Details of the Target

General Information of Target

Target ID LDTP13213
Target Name CCR4-NOT transcription complex subunit 8 (CNOT8)
Gene Name CNOT8
Gene ID 9337
Synonyms
CALIF; POP2; CCR4-NOT transcription complex subunit 8; EC 3.1.13.4; CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFK
NVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKEN
GIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLER
LTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGD
IDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDH
ETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKL
KEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVL
SEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQAL
EAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFI
DRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERT
EEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQ
AYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSS
DEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQA
YSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDE
MLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTS
QSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK
Target Bioclass
Enzyme
Family
CAF1 family
Subcellular location
Cytoplasm
Function
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Uniprot ID
Q9UFF9
Ensemble ID
ENST00000285896.11
HGNC ID
HGNC:9207

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE180 SNV: p.H135N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y260(10.14)  LDD0257  [1]
m-APA
 Probe Info  		13.42  LDD0403  [2]
IA-alkyne
 Probe Info  		C67(0.61); C256(0.66)  LDD2182  [3]
IPM
 Probe Info  		C67(2.03)  LDD1702  [4]
DBIA
 Probe Info  		C67(0.85)  LDD0533  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
SF
 Probe Info  		N.A.  LDD0028  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
HHS-465
 Probe Info  		N.A.  LDD2240  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C67(1.11); C148(0.93)  LDD1508  [11]
 LDCM0216  AC100 HCT 116 C67(0.85)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C67(1.02)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C67(0.87)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C67(1.00)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C67(1.00)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C67(1.03)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C67(1.04)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C67(1.01)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C67(0.94)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C67(0.99)  LDD0542  [5]
 LDCM0227  AC110 HCT 116 C67(0.91)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C67(0.83)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C67(0.99)  LDD0546  [5]
 LDCM0237  AC12 HEK-293T C67(1.08); C148(1.00)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C67(1.10)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C67(1.10)  LDD1513  [11]
 LDCM0277  AC18 HEK-293T C67(0.98); C148(0.75)  LDD1516  [11]
 LDCM0279  AC2 HEK-293T C67(1.05); C148(1.01)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C67(1.02); C148(1.01)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C67(0.94)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C67(1.08)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C67(1.02)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C67(0.99); C148(0.99)  LDD1523  [11]
 LDCM0286  AC26 HEK-293T C67(1.06); C148(0.85)  LDD1525  [11]
 LDCM0288  AC28 HEK-293T C67(1.02); C148(0.90)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C67(1.00)  LDD1528  [11]
 LDCM0291  AC30 HEK-293T C67(1.02)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C67(1.05)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C67(1.01); C148(0.99)  LDD1532  [11]
 LDCM0295  AC34 HEK-293T C67(1.22); C148(0.82)  LDD1534  [11]
 LDCM0296  AC35 HCT 116 C67(0.83)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C67(1.11)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C67(0.96)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C67(0.83)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C67(1.01)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C67(1.00); C148(0.93)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C67(1.08)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C67(1.02)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C67(1.01)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C67(1.02)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C67(1.03)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C67(1.19)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C67(0.94)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C67(0.96)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C67(0.98)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C67(0.94)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C67(0.97)  LDD1551  [11]
 LDCM0313  AC50 HCT 116 C67(1.05)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C67(0.98)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C67(0.95)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C67(1.03)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C67(1.06)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C67(1.12)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C67(1.15)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C67(1.34)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C67(1.34)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C67(1.41)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C67(1.03)  LDD1562  [11]
 LDCM0324  AC60 HCT 116 C67(1.34)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C67(1.33)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C67(1.44)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C67(1.37)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C67(1.48)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C67(1.94)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C67(1.82)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C67(1.50)  LDD0648  [5]
 LDCM0334  AC7 HEK-293T C67(1.04)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C67(0.99); C148(0.99)  LDD1569  [11]
 LDCM0349  AC83 HCT 116 C67(1.11)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C67(1.06)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C67(0.98)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C67(1.12)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C67(0.93)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C67(1.01)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C67(1.04)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C67(1.15)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C67(1.10)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C67(1.13)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C67(0.98)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C67(0.92)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C67(0.91)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C67(0.97)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C67(0.96)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C67(0.90)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C67(0.85)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C67(1.01)  LDD1511  [11]
 LDCM0275  AKOS034007705 HEK-293T C67(1.05); C148(1.05)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 13.42  LDD0403  [2]
 LDCM0632  CL-Sc Hep-G2 C256(0.58)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C67(0.95); C148(1.11)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C67(1.04)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C148(1.32)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C67(0.95); C148(1.06)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C67(0.94); C148(1.02)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C148(0.96)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C148(1.22)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C67(1.01); C148(1.03)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C67(1.05); C148(0.85)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C148(0.91)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C148(1.08)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C67(1.01); C148(1.07)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C67(1.21)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C67(1.01); C148(1.03)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C148(0.92)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C148(1.12)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C67(1.01); C148(1.05)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C67(0.94); C148(1.31)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C148(1.01)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C148(0.89)  LDD1590  [11]
 LDCM0387  CL117 HCT 116 C67(0.93)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C67(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C67(0.96)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C67(1.08); C148(1.44)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C67(1.05)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C67(0.97)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C67(1.02)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C67(0.94)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C67(1.08)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C67(1.22)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C67(1.22)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C67(1.23)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C67(1.46)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C67(0.89); C148(1.12)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C67(0.97); C148(0.99)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C148(0.95)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C148(0.99)  LDD1607  [11]
 LDCM0405  CL18 HEK-293T C67(1.07); C148(0.97)  LDD1609  [11]
 LDCM0407  CL2 HEK-293T C67(0.96); C148(0.95)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C67(1.15); C148(1.24)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C67(0.99)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C67(1.27)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C67(1.26)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C67(1.13); C148(1.39)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C67(0.95); C148(0.98)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C67(1.01); C148(0.85)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C148(0.97)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C148(1.18)  LDD1620  [11]
 LDCM0418  CL3 HEK-293T C148(1.00)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C67(1.14); C148(0.98)  LDD1623  [11]
 LDCM0421  CL32 HEK-293T C67(1.14); C148(1.19)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C67(1.06)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C67(1.25)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C67(1.27)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C67(1.16); C148(1.43)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C67(1.01); C148(1.14)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C148(1.00)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C148(1.20)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C148(1.26)  LDD1634  [11]
 LDCM0432  CL42 HEK-293T C67(1.14); C148(1.00)  LDD1636  [11]
 LDCM0434  CL44 HEK-293T C67(1.10); C148(1.19)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C67(1.10)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C67(0.86)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C67(0.84)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C67(0.87)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C67(1.00)  LDD0756  [5]
 LDCM0441  CL50 HCT 116 C67(0.99)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C67(1.06)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C67(0.98)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C67(0.87)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C67(0.94)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C67(0.91)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C67(1.06)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C67(0.96)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C67(0.89)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C67(0.90)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C67(1.21); C148(0.94)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C67(0.83)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C67(1.00); C148(1.07)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C67(1.00); C148(0.95)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C148(1.05)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C148(2.47)  LDD1659  [11]
 LDCM0458  CL66 HEK-293T C67(1.09); C148(0.96)  LDD1661  [11]
 LDCM0460  CL68 HEK-293T C67(1.19); C148(1.23)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C67(1.10)  LDD1664  [11]
 LDCM0463  CL70 HEK-293T C67(1.21)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C67(1.19)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C67(1.13); C148(1.29)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C67(0.98); C148(0.98)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C67(1.10); C148(0.96)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C148(0.95)  LDD1672  [11]
 LDCM0471  CL78 HEK-293T C67(1.20); C148(0.98)  LDD1674  [11]
 LDCM0473  CL8 HEK-293T C67(1.01); C148(1.33)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C67(1.17); C148(1.06)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C67(1.09)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C67(1.20)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C67(1.17)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C67(1.11); C148(1.30)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C67(0.98); C148(1.17)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C67(0.96); C148(0.97)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C148(1.01)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C148(1.50)  LDD1685  [11]
 LDCM0484  CL9 HEK-293T C67(1.08)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C67(1.12); C148(1.02)  LDD1688  [11]
 LDCM0487  CL92 HEK-293T C67(1.09); C148(1.08)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C67(1.04)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C67(1.04)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C67(1.02)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C67(1.11); C148(1.32)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C67(1.01); C148(1.23)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C67(0.95); C148(1.05)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C148(1.08)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C148(0.89)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C67(2.03)  LDD1702  [4]
 LDCM0625  F8 Ramos C67(0.59); C256(0.83)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C67(0.69); C256(0.99)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C256(0.90)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C67(0.67); C256(1.26)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C67(0.99)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C67(0.66); C256(0.67)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C67(0.63)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C67(0.82); C256(0.86)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C67(0.96); C256(1.32)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C67(0.85)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C67(0.83); C256(1.06)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C67(0.83); C256(0.96)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C67(0.84); C256(1.07)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C67(0.51); C256(0.84)  LDD2201  [3]
 LDCM0468  Fragment33 HEK-293T C148(0.92)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C67(0.74); C256(1.22)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C67(0.71); C256(0.88)  LDD2184  [3]
 LDCM0427  Fragment51 HEK-293T C67(1.00); C148(0.91)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C67(0.96); C256(1.09)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C67(0.96); C256(0.75)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C67(0.59); C256(0.94)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C67(0.62); C256(0.86)  LDD2188  [3]
 LDCM0022  KB02 Ramos C67(0.61); C256(0.66)  LDD2182  [3]
 LDCM0023  KB03 Ramos C67(0.72); C256(0.76)  LDD2183  [3]
 LDCM0024  KB05 Ramos C67(0.58); C256(1.00)  LDD2185  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 6 (CNOT6) CCR4/nocturin family Q9ULM6
CCR4-NOT transcription complex subunit 6-like (CNOT6L) CCR4/nocturin family Q96LI5
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BTG1 (BTG1) BTG family P62324
Protein BTG2 (BTG2) BTG family P78543
Protein Tob2 (TOB2) BTG family Q14106
CCR4-NOT transcription complex subunit 1 (CNOT1) CNOT1 family A5YKK6
CCR4-NOT transcription complex subunit 2 (CNOT2) CNOT2/3/5 family Q9NZN8
CCR4-NOT transcription complex subunit 3 (CNOT3) CNOT2/3/5 family O75175
Protein PAT1 homolog 1 (PATL1) PAT1 family Q86TB9

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402