Details of the Target

General Information of Target

Target ID LDTP13263
Target Name DNA mismatch repair protein Mlh3 (MLH3)
Gene Name MLH3
Gene ID 27030
Synonyms
DNA mismatch repair protein Mlh3; MutL protein homolog 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEKQVPGGGGGGGSGGGGGSGGGGSGGGRGAGGEENKENERPSAGSKANKEFGDSLSL
EILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTD
NRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDA
KTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLASAFTEEQAVLYNQRVEEI
SPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRG
RTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQVVREELKPDQK
QRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNENMAKGLQRALLQQQPEDDSKRSPR
PQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWS
EALVLYDRVLKYANEVNSDAGAFKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDAHQ
TETSSSQVKDNKPLVERFETFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAF
PPLEDKLEQKTKSGLTGYIKGIFGFRS
Target Bioclass
Other
Family
DNA mismatch repair MutL/HexB family
Subcellular location
Nucleus
Function Probably involved in the repair of mismatches in DNA.
Uniprot ID
Q9UHC1
Ensemble ID
ENST00000355774.7
HGNC ID
HGNC:7128

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.R1180C .
HCC1395 SNV: p.I609L DBIA    Probe Info 
HEP3B217 SNV: p.S663N .
IGR37 SNV: p.R1232S DBIA    Probe Info 
IGR39 SNV: p.R1232S .
Ishikawa (Heraklio) 02 ER SNV: p.N945S DBIA    Probe Info 
LNCaP clone FGC SNV: p.I541V DBIA    Probe Info 
SF295 SNV: p.A557T .
SHP77 SNV: p.G762V .
SNU1 SNV: p.S1377N .
SUPT1 SNV: p.V534D DBIA    Probe Info 
YSCCC SNV: p.L1203F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1031(0.96); C1040(0.96); C1041(0.96)  LDD0078  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1040(1.87); C1041(0.32); C1031(1.10)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C1040(0.95); C1031(0.95)  LDD1094  [1]
 LDCM0216  AC100 HCT 116 C1031(0.95)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C1031(1.93)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C1031(1.96)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C1031(1.74)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C1031(1.47)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C1031(1.06)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C1031(1.61)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C1031(1.26)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C1031(1.31)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C1031(1.46)  LDD0542  [1]
 LDCM0226  AC11 PaTu 8988t C1040(1.19); C1031(1.19)  LDD1105  [1]
 LDCM0227  AC110 HCT 116 C1031(1.82)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C1031(0.89)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C1031(1.44)  LDD0546  [1]
 LDCM0230  AC113 PaTu 8988t C1041(1.04); C1031(1.04)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C1041(0.95); C1031(0.95)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C1041(1.06); C1031(1.06)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C1041(0.98); C1031(0.98)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C1041(1.46); C1031(1.46)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C1041(1.15); C1031(1.15)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C1041(1.14); C1031(1.14)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C1040(1.03); C1031(1.03)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C1041(0.96); C1031(0.96)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C1041(1.05); C1031(1.05)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C1041(0.92); C1031(0.92)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C1041(0.98); C1031(0.98)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C1041(0.82); C1031(0.82)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C1041(1.13); C1031(1.13)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C1041(0.96); C1031(0.96)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C1041(0.87); C1031(0.87)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C1040(0.94); C1031(0.94)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C1040(1.10); C1031(1.10)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C1040(0.85); C1031(0.85)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C1040(0.73); C1031(0.73)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C1040(0.84); C1031(0.84)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C1040(1.30); C1031(1.30)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C1040(1.11); C1031(1.11)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C1040(1.35); C1031(1.35)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C1040(1.01); C1031(1.01)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C1040(1.14); C1031(1.14)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C1040(0.96); C1031(0.96)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C1040(1.20); C1031(1.20)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C1040(0.83); C1031(0.83)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C1040(1.33); C1031(1.33)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C1040(0.91); C1031(0.91)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C1040(0.92); C1031(0.92)  LDD1141  [1]
 LDCM0263  AC143 PaTu 8988t C1041(1.31); C1031(1.31)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C1041(1.28); C1031(1.28)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C1041(1.05); C1031(1.05)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C1041(0.98); C1031(0.98)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C1041(1.08); C1031(1.08)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C1041(1.52); C1031(1.52)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C1041(1.72); C1031(1.72)  LDD1148  [1]
 LDCM0270  AC15 PaTu 8988t C1040(0.94); C1031(0.94)  LDD1149  [1]
 LDCM0271  AC150 PaTu 8988t C1041(1.25); C1031(1.25)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C1041(2.54); C1031(2.54)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C1041(1.21); C1031(1.21)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C1041(1.51); C1031(1.51)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C1041(1.90); C1031(1.90)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C1041(2.03); C1031(2.03)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C1041(1.34); C1031(1.34)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C1041(0.99); C1031(0.99)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C1040(0.92); C1031(0.92)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C1040(1.13); C1031(1.13)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C1040(0.72); C1031(0.72)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C1040(1.62); C1041(0.30); C1031(0.96)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C1040(1.05); C1031(1.05)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C1040(1.03); C1031(1.03)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C1040(0.75); C1031(0.75)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C1040(1.14); C1031(1.14)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C1040(1.00); C1031(1.00)  LDD1163  [1]
 LDCM0285  AC25 HCT 116 C1031(1.40)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C1031(1.33)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C1031(1.31)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C1031(1.47)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C1031(1.66)  LDD0606  [1]
 LDCM0290  AC3 PaTu 8988t C1040(1.41); C1041(0.26); C1031(0.83)  LDD1169  [1]
 LDCM0291  AC30 HCT 116 C1031(1.01)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C1031(1.24)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C1031(2.38)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C1031(1.25)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C1031(1.83)  LDD0612  [1]
 LDCM0296  AC35 PaTu 8988t C1041(1.48); C1031(1.48)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C1041(1.19); C1031(1.19)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C1041(1.06); C1031(1.06)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C1041(1.36); C1031(1.36)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C1041(1.50); C1031(1.50)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C1040(1.36); C1041(0.27); C1031(0.82)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C1041(1.54); C1031(1.54)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C1041(1.26); C1031(1.26)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C1041(1.33); C1031(1.33)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C1041(1.26); C1031(1.26)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C1041(1.45); C1031(1.45)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C1041(1.23); C1031(1.23)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C1041(1.32); C1031(1.32)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C1041(1.08); C1031(1.08)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C1041(1.42); C1031(1.42)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C1041(1.08); C1031(1.08)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C1040(1.90); C1041(0.25); C1031(1.07)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C1041(1.37); C1031(1.37)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C1041(0.62); C1031(0.62)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C1041(1.20); C1031(1.20)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C1041(1.58); C1031(1.58)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C1041(1.65); C1031(1.65)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C1041(1.36); C1031(1.36)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C1041(1.83); C1031(1.83)  LDD1198  [1]
 LDCM0320  AC57 HCT 116 C1031(1.02)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C1031(1.27)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C1031(1.19)  LDD0639  [1]
 LDCM0323  AC6 PaTu 8988t C1040(1.05); C1031(1.05)  LDD1202  [1]
 LDCM0324  AC60 HCT 116 C1031(1.08)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C1031(1.28)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C1031(1.01)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C1031(1.92)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C1031(1.50)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C1031(1.00)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C1031(1.09)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C1031(1.21)  LDD0648  [1]
 LDCM0332  AC68 PaTu 8988t C1041(0.90); C1031(0.90)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C1041(0.94); C1031(0.94)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C1040(0.91); C1031(0.91)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C1041(0.69); C1031(0.69)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C1041(0.74); C1031(0.74)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C1041(0.76); C1031(0.76)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C1041(0.69); C1031(0.69)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C1041(0.86); C1031(0.86)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C1041(1.33); C1031(1.33)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C1041(0.89); C1031(0.89)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C1041(0.81); C1031(0.81)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C1041(0.70); C1031(0.70)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C1041(0.75); C1031(0.75)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C1040(0.70); C1031(0.70)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C1041(1.14); C1031(1.14)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C1041(0.86); C1031(0.86)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C1041(0.73); C1031(0.73)  LDD1227  [1]
 LDCM0349  AC83 HCT 116 C1031(1.87)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C1031(1.64)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C1031(1.12)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1031(0.90)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C1031(0.85)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C1031(1.23)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1031(1.27)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1031(0.57)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1031(1.62)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C1031(1.36)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C1031(0.69)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C1031(0.71)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1031(1.03)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C1031(1.14)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1031(1.35)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C1031(2.80)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C1031(0.95)  LDD0683  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C1040(1.10); C1031(1.10)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C1040(1.35); C1031(1.35)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C1040(1.17); C1031(1.17)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C1031(0.96); C1040(0.96); C1041(0.96)  LDD0078  [1]
 LDCM0367  CL1 PaTu 8988t C1041(1.58); C1031(1.58)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C1041(3.86); C1031(3.86)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C1040(1.31); C1041(0.27); C1031(0.79)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C1040(1.23); C1031(1.23)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C1040(1.19); C1031(1.19)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C1040(1.36); C1031(1.36)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C1040(1.04); C1031(1.04)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C1040(0.74); C1031(0.74)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C1040(0.87); C1031(0.87)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C1040(1.22); C1031(1.22)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C1040(0.58); C1031(0.58)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C1040(0.92); C1031(0.92)  LDD1257  [1]
 LDCM0379  CL11 PaTu 8988t C1041(1.15); C1031(1.15)  LDD1258  [1]
 LDCM0380  CL110 PaTu 8988t C1040(1.37); C1031(1.37)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C1040(0.97); C1031(0.97)  LDD1260  [1]
 LDCM0382  CL112 HCT 116 C1031(1.48)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C1031(1.02)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C1031(1.13)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C1031(2.50)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C1031(1.00)  LDD0703  [1]
 LDCM0387  CL117 PaTu 8988t C1041(1.60); C1031(1.60)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C1041(1.21); C1031(1.21)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C1041(1.47); C1031(1.47)  LDD1268  [1]
 LDCM0390  CL12 PaTu 8988t C1041(1.15); C1031(1.15)  LDD1269  [1]
 LDCM0391  CL120 PaTu 8988t C1041(1.03); C1031(1.03)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C1041(2.05); C1031(2.05)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C1041(2.31); C1031(2.31)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C1041(1.72); C1031(1.72)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C1041(1.54); C1031(1.54)  LDD1274  [1]
 LDCM0396  CL125 HCT 116 C1031(0.67)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C1031(1.24)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C1031(0.99)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C1031(1.34)  LDD0716  [1]
 LDCM0400  CL13 PaTu 8988t C1041(1.64); C1031(1.64)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C1041(1.92); C1031(1.92)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C1041(2.15); C1031(2.15)  LDD1281  [1]
 LDCM0403  CL16 PaTu 8988t C1041(1.29); C1031(1.29)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C1041(1.20); C1031(1.20)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C1041(1.20); C1031(1.20)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C1041(1.23); C1031(1.23)  LDD1285  [1]
 LDCM0407  CL2 PaTu 8988t C1041(1.19); C1031(1.19)  LDD1286  [1]
 LDCM0408  CL20 PaTu 8988t C1041(1.47); C1031(1.47)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C1041(3.26); C1031(3.26)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C1041(1.51); C1031(1.51)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C1041(1.04); C1031(1.04)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C1041(0.79); C1031(0.79)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C1041(1.31); C1031(1.31)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C1041(1.24); C1031(1.24)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C1041(0.91); C1031(0.91)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C1041(1.55); C1031(1.55)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C1041(1.39); C1031(1.39)  LDD1296  [1]
 LDCM0418  CL3 PaTu 8988t C1041(1.38); C1031(1.38)  LDD1297  [1]
 LDCM0419  CL30 PaTu 8988t C1041(1.18); C1031(1.18)  LDD1298  [1]
 LDCM0420  CL31 PaTu 8988t C1040(0.90); C1041(1.59); C1031(1.25)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C1040(0.87); C1041(1.31); C1031(1.09)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C1040(1.21); C1041(1.38); C1031(1.30)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C1040(0.96); C1041(1.08); C1031(1.02)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C1041(1.39); C1031(1.50); C1040(1.61)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C1040(1.31); C1041(2.17); C1031(1.74)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C1040(0.86); C1041(1.60); C1031(1.23)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C1040(0.86); C1041(1.27); C1031(1.07)  LDD1307  [1]
 LDCM0429  CL4 PaTu 8988t C1041(1.23); C1031(1.23)  LDD1308  [1]
 LDCM0430  CL40 PaTu 8988t C1040(0.88); C1041(1.28); C1031(1.08)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C1040(1.31); C1041(2.09); C1031(1.70)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C1040(1.01); C1041(2.79); C1031(1.90)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C1040(1.64); C1041(2.08); C1031(1.86)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C1040(1.32); C1041(1.23); C1031(1.27)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C1040(1.68); C1041(1.18); C1031(1.43)  LDD1314  [1]
 LDCM0440  CL5 PaTu 8988t C1041(1.59); C1031(1.59)  LDD1319  [1]
 LDCM0451  CL6 PaTu 8988t C1041(2.01); C1031(2.01)  LDD1330  [1]
 LDCM0453  CL61 PaTu 8988t C133(1.02); C1041(1.26); C1031(1.26)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C133(1.53); C1041(1.40); C1031(1.40)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C133(1.45); C1041(1.31); C1031(1.31)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C133(1.50); C1041(1.72); C1031(1.72)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C133(1.69); C1041(1.34); C1031(1.34)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C133(2.42); C1041(1.71); C1031(1.71)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C133(1.17); C1041(1.43); C1031(1.43)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C133(1.27); C1041(2.02); C1031(2.02)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C133(0.98); C1041(1.46); C1031(1.46)  LDD1340  [1]
 LDCM0462  CL7 PaTu 8988t C1041(1.79); C1031(1.79)  LDD1341  [1]
 LDCM0463  CL70 PaTu 8988t C133(0.99); C1041(1.45); C1031(1.45)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C133(1.10); C1041(1.65); C1031(1.65)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C133(1.08); C1041(1.61); C1031(1.61)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C133(1.71); C1041(2.17); C1031(2.17)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C133(1.13); C1041(1.54); C1031(1.54)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C133(0.59); C1041(0.89); C1031(0.89)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C133(0.77); C1041(1.07); C1031(1.07)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C133(0.75); C1041(2.07); C1031(2.07)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C133(0.75); C1041(1.14); C1031(1.14)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C1041(2.65); C1031(2.65)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C133(0.80); C1041(1.33); C1031(1.33)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C133(0.78); C1041(1.31); C1031(1.31)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C133(0.81); C1041(1.28); C1031(1.28)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C133(0.97); C1041(1.06); C1031(1.06)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C133(0.70); C1041(1.16); C1031(1.16)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C133(0.60); C1041(0.94); C1031(0.94)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C133(0.58); C1041(1.20); C1031(1.20)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C133(0.70); C1041(1.30); C1031(1.30)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C133(0.80); C1041(1.27); C1031(1.27)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C133(0.99); C1041(1.35); C1031(1.35)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C1041(1.00); C1031(1.00)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C133(0.97); C1041(3.86); C1031(3.86)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C1040(1.28); C1041(0.21); C1031(0.75)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C1040(1.79); C1041(0.32); C1031(1.05)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C1040(1.73); C1041(0.25); C1031(0.99)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C1040(1.59); C1041(0.31); C1031(0.95)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C1040(4.02); C1041(0.63); C1031(2.33)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C1040(1.86); C1041(0.18); C1031(1.02)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C1040(1.50); C1041(0.35); C1031(0.92)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C1040(1.25); C1041(0.34); C1031(0.79)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C1040(2.15); C1041(0.22); C1031(1.18)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C133(1.15); C1041(1.25); C1031(1.25)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C1040(1.12); C1041(1.22); C1031(1.17)  LDD1306  [1]
 LDCM0022  KB02 A101D C212(1.79)  LDD2250  [3]
 LDCM0023  KB03 A101D C212(2.48)  LDD2667  [3]
 LDCM0024  KB05 SH4 C212(2.05)  LDD3321  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840