Details of the Target

General Information of Target

Target ID LDTP13914
Target Name Kelch domain-containing protein 2 (KLHDC2)
Gene Name KLHDC2
Gene ID 23588
Synonyms
HCA33; Kelch domain-containing protein 2; Hepatocellular carcinoma-associated antigen 33; Host cell factor homolog LCP; Host cell factor-like protein 1; HCLP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRG
NKTRNSNNNNTAAATVAAAGPAAAAAAGMGVRPVSGDLSYLRTPGGLCRISASGPESLLG
GPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWA
SRTVNGSRLVPYSCRENYSDSEEEDDDDVASSRQVLKDDSLSRHRPRRTHSKPLPPLTAK
SAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASS
SLRINHANHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGSFSAHYLSMFLLTA
ACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEGIFNTSLQWILENGKDVGIRCVGFGPEE
ELTNITDVQFLQSTRPLMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEE
EETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAV
DFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPN
SLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLS
PEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTSNTPLKPSNKHMNSMSHLRL
RTGLTNSQGSS
Target Bioclass
Other
Subcellular location
Nucleus
Function
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.
Uniprot ID
Q9Y2U9
Ensemble ID
ENST00000298307.10
HGNC ID
HGNC:20231

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN18 SNV: p.Y300H DBIA    Probe Info 
MDAMB453 SNV: p.E67Q .
SKN SNV: p.W151R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C223(2.41)  LDD3311  [1]
BTD
 Probe Info  		C223(0.76)  LDD2091  [2]
IPM
 Probe Info  		C223(3.04)  LDD1701  [2]
NAIA_5
 Probe Info  		C223(0.00); C301(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C223(0.65)  LDD0813  [4]
 LDCM0226  AC11 HEK-293T C223(0.70)  LDD0824  [4]
 LDCM0230  AC113 HEK-293T C223(0.95)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C223(0.95)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C223(1.02)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C223(0.99)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C223(0.94)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C223(1.06)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C223(1.13)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C223(0.54)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C223(1.08)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C223(0.85)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C223(0.93)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C223(0.99)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C223(1.07)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C223(1.23)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C223(0.96)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C223(0.90)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C223(1.02)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C223(1.17)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C223(1.10)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C223(1.15)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C223(1.12)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C223(1.08)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C223(1.25)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C223(0.88)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C223(1.04)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C223(1.16)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C223(1.16)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C223(1.18)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C223(0.51)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C223(1.15)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C223(1.29)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C223(1.19)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C223(0.56)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C223(0.70)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C223(0.53)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C223(0.77)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C223(0.65)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C223(0.64)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C223(0.64)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C223(0.51)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C223(0.55)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C223(0.58)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C223(0.76)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C223(0.60)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C223(0.70)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C223(0.68)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C223(0.59)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C223(0.64)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C223(0.42)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C223(0.76)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C223(0.61)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C374(0.96)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C223(0.44)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C223(0.39)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C223(0.57)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C223(0.40)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C223(0.74)  LDD0882  [4]
 LDCM0286  AC26 HEK-293T C374(0.88)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C374(0.93)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C374(1.11)  LDD1527  [5]
 LDCM0290  AC3 HEK-293T C374(0.98)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C374(1.03)  LDD1530  [5]
 LDCM0293  AC32 HEK-293T C223(0.90)  LDD1532  [5]
 LDCM0295  AC34 HEK-293T C374(1.02)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C223(0.81)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C223(0.82)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C223(0.80)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C223(1.17)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C223(0.86)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C374(1.09)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C223(1.22)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C223(1.05)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C223(1.19)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C223(0.99)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C223(1.09)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C223(0.97)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C223(0.57)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C223(0.52)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C223(0.54)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C223(0.74)  LDD0909  [4]
 LDCM0313  AC50 HEK-293T C223(0.67)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C223(0.51)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C223(0.66)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C223(0.63)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C223(0.57)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C223(0.56)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C223(0.66)  LDD0917  [4]
 LDCM0321  AC58 HEK-293T C374(1.02)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C374(1.05)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C223(1.45)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C374(1.03)  LDD1563  [5]
 LDCM0326  AC62 HEK-293T C374(1.00)  LDD1565  [5]
 LDCM0328  AC64 HEK-293T C223(0.98)  LDD1567  [5]
 LDCM0332  AC68 HEK-293T C223(0.88)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C223(1.01)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C223(0.77)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C223(1.00)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C223(1.02)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C223(0.75)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C223(1.00)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C223(0.69)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C223(1.09)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C223(0.92)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C223(0.86)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C223(1.02)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C223(0.82)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C223(0.65)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C223(0.82)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C223(1.12)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C223(0.91)  LDD0946  [4]
 LDCM0545  Acetamide MDA-MB-231 C223(0.43)  LDD2138  [2]
 LDCM0248  AKOS034007472 HEK-293T C223(0.60)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C223(0.57)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C223(0.60)  LDD0873  [4]
 LDCM0498  BS-3668 MDA-MB-231 C223(0.76)  LDD2091  [2]
 LDCM0367  CL1 HEK-293T C223(1.32)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C223(0.62)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C374(0.98)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C223(0.67)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C223(0.70)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C223(0.56)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C223(0.59)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C223(0.72)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C223(0.51)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C223(0.66)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C223(0.46)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C223(0.62)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C223(0.56)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C223(0.56)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C223(1.07)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C374(0.93)  LDD1586  [5]
 LDCM0386  CL116 HEK-293T C374(0.97)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C223(0.80)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C223(0.75)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C223(1.06)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C223(0.81)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C223(1.11)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C223(0.73)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C223(0.66)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C223(0.62)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C223(0.70)  LDD0993  [4]
 LDCM0399  CL128 HEK-293T C374(1.04)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C223(0.84)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C223(0.84)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C223(0.71)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C223(1.41)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C223(2.09)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C223(1.20)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C223(1.04)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C223(1.04)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C223(0.80)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C223(0.70)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C223(1.17)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C223(0.97)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C223(1.14)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C223(1.22)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C223(0.76)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C223(0.69)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C223(0.72)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C223(0.96)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C223(1.06)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C223(0.92)  LDD1017  [4]
 LDCM0420  CL31 PaTu 8988t C325(1.26); C338(1.26)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C325(0.87); C338(0.87)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C325(0.84); C338(0.84)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C325(0.77); C338(0.77)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C325(0.70); C338(0.70)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C325(0.85); C338(0.85)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C325(0.55); C338(0.55)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C325(0.86); C338(0.86)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C223(0.89)  LDD1027  [4]
 LDCM0430  CL40 PaTu 8988t C325(1.22); C338(1.22)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C325(0.70); C338(0.70)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C325(0.56); C338(0.56)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C325(0.51); C338(0.51)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C325(0.62); C338(0.62)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C325(1.18); C338(1.18)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C223(1.24)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C223(1.06)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C223(1.32)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C223(1.19)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C223(0.77)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C223(0.94)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C223(0.96)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C223(1.23)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C223(1.31)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C223(0.95)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C223(1.11)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C223(1.14)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C223(1.08)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C223(1.07)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C223(1.00)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C223(0.99)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C223(0.94)  LDD1050  [4]
 LDCM0456  CL64 HEK-293T C374(0.84)  LDD1659  [5]
 LDCM0458  CL66 HEK-293T C374(0.94)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C374(1.10)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C374(1.07)  LDD1663  [5]
 LDCM0462  CL7 HEK-293T C223(0.76)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C374(1.12)  LDD1666  [5]
 LDCM0465  CL72 HEK-293T C223(0.94)  LDD1668  [5]
 LDCM0469  CL76 PaTu 8988t C325(0.93); C338(0.93)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C325(0.86); C338(0.86)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C325(0.67); C338(0.67)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C325(0.87); C338(0.87)  LDD1351  [4]
 LDCM0473  CL8 HEK-293T C223(1.90)  LDD1071  [4]
 LDCM0474  CL80 PaTu 8988t C325(1.11); C338(1.11)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C325(0.69); C338(0.69)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C325(0.86); C338(0.86)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C325(0.74); C338(0.74)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C325(0.52); C338(0.52)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C325(0.94); C338(0.94)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C325(0.99); C338(0.99)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C325(0.52); C338(0.52)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C325(0.69); C338(0.69)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C325(0.61); C338(0.61)  LDD1362  [4]
 LDCM0484  CL9 HEK-293T C223(1.32)  LDD1082  [4]
 LDCM0485  CL90 PaTu 8988t C325(0.62); C338(0.62)  LDD1364  [4]
 LDCM0486  CL91 HEK-293T C374(1.07)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C374(1.08)  LDD1690  [5]
 LDCM0489  CL94 HEK-293T C374(1.22)  LDD1692  [5]
 LDCM0491  CL96 HEK-293T C223(1.02)  LDD1694  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C223(1.45)  LDD1702  [2]
 LDCM0427  Fragment51 PaTu 8988t C325(0.90); C338(0.90)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C264(1.26)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C264(1.06)  LDD1497  [5]
 LDCM0024  KB05 G361 C223(2.41)  LDD3311  [1]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C223(0.74)  LDD2121  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C223(1.16)  LDD2111  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C223(0.46)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NudC domain-containing protein 3 (NUDCD3) . Q8IVD9

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402