Details of the Target

General Information of Target

Target ID LDTP13734
Target Name Cystine/glutamate transporter (SLC7A11)
Gene Name SLC7A11
Gene ID 23657
Synonyms
Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNT
IVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQQVSAVRTHSDLK
VGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLA
ILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDL
VVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISK
QILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCE
EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDE
DEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFIT
GHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLP
TEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETD
IDPVMDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPD
GTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETV
KYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTP
LPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSL
QMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDI
EKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKF
PSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKR
KAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGV
GVRSLPADFRYPNLDFGWKKSIDSKSFISISNSSSAENDNYCKHSTIVPENAAHQGANRT
SSLENHDQMSVNCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDFCQGN
QLNYYKQEIPVQPTTSYSIQNLYSYENQPQPSDECTLLSNKYLDGNANKSTSDGSPVMAV
MPGTTDTIQVLKGRMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGD
SFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNW
LPPGYVVNQDKSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYED
DFLEYDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFED
FDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIA
DCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVS
CAAASVASSRSSVLKDSEYGCLKIPPRCMFDHPDADKTLNHLISGFENFEKKINYRFKNK
AYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALV
NNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEE
DIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEM
EPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVP
NS
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Subcellular location
Cell membrane
Function
Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress. The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis. In vitro can also transport L-aspartate. May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons. Controls the production of pheomelanin pigment directly.
TTD ID
T11615
Uniprot ID
Q9UPY5
DrugMap ID
TTBZMIO
Ensemble ID
ENST00000280612.9
HGNC ID
HGNC:11059
ChEMBL ID
CHEMBL1075149

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K483(1.50)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K222(2.71)  LDD3494  [2]
DBIA
 Probe Info  		C414(2.23)  LDD3352  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		11.71  LDD1838  [4]
C226
 Probe Info  		7.57  LDD1899  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C414(1.15)  LDD1093  [5]
 LDCM0215  AC10 HEK-293T C414(0.96)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C414(1.01); C158(0.71)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C158(1.01)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C414(1.05); C158(0.98)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C414(0.98); C158(0.99)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C414(1.07); C158(0.86)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C414(0.92)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C414(0.96); C158(0.83)  LDD1517  [6]
 LDCM0279  AC2 PaTu 8988t C414(1.17)  LDD1158  [5]
 LDCM0280  AC20 HEK-293T C158(0.85)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C414(1.02)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C414(1.15); C158(1.08)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C414(0.99); C158(0.89)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C414(0.90); C158(0.73)  LDD1523  [6]
 LDCM0285  AC25 PaTu 8988t C414(1.12)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C414(1.04)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C414(1.03)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C414(1.01)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C414(1.08)  LDD1168  [5]
 LDCM0290  AC3 PaTu 8988t C414(1.20)  LDD1169  [5]
 LDCM0291  AC30 PaTu 8988t C414(1.09)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C414(1.03)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C414(1.01)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C414(1.03)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C414(1.17)  LDD1174  [5]
 LDCM0296  AC35 HEK-293T C414(1.07); C158(0.58)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C158(1.09)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C414(0.92)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C414(1.08); C158(0.98)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C414(1.10); C158(0.94)  LDD1539  [6]
 LDCM0301  AC4 PaTu 8988t C414(1.09)  LDD1180  [5]
 LDCM0302  AC40 HEK-293T C414(0.96); C158(1.20)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C414(1.04); C158(0.87)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C414(1.01)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C414(1.02); C158(0.81)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C158(1.11)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C414(0.93)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C414(1.05); C158(0.94)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C414(0.99); C158(0.99)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C414(0.95); C158(1.12)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C414(1.18); C158(0.96)  LDD1550  [6]
 LDCM0312  AC5 PaTu 8988t C414(1.21)  LDD1191  [5]
 LDCM0313  AC50 HEK-293T C414(0.98)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C414(0.96); C158(0.89)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C158(0.96)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C414(1.00)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C414(1.12); C158(1.14)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C414(1.09); C158(0.97)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C414(0.97); C158(1.52)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C414(1.09); C158(0.91)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C414(1.08)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C414(1.05); C158(1.01)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C414(1.05); C158(2.20)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C158(1.10)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C414(1.16)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C414(1.14); C158(1.40)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C414(1.11); C158(1.01)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C414(0.98); C158(0.94)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C414(1.02); C158(1.01)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C414(0.92); C158(1.05)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C414(1.02)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C414(1.11); C158(1.00)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C414(1.03); C158(1.22)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C414(1.25); C158(1.44)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C414(3.16); C158(1.93)  LDD1572  [6]
 LDCM0369  CL100 PaTu 8988t C414(1.06)  LDD1248  [5]
 LDCM0370  CL101 HEK-293T C414(1.06); C158(1.14)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C414(1.19)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C414(1.14); C158(0.77)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C414(0.97)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C414(1.20); C158(1.04)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C414(0.99)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C414(0.98); C158(1.06)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C414(0.99)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C414(1.14); C158(1.01)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C414(1.61); C158(1.48)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C414(1.19)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C414(1.23); C158(1.15)  LDD1585  [6]
 LDCM0382  CL112 PaTu 8988t C414(1.00)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C414(1.05)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C414(0.89)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C414(0.97)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C414(0.97)  LDD1265  [5]
 LDCM0387  CL117 HEK-293T C414(1.13); C158(1.11)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C414(0.98)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C414(1.05); C158(0.72)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C414(1.26); C158(2.01)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C414(0.94)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C414(0.98); C158(1.07)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C414(1.15)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C414(2.11); C158(0.75)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C414(1.08)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C414(1.07); C158(1.38)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C414(1.25)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C414(1.05); C158(0.79)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C414(1.01)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C414(1.07); C158(1.08)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C414(1.09)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C414(1.71); C158(1.34)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C414(1.02)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C414(2.02); C158(1.00)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C414(1.13)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C414(1.13); C158(1.07)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C414(1.14)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C158(1.11)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C414(1.61)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C414(1.48); C158(2.38)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C414(1.19); C158(1.23)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C414(1.29); C158(2.05)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C414(2.37); C158(1.11)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C414(1.03)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C414(0.93); C158(0.75)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C414(1.01)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C414(0.97); C158(0.93)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C414(1.56); C158(1.13)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C414(0.90)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C414(1.30); C158(0.74)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C158(1.08)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C414(4.58)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C414(1.45); C158(2.09)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C414(1.30); C158(1.17)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C414(1.28); C158(1.43)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C414(1.22); C158(1.34)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C414(1.34); C158(1.03)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C414(1.39)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C414(0.93)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C414(1.10); C158(0.88)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C414(0.95)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C414(1.10); C158(0.75)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C158(0.95)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C414(1.86)  LDD1639  [6]
 LDCM0436  CL46 PaTu 8988t C414(1.03)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C414(1.05)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C414(1.00)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C414(1.04)  LDD1318  [5]
 LDCM0440  CL5 HEK-293T C414(1.25); C158(0.89)  LDD1644  [6]
 LDCM0441  CL50 PaTu 8988t C414(1.16)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C414(1.06)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C414(1.22)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C414(1.03)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C414(1.05)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C414(0.93)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C414(0.93)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C414(0.98)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C414(1.07)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C414(1.03)  LDD1329  [5]
 LDCM0451  CL6 HEK-293T C414(1.61)  LDD1654  [6]
 LDCM0452  CL60 PaTu 8988t C414(1.07)  LDD1331  [5]
 LDCM0453  CL61 PaTu 8988t C414(1.12)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C414(0.97)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C414(1.07)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C414(0.99)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C414(1.15)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C414(1.06)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C414(1.27)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C414(1.15)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C414(1.10)  LDD1340  [5]
 LDCM0462  CL7 HEK-293T C414(1.42); C158(0.88)  LDD1665  [6]
 LDCM0463  CL70 PaTu 8988t C414(1.32)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C414(1.01)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C414(1.05)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C414(1.01)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C414(1.12)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C414(0.97)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C414(0.94)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C414(1.02)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C414(1.19)  LDD1351  [5]
 LDCM0473  CL8 HEK-293T C158(1.49)  LDD1676  [6]
 LDCM0474  CL80 PaTu 8988t C414(0.94)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C414(1.04)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C414(1.11)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C414(0.99)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C414(1.00)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C414(0.98)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C414(0.88)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C414(1.00)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C414(0.91)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C414(1.06)  LDD1362  [5]
 LDCM0484  CL9 HEK-293T C414(1.44)  LDD1687  [6]
 LDCM0485  CL90 PaTu 8988t C414(0.93)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C414(1.04)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C414(1.05)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C414(1.06)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C414(1.05)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C414(1.03)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C414(0.99)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C414(1.14)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C414(1.29)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C414(1.12)  LDD1373  [5]
 LDCM0495  E2913 HEK-293T C414(1.33); C158(0.87)  LDD1698  [6]
 LDCM0468  Fragment33 PaTu 8988t C414(1.13)  LDD1347  [5]
 LDCM0427  Fragment51 HEK-293T C414(0.90)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C414(0.85)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C414(0.94)  LDD1497  [6]
 LDCM0024  KB05 NCI-H1975 C414(2.23)  LDD3352  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD44 antigen (CD44) . P16070
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetylcysteine Small molecular drug DB06151
Cystine Small molecular drug DB00138
Glutamic Acid Small molecular drug DB00142
Riluzole Small molecular drug DB00740
Rosuvastatin Small molecular drug DB01098
Sulfasalazine Small molecular drug DB00795
Taurocholic Acid Small molecular drug DB04348
Tauroursodeoxycholic Acid Small molecular drug DB08834
Thimerosal . DB11590
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sxc-2023 Small molecular drug D1KO3P
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alanosine . DB05540

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402