Details of the Target

General Information of Target

Target ID LDTP13013
Target Name Protein Daple (CCDC88C)
Gene Name CCDC88C
Gene ID 440193
Synonyms
DAPLE; KIAA1509; Protein Daple; Coiled-coil domain-containing protein 88C; Dvl-associating protein with a high frequency of leucine residues; hDaple; Hook-related protein 2; HkRP2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSGDPAHLGLCLWLWLGATLGREQVQASGLLRLAVLPEDRLQMKWRESEGSGLGYLVQV
KPMAGDSEQEVILTTKTPKATVGGLSPSKGYTLQIFELTGSGRFLLARREFVIEDLKSSS
LDRSSQRPLGSGAPEPTPSHTGSPDPEQASEPQVAFTPSQDPRTPAGPQFRCLPPVPADM
VFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLSTKE
QVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLRPEAAKVVILVTDGKSQDDVHTAA
RVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLICQRLQ
GGSPRQGPAAAPALDTLPAPTSLVLSQVTSSSIRLSWTPAPRHPLKYLIVWRASRGGTPR
EVVVEGPAASTELHNLASRTEYLVSVFPIYEGGVGEGLRGLVTTAPLPPPRALTLAAVTP
RTVHLTWQPSAGATHYLVRCSPASPKGEEEEREVQVGRPEVLLDGLEPGRDYEVSVQSLR
GPEGSEARGIRARTPTLAPPRHLGFSDVSHDAARVFWEGAPRPVRLVRVTYVSSEGGHSG
QTEAPGNATSATLGPLSSSTTYTVRVTCLYPGGGSSTLTGRVTTKKAPSPSQLSMTELPG
DAVQLAWVAAAPSGVLVYQITWTPLGEGKAHEISVPGNLGTAVLPGLGRHTEYDVTILAY
YRDGARSDPVSLRYTPSTVSRSPPSNLALASETPDSLQVSWTPPLGRVLHYWLTYAPASG
LGPEKSVSVPGARSHVTLPDLQAATKYRVLVSAIYAAGRSEAVSATGQTACPALRPDGSL
PGFDLMVAFSLVEKAYASIRGVAMEPSAFGGTPTFTLFKDAQLTRRVSDVYPAPLPPEHT
IVFLVRLLPETPREAFALWQMTAEDFQPLLGVLLDAGKKSLTYFHRDPRAALQEATFDPQ
EVRKIFFGSFHKVHVAVGRSKVRLYVDCRKVAERPLGEMGSPPAAGFVTLGRLAKARGPR
SSSAAFQLQMLQIVCSDTWADEDRCCELPASRDGETCPAFVSACSCSSETPGPPGPQGPP
GLPGRNGTPGEQGFPGPRGPPGVKGEKGDHGLPGLQGHPGHQGIPGRVGLQGPKGMRGLE
GTAGLPGPPGPRGFQGMAGARGTSGERGPPGTVGPTGLPGPKGERGEKGEPQSLATLYQL
VSQASHVSKFDSFHENTRPPMPILEQKLEPGTEPLGSPGTRSKALVPGEWGRGGRHLEGR
GEPGAVGQMGSPGQQGASTQGLWE
Target Bioclass
Other
Family
CCDC88 family
Subcellular location
Cytoplasm
Function
Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling. Promotes apical constriction of cells via ARHGEF18.
Uniprot ID
Q9P219
Ensemble ID
ENST00000389857.11
HGNC ID
HGNC:19967

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.P1941H .
AU565 SNV: p.E167Q DBIA    Probe Info 
CAL78 SNV: p.S486F .
CCK81 SNV: p.R1155G DBIA    Probe Info 
COLO320 SNV: p.D304G DBIA    Probe Info 
COLO792 SNV: p.E419K .
FTC133 SNV: p.A347T .
HCC44 SNV: p.Q1154K .
HCT15 SNV: p.K874N .
HEC1 SNV: p.L475I DBIA    Probe Info 
HEC1B SNV: p.R554M .
HT SNV: p.A1722V .
IM95 SNV: p.F27I DBIA    Probe Info 
JHH7 SNV: p.G1590C .
JURKAT SNV: p.H666Y; p.V713M; p.A1221T .
KARPAS422 SNV: p.T1533P .
KYM1 SNV: p.H1320D .
KYSE150 SNV: p.P1689L DBIA    Probe Info 
LNCaP clone FGC SNV: p.S507G .
MCC13 SNV: p.P1534S .
MEC1 Substitution: p.L1992P .
MEWO SNV: p.P1768S .
MFE319 SNV: p.W845Ter DBIA    Probe Info 
MOLT4 SNV: p.K590R IA-alkyne    Probe Info 
NCIH1155 SNV: p.Q597Ter; p.L1286V .
NCIH1793 SNV: p.G1711V .
OCILY3 Deletion: p.L9WfsTer2 .
OVCAR8 SNV: p.E297D .
RL SNV: p.P56R .
RPMI7951 SNV: p.E1385K .
TOV21G SNV: p.R1618L; p.E1619Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K1030(5.56)  LDD0277  [2]
DBIA
 Probe Info  		C134(0.99)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_5
 Probe Info  		C1821(0.00); C1467(0.00); C1520(0.00)  LDD2224  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
IPM
 Probe Info  		N.A.  LDD0005  [7]
Phosphinate-6
 Probe Info  		C1871(0.00); C1821(0.00)  LDD0018  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C134(0.99)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C1321(1.20); C134(0.96)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C134(1.18)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C134(1.11)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C134(1.18)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C134(1.05)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C134(1.27)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C134(1.35)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C134(1.16)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C134(0.91)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C134(1.31)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C134(1.17)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C1321(1.11); C134(0.97)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C134(1.33)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C134(1.38)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C134(1.24)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C134(0.89)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C134(1.35)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C134(1.10)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C134(0.99)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C134(0.90)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C134(0.86)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C134(1.04)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C1321(1.07); C134(1.02)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C134(0.95)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C134(0.83)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C134(0.86)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C134(0.87)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C134(0.92)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C134(0.79)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C134(1.09)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C134(1.15)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C134(0.71)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C134(0.88)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C134(0.81)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C134(0.82)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C134(0.83)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C134(0.82)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C134(1.02)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C134(0.82)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C134(0.86)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C134(0.86)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C134(0.84)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C134(0.88)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C1321(1.26); C134(1.11)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C134(0.75)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C134(0.97)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C134(0.90)  LDD0860  [3]
 LDCM0270  AC15 HCT 116 C134(1.06); C1321(1.41)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C1321(0.87)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1321(1.09)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1321(0.79)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C134(1.02)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C1321(0.82)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1321(1.00)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1321(0.90)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1321(0.73)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1321(0.79)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C1321(1.04)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1321(1.11)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1321(1.17)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1321(1.15)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1321(1.07)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C134(1.02)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C1321(1.05)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1321(1.19)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1321(1.34)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1321(1.27)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C1321(1.42)  LDD0612  [3]
 LDCM0296  AC35 PaTu 8988t C130(1.00); C134(1.00)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C130(0.73); C134(0.73)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C130(0.95); C134(0.95)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C130(1.15); C134(1.15)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C130(1.16); C134(1.16)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C134(1.13)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C130(1.11); C134(1.11)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C130(1.23); C134(1.23)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C130(1.01); C134(1.01)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C130(1.01); C134(1.01)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C130(1.35); C134(1.35)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C130(1.09); C134(1.09)  LDD1186  [3]
 LDCM0312  AC5 HCT 116 C134(1.16)  LDD0629  [3]
 LDCM0323  AC6 HCT 116 C134(1.19); C1321(1.21)  LDD0640  [3]
 LDCM0334  AC7 HCT 116 C134(0.91); C1321(1.19)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C134(0.87); C1321(1.21)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C1321(1.68)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1321(1.71)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1321(1.24)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1321(1.17)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1321(1.01)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1321(1.15)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1321(1.41)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1321(0.92)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1321(1.69)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1321(1.57)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1321(1.12)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1321(1.09)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1321(1.29)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1321(1.23)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1321(1.39)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C134(0.92)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C134(1.05)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C1321(1.01); C134(1.12)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C134(0.91); C1321(1.24)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C134(1.66); C1321(1.83)  LDD0592  [3]
 LDCM0367  CL1 PaTu 8988t C130(1.16); C134(1.16)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C130(1.24); C134(1.24)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C134(1.08)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C134(1.02); C1321(1.46)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C1321(1.06); C134(1.07)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1321(1.06); C134(1.12)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C134(1.01); C1321(1.11)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1321(1.04)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1321(1.35)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1321(1.44)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1321(1.79)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1321(0.94)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C130(0.83); C134(0.83)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C1321(0.94)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1321(0.99)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C1321(1.11)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1321(1.25)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1321(1.23)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C1321(1.30)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C1321(1.21)  LDD0703  [3]
 LDCM0387  CL117 PaTu 8988t C130(1.01); C134(1.01)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C130(0.76); C134(0.76)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C130(1.24); C134(1.24)  LDD1268  [3]
 LDCM0390  CL12 PaTu 8988t C130(1.11); C134(1.11)  LDD1269  [3]
 LDCM0391  CL120 PaTu 8988t C130(1.29); C134(1.29)  LDD1270  [3]
 LDCM0400  CL13 PaTu 8988t C130(1.66); C134(1.66)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C130(1.67); C134(1.67)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C130(1.11); C134(1.11)  LDD1281  [3]
 LDCM0407  CL2 PaTu 8988t C130(1.13); C134(1.13)  LDD1286  [3]
 LDCM0418  CL3 PaTu 8988t C130(0.85); C134(0.85)  LDD1297  [3]
 LDCM0429  CL4 PaTu 8988t C130(0.85); C134(0.85)  LDD1308  [3]
 LDCM0440  CL5 PaTu 8988t C130(1.69); C134(1.69)  LDD1319  [3]
 LDCM0451  CL6 PaTu 8988t C130(1.30); C134(1.30)  LDD1330  [3]
 LDCM0453  CL61 HCT 116 C134(0.93)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C134(1.01)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C134(1.00)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C134(1.33)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C134(0.90)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C134(1.04)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C134(1.28)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C134(0.89)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C134(0.80)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C130(1.50); C134(1.50)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C134(1.24)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C134(1.52)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C134(0.95)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C134(0.73)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C134(1.11)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C134(1.12)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C134(1.06)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C134(1.31)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C134(1.46)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C130(1.10); C134(1.10)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C134(0.97)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C134(1.11)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C134(1.88)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C134(1.36)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C134(1.84)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C134(1.32)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C134(1.19)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C134(1.31)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C134(2.00)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C134(2.42)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C130(1.27); C134(1.27)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C134(1.01)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C134(0.90)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C134(0.81)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C134(0.92)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C134(0.83)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C134(1.00)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C134(0.94)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C134(1.03)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C134(1.07)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C134(1.04)  LDD0811  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1871(0.97)  LDD1702  [9]
 LDCM0625  F8 Ramos C1871(1.61); C1821(2.60); C1520(2.24)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C1871(2.14); C1821(1.55); C1520(1.86)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C1871(0.81); C1821(1.64); C1520(9.62)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C1871(0.83); C1821(0.87); C1520(0.97); C1467(1.19)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C1871(0.92); C1821(1.21); C1520(1.60); C1467(1.17)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C1871(0.90); C1821(0.64); C1520(1.08)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C1871(0.89); C1821(0.85); C1520(0.97); C1467(0.85)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C1871(0.88); C1821(1.58); C1520(1.20); C1467(1.71)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C1871(1.19); C1821(2.07); C1520(2.05); C1467(1.24)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C1871(0.81); C1821(1.29); C1520(1.15); C1467(1.27)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C1871(0.81); C1821(0.86); C1520(0.73)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C1871(1.23); C1821(1.43); C1520(1.66); C1467(1.69)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C1871(1.11); C1821(1.42); C1520(1.44); C1467(1.43)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C1871(2.76); C1821(2.18); C1520(1.97); C1467(1.64)  LDD2201  [10]
 LDCM0468  Fragment33 HCT 116 C134(1.00)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C1871(0.89); C1821(1.16); C1520(1.00); C1467(1.80)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C1871(1.08); C1821(0.99); C1520(1.26); C1467(0.70)  LDD2184  [10]
 LDCM0610  Fragment52 Ramos C1871(1.10); C1821(2.38); C1520(1.79); C1467(1.99)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C1871(1.43); C1821(1.57); C1520(1.80); C1467(2.61)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C1871(1.31); C1821(1.00); C1520(1.21); C1467(0.67)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C1871(1.23); C1821(0.95); C1520(1.35); C1467(1.45)  LDD2188  [10]
 LDCM0022  KB02 T cell C460(12.01)  LDD1703  [11]
 LDCM0023  KB03 Ramos C1871(1.07); C1821(0.85); C1520(0.99)  LDD2183  [10]
 LDCM0024  KB05 MKN-1 C395(2.17)  LDD3331  [12]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840