Details of the Target

General Information of Target

Target ID LDTP14368
Target Name Rho GTPase-activating protein 42 (ARHGAP42)
Gene Name ARHGAP42
Gene ID 143872
Synonyms
GRAF3; TMEM133; Rho GTPase-activating protein 42; Rho GTPase-activating protein 10-like; Rho-type GTPase-activating protein 42
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSLTETPEDYTIIVDEEGF
LELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKSVIAPLADQNISVFMLSTY
QTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLGITNGFVKPKLVQRPVIHPLS
SPSNRFCVTSLDPDTLPAVATLLMDVMFYSNGVKDPMATGDDCGHIRFFSFSLIEGYISL
VMDVQTQQRFPSNLLFTSASGELWKMVRIGGQPLGFDECGIVAQISEPLAAADIPAYYIS
TFKFDHALVPEENINGVISALKVSQAEKH
Target Bioclass
Other
Function May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.
Uniprot ID
A6NI28
Ensemble ID
ENST00000298815.13
HGNC ID
HGNC:26545

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0227  [1]
DBIA
 Probe Info  		C653(0.91)  LDD0580  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
YN-1
 Probe Info  		N.A.  LDD0447  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C24(0.98)  LDD1507  [5]
 LDCM0237  AC12 HEK-293T C598(0.96); C653(0.98)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C598(1.35)  LDD1512  [5]
 LDCM0263  AC143 HCT 116 C653(0.91)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C653(1.25)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C653(0.97)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C653(1.10)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C653(1.32)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C653(1.94)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C653(1.12)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C598(0.89)  LDD1513  [5]
 LDCM0271  AC150 HCT 116 C653(1.02)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C653(1.11)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C653(1.10)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C653(2.57)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C653(1.13)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C653(1.26)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C653(0.99)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C653(1.47)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C24(0.97)  LDD1515  [5]
 LDCM0280  AC20 HEK-293T C598(0.83); C653(1.18)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C598(1.12)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C598(0.98)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C598(0.95)  LDD1522  [5]
 LDCM0285  AC25 HEK-293T C24(1.11)  LDD1524  [5]
 LDCM0288  AC28 HEK-293T C598(0.79); C653(0.89)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C598(0.85)  LDD1528  [5]
 LDCM0291  AC30 HEK-293T C598(0.91)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C598(0.99)  LDD1531  [5]
 LDCM0294  AC33 HEK-293T C24(0.94)  LDD1533  [5]
 LDCM0297  AC36 HEK-293T C598(0.95); C653(1.18)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C598(0.97)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C598(0.88)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C598(0.90)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C598(0.83); C653(0.97)  LDD1540  [5]
 LDCM0303  AC41 HEK-293T C24(1.01)  LDD1542  [5]
 LDCM0306  AC44 HEK-293T C598(1.07); C653(1.01)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C598(1.21)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C598(1.23)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C598(0.87)  LDD1548  [5]
 LDCM0311  AC49 HEK-293T C24(1.09)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C598(0.91)  LDD1551  [5]
 LDCM0315  AC52 HEK-293T C598(0.84); C653(1.24)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C598(0.91)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C598(1.03)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C598(0.84)  LDD1557  [5]
 LDCM0320  AC57 HEK-293T C24(0.98)  LDD1559  [5]
 LDCM0323  AC6 HEK-293T C598(0.96)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C598(0.91); C653(1.12)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C598(0.92)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C598(1.20)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C598(1.04)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C598(1.15)  LDD1568  [5]
 LDCM0349  AC83 HCT 116 C653(1.49)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C653(1.95)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C653(1.01)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C653(1.29)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C653(1.17)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C653(1.31)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C653(1.45)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C653(1.09)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C653(1.71)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C653(1.55)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C653(1.33)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C653(1.56)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C653(1.39)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C653(1.80)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C653(1.86)  LDD0681  [2]
 LDCM0248  AKOS034007472 HEK-293T C598(1.02)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C24(1.06)  LDD1570  [5]
 LDCM0367  CL1 HCT 116 C653(0.47)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C653(0.68)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C598(1.02)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C24(0.93)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C24(1.02)  LDD1575  [5]
 LDCM0373  CL104 HEK-293T C598(0.86)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C24(0.95)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C24(1.10)  LDD1579  [5]
 LDCM0377  CL108 HEK-293T C598(0.79)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C24(0.93)  LDD1582  [5]
 LDCM0379  CL11 HCT 116 C653(0.78)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C24(1.00)  LDD1584  [5]
 LDCM0382  CL112 HEK-293T C598(0.71)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C24(0.98)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C24(0.96)  LDD1588  [5]
 LDCM0386  CL116 HEK-293T C598(1.27)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C24(0.81)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C24(1.05)  LDD1592  [5]
 LDCM0390  CL12 HCT 116 C653(0.70)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C598(0.94)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C24(0.99)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C24(1.01)  LDD1597  [5]
 LDCM0395  CL124 HEK-293T C598(0.81)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C24(0.95)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C24(1.07)  LDD1601  [5]
 LDCM0399  CL128 HEK-293T C598(0.95)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C653(0.83)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C653(0.75)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C653(0.65)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C653(0.85)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C653(0.61)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C653(0.90)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C653(0.78)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C653(0.56)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C653(0.77)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C653(1.01)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C653(1.67)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C653(1.33)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C653(1.13)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C653(1.13)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C653(0.97)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C653(0.80)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C653(0.75)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C653(1.34)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C653(0.70)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C653(1.04)  LDD0736  [2]
 LDCM0421  CL32 HCT 116 C653(0.98)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C653(1.07)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C653(1.18)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C653(0.92)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C653(0.58)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C653(1.19)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C653(0.89)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C653(0.50)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C653(0.74)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C653(1.09)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C653(0.83)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C653(0.91)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C653(0.92)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C653(1.06)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C598(0.81)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C598(0.96)  LDD1641  [5]
 LDCM0439  CL49 HEK-293T C24(1.09)  LDD1643  [5]
 LDCM0440  CL5 HCT 116 C653(0.77)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C24(1.01)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C598(1.08)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C24(1.01)  LDD1647  [5]
 LDCM0447  CL56 HEK-293T C598(1.18); C653(1.27)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C598(1.03)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C598(1.19)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C598(1.17)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C653(1.45)  LDD0768  [2]
 LDCM0453  CL61 HEK-293T C24(0.96)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C24(1.03)  LDD1657  [5]
 LDCM0456  CL64 HEK-293T C598(0.84)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C24(0.97)  LDD1660  [5]
 LDCM0460  CL68 HEK-293T C598(0.92); C653(1.47)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C598(0.89)  LDD1664  [5]
 LDCM0462  CL7 HCT 116 C653(0.74)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C598(1.23)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C598(1.04)  LDD1667  [5]
 LDCM0466  CL73 HEK-293T C24(0.93)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C24(1.07)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C598(0.73)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C24(0.97)  LDD1673  [5]
 LDCM0473  CL8 HCT 116 C653(0.46)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C598(0.98); C653(0.92)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C598(1.03)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C598(0.91)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C598(0.96)  LDD1680  [5]
 LDCM0479  CL85 HEK-293T C24(0.91)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C24(1.06)  LDD1683  [5]
 LDCM0482  CL88 HEK-293T C598(0.81)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C24(0.97)  LDD1686  [5]
 LDCM0484  CL9 HCT 116 C653(0.90)  LDD0801  [2]
 LDCM0487  CL92 HEK-293T C598(0.93); C653(1.03)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C598(1.13)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C598(0.92)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C598(1.05)  LDD1693  [5]
 LDCM0492  CL97 HEK-293T C24(0.98)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C24(1.00)  LDD1696  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C653(1.17)  LDD1702  [6]
 LDCM0427  Fragment51 HCT 116 C653(0.83)  LDD0744  [2]
 LDCM0022  KB02 769-P C653(1.68)  LDD2246  [7]
 LDCM0023  KB03 769-P C653(1.57)  LDD2663  [7]
 LDCM0024  KB05 MKN45 C653(1.56)  LDD3332  [7]
 LDCM0109  NEM HeLa N.A.  LDD0227  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840