Details of the Target

General Information of Target

Target ID LDTP14706
Target Name Zinc finger protein 136 (ZNF136)
Gene Name ZNF136
Gene ID 7695
Synonyms
Zinc finger protein 136
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL
CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV
QSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMT
AYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDT
LNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.
Uniprot ID
P52737
Ensemble ID
ENST00000343979.6
HGNC ID
HGNC:12920

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C310(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C291(0.91)  LDD0580  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C310(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C310(2.25)  LDD0171  [1]
 LDCM0215  AC10 HEK-293T C235(1.04)  LDD1508  [5]
 LDCM0237  AC12 HEK-293T C291(0.98)  LDD1510  [5]
 LDCM0263  AC143 HCT 116 C291(0.91)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C291(0.86)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C291(0.79)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C291(1.08)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C291(0.96)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C291(2.19)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C291(1.30)  LDD0586  [2]
 LDCM0271  AC150 HCT 116 C291(0.83)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C291(0.84)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C291(0.82)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C291(1.21)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C291(0.81)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C291(0.87)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C291(0.96)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C291(0.90)  LDD2161  [2]
 LDCM0277  AC18 HEK-293T C235(1.02)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C235(1.01)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C291(0.99)  LDD1519  [5]
 LDCM0286  AC26 HEK-293T C235(0.98)  LDD1525  [5]
 LDCM0288  AC28 HEK-293T C291(1.06)  LDD1527  [5]
 LDCM0295  AC34 HEK-293T C235(1.10)  LDD1534  [5]
 LDCM0297  AC36 HEK-293T C291(0.96)  LDD1536  [5]
 LDCM0301  AC4 HEK-293T C291(1.06)  LDD1540  [5]
 LDCM0304  AC42 HEK-293T C235(1.20)  LDD1543  [5]
 LDCM0306  AC44 HEK-293T C291(1.00)  LDD1545  [5]
 LDCM0313  AC50 HEK-293T C235(1.01)  LDD1552  [5]
 LDCM0315  AC52 HEK-293T C291(1.07)  LDD1554  [5]
 LDCM0321  AC58 HEK-293T C235(1.04)  LDD1560  [5]
 LDCM0324  AC60 HEK-293T C291(1.06)  LDD1563  [5]
 LDCM0367  CL1 HCT 116 C291(0.86)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C291(0.80)  LDD0685  [2]
 LDCM0372  CL103 HEK-293T C235(1.06)  LDD1576  [5]
 LDCM0376  CL107 HEK-293T C235(0.91)  LDD1580  [5]
 LDCM0379  CL11 HCT 116 C291(0.74)  LDD0696  [2]
 LDCM0381  CL111 HEK-293T C235(1.07)  LDD1585  [5]
 LDCM0385  CL115 HEK-293T C235(1.23)  LDD1589  [5]
 LDCM0389  CL119 HEK-293T C235(1.03)  LDD1593  [5]
 LDCM0390  CL12 HCT 116 C291(0.75)  LDD0707  [2]
 LDCM0394  CL123 HEK-293T C235(1.09)  LDD1598  [5]
 LDCM0398  CL127 HEK-293T C235(1.09)  LDD1602  [5]
 LDCM0400  CL13 HCT 116 C291(0.82)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C291(0.78)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C291(0.86)  LDD0719  [2]
 LDCM0405  CL18 HEK-293T C235(1.29)  LDD1609  [5]
 LDCM0407  CL2 HCT 116 C291(0.79)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C291(1.07)  LDD1612  [5]
 LDCM0415  CL27 HEK-293T C235(1.04)  LDD1619  [5]
 LDCM0418  CL3 HCT 116 C291(0.82)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C235(1.09)  LDD1623  [5]
 LDCM0420  CL31 HCT 116 C291(1.15)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C291(1.08)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C291(1.14)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C291(1.10)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C291(1.01)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C291(1.02)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C291(1.09)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C291(1.14)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C291(0.80)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C291(1.04)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C291(0.95)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C291(0.81)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C291(1.06)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C291(1.05)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C291(1.37)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C291(1.09)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C291(1.03)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C291(1.04)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C291(0.97)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C291(0.83)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C291(0.94)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C291(1.12)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C291(1.05)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C291(0.94)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C291(1.18)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C291(0.90)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C291(1.00)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C291(1.07)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C291(1.13)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C291(0.89)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C291(0.88)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C291(1.00)  LDD0769  [2]
 LDCM0455  CL63 HEK-293T C235(1.02)  LDD1658  [5]
 LDCM0458  CL66 HEK-293T C235(1.20)  LDD1661  [5]
 LDCM0460  CL68 HEK-293T C291(1.15)  LDD1663  [5]
 LDCM0462  CL7 HCT 116 C291(0.88)  LDD0779  [2]
 LDCM0471  CL78 HEK-293T C235(1.19)  LDD1674  [5]
 LDCM0473  CL8 HCT 116 C291(0.92)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C291(0.98)  LDD1677  [5]
 LDCM0481  CL87 HEK-293T C235(0.98)  LDD1684  [5]
 LDCM0484  CL9 HCT 116 C291(0.93)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C235(1.31)  LDD1688  [5]
 LDCM0487  CL92 HEK-293T C291(1.23)  LDD1690  [5]
 LDCM0494  CL99 HEK-293T C235(1.12)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C235(1.06)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C235(1.12)  LDD1671  [5]
 LDCM0427  Fragment51 HCT 116 C291(1.10)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C375(0.88)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C375(1.10)  LDD1497  [5]
 LDCM0024  KB05 MOLM-16 C291(2.83)  LDD3334  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Syntaxin-1A (STX1A) Syntaxin family Q16623
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840