Details of the Target

General Information of Target

Target ID LDTP14846
Target Name Zinc finger protein 273 (ZNF273)
Gene Name ZNF273
Gene ID 10793
Synonyms
Zinc finger protein 273; Zinc finger protein HZF9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKFQEAVTFKDVAVAFTEEELGLLDSAQRKLYRDVMLENFRNLVSVGHQSFKPDMISQL
EREEKLWMKELQTQRGKHSGDRNQNEMATLHKAGLRCFSLGELSCWQIKRHIASKLARSQ
DSMINIEGKSSQFPKHHDSPCQVGAGESIQASVDDNCLVNHIGDHSSIIENQEFPTGKVP
NSWSKIYLNETQNYQRSCKQTQMKNKLCIFAPYVDIFSCISHHHDDNIVHKRDKVHSNSD
CGKDTLKVSPLTQRSIHTGQKTYQGNECEEAFNDSSSLELHKQVHLGKKSPACSTHEKDT
SYSSGIPVQQSVRTGKKRYWCHECGKGFSQSSNLQTHQRVHTGEKPYTCHECGKSFNQSS
HLYAHLPIHTGEKPYRCDSCGKGFSRSTDLNIHCRVHTGEKPYKCEVCGKGFTQRSHLQA
HERIHTGEKPYKCGDCGKRFSCSSNLHTHQRVHTEEKPYKCDECGKCFSLSFNLHSHQRV
HTGEKPYKCEECGKGFSSASSFQSHQRVHTGEKPFRCNVCGKGFSQSSYFQAHQRVHTGE
KPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFK
CDACQKRFSQASHLQAHQRVHTGEKPYKCDTCGKAFSQRSNLQVHQIIHTGEKPFKCEEC
GKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDVCCKGF
SQRSHLIYHQRVHTGGNL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q14593
Ensemble ID
ENST00000476120.2
HGNC ID
HGNC:13067

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAKI1 Deletion: p.H188IfsTer34 .
HT SNV: p.K288N .
HT115 SNV: p.S2F .
TE4 Deletion: p.R147EfsTer24 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C180(4.36)  LDD0209  [1]
HHS-465
 Probe Info  		K344(0.00); K347(0.00); Y346(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C215(1.03); C216(1.03)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C215(0.86); C216(0.86)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C215(1.09); C216(1.09)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C215(1.06); C216(1.06)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C215(1.12); C216(1.12)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C215(1.13); C216(1.13)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C215(1.14); C216(1.14)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C215(0.98); C216(0.98)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C215(1.36); C216(0.93)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C215(1.18); C216(1.28)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C215(0.92); C216(0.92)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C215(0.99); C216(0.99)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C215(0.91); C216(1.02)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C215(0.98); C216(1.15)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C215(1.10); C216(1.32)  LDD0546  [3]
 LDCM0237  AC12 HCT 116 C215(0.94); C216(0.94)  LDD0554  [3]
 LDCM0246  AC128 HCT 116 C215(0.89); C216(0.89)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C215(0.95); C216(0.95)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C215(0.96); C216(0.96)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C215(1.19); C216(1.19)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C215(1.41); C216(1.41)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C215(1.03); C216(1.03)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C215(1.07); C216(1.07)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C215(1.09); C216(1.09)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C215(1.18); C216(1.18)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C215(1.06); C216(1.06)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C215(1.16); C216(1.16)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C215(1.15); C216(1.15)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C215(1.06); C216(1.06)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C215(1.34); C216(1.34)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C215(1.25); C216(1.25)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C215(1.05); C216(1.05)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C215(1.11); C216(1.11)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C215(1.17); C216(1.17)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C215(1.35); C216(1.35)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C215(1.20); C216(1.20)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C215(1.29); C216(1.29)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C215(1.51); C216(1.51)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C215(1.19); C216(1.19)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C215(1.03); C216(1.03)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C215(1.19); C216(1.19)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C215(0.96); C216(0.96)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C215(1.44); C216(1.44)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C215(1.51); C216(1.51)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C215(1.39); C216(1.39)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C215(1.21); C216(1.21)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C215(1.13); C216(1.13)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C215(1.32); C216(1.32)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C215(0.91); C216(0.91)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C215(1.69); C216(1.69)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C215(0.84); C216(0.84)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C215(0.91); C216(0.91)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C215(1.11); C216(1.11)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C215(1.03); C216(1.03)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C215(1.32); C216(1.32)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C215(0.90); C216(0.90)  LDD0601  [3]
 LDCM0296  AC35 HCT 116 C215(0.79); C216(0.79)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C215(0.82); C216(0.82)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C215(0.77); C216(0.77)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C215(0.76); C216(0.76)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C215(0.92); C216(0.92)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C215(0.93); C216(0.93)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C215(1.01); C216(1.01)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C215(1.02); C216(1.02)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C215(0.98); C216(0.98)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C215(0.96); C216(0.96)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C215(1.03); C216(1.03)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C215(1.00); C216(1.00)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C215(1.08); C216(1.08)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C215(0.84); C216(0.84)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C215(1.04); C216(1.04)  LDD0628  [3]
 LDCM0313  AC50 HCT 116 C215(1.09); C216(1.09)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C215(0.99); C216(0.99)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C215(0.87); C216(0.87)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C215(1.05); C216(1.05)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C215(0.96); C216(0.96)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C215(1.14); C216(1.14)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C215(0.98); C216(0.98)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C215(1.35); C216(1.35)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C215(1.27); C216(1.27)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C215(1.46); C216(1.46)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C215(1.05); C216(1.05)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C215(1.52); C216(1.52)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C215(1.39); C216(1.39)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C215(1.57); C216(1.57)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C215(1.44); C216(1.44)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C215(1.86); C216(1.86)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C215(1.32); C216(1.32)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C215(1.34); C216(1.34)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C215(1.56); C216(1.56)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C215(0.97); C216(0.97)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C215(0.94); C216(0.94)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C215(1.57); C216(1.57)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C215(1.64); C216(1.64)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C215(1.30); C216(1.30)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C215(1.12); C216(1.12)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C215(1.04); C216(1.04)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C215(1.03); C216(1.03)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C215(1.16); C216(1.16)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C215(1.03); C216(1.03)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C215(1.57); C216(1.57)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C215(1.32); C216(1.32)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C215(1.35); C216(1.35)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C215(1.18); C216(1.18)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C215(0.90); C216(0.90)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C215(1.37); C216(1.37)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C215(1.36); C216(1.36)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C215(1.10); C216(1.10)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C215(0.87); C216(0.87)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C215(0.99); C216(0.99)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C215(0.77); C216(0.77)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C215(1.08); C216(1.08)  LDD0592  [3]
 LDCM0370  CL101 HCT 116 C215(1.14); C216(1.14)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C215(1.09); C216(1.09)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C215(0.99); C216(0.99)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C215(1.03); C216(1.03)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C215(1.33); C216(1.33)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C215(1.43); C216(1.43)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C215(1.36); C216(1.36)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C215(1.40); C216(1.40)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C215(1.11); C216(1.11)  LDD0695  [3]
 LDCM0380  CL110 HCT 116 C215(1.46); C216(1.46)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C215(1.10); C216(1.10)  LDD0698  [3]
 LDCM0387  CL117 HCT 116 C215(1.06); C216(1.06)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C215(0.99); C216(0.99)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C215(0.85); C216(0.85)  LDD0706  [3]
 LDCM0391  CL120 HCT 116 C215(0.87); C216(0.87)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C215(1.10); C216(1.10)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C215(1.02); C216(1.02)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C215(0.85); C216(0.85)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C215(1.00); C216(1.00)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C215(1.17); C216(1.17)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C215(1.25); C216(1.25)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C215(1.17); C216(1.17)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C215(1.33); C216(1.33)  LDD0716  [3]
 LDCM0403  CL16 HCT 116 C215(1.26); C216(1.26)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C215(1.15); C216(1.15)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C215(1.06); C216(1.06)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C215(0.96); C216(0.96)  LDD0723  [3]
 LDCM0408  CL20 HCT 116 C215(1.07); C216(1.07)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C215(1.25); C216(1.25)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C215(0.98); C216(0.98)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C215(1.17); C216(1.17)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C215(1.08); C216(1.08)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C215(1.20); C216(1.20)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C215(1.39); C216(1.39)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C215(1.17); C216(1.17)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C215(1.18); C216(1.18)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C215(1.17); C216(1.17)  LDD0734  [3]
 LDCM0419  CL30 HCT 116 C215(1.04); C216(1.04)  LDD0736  [3]
 LDCM0436  CL46 HCT 116 C215(1.10); C216(1.10)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C215(1.05); C216(1.05)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C215(1.11); C216(1.11)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C215(1.08); C216(1.08)  LDD0756  [3]
 LDCM0441  CL50 HCT 116 C215(1.13); C216(1.13)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C215(1.27); C216(1.27)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C215(1.20); C216(1.20)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C215(1.17); C216(1.17)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C215(1.13); C216(1.13)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C215(1.06); C216(1.06)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C215(1.03); C216(1.03)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C215(1.24); C216(1.24)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C215(1.25); C216(1.25)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C215(1.07); C216(1.07)  LDD0767  [3]
 LDCM0452  CL60 HCT 116 C215(1.08); C216(1.08)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C215(0.90); C216(0.90)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C215(1.06); C216(1.06)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C215(1.12); C216(1.12)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C215(1.15); C216(1.15)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C215(1.02); C216(1.02)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C215(1.45); C216(1.45)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C215(1.00); C216(1.00)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C215(0.96); C216(0.96)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C215(1.04); C216(1.04)  LDD0778  [3]
 LDCM0463  CL70 HCT 116 C215(0.94); C216(0.94)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C215(0.97); C216(0.97)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C215(1.02); C216(1.02)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C215(1.02); C216(1.02)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C215(1.09); C216(1.09)  LDD0784  [3]
 LDCM0468  Fragment33 HCT 116 C215(1.09); C216(1.09)  LDD0785  [3]
 LDCM0023  KB03 Jurkat C180(4.36)  LDD0209  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.