94); C234(0.99); C250(1.13)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C316(0.93); C234(0.88)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C316(0.94); C234(0.89)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C316(1.41)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C316(1.00); C234(0.91)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C316(0.94); C234(0.91)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C316(0.99); C234(0.99)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C316(0.85); C234(0.96)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C316(0.97); C234(0.97)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C316(1.05); C234(1.01); C250(1.18)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C316(0.96); C234(0.90)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C316(1.09); C234(0.89)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C316(1.08); C234(0.96)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C316(1.06); C234(0.92)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C316(1.08); C234(0.97)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C316(0.98); C234(0.97)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C316(0.92); C234(0.97)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C316(1.05); C234(0.87)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C316(1.05); C234(0.96); C250(1.08)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C316(1.00); C234(0.89)  LDD1567  [7]
 LDCM0332  AC68 HEK-293T C316(1.02)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C316(0.85)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C316(0.98); C234(0.93); C250(1.26)  LDD1568  [7]
 LDCM0335  AC70 HEK-293T C316(1.07)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C316(1.16)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C316(0.94)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C316(0.75)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C316(1.18)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C316(1.17)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C316(0.92)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C316(1.12)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C316(1.14)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C316(0.97)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C316(0.97); C234(0.95)  LDD1569  [7]
 LDCM0346  AC80 HEK-293T C316(1.22)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C316(1.24)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C316(1.64)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C316(0.95)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C316(1.26)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C316(0.99)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C316(1.00)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C316(1.05)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C316(1.13)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C316(1.14)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C316(0.98)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C316(0.95)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C316(1.42)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C316(1.18)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C316(1.15)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C316(1.12)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C316(1.06)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C316(1.14)  LDD0962  [6]
 LDCM0248  AKOS034007472 HEK-293T C316(0.92); C234(0.98)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C316(1.02); C234(0.90)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C316(1.05); C234(0.93)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C316(1.06); C234(0.98); C250(1.34)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C316(1.81); C234(1.37)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C316(1.52)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C316(1.06); C234(0.87); C250(1.00)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C316(1.17); C234(0.92)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C316(1.02); C234(0.93); C250(1.09)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C316(0.96); C234(1.00)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C316(1.01); C234(0.67); C250(1.08)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C316(1.02); C234(0.98)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C316(0.97); C234(0.99); C250(1.02)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C316(0.96); C234(0.95)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C316(1.08); C234(0.93); C250(1.16)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C316(1.36); C234(1.31); C250(1.66)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C316(1.27); C234(0.91)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C316(1.30); C234(1.00); C250(1.11)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C316(0.97); C234(0.92)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C316(0.96); C234(0.88); C250(0.90)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C316(1.20); C234(0.86)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C316(0.95); C234(0.92); C250(1.10)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C316(1.00); C234(0.99)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C316(0.85)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C316(0.58)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C316(1.12)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C316(1.49); C234(1.11)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C316(1.09)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C316(0.99); C234(0.78); C250(1.09)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C316(1.14); C234(0.94)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C316(1.20); C234(1.05); C250(1.17)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C316(1.09); C234(0.94)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C316(1.06); C234(0.84); C250(1.33)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C316(1.16); C234(0.86)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C316(1.15); C234(0.90); C250(1.05)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C316(1.05); C234(0.95)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C316(0.96); C234(0.97); C250(1.13)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C316(0.96); C234(0.95)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C316(1.42); C234(0.99); C250(1.21)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C316(1.26)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C316(1.65)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C316(1.48)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C316(1.46)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C316(1.01); C234(0.92)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C316(1.05)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C316(2.60)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C316(1.30)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C316(0.84)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C316(1.53)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C316(1.09)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C316(1.03)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C316(0.86)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C316(0.89)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C316(1.19)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C316(1.18); C234(0.97); C250(1.04)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C316(1.89)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C316(1.19); C234(1.06)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C316(1.10); C234(1.03)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C316(2.28); C234(1.18)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C316(1.27); C234(1.18)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C316(1.41); C234(1.40); C250(1.46)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C316(1.27); C234(1.26)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C316(1.10); C234(0.83); C250(1.17)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C316(1.00); C234(0.95); C250(1.00)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C316(1.26); C234(1.08)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C316(1.09); C234(0.96)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C316(1.07); C234(0.96)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C316(1.07); C234(0.99)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C316(1.23); C234(1.09)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C316(1.14); C234(1.01)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C316(1.51); C234(0.98)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C316(1.40); C234(1.24)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C316(1.33); C234(1.34); C250(1.26)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C316(1.44); C234(1.22)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C316(1.05); C234(0.83); C250(1.34)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C316(1.09); C234(0.91)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C316(1.06); C234(0.97)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C316(1.03); C234(1.03)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C316(1.23); C234(0.93)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C316(1.33); C234(1.26)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C316(1.16); C234(1.01)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C316(1.15); C234(0.96)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C316(1.38); C234(0.83)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C316(1.38); C234(1.21)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C316(1.28); C234(1.34); C250(1.44)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C316(1.41); C234(0.95)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C316(1.31); C234(1.20)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C316(0.97); C234(0.81); C250(1.23)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C316(0.93); C234(0.91)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C316(1.01); C234(0.97); C250(1.02)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C316(1.15); C234(1.05)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C316(0.93); C234(0.90)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C316(1.10); C234(0.95)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C316(1.13); C234(1.05)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C316(1.15); C234(0.97)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C316(1.28); C234(0.98)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C316(1.24); C234(1.09)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C316(1.27); C234(1.21)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C316(1.23); C234(1.19); C250(1.46)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C316(1.28); C234(1.12)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C316(1.08); C234(0.80); C250(1.02)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C316(0.92); C234(0.93)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C316(0.96); C234(1.04)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C316(1.33); C234(0.89)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C316(1.07); C234(0.96)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C316(1.10); C234(1.03)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C316(1.85); C234(1.39)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C316(1.05); C234(1.04)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C316(1.17); C234(1.00)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C316(1.28); C234(1.16)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C316(1.24); C234(1.28); C250(1.37)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C316(1.41); C234(1.20)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C316(1.12); C234(0.72); C250(1.23)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C316(1.13); C234(0.87)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C316(1.16); C234(0.85); C250(1.26)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C316(0.99); C234(0.96)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C316(1.06); C234(0.89)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C316(1.25); C234(0.96)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C316(1.67); C234(1.17)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C316(1.38)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C316(1.14)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C316(1.29)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C316(1.60)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C316(2.83)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C316(1.47)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C316(1.67)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C316(1.23)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C316(1.01)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C316(1.00); C234(0.93); C250(1.01)  LDD1698  [7]
 LDCM0625  F8 Ramos C316(1.01); C234(0.57)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C234(1.38)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C316(0.39); C234(0.30); 20.00  LDD2190  [8]
 LDCM0575  Fragment13 Ramos C234(0.88)  LDD2192  [8]
 LDCM0580  Fragment21 Ramos C316(0.75); C234(0.75)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C316(0.77)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C316(0.78); C234(0.70)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C316(0.61); C234(0.79)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C316(0.82); C234(1.52)  LDD2199  [8]
 LDCM0468  Fragment33 HEK-293T C316(1.02); C234(0.92); C250(0.89)  LDD1671  [7]
 LDCM0596  Fragment38 Ramos C316(3.01); C234(2.28)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C316(1.28)  LDD2184  [8]
 LDCM0427  Fragment51 HEK-293T C316(0.92); C234(0.97)  LDD1631  [7]
 LDCM0614  Fragment56 Ramos C234(0.71)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C316(0.63); C234(0.69)  LDD2186  [8]
 LDCM0022  KB02 HEK-293T C316(0.87); C234(0.91); C23(0.78)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C316(1.12); C234(0.93); C23(0.91)  LDD1497  [7]
 LDCM0024  KB05 SK-MEL-28 C234(2.78)  LDD3427  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578