Details of the Target

General Information of Target

Target ID LDTP13921
Target Name Proton-associated sugar transporter A (SLC45A1)
Gene Name SLC45A1
Gene ID 50651
Synonyms
DNB5; Proton-associated sugar transporter A; PAST-A; Deleted in neuroblastoma 5 protein; DNb-5; Solute carrier family 45 member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKL
DEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQ
LSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAV
SILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQMYGRKVGFALDLPPRRRDEDMLYSPEL
AQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDTDKSDGESDGDEFVHRDNGERDNNE
EKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEDDDEDD
SDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPP
LRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPP
GPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNL
IQRPKADDTSAATIEKKATATISAKPQITNPKAEITRFVPTALRVRRENKGATAAPQRKS
EDDSAVPLAKAAPKSGPSVPVSVQTKDDVYEAFMKEMEGLL
Target Bioclass
Transporter and channel
Family
Glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family
Subcellular location
Membrane
Function Proton-associated glucose transporter in the brain.
Uniprot ID
Q9Y2W3
Ensemble ID
ENST00000471889.7
HGNC ID
HGNC:17939

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C55(1.02); C68(1.02)  LDD0531  [1]
W1
 Probe Info  		N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C55(1.02); C68(1.02)  LDD0531  [1]
 LDCM0216  AC100 HCT 116 C55(1.17); C68(1.17)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C55(1.21); C68(1.21)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C55(1.14); C68(1.14)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C55(1.43); C68(1.43)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C55(1.49); C68(1.49)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C55(1.52); C68(1.52)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C55(1.69); C68(1.69)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C55(1.12); C68(1.12)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C55(1.33); C68(1.33)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C55(1.34); C68(1.34)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C55(1.64); C68(1.64)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C55(1.64); C68(1.64)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C55(1.74); C68(1.74)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C55(1.13); C68(1.13)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C55(0.94); C68(0.94)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C55(1.00); C68(1.00)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C55(1.01); C68(1.01)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C55(0.99); C68(0.99)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C55(1.14); C68(1.14)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C55(1.30); C68(1.30)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C55(0.94); C68(0.94)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C55(0.90); C68(0.90)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C55(0.97); C68(0.97)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C55(0.90); C68(0.90)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C55(0.90); C68(0.90)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C55(0.96); C68(0.96)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C55(1.07); C68(1.07)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C55(0.91); C68(0.91)  LDD0562  [1]
 LDCM0276  AC17 HCT 116 C55(1.14); C68(1.14)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C55(1.19); C68(1.19)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C55(1.31); C68(1.31)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C55(1.09); C68(1.09)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C55(1.38); C68(1.38)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C55(1.37); C68(1.37)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C55(1.23); C68(1.23)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C55(1.46); C68(1.46)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C55(1.22); C68(1.22)  LDD0601  [1]
 LDCM0290  AC3 HCT 116 C55(1.15); C68(1.15)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C55(1.07); C68(1.07)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C55(1.03); C68(1.03)  LDD0629  [1]
 LDCM0349  AC83 HCT 116 C55(1.10); C68(1.10)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C55(1.22); C68(1.22)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C55(1.10); C68(1.10)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C55(1.35); C68(1.35)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C55(1.05); C68(1.05)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C55(1.03); C68(1.03)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C55(1.20); C68(1.20)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C55(1.25); C68(1.25)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C55(1.26); C68(1.26)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C55(1.20); C68(1.20)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C55(1.24); C68(1.24)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C55(1.50); C68(1.50)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C55(1.21); C68(1.21)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C55(1.59); C68(1.59)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C55(1.30); C68(1.30)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C55(1.26); C68(1.26)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C55(1.24); C68(1.24)  LDD0683  [1]
 LDCM0369  CL100 HCT 116 C55(1.13); C68(1.13)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C55(1.27); C68(1.27)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C55(1.39); C68(1.39)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C55(1.70); C68(1.70)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C55(1.72); C68(1.72)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C55(1.52); C68(1.52)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C55(1.56); C68(1.56)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C55(1.93); C68(1.93)  LDD0698  [1]
 LDCM0420  CL31 HCT 116 C55(1.91); C68(1.91)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C55(1.39); C68(1.39)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C55(2.85); C68(2.85)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C55(2.34); C68(2.34)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C55(3.06); C68(3.06)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C55(2.07); C68(2.07)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C55(5.83); C68(5.83)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C55(2.04); C68(2.04)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C55(1.62); C68(1.62)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C55(2.81); C68(2.81)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C55(3.67); C68(3.67)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C55(1.51); C68(1.51)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C55(1.76); C68(1.76)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C55(1.99); C68(1.99)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C55(1.24); C68(1.24)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C55(1.24); C68(1.24)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C55(0.98); C68(0.98)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C55(1.22); C68(1.22)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C55(1.29); C68(1.29)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C55(1.27); C68(1.27)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C55(1.23); C68(1.23)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C55(1.07); C68(1.07)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C55(1.23); C68(1.23)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C55(1.05); C68(1.05)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C55(1.18); C68(1.18)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C55(1.58); C68(1.58)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C55(1.08); C68(1.08)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C55(1.16); C68(1.16)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C55(1.31); C68(1.31)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C55(1.04); C68(1.04)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C55(1.00); C68(1.00)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C55(1.53); C68(1.53)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C55(1.54); C68(1.54)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C55(1.06); C68(1.06)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C55(2.32); C68(2.32)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C55(0.90); C68(0.90)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C55(1.24); C68(1.24)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C55(1.15); C68(1.15)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C55(1.36); C68(1.36)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C55(1.15); C68(1.15)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C55(1.04); C68(1.04)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C55(1.47); C68(1.47)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C55(1.37); C68(1.37)  LDD0784  [1]
 LDCM0486  CL91 HCT 116 C55(1.04); C68(1.04)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C55(1.20); C68(1.20)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C55(1.05); C68(1.05)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C55(1.23); C68(1.23)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C55(1.27); C68(1.27)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C55(1.10); C68(1.10)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C55(1.25); C68(1.25)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C55(1.06); C68(1.06)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C55(1.11); C68(1.11)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C55(1.97); C68(1.97)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C55(1.98); C68(1.98)  LDD0744  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.