Details of the Target

General Information of Target

Target ID LDTP13135
Target Name Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)
Gene Name TNFRSF10D
Gene ID 8793
Synonyms
DCR2; TRAILR4; TRUNDD; Tumor necrosis factor receptor superfamily member 10D; Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD antigen CD264
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI
PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAA
MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK
SDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVT
DIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIP
GLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYD
LNLPDTVTHEDYVTTRL
Target Bioclass
Cytokine and receptor
Subcellular location
Membrane
Function
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According toit cannot but according toit can induce the NF-kappa-B pathway.
Uniprot ID
Q9UBN6
Ensemble ID
ENST00000312584.4
HGNC ID
HGNC:11907

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
BTD
 Probe Info  		C244(1.59)  LDD2100  [2]
DBIA
 Probe Info  		C326(0.86)  LDD0533  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_4
 Probe Info  		C264(0.00); 0.00; C326(0.00)  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD0147  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C244(1.04)  LDD2142  [2]
 LDCM0214  AC1 HEK-293T C131(1.10); C244(1.00); C326(1.02); C141(1.08)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C131(1.07); C83(1.07); C244(1.01); C326(0.97)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C326(0.86)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C326(0.97)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C326(0.93)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C326(1.15)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C326(0.99)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C326(1.10)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C326(1.06)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C326(1.13)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C326(0.76)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C326(0.73)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C131(1.07); C83(1.06); C172(0.97); C244(0.96)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C326(0.80)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C326(0.78)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C326(1.05)  LDD0546  [3]
 LDCM0237  AC12 HEK-293T C131(0.99); C172(0.92); C244(0.99); C326(1.17)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C131(1.08); C172(0.99); C244(1.03); C326(0.86)  LDD1512  [8]
 LDCM0263  AC143 HCT 116 C326(0.97)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C326(1.04)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C326(0.74)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C326(0.96)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C326(0.88)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C326(0.76)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C326(0.82)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C131(1.03); C83(0.93); C172(0.93); C244(1.19)  LDD1513  [8]
 LDCM0271  AC150 HCT 116 C326(0.96)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C326(0.84)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C326(0.85)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C326(0.74)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C326(0.90)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C326(0.86)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C326(1.03)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C326(0.84)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C326(0.90)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C326(1.01)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C326(1.00)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C131(1.01); C83(0.87); C244(0.96); C326(0.85)  LDD1518  [8]
 LDCM0280  AC20 HCT 116 C326(0.67)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C326(0.85)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C326(0.79)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C326(0.75)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C326(0.79)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C131(1.08); C244(0.95); C326(1.11); C141(1.31)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C131(1.02); C83(0.89); C244(1.01); C326(0.96)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C131(1.07); C83(0.94); C172(1.05); C244(0.98)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C131(0.96); C172(1.18); C244(0.97); C326(0.85)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C131(1.07); C83(1.02); C172(1.05); C244(1.02)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C131(1.07); C83(1.01); C172(0.91); C244(1.01)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C131(0.97); C172(1.11); C244(0.95); C326(1.04)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C131(1.03); C83(0.82); C172(0.93); C244(1.38)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C131(0.99); C83(0.93); C172(1.00); C244(0.96)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C131(1.06); C244(0.93); C326(1.21); C141(1.16)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C131(0.92); C83(1.10); C244(1.06); C326(1.12)  LDD1534  [8]
 LDCM0296  AC35 HCT 116 C326(0.66)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C326(0.59)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C326(0.61)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C326(0.75)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C326(0.92)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C131(1.07); C172(0.97); C244(0.96); C326(0.90)  LDD1540  [8]
 LDCM0302  AC40 HCT 116 C326(0.93)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C326(0.71)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C326(0.91)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C326(0.87)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C326(0.90)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C326(1.02)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C326(1.08)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C326(1.15)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C326(0.99)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C326(1.33)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C131(1.03); C83(1.03); C172(0.94); C244(0.98)  LDD1551  [8]
 LDCM0313  AC50 HCT 116 C326(1.38)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C326(0.74)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C326(0.85)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C326(1.09)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C326(1.29)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C326(1.35)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C326(1.63)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C131(1.13); C244(1.07); C326(1.04); C141(1.19)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C131(1.13); C83(0.93); C244(1.02); C326(1.00)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C131(1.08); C83(0.98); C172(1.15); C244(1.00)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C131(1.18); C172(0.99); C244(0.99); C326(1.06)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C131(1.09); C172(0.91); C244(0.96); C326(1.05)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C131(1.03); C83(0.93); C172(1.01); C244(1.00)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C131(1.03); C172(0.94); C244(0.96); C326(1.04)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C131(1.01); C83(0.71); C172(1.06); C244(1.05)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C131(0.91); C83(1.01); C172(1.07); C244(0.97)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C131(1.02); C83(0.83); C172(0.97); C244(0.99)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C131(0.95); C83(1.06); C172(1.00); C244(0.94)  LDD1569  [8]
 LDCM0365  AC98 HCT 116 C326(1.30)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C326(0.69)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C131(1.11); C83(0.93); C172(1.08); C244(0.99)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C131(1.12); C244(1.00); C326(1.06); C141(1.20)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C131(0.90); C83(1.02); C172(0.99); C244(0.91)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C131(1.03); C83(0.96); C172(1.20); C244(0.91)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C131(1.03); C172(1.12); C244(1.69); C326(1.19)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C131(1.11); C172(1.00); C244(1.06); C326(0.91)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C131(1.02); C83(1.05); C172(1.08); C244(1.04)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C131(1.11); C83(1.08); C244(1.11); C326(1.01)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C131(1.11); C172(1.19); C244(0.93); C155(1.26)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C131(1.15); C172(1.07); C244(1.01); C326(1.04)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C326(0.79)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C326(0.83)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C326(0.81)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C326(0.80)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C326(0.89)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C131(0.96); C83(0.86); C172(0.96); C244(1.12)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C326(0.81)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C326(0.81)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C131(1.07); C172(0.92); C244(1.02); C326(1.03)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C131(1.01); C83(0.99); C172(1.04); C244(0.84)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C131(1.00); C83(0.72); C244(1.25); C326(0.95)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C131(0.95); C172(1.04); C244(0.90); C155(1.11)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C131(1.08); C172(1.11); C244(1.00); C326(0.96)  LDD1590  [8]
 LDCM0387  CL117 HCT 116 C326(1.36)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C326(0.93)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C326(0.88)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C131(1.02); C83(0.99); C172(0.89); C244(1.01)  LDD1594  [8]
 LDCM0391  CL120 HCT 116 C326(0.82)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C326(1.12)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C326(1.16)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C326(1.54)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C326(1.27)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C131(1.06); C83(0.92); C172(1.20); C244(0.98)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C131(1.01); C83(0.95); C244(0.95); C326(1.15)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C131(1.03); C172(1.01); C244(0.97); C155(1.10)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C131(1.13); C172(1.06); C244(1.00); C326(1.02)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C131(1.21); C83(1.18); C172(1.48); C244(0.91)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C131(1.04); C83(0.87); C244(0.89); C326(0.97)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C131(1.06); C172(1.11); C244(1.35); C155(1.06)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C131(1.05); C172(1.00); C244(0.98); C326(1.11)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C131(1.09); C244(1.41); C326(0.86); C141(1.10)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C131(0.99); C83(0.99); C244(0.99); C326(1.30)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C131(1.05); C83(1.19); C172(1.08); C244(1.04)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C131(0.91); C83(1.09); C244(0.90); C326(1.29)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C131(1.03); C172(0.86); C244(0.98); C326(1.01)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C131(1.06); C83(0.96); C172(1.18); C244(1.16)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C131(1.05); C172(1.18); C244(1.07); C326(0.86)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C131(0.97); C83(0.96); C172(0.90); C244(1.12)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C131(0.96); C83(0.84); C172(0.90); C244(1.06)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C131(1.03); C83(0.89); C172(0.85); C244(1.15)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C131(0.94); C83(0.81); C244(0.90); C326(0.88)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C131(0.99); C172(0.93); C244(0.97); C155(1.06)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C131(1.02); C172(1.03); C244(0.93); C326(1.08)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C131(1.09); C244(0.94); C326(1.01); C141(1.19)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C131(0.93); C172(0.89); C244(0.99); C155(1.13)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C131(1.00); C83(0.99); C244(1.00); C326(1.02)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C131(1.15); C83(1.00); C172(1.05); C244(0.99)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C131(0.98); C172(0.86); C244(1.03); C326(0.81)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C131(1.10); C83(0.97); C172(1.09); C244(1.78)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C131(1.03); C172(1.01); C244(1.11); C326(0.92)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C131(0.93); C83(0.91); C172(0.99); C244(1.37)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C131(1.01); C83(1.00); C172(0.97); C244(1.07)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C131(0.96); C83(0.96); C172(1.06); C244(1.00)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C131(0.98); C172(0.91); C244(0.92); C155(0.94)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C131(1.01); C172(0.91); C244(1.12); C326(0.89)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C131(1.09); C172(1.03); C244(0.96); C326(0.97)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C131(1.05); C244(0.95); C326(0.97); C141(1.31)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C131(1.01); C83(1.09); C244(0.99); C326(0.98)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C131(1.04); C83(1.06); C172(1.11); C244(0.95)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C131(1.06); C172(0.95); C244(1.02); C326(1.20)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C131(1.17); C83(0.93); C172(1.04); C244(1.10)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C131(1.08); C172(1.16); C244(1.14); C326(0.85)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C131(1.06); C83(1.23); C172(1.12); C244(1.30)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C131(1.18); C83(0.80); C172(0.91); C244(1.12)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C131(0.92); C83(0.86); C172(0.97); C244(0.90)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C131(0.93); C244(0.98); C326(1.16); C141(1.24)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C131(1.02); C83(0.93); C244(0.96); C326(0.87)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C131(1.06); C172(1.14); C244(1.03); C326(1.03)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C131(1.08); C244(1.20); C326(1.13); C141(1.30)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C131(0.98); C83(0.94); C244(1.53); C326(1.21)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C131(1.13); C83(1.18); C172(1.05); C244(0.96)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C131(1.07); C172(0.90); C244(0.99); C326(0.92)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C131(1.41); C83(0.98); C172(1.23); C244(1.10)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C131(1.05); C172(1.11); C244(1.19); C326(0.95)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C131(1.01); C83(1.04); C172(1.01); C244(1.03)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C131(1.04); C83(0.89); C244(1.27); C326(0.87)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C131(1.06); C83(1.20); C172(0.96); C244(1.03)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C131(0.96); C83(0.87); C172(0.95); C244(0.89)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C131(0.98); C83(1.06); C244(0.92); C326(1.10)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C131(0.99); C172(0.93); C244(0.90); C155(1.17)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C131(1.02); C172(0.97); C244(1.16); C326(1.00)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C131(1.09); C244(0.91); C326(1.09); C141(1.32)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C131(1.06); C83(1.10); C244(0.98); C326(0.92)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C131(1.11); C83(1.03); C172(1.02); C244(1.04)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C131(1.02); C172(0.83); C244(1.00); C326(0.95)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C131(1.14); C83(1.09); C172(1.04); C244(1.08)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C131(1.04); C83(1.05); C172(1.12); C244(1.01)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C131(1.04); C172(1.13); C244(1.02); C326(1.20)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C131(0.97); C83(0.92); C172(0.91); C244(0.97)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C131(0.97); C83(0.96); C172(1.11); C244(1.00)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C131(1.04); C83(0.97); C172(0.91); C244(0.99)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C131(0.94); C83(0.92); C244(0.91); C326(0.89)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C131(1.02); C172(0.93); C244(1.03); C326(0.83)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C131(1.00); C244(1.10); C326(1.11); C141(1.23)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C131(1.01); C83(0.97); C244(0.97); C326(1.15)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C131(0.98); C83(0.89); C172(0.94); C244(1.01)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C131(1.05); C172(1.01); C244(2.69); C326(0.79)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C131(1.00); C172(0.92); C244(0.95); C326(1.07)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C131(1.03); C83(1.00); C172(1.09); C244(1.02)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C131(1.08); C172(1.16); C244(1.09); C326(0.96)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C131(0.94); C83(1.05); C172(0.93); C244(1.20)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C131(0.98); C83(1.13); C172(0.91); C244(1.21)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C131(0.95); C83(0.91); C172(1.05); C244(0.88)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C131(0.97); C83(0.86); C244(1.02); C326(0.88)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C131(0.99); C172(0.94); C244(0.92); C155(1.10)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C131(1.12); C172(1.04); C244(0.93); C326(1.01)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C131(1.02); C244(1.00); C326(1.06); C141(1.25)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C131(1.07); C83(1.04); C172(1.03); C244(1.05)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C131(1.00); C83(1.00); C244(1.99); C326(0.91)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C131(1.07); C83(0.93); C172(1.07); C244(0.93)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C131(1.02); C172(0.94); C244(1.03); C326(0.99)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C131(1.07); C83(1.03); C172(0.97); C244(1.11)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C131(1.06); C172(1.06); C244(1.01); C326(0.99)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C131(1.06); C83(0.77); C172(1.10); C244(2.55)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C131(1.03); C83(0.89); C172(0.94); C244(1.10)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C131(1.05); C83(0.85); C172(1.09); C244(1.12)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C131(0.95); C83(0.71); C244(0.99); C326(0.99)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C131(1.07); C172(0.98); C244(0.87); C155(1.02)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C131(0.98); C172(0.82); C244(0.86); C155(1.35)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C172(3.18)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C131(1.05); C172(0.99); C244(1.02); C155(1.11)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C131(1.00); C83(0.91); C244(0.90); C326(0.97)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C244(0.89); C326(0.98); C83(0.79); C141(1.05)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C244(0.97); C326(1.02); C83(1.03); C141(1.16)  LDD1497  [8]
 LDCM0024  KB05 NUGC-3 C83(1.25); C326(1.75); C155(1.64); C131(1.72)  LDD3367  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C244(1.59)  LDD2100  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C244(0.96)  LDD2104  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C244(0.90)  LDD2108  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C244(0.71)  LDD2114  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C244(0.84)  LDD2141  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Threonine--tRNA ligase, mitochondrial (TARS2) Class-II aminoacyl-tRNA synthetase family Q9BW92
Choline-phosphate cytidylyltransferase A (PCYT1A) Cytidylyltransferase family P49585
FAST kinase domain-containing protein 4 (TBRG4) FAST kinase family Q969Z0
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
Inositol polyphosphate 5-phosphatase K (INPP5K) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q9BT40
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) PA-phosphatase related phosphoesterase family Q8IY26
Sentrin-specific protease 2 (SENP2) Peptidase C48 family Q9HC62
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) Succinate/malate CoA ligase beta subunit family Q9P2R7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc transporter SLC39A7 (SLC39A7) ZIP transporter (TC 2.A.5) family Q92504
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinol-binding protein 1 (RBP1) Fatty-acid binding protein (FABP) family P09455
Proteasome adapter and scaffold protein ECM29 (ECPAS) ECM29 family Q5VYK3
Protein NOXP20 (FAM114A1) FAM114 family Q8IWE2
Heat shock factor-binding protein 1-like protein 1 (HSBP1L1) HSBP1 family C9JCN9
Cytosolic iron-sulfur assembly component 2A (CIAO2A) MIP18 family Q9H5X1
Transcription termination factor 4, mitochondrial (MTERF4) MTERF family Q7Z6M4
Regulator of microtubule dynamics protein 2 (RMDN2) RMDN family Q96LZ7
Mitochondrial dynamics protein MIEF1 (MIEF1) SMCR7 family Q9NQG6
Arfaptin-1 (ARFIP1) . P53367

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840