Details of the Target

General Information of Target

Target ID LDTP13889
Target Name Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1)
Gene Name LRCH1
Gene ID 23143
Synonyms
CHDC1; KIAA1016; Leucine-rich repeat and calponin homology domain-containing protein 1; Calponin homology domain-containing protein 1; Neuronal protein 81; NP81
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN
QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT
PWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS
YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ
IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPL
QLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL
LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPE
LQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPY
PAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSAL
LLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAE
DHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDG
PLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSV
VNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKF
HPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVV
YNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPD
RRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTF
GGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLP
DTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLN
VRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNL
SENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFY
RSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQ
HHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESF
NHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQL
KSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.
Uniprot ID
Q9Y2L9
Ensemble ID
ENST00000311191.10
HGNC ID
HGNC:20309

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C251(2.48)  LDD3321  [2]
AHL-Pu-1
 Probe Info  		C421(2.44); C366(2.60); C292(3.88)  LDD0170  [3]
IA-alkyne
 Probe Info  		C242(0.00); C251(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C242(0.00); C653(0.00); C251(0.00); C292(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
W1
 Probe Info  		C653(0.00); C251(0.00)  LDD0236  [7]
AOyne
 Probe Info  		13.20  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C421(2.44); C366(2.60); C292(3.88)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C421(2.36); C292(2.30)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C251(0.84); C421(0.98)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C251(0.97); C421(0.98)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C251(0.98); C421(1.03); C292(0.98)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C251(0.97); C421(0.92); C292(0.95)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C251(0.86); C421(1.00)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C251(0.90); C421(1.05); C292(1.05)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C251(0.94); C421(1.00)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C251(0.90); C421(0.98)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C251(0.85); C421(1.03); C292(0.87)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C251(0.90); C421(0.90)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C251(0.95); C421(0.93); C292(0.94)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C251(1.17); C421(1.09)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C251(0.87); C421(0.97)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C251(0.89); C421(0.93); C292(0.98)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C251(1.01); C421(0.97); C292(1.02)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C251(0.96); C421(0.96)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C251(0.90); C421(0.95)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C251(1.03); C421(0.91); C292(1.15)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C251(0.96); C421(0.91); C292(0.86)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C251(1.02); C421(1.00)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C251(0.89); C421(1.05); C292(0.90)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C251(0.93); C421(0.95)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C251(0.86); C421(1.09); C292(1.08)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C251(1.07); C421(0.95); C292(0.99)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C251(0.95); C421(0.96)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C251(0.88); C421(0.98)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C251(0.98); C421(0.98); C292(1.00)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C251(1.07); C421(0.92); C292(1.03)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C251(1.01); C421(1.01)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C251(0.96); C421(1.00)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C251(0.87); C421(1.16); C292(1.17)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C251(1.05); C421(0.93); C292(0.95)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C251(0.87); C421(0.96); C292(1.17)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C251(1.03); C421(0.97)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C251(0.80); C421(0.99)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C251(1.05); C421(1.00); C292(1.02)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C251(1.04); C421(0.92); C292(0.98)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C251(0.96); C421(1.03)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C251(0.85); C421(0.95)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C251(0.98); C421(0.98); C292(1.14)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C251(1.10); C421(1.00); C292(1.05)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C251(0.96); C421(0.97)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C251(1.00); C421(0.99)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C251(0.88); C421(0.98)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C251(1.01); C421(1.01); C292(0.88)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C251(0.94); C421(0.94); C292(0.95)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C251(1.08); C421(1.02)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C251(0.93); C421(0.95)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C251(0.97); C421(0.99); C292(0.89)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C251(1.13); C421(1.00); C292(1.11)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C251(0.97); C421(1.00)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C251(0.91); C421(0.98)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C251(0.99); C421(1.02); C292(1.07)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C251(0.82); C421(0.99)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C251(1.01); C421(0.90); C292(0.97)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C251(0.97); C421(0.96)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C251(0.77); C421(1.02)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C251(1.00); C421(1.04); C292(0.92)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C251(1.04); C421(0.99); C292(1.19)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C251(0.92); C421(1.00); C292(1.03)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C251(0.95); C421(0.95); C292(1.09)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C251(1.08); C421(1.02)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C251(0.98); C421(0.96)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C251(0.95); C421(0.98); C292(1.08)  LDD1514  [9]
 LDCM0632  CL-Sc Hep-G2 C251(0.61)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C251(1.13); C421(0.91); C292(1.00); C161(1.20)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C251(0.76); C421(1.18)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C251(0.87); C421(1.06)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C251(1.11); C421(0.94); C292(1.03); C161(1.11)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C251(1.02); C421(1.03); C161(0.80)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C251(1.10); C421(1.03); C292(0.64)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C251(0.93); C421(0.94)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C251(1.16); C421(0.98); C292(0.88); C161(1.16)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C251(0.94); C421(0.94); C161(1.19)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C251(1.09); C421(0.99); C292(0.75)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C251(0.89); C421(0.98)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C251(1.17); C421(0.94); C292(1.02); C161(0.93)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C251(1.12); C421(1.21); C292(0.92)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C251(0.87); C421(0.92); C161(0.98)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C251(1.04); C421(0.96); C292(0.84)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C251(0.96); C421(1.02)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C251(1.10); C421(1.02); C292(0.95); C161(1.01)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C251(0.97); C421(1.01); C161(0.87)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C251(1.05); C421(0.97); C292(0.73)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C251(0.80); C421(0.98)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C251(1.07); C421(0.95); C292(1.01); C161(1.14)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C251(0.99); C421(0.95); C161(0.97)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C251(0.97); C421(1.02); C292(0.76)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C251(1.16); C421(1.04); C292(1.33)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C251(0.92); C421(1.03)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C251(1.00); C421(0.96); C292(1.00); C161(1.08)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C251(1.01); C421(1.03); C161(0.85)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C251(1.05); C421(0.94); C292(0.74)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C251(0.94); C421(1.04)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C251(1.22); C421(0.93); C292(1.06); C161(1.33)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C251(0.96); C421(0.92); C161(0.85)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C251(1.07); C421(0.99); C292(0.99)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C251(0.86); C421(1.00)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C251(1.08); C421(0.94); C292(0.95); C161(1.06)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C251(0.98); C421(1.13); C161(0.84)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C251(0.95); C421(0.92); C292(0.68)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C251(1.02); C421(1.04)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C251(0.99); C421(1.12)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C251(1.02); C421(1.08)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C251(1.00); C421(1.10); C292(1.10)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C251(1.10); C421(1.18); C161(1.03)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C251(0.92); C421(1.09); C292(1.01)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C251(0.85); C421(1.34)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C251(0.89); C421(1.28)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C251(1.08); C421(1.25); C292(1.07)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C251(1.06); C421(1.09); C292(1.22)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C251(1.10); C421(0.86); C292(0.78); C161(0.82)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C251(0.91); C421(1.06); C161(0.97)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C251(1.13); C421(0.96); C292(0.98)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C251(0.82); C421(0.98)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C251(0.89); C421(1.02)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C251(1.07); C421(1.11); C292(0.72)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C251(0.98); C421(0.95)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C251(1.06); C421(1.07); C292(0.99)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C251(0.94); C421(1.05); C292(1.03)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C251(0.88); C421(1.11)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C251(0.82); C421(1.14)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C251(0.82); C421(1.09); C292(1.18)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C251(1.14); C421(1.08); C292(1.16)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C251(0.98); C421(0.91); C292(0.89); C161(0.98)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C251(1.04); C421(0.96); C292(0.81)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C251(1.07); C421(1.11)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C251(0.98); C421(0.97)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C251(1.05); C421(1.10)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C251(0.93); C421(1.00)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C251(0.99); C421(1.04); C292(1.13)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C251(1.07); C421(1.05); C292(1.02)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C251(1.03); C421(1.15)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C251(0.86); C421(1.23)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C251(1.00); C421(1.17); C292(0.97)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C251(1.09); C421(1.13); C292(1.15)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C251(0.97); C421(0.92); C292(1.09); C161(1.42)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C251(1.06); C421(1.01)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C251(0.92); C421(1.07); C161(0.96)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C251(1.02); C421(0.94)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C251(0.89); C421(1.03)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C251(0.85); C421(0.90)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C251(0.92); C421(1.09); C292(1.05)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C251(1.04); C421(1.01); C292(0.99)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C251(0.87); C421(1.28)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C251(1.05); C421(1.15)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C251(1.09); C421(1.18); C292(1.30)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C251(0.83); C421(0.97)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C251(0.91); C421(1.10); C292(1.13)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C251(1.11); C421(0.91); C292(1.10); C161(1.26)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C251(0.90); C421(1.10); C161(1.04)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C251(1.11); C421(1.03); C292(0.89)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C251(0.88); C421(1.06)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C251(1.01); C421(0.96)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C251(0.87); C421(0.99)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C251(0.97); C421(1.04); C292(0.92)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C251(0.91); C421(1.01); C292(1.00)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C251(1.13); C421(1.30)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C251(0.94); C421(1.04); C292(0.98)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C251(0.88); C421(1.12)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C251(0.98); C421(1.13); C292(1.04)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C251(1.07); C421(1.13); C292(1.24)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C251(0.94); C421(0.94); C292(1.07); C161(1.29)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C251(0.94); C421(0.92); C161(0.90)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C251(0.96); C421(1.01)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C251(0.92); C421(1.08)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C251(0.84); C421(1.09)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C251(1.01); C421(1.00); C292(1.10)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C251(0.80); C421(0.98); C292(1.37)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C251(0.92); C421(1.07); C292(1.01)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C251(1.08); C421(1.23)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C251(0.88); C421(1.06)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C251(1.01); C421(1.07); C292(1.10)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C251(1.02); C421(1.11); C292(1.19)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C251(1.04); C421(0.89); C292(0.89); C161(1.13)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C251(1.01); C421(0.99); C161(1.02)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C251(0.92); C421(0.96); C292(0.69)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C251(0.81); C421(1.02)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C251(0.91); C421(1.00)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C251(1.06); C421(1.35)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C251(0.83); C421(0.93)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C251(1.03); C421(1.06); C292(1.06)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C251(0.94); C421(0.94); C292(1.04)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C251(0.97); C421(1.19)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C251(1.05); C421(1.20)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C251(0.83); C421(1.06); C292(1.03)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C251(0.98); C421(0.99); C292(1.18)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C251(0.93); C421(0.98); C292(1.17); C161(0.48)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C251(0.90); C421(0.95); C161(1.02)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C251(1.05); C421(0.99); C292(0.83)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C251(1.07); C421(0.97); C292(0.79)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C251(1.27); C292(1.12)  LDD1702  [10]
 LDCM0625  F8 Ramos C251(1.13); C292(1.03)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C251(0.59); C292(0.33)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C292(0.77)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C251(0.58)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C251(0.93)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C251(1.14); C292(0.89)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C251(0.48); C292(0.30)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C251(0.99); C292(1.11)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C251(1.14); C292(0.41)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C251(0.98); C292(1.05)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C251(0.79); C292(2.19)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C251(0.87); C292(0.25)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C251(1.06); C292(0.60)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C251(0.54); C292(0.31)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C251(0.95); C421(0.96); C292(0.75)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C251(0.68); C292(0.51)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C251(0.84); C292(0.73)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C251(0.92); C421(1.01); C161(0.97)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C251(1.20); C292(0.72)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C251(0.98); C292(0.61)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C251(0.60); C292(0.70)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C251(0.62); C292(0.23)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C421(0.94); C251(1.01); C242(1.02)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C421(1.06); C251(1.07); C242(0.88)  LDD1497  [9]
 LDCM0024  KB05 SH4 C251(2.48)  LDD3321  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 14A (TMEM14A) TMEM14 family Q9Y6G1
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dedicator of cytokinesis protein 8 (DOCK8) DOCK family Q8NF50

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578