Details of the Target

General Information of Target

Target ID LDTP14307
Target Name Zinc fingers and homeoboxes protein 2 (ZHX2)
Gene Name ZHX2
Gene ID 22882
Synonyms
AFR1; KIAA0854; RAF; Zinc fingers and homeoboxes protein 2; Alpha-fetoprotein regulator 1; AFP regulator 1; Regulator of AFP; Zinc finger and homeodomain protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKAFQKQEGFLKRLKHAKNPKVHFNL
TDMLQDAIIHHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVN
HQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYL
DENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSL
ILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFI
EEMLLKAEIAWEEKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEK
DIMFKDATKGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYE
IQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERA
FHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVCILEAFG
HAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLM
DGLSAEEKYGLHLNNLCAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVE
NLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFK
GDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIF
GFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDF
FFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGT
AFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAY
PSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQL
RKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPV
RLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQL
NDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALV
IQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAV
DGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLS
AAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAP
GAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLP
DDGGPGAGSFLLHGASPPLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPV
TCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLAL
FNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKP
NSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFN
SGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSS
AITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQE
LLDWRRKLCEEGQDWQQILHHAEPRVPPPPPCKKPSLLKKPEGASCNRLPSELWDTTI
Target Bioclass
Transcription factor
Family
ZHX family
Subcellular location
Nucleus
Function
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.
Uniprot ID
Q9Y6X8
Ensemble ID
ENST00000314393.6
HGNC ID
HGNC:18513

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.85  LDD0402  [1]
TH216
 Probe Info  		Y122(9.82)  LDD0259  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
DBIA
 Probe Info  		C11(4.48)  LDD3339  [4]
AHL-Pu-1
 Probe Info  		C759(2.56)  LDD0170  [5]
IA-alkyne
 Probe Info  		C11(3.23); C738(1.65)  LDD2182  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
Phosphinate-6
 Probe Info  		C738(0.00); C11(0.00)  LDD0018  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C759(2.56)  LDD0170  [5]
 LDCM0215  AC10 HEK-293T C11(1.09)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C11(1.00)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C11(0.99)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C11(1.02)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C11(1.01)  LDD1513  [10]
 LDCM0277  AC18 HEK-293T C11(1.13)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C11(1.04)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C11(1.00)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C11(1.04)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C11(0.97); C738(0.98)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C11(0.89)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C11(0.98)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C11(0.99)  LDD1523  [10]
 LDCM0286  AC26 HEK-293T C11(1.09)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C11(1.03)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C11(0.97)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C11(0.95); C738(1.08)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C11(1.01)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C11(0.98)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C11(0.97)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C11(1.02)  LDD1532  [10]
 LDCM0295  AC34 HEK-293T C11(1.12)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C11(1.00)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C11(1.06)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C11(1.01); C738(1.08)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C11(0.96)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C11(1.06)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C11(1.04)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C11(1.08)  LDD1541  [10]
 LDCM0304  AC42 HEK-293T C11(1.19)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C11(1.05)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C11(1.01)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C11(1.07); C738(1.04)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C11(0.98)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C11(1.00)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C11(1.03)  LDD1549  [10]
 LDCM0312  AC5 HEK-293T C11(1.02); C738(1.06)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C11(1.06)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C11(1.02)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C11(1.03)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C11(0.98); C738(1.03)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C11(0.97)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C11(1.02)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C11(1.03)  LDD1558  [10]
 LDCM0321  AC58 HEK-293T C11(1.01)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C11(1.03)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C11(1.09)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C11(1.05)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C11(1.03); C738(1.09)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C11(0.99)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C11(1.03)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C11(1.07)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C11(0.96)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C11(1.03)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C11(1.05); C738(1.05)  LDD1511  [10]
 LDCM0275  AKOS034007705 HEK-293T C11(1.01)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 6.22  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C738(0.44)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C11(0.89)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C11(0.99)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C11(0.99); C738(1.07)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C11(1.11)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C11(0.91)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C11(1.00)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C11(1.02); C738(1.01)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C11(1.03)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C11(0.93)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C11(0.97)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C11(1.02); C738(1.05)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C11(1.06)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C11(1.00)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C11(0.84)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C11(1.03)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C11(1.17); C738(1.09)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C11(1.08)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C11(0.90)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C11(1.04)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C11(1.05); C738(1.12)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C11(1.06)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C11(0.97)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C11(1.01)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C11(1.02)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C11(1.01); C738(1.14)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C11(1.04)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C11(1.06)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C11(0.89)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C11(1.02); C738(1.10)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C11(1.04)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C11(0.99)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C11(0.99)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C11(1.10); C738(1.08)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C11(1.02)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C11(1.04)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C11(0.85)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C11(1.00); C738(1.03)  LDD1607  [10]
 LDCM0405  CL18 HEK-293T C11(1.06)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C11(1.01)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C11(1.07)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C11(1.04)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C11(0.96); C738(1.03)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C11(1.03)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C11(0.97)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C11(1.17)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C11(0.97)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C11(0.87)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C11(0.95)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C11(1.04); C738(1.05)  LDD1620  [10]
 LDCM0418  CL3 HEK-293T C11(0.89)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C11(1.08)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C11(1.02)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C11(1.10)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C11(0.91); C738(0.95)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C11(1.06)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C11(1.12)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C11(1.12)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C11(0.96)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C11(1.03)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C11(0.96); C738(1.06)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C11(1.02); C738(0.98)  LDD1634  [10]
 LDCM0432  CL42 HEK-293T C11(1.10)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C11(1.07)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C11(1.06)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C11(1.13); C738(0.99)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C11(1.05)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C11(1.08)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C11(1.10)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C11(0.95)  LDD1643  [10]
 LDCM0441  CL50 HEK-293T C11(1.03)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C11(1.03); C738(1.06)  LDD1646  [10]
 LDCM0445  CL54 HEK-293T C11(1.01)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C11(1.02)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C11(1.15)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C11(1.05); C738(1.08)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C11(1.05)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C11(1.05)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C11(1.06)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C11(1.12)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C11(0.99)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C11(0.89)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C11(1.02)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C11(0.99); C738(1.05)  LDD1659  [10]
 LDCM0458  CL66 HEK-293T C11(1.08)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C11(1.02)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C11(1.04)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C11(1.00); C738(1.06)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C11(0.96)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C11(0.99)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C11(1.06)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C11(1.15)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C11(0.98)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C11(0.99)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C11(1.01); C738(1.05)  LDD1672  [10]
 LDCM0471  CL78 HEK-293T C11(1.06)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C11(1.02)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C11(0.85)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C11(0.98)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C11(1.02); C738(1.06)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C11(1.01)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C11(0.99)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C11(1.09)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C11(0.99)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C11(0.99)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C11(1.01)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C11(1.04); C738(1.11)  LDD1685  [10]
 LDCM0484  CL9 HEK-293T C11(1.08); C738(0.96)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C11(0.86)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C11(0.94)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C11(1.01)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C11(1.02); C738(1.06)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C11(1.12)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C11(1.08)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C11(1.07)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C11(1.01)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C11(0.90)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C11(1.06)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C11(1.10)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C11(1.14)  LDD1702  [11]
 LDCM0625  F8 Ramos C11(1.15); C738(1.33)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C738(0.29)  LDD2189  [6]
 LDCM0573  Fragment11 Ramos C11(1.18); C738(6.92)  LDD2190  [6]
 LDCM0574  Fragment12 Ramos C11(0.97); C738(0.22)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C11(0.78); C738(0.81)  LDD2192  [6]
 LDCM0576  Fragment14 Ramos C11(0.76); C738(0.74)  LDD2193  [6]
 LDCM0579  Fragment20 Ramos C11(0.88); C738(0.26)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C11(0.82)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C11(0.76)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C11(0.67)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C11(0.65); C738(0.82)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C11(1.23)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C11(0.82); C738(0.57)  LDD2200  [6]
 LDCM0590  Fragment32 Ramos C11(5.89); C738(0.30)  LDD2201  [6]
 LDCM0468  Fragment33 HEK-293T C11(0.99)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C11(0.84)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C11(0.88); C738(0.84)  LDD2184  [6]
 LDCM0427  Fragment51 HEK-293T C11(0.93)  LDD1631  [10]
 LDCM0614  Fragment56 Ramos C11(1.00); C738(0.39)  LDD2205  [6]
 LDCM0569  Fragment7 Ramos C11(1.10); C738(0.74)  LDD2186  [6]
 LDCM0571  Fragment9 Ramos C11(1.30); C738(0.70)  LDD2188  [6]
 LDCM0022  KB02 HEK-293T C11(0.93)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C11(1.03)  LDD1497  [10]
 LDCM0024  KB05 NALM-6 C11(4.48)  LDD3339  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc fingers and homeoboxes protein 1 (ZHX1) ZHX family Q9UKY1
Zinc fingers and homeoboxes protein 2 (ZHX2) ZHX family Q9Y6X8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Trefoil factor 2 (TFF2) . Q03403

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761