Details of the Target

General Information of Target

Target ID LDTP13297
Target Name DNA polymerase subunit gamma-2 (POLG2)
Gene Name POLG2
Gene ID 11232
Synonyms
MTPOLB; DNA polymerase subunit gamma-2; DNA polymerase gamma accessory 55 kDa subunit; p55; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPL
PTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMS
FTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFG
VASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLC
CFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLL
VILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVA
IAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGW
THMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRM
Target Bioclass
Enzyme
Subcellular location
Mitochondrion
Function
Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA.
Uniprot ID
Q9UHN1
Ensemble ID
ENST00000539111.7
HGNC ID
HGNC:9180
ChEMBL ID
CHEMBL3430903

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.12  LDD0066  [1]
STPyne
 Probe Info  		K463(10.00)  LDD0277  [2]
BTD
 Probe Info  		C377(1.16)  LDD2099  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C377(1.24)  LDD0532  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C95(0.00); C377(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		C95(0.00); C196(0.00)  LDD2156  [7]
TFBX
 Probe Info  		C95(0.00); C377(0.00)  LDD0148  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C377(0.75)  LDD2117  [3]
 LDCM0214  AC1 HEK-293T C278(0.90); C377(0.99); C196(0.98)  LDD1507  [9]
 LDCM0215  AC10 HCT 116 C377(1.24)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C377(0.66)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C377(0.62)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C377(0.70)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C377(0.58)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C377(0.81)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C377(0.58)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C377(0.57)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C377(0.64)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C377(0.63)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C377(0.99)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C377(1.66)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C377(0.62)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C377(0.65)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C377(0.59)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C377(1.51)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C377(1.34)  LDD0576  [5]
 LDCM0270  AC15 HCT 116 C377(1.03)  LDD0587  [5]
 LDCM0276  AC17 HCT 116 C377(1.05)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C377(1.09)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C377(1.13)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C278(0.97); C377(0.97); C196(0.95); C334(1.20)  LDD1518  [9]
 LDCM0280  AC20 HCT 116 C377(0.96)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C377(0.97)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C377(0.93)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C377(1.18)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C377(0.95)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C278(2.71)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C278(1.84)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C278(2.64)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C278(1.77)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C278(2.13)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C278(0.95); C377(0.88); C95(1.05); C196(1.01)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C278(1.64)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C278(1.70)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C278(2.30)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C278(1.81)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C278(1.72)  LDD0893  [5]
 LDCM0296  AC35 HCT 116 C377(0.99); C278(1.15)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C377(0.82); C278(1.13)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C377(0.92); C278(1.04)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C377(0.81); C278(0.99)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C377(0.83); C278(1.34)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C278(1.03); C377(0.96); C196(0.97); C334(0.90)  LDD1540  [9]
 LDCM0302  AC40 HCT 116 C377(0.77); C278(1.28)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C377(0.67); C278(1.05)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C377(0.75); C278(1.44)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C377(0.66); C278(1.11)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C377(0.86); C278(1.34)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C377(0.78); C278(1.20)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C377(0.82)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C377(0.98)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C377(0.79)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C377(0.70)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C278(1.02); C377(1.04); C196(1.01)  LDD1551  [9]
 LDCM0313  AC50 HCT 116 C377(0.80)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C377(0.76)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C377(0.81)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C377(1.20)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C377(0.89)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C377(1.35)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C377(0.77)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C278(0.72)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C278(0.83)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C278(0.77)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C377(0.90)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C278(0.76)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C278(0.70)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C278(0.76)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C278(0.68)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C278(0.72)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C278(0.74)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C278(0.82)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C278(0.64)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C377(0.76)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C377(0.97)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C377(0.97)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C377(1.43)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C377(1.36)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C377(1.45)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C377(1.54)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C377(1.35)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C377(1.10)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C377(1.19)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C377(0.75)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C377(1.02)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C377(1.25)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C377(1.01)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C377(1.29)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C377(1.46)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C377(1.23)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C278(1.04)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C278(0.78)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C278(1.15)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C278(0.81)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C278(0.75)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C278(0.95)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C278(1.18)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C278(0.97)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C278(0.70)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C278(1.03)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C278(0.96)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C278(0.81)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C278(0.92)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C278(0.89)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C278(0.88)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C377(0.61)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C377(0.68)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C377(1.42)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C377(1.49)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C377(0.86)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C278(0.89); C377(0.99); C196(1.09)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C278(0.85); C377(0.79); C196(1.09)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C278(0.85); C377(0.90); C196(0.88)  LDD1573  [9]
 LDCM0370  CL101 HCT 116 C377(1.04)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C377(1.46)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C377(1.66)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C377(1.17)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C377(1.12)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C377(1.14)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C377(1.17)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C377(1.20)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C377(0.92)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C278(0.86); C377(1.04); C196(1.30)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C377(1.05)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C377(0.96)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C278(1.83)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C278(1.67)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C278(2.73)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C278(1.63)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C278(2.11)  LDD0984  [5]
 LDCM0387  CL117 HCT 116 C377(0.75); C278(1.27)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C377(0.80); C278(1.09)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C377(0.72); C278(1.18)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C278(0.95); C377(1.01); C196(1.22); C334(0.98)  LDD1594  [9]
 LDCM0391  CL120 HCT 116 C377(0.68); C278(1.11)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C377(0.85)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C377(0.64)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C377(0.90)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C377(0.80)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C278(0.73)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C278(0.68)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C278(0.70)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C278(0.74)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C278(0.91); C377(0.94); C196(0.98)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C278(0.90); C377(1.06); C196(0.96)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C278(0.87); C377(0.92); C196(0.92)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C278(0.95); C377(1.01); C196(0.92)  LDD1607  [9]
 LDCM0404  CL17 HCT 116 C377(0.90); C278(0.93)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C278(0.83); C377(0.90)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C278(0.89); C377(1.07)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C278(1.03); C377(0.93); C196(1.70)  LDD1611  [9]
 LDCM0408  CL20 HCT 116 C377(0.70); C278(0.91)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C377(0.80); C278(1.21)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C377(0.82); C278(0.98)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C377(1.07); C278(1.36)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C377(0.82); C278(1.06)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C278(0.65); C377(0.93)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C278(0.98); C377(1.00)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C278(1.00); C377(0.99)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C278(1.06); C377(0.88)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C278(0.94); C377(0.76)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C278(0.93); C377(1.00); C196(1.03)  LDD1622  [9]
 LDCM0419  CL30 HCT 116 C278(0.87); C377(0.90)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C278(0.95); C377(0.86)  LDD0737  [5]
 LDCM0421  CL32 HEK-293T C278(0.97)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C278(0.86)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C278(0.97)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C278(1.02)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C278(1.03)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C278(1.00)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C278(1.36)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C278(0.88); C377(0.99); C196(1.00)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C278(1.01)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C278(1.27)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C278(1.39)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C278(1.35)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C278(1.05)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C278(1.27)  LDD1033  [5]
 LDCM0436  CL46 HCT 116 C377(0.91)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C377(0.88)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C377(0.97)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C377(1.11)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C278(0.96); C377(1.00); C196(1.08)  LDD1644  [9]
 LDCM0441  CL50 HCT 116 C377(0.92)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C377(0.98)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C377(0.98)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C377(0.72)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C377(0.87)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C377(0.84)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C377(0.79)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C377(0.94)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C377(1.07)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C377(0.85)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C278(0.79); C377(0.86); C196(1.22); C334(0.92)  LDD1654  [9]
 LDCM0452  CL60 HCT 116 C377(1.01)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C377(1.51)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C377(1.47)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C377(1.16)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C377(1.65)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C377(1.42)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C377(1.51)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C377(1.05)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C377(0.80)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C377(1.38)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C278(1.03); C377(0.92); C95(1.00); C196(1.09)  LDD1665  [9]
 LDCM0463  CL70 HCT 116 C377(1.24)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C377(1.22)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C377(1.29)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C377(0.94)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C377(1.12)  LDD0784  [5]
 LDCM0469  CL76 HEK-293T C278(0.94); C377(1.09); C196(0.85)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C278(0.82); C377(0.87); C196(0.92)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C278(0.84); C377(0.94); C196(1.07); C334(1.09)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C278(0.91); C377(0.94); C95(0.75); C196(1.00)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C278(0.78); C377(0.79); C196(1.05); C334(0.89)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C278(1.10); C377(1.09); C196(1.02); C334(0.89)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C278(0.99); C377(1.07); C196(1.03)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C278(0.89); C377(0.97); C196(1.10)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C278(0.88); C377(1.06); C196(1.03)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C278(0.97); C377(1.06); C196(1.23); C334(1.03)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C278(0.98); C377(1.10); C196(0.96)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C278(1.05); C377(0.98); C196(0.96)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C278(1.04); C377(0.99); C196(0.91)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C278(0.88); C377(1.08); C196(0.93)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C278(0.91); C377(0.94); C196(1.02)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C278(1.02); C377(1.00); C196(1.09)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C278(0.70); C377(0.67); C196(3.47); C334(1.42)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C278(1.17); C377(0.98); C95(0.90); C196(0.99)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C278(0.92); C377(0.95); C196(1.16); C334(0.89)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C278(1.00); C377(1.02); C196(1.01)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C278(1.03); C377(0.95); C196(0.75)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C278(0.75); C377(0.81); C196(0.93)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C278(0.88); C377(0.96); C196(0.92); C334(0.92)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C278(0.86); C377(1.05); C196(0.98)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C278(0.96); C377(1.00); C196(1.06)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C278(1.01); C377(1.01); C196(0.94)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C278(0.98); C377(1.04); C196(1.36)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C377(1.41)  LDD0785  [5]
 LDCM0427  Fragment51 HEK-293T C278(1.10)  LDD1025  [5]
 LDCM0022  KB02 HEK-293T C278(1.05); C377(1.03); C196(0.95)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C278(1.07); C377(1.04); C196(0.96)  LDD1497  [9]
 LDCM0024  KB05 HMCB C334(2.07)  LDD3312  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C377(1.16)  LDD2099  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C377(1.25)  LDD2119  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA polymerase subunit gamma-1 (POLG) DNA polymerase type-A family P54098

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840