Details of the Target

General Information of Target

Target ID LDTP12918
Target Name BRD4-interacting chromatin-remodeling complex-associated protein (BICRA)
Gene Name BICRA
Gene ID 29998
Synonyms
GLTSCR1; BRD4-interacting chromatin-remodeling complex-associated protein; Glioma tumor suppressor candidate region gene 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL
IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD
EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL
ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK
LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV
KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA
RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC
QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG
EVWVRFDLQLFEQKTLL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May play a role in BRD4-mediated gene transcription.
Uniprot ID
Q9NZM4
Ensemble ID
ENST00000396720.7
HGNC ID
HGNC:4332

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A41T .
CAMA1 SNV: p.E40K DBIA    Probe Info 
CCK81 SNV: p.A393V; p.P828T DBIA    Probe Info 
ETK1 SNV: p.T1531P .
GB1 SNV: p.P912L .
HCC1187 SNV: p.P651H
Substitution: .		 DBIA    Probe Info 
HDQP1 SNV: p.R1540K DBIA    Probe Info 
HEC1 SNV: p.S667R; p.K1420N DBIA    Probe Info 
HEC1B SNV: p.K1420N .
HT SNV: p.N396S .
HT115 SNV: p.A296T .
HT3 Deletion: p.P1010LfsTer35 .
IM95 SNV: p.R1474W DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.P388RfsTer10 .
JVM3 SNV: p.T1339P DBIA    Probe Info 
KO52 SNV: p.T1339P .
KYSE410 SNV: p.S1094F DBIA    Probe Info 
MCC13 Substitution: p.P760S DBIA    Probe Info 
MFE319 SNV: p.V297A; p.L1000P DBIA    Probe Info 
MOLT4 SNV: p.P353L; p.E1438K; p.G1530D .
NALM6 SNV: p.A1455T DBIA    Probe Info 
NCIH1944 SNV: p.P817T .
NCIH2286 SNV: p.Q584H .
RKO SNV: p.P954S DBIA    Probe Info 
RL952 SNV: p.T398A DBIA    Probe Info 
RVH421 Substitution: p.L1031P DBIA    Probe Info 
SKMEL5 SNV: p.T317I; p.S1052F DBIA    Probe Info 
SKOV3 SNV: p.A1264V DBIA    Probe Info 
SNGM Deletion: p.P653HfsTer71 .
SNU449 Deletion: p.A730EfsTer27 DBIA    Probe Info 
SUPT1 SNV: p.L124P DBIA    Probe Info 
TCCSUP SNV: p.P924L .
TOV21G SNV: p.S1522Ter DBIA    Probe Info 
UMUC3 SNV: p.Q707H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C1083(5.25)  LDD1703  [1]
DBIA
 Probe Info  		C1083(0.94)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]
AOyne
 Probe Info  		10.40  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1083(0.72)  LDD1093  [2]
 LDCM0215  AC10 HEK-293T C1382(1.01); C1083(0.99)  LDD1508  [6]
 LDCM0216  AC100 PaTu 8988t C1083(1.01)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C1083(0.90)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C1083(0.83)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C1083(1.10)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C1083(0.86)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C1083(0.89)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C1083(0.96)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C1083(0.84)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C1083(1.01)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C1083(1.05)  LDD1104  [2]
 LDCM0226  AC11 HEK-293T C1382(0.85); C1083(0.93)  LDD1509  [6]
 LDCM0227  AC110 PaTu 8988t C1083(1.05)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C1083(1.17)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C1083(1.08)  LDD1108  [2]
 LDCM0230  AC113 HEK-293T C1083(0.79)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C1083(0.75)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C1083(0.94)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C1083(0.86)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C1083(0.96)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C1083(0.93)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C1083(0.91)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C1083(0.98)  LDD1510  [6]
 LDCM0238  AC120 HEK-293T C1083(0.83)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C1083(0.93)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C1083(0.91)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C1083(1.00)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C1083(0.75)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C1083(0.91)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C1083(0.97)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C1083(1.14)  LDD0843  [2]
 LDCM0246  AC128 PaTu 8988t C1083(1.21)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C1083(1.21)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C1083(1.22)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C1083(0.93)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C1083(1.01)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C1083(1.15)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C1083(1.15)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C1083(1.27)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C1083(1.39)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C1083(1.20)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C1083(1.24)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C1083(1.17)  LDD1137  [2]
 LDCM0259  AC14 HEK-293T C1382(1.02); C1083(1.00)  LDD1512  [6]
 LDCM0260  AC140 PaTu 8988t C1083(1.32)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C1083(1.25)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C1083(1.24)  LDD1141  [2]
 LDCM0263  AC143 HEK-293T C1083(0.83)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C1083(0.94)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C1083(1.10)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C1083(0.93)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C1083(0.80)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C1083(1.11)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C1083(0.82)  LDD0867  [2]
 LDCM0271  AC150 HEK-293T C1083(0.95)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C1083(1.04)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C1083(0.87)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C1083(0.92)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C1083(0.89)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C1083(1.04)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C1083(1.15)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C1083(0.85)  LDD2165  [2]
 LDCM0276  AC17 PaTu 8988t C1083(0.95)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C1083(1.08)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C1083(0.86)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C1083(0.67)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C1083(1.04)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C1083(0.96)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C1083(0.97)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C1083(1.19)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C1083(1.05)  LDD1163  [2]
 LDCM0285  AC25 HEK-293T C1083(1.05)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C1382(1.07); C1083(1.00)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C1382(0.91); C1083(1.28)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C1083(0.94)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C1382(0.98); C1083(0.96)  LDD1528  [6]
 LDCM0290  AC3 PaTu 8988t C1083(0.77)  LDD1169  [2]
 LDCM0291  AC30 HEK-293T C1382(1.02); C1083(0.93)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C1382(0.95); C1083(1.04)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C1083(1.12)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C1382(1.06); C1083(1.02)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C1083(0.99)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C1083(1.04)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C1083(0.94)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C1083(1.10)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C1083(1.06)  LDD0898  [2]
 LDCM0301  AC4 PaTu 8988t C1083(0.66)  LDD1180  [2]
 LDCM0302  AC40 HEK-293T C1083(1.15)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C1083(0.89)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C1083(1.03)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C1083(1.02)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C1083(1.11)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C1083(1.10)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C1382(0.92); C1083(1.00)  LDD1547  [6]
 LDCM0310  AC48 HEK-293T C1382(0.97); C1083(1.05)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C1083(1.02)  LDD1550  [6]
 LDCM0312  AC5 PaTu 8988t C1083(0.72)  LDD1191  [2]
 LDCM0313  AC50 HEK-293T C1382(1.04); C1083(0.98)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C1382(0.86); C1083(1.25)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C1083(1.00)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C1382(0.96); C1083(0.99)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C1382(1.02); C1083(1.02)  LDD1556  [6]
 LDCM0319  AC56 HEK-293T C1382(1.03); C1083(1.03)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C1083(1.19)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C1083(0.98)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C1083(1.23)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C1382(1.05); C1083(0.99)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C1083(1.80)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C1083(0.98)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C1083(0.85)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C1083(0.94)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C1083(0.90)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C1083(0.98)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C1083(1.02)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C1083(0.97)  LDD0929  [2]
 LDCM0345  AC8 HEK-293T C1382(1.01); C1083(1.02)  LDD1569  [6]
 LDCM0349  AC83 PaTu 8988t C1083(0.94)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C1083(0.96)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C1083(0.99)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C1083(1.01)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C1083(1.04)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C1083(0.96)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C1083(0.99)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C1083(0.94)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C1083(0.96)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C1083(0.97)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C1083(0.92)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C1083(0.85)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C1083(1.02)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C1083(0.86)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C1083(0.93)  LDD1243  [2]
 LDCM0365  AC98 PaTu 8988t C1083(0.99)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C1083(0.85)  LDD1245  [2]
 LDCM0248  AKOS034007472 HEK-293T C1382(1.00); C1083(0.97)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C1083(1.03)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C1382(0.92); C1083(1.02)  LDD1514  [6]
 LDCM0020  ARS-1620 HCC44 C1083(0.94)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C1382(0.92); C1083(2.77)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C1382(0.95); C1083(5.52)  LDD1572  [6]
 LDCM0369  CL100 PaTu 8988t C1083(0.59)  LDD1248  [2]
 LDCM0370  CL101 HEK-293T C1382(1.06); C1083(1.18)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C1382(0.97); C1083(1.96)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C1382(0.98); C1083(0.99)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C1382(1.03); C1083(1.06)  LDD1577  [6]
 LDCM0374  CL105 PaTu 8988t C1083(1.13)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C1083(0.93)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C1083(0.93)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C1083(1.01)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C1083(1.10)  LDD1257  [2]
 LDCM0380  CL110 PaTu 8988t C1083(1.08)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C1083(1.15)  LDD1260  [2]
 LDCM0382  CL112 HEK-293T C1382(1.07); C1083(1.29)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C1382(1.00); C1083(1.07)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C1382(1.01); C1083(2.55)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C1382(1.16); C1083(0.96)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C1382(1.00); C1083(1.07)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C1083(0.93)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C1083(0.99)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C1083(0.99)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C1382(1.02); C1083(1.32)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C1083(0.94)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C1382(1.08); C1083(1.16)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C1382(0.99); C1083(1.46)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C1382(0.89); C1083(2.56)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C1382(1.01); C1083(1.42)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C1083(1.03)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C1083(1.06)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C1083(1.05)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C1083(1.02)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C1382(1.19); C1083(1.29)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C1382(0.98); C1083(1.16)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C1382(0.94); C1083(3.30)  LDD1606  [6]
 LDCM0403  CL16 PaTu 8988t C1083(1.10)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C1083(1.11)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C1083(1.19)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C1083(1.14)  LDD1285  [2]
 LDCM0407  CL2 HEK-293T C1382(1.15); C1083(1.14)  LDD1611  [6]
 LDCM0408  CL20 PaTu 8988t C1083(1.22)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C1083(1.30)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C1083(1.22)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C1083(1.22)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C1083(1.27)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C1083(1.24)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C1083(1.13)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C1083(1.33)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C1083(1.23)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C1083(1.14)  LDD1296  [2]
 LDCM0418  CL3 HEK-293T C1382(0.99); C1083(1.01)  LDD1622  [6]
 LDCM0419  CL30 PaTu 8988t C1083(1.37)  LDD1298  [2]
 LDCM0420  CL31 HEK-293T C1382(0.99); C1083(1.40)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C1083(1.13)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C1382(0.96); C1083(4.48)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C1382(1.03); C1083(2.02)  LDD1627  [6]
 LDCM0425  CL36 HEK-293T C1382(0.96); C1083(1.38)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C1382(0.92); C1083(1.39)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C1382(0.97); C1083(1.41)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C1382(0.99); C1083(1.73)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C1382(1.01); C1083(1.01)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C1083(1.72)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C1382(1.06); C1083(0.93)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C1382(0.86); C1083(1.30)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C1083(1.01)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C1382(1.05); C1083(2.37)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C1083(1.00)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C1083(1.10)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C1083(0.89)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C1083(0.98)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C1083(1.08)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C1083(1.00)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C1083(1.03)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C1083(1.17)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C1083(1.11)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C1083(1.05)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C1083(0.99)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C1083(0.83)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C1083(1.22)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C1083(1.13)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C1083(1.14)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C1382(0.94); C1083(2.43)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C1083(1.11)  LDD1050  [2]
 LDCM0453  CL61 PaTu 8988t C1083(1.12)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C1083(1.17)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C1083(1.30)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C1083(1.29)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C1083(1.27)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C1083(1.43)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C1083(1.11)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C1083(1.27)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C1083(1.41)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C1382(1.12); C1083(0.91)  LDD1665  [6]
 LDCM0463  CL70 PaTu 8988t C1083(1.28)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C1083(1.10)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C1083(1.41)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C1083(1.27)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C1083(1.29)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C1083(1.07)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C1083(1.60)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C1083(1.76)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C1083(1.37)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C1083(8.37)  LDD1676  [6]
 LDCM0474  CL80 PaTu 8988t C1083(1.41)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C1083(1.88)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C1083(1.81)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C1083(1.90)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C1083(1.60)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C1083(1.20)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C1083(1.38)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C1083(1.30)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C1083(1.47)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C1083(1.09)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C1382(0.91); C1083(1.26)  LDD1687  [6]
 LDCM0485  CL90 PaTu 8988t C1083(1.43)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C1083(0.58)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C1083(0.57)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C1083(0.59)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C1083(0.54)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C1083(0.68)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C1083(0.56)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C1083(0.57)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C1083(0.65)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C1083(0.51)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C1382(1.34); C1083(1.03)  LDD1698  [6]
 LDCM0468  Fragment33 PaTu 8988t C1083(1.28)  LDD1347  [2]
 LDCM0427  Fragment51 HEK-293T C1382(0.99); C1083(1.07)  LDD1631  [6]
 LDCM0022  KB02 HCT 116 C1083(3.83)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1083(3.06)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1083(2.84)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adapter molecule crk (CRK) CRK family P46108
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402