Details of the Target

General Information of Target

Target ID LDTP12907
Target Name Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Gene Name EIF2AK3
Gene ID 9451
Synonyms
PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; EC 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METKENRWVPVTVLPGCVGCRTVAALASWTVRDVKERIFAETGFPVSEQRLWRGGRELSD
WIKIGDLTSKNCHLFVNLQSKGLKGGGRFGQTTPPLVDFLKDILRRYPEGGQILKELIQN
AEDAGATEVKFLYDETQYGTETLWSKDMAPYQGPALYVYNNAVFTPEDWHGIQEIARSRK
KDDPLKVGRFGIGFNSVYHITDVPCIFSGDQIGMLDPHQTLFGPHESGQCWNLKDDSKEI
SELSDQFAPFVGIFGSTKETFINGNFPGTFFRFPLRLQPSQLSSNLYNKQKVLELFESFR
ADADTVLLFLKSVQDVSLYVREADGTEKLVFRVTSSESKALKHERPNSIKILGTAISNYC
KKTPSNNITCVTYHVNIVLEEESTKDAQKTSWLVCNSVGGRGISSKLDSLADELKFVPII
GIAMPLSSRDDEAKGATSDFSGKAFCFLPLPPGEESSTGLPVHISGFFGLTDNRRSIKWR
ELDQWRDPAALWNEFLVMNVVPKAYATLILDSIKRLEMEKSSDFPLSVDVIYKLWPEASK
VKVHWQPVLEPLFSELLQNAVIYSISCDWVRLEQVYFSELDENLEYTKTVLNYLQSSGKQ
IAKVPGNVDAAVQLTAASGTTPVRKVTPAWVRQVLRKCAHLGCAEEKLHLLEFVLSDQAY
SELLGLELLPLQNGNFVPFSSSVSDQDVIYITSAEYPRSLFPSLEGRFILDNLKPHLVAA
LKEAAQTRGRPCTQLQLLNPERFARLIKEVMNTFWPGRELIVQWYPFDENRNHPSVSWLK
MVWKNLYIHFSEDLTLFDEMPLIPRTILEEGQTCVELIRLRIPSLVILDDESEAQLPEFL
ADIVQKLGGFVLKKLDASIQHPLIKKYIHSPLPSAVLQIMEKMPLQKLCNQITSLLPTHK
DALRKFLASLTDSSEKEKRIIQELAIFKRINHSSDQGISSYTKLKGCKVLHHTAKLPADL
RLSISVIDSSDEATIRLANMLKIEQLKTTSCLKLVLKDIENAFYSHEEVTQLMLWVLENL
SSLKNENPNVLEWLTPLKFIQISQEQMVSAGELFDPDIEVLKDLFCNEEGTYFPPSVFTS
PDILHSLRQIGLKNEASLKEKDVVQVAKKIEALQVGACPDQDVLLKKAKTLLLVLNKNHT
LLQSSEGKMTLKKIKWVPACKERPPNYPGSLVWKGDLCNLCAPPDMCDVGHAILIGSSLP
LVESIHVNLEKALGIFTKPSLSAVLKHFKIVVDWYSSKTFSDEDYYQFQHILLEIYGFMH
DHLNEGKDSFRALKFPWVWTGKKFCPLAQAVIKPIHDLDLQPYLHNVPKTMAKFHQLFKV
CGSIEELTSDHISMVIQKIYLKSDQDLSEQESKQNLHLMLNIIRWLYSNQIPASPNTPVP
IHHSKNPSKLIMKPIHECCYCDIKVDDLNDLLEDSVEPIILVHEDIPMKTAEWLKVPCLS
TRLINPENMGFEQSGQREPLTVRIKNILEEYPSVSDIFKELLQNADDANATECSFLIDMR
RNMDIRENLLDPGMAACHGPALWSFNNSQFSDSDFVNITRLGESLKRGEVDKVGKFGLGF
NSVYHITDIPIIMSREFMIMFDPNINHISKHIKDKSNPGIKINWSKQQKRLRKFPNQFKP
FIDVFGCQLPLTVEAPYSYNGTLFRLSFRTQQEAKVSEVSSTCYNTADIYSLVDEFSLCG
HRLIIFTQSVKSMYLKYLKIEETNPSLAQDTVIIKKKSCSSKALNTPVLSVLKEAAKLMK
TCSSSNKKLPSDEPKSSCILQITVEEFHHVFRRIADLQSPLFRGPDDDPAALFEMAKSGQ
SKKPSDELSQKTVECTTWLLCTCMDTGEALKFSLSESGRRLGLVPCGAVGVQLSEIQDQK
WTVKPHIGEVFCYLPLRIKTGLPVHINGCFAVTSNRKEIWKTDTKGRWNTTFMRHVIVKA
YLQVLSVLRDLATSGELMDYTYYAVWPDPDLVHDDFSVICQGFYEDIAHGKGKELTKVFS
DGSTWVSMKNVRFLDDSILKRRDVGSAAFKIFLKYLKKTGSKNLCAVELPSSVKLGFEEA
GCKQILLENTFSEKQFFSEVFFPNIQEIEAELRDPLMIFVLNEKVDEFSGVLRVTPCIPC
SLEGHPLVLPSRLIHPEGRVAKLFDIKDGRFPYGSTQDYLNPIILIKLVQLGMAKDDILW
DDMLERAVSVAEINKSDHVAACLRSSILLSLIDEKLKIRDPRAKDFAAKYQTIRFLPFLT
KPAGFSLDWKGNSFKPETMFAATDLYTAEHQDIVCLLQPILNENSHSFRGCGSVSLAVKE
FLGLLKKPTVDLVINQLKEVAKSVDDGITLYQENITNACYKYLHEALMQNEITKMSIIDK
LKPFSFILVENAYVDSEKVSFHLNFEAAPYLYQLPNKYKNNFRELFETVGVRQSCTVEDF
ALVLESIDQERGTKQITEENFQLCRRIISEGIWSLIREKKQEFCEKNYGKILLPDTNLML
LPAKSLCYNDCPWIKVKDTTVKYCHADIPREVAVKLGAVPKRHKALERYASNVCFTTLGT
EFGQKEKLTSRIKSILNAYPSEKEMLKELLQNADDAKATEICFVFDPRQHPVDRIFDDKW
APLQGPALCVYNNQPFTEDDVRGIQNLGKGTKEGNPYKTGQYGIGFNSVYHITDCPSFIS
GNDILCIFDPHARYAPGATSISPGRMFRDLDADFRTQFSDVLDLYLGTHFKLDNCTMFRF
PLRNAEMAKVSEISSVPASDRMVQNLLDKLRSDGAELLMFLNHMEKISICEIDKSTGALN
VLYSVKGKITDGDRLKRKQFHASVIDSVTKKRQLKDIPVQQITYTMDTEDSEGNLTTWLI
CNRSGFSSMEKVSKSVISAHKNQDITLFPRGGVAACITHNYKKPHRAFCFLPLSLETGLP
FHVNGHFALDSARRNLWRDDNGVGVRSDWNNSLMTALIAPAYVELLIQLKKRYFPGSDPT
LSVLQNTPIHVVKDTLKKFLSFFPVNRLDLQPDLYCLVKALYNCIHEDMKRLLPVVRAPN
IDGSDLHSAVIITWINMSTSNKTRPFFDNLLQDELQHLKNADYNITTRKTVAENVYRLKH
LLLEIGFNLVYNCDETANLYHCLIDADIPVSYVTPADIRSFLMTFSSPDTNCHIGKLPCR
LQQTNLKLFHSLKLLVDYCFKDAEENEIEVEGLPLLITLDSVLQTFDAKRPKFLTTYHEL
IPSRKDLFMNTLYLKYSNILLNCKVAKVFDISSFADLLSSVLPREYKTKSCTKWKDNFAS
ESWLKNAWHFISESVSVKEDQEETKPTFDIVVDTLKDWALLPGTKFTVSANQLVVPEGDV
LLPLSLMHIAVFPNAQSDKVFHALMKAGCIQLALNKICSKDSAFVPLLSCHTANIESPTS
ILKALHYMVQTSTFRAEKLVENDFEALLMYFNCNLNHLMSQDDIKILKSLPCYKSISGRY
VSIGKFGTCYVLTKSIPSAEVEKWTQSSSSAFLEEKIHLKELYEVIGCVPVDDLEVYLKH
LLPKIENLSYDAKLEHLIYLKNRLSSAEELSEIKEQLFEKLESLLIIHDANSRLKQAKHF
YDRTVRVFEVMLPEKLFIPNDFFKKLEQLIKPKNHVTFMTSWVEFLRNIGLKYILSQQQL
LQFAKEISVRANTENWSKETLQNTVDILLHHIFQERMDLLSGNFLKELSLIPFLCPERAP
AEFIRFHPQYQEVNGTLPLIKFNGAQVNPKFKQCDVLQLLWTSCPILPEKATPLSIKEQE
GSDLGPQEQLEQVLNMLNVNLDPPLDKVINNCRNICNITTLDEEMVKTRAKVLRSIYEFL
SAEKREFRFQLRGVAFVMVEDGWKLLKPEEVVINLEYESDFKPYLYKLPLELGTFHQLFK
HLGTEDIISTKQYVEVLSRIFKNSEGKQLDPNEMRTVKRVVSGLFRSLQNDSVKVRSDLE
NVRDLALYLPSQDGRLVKSSILVFDDAPHYKSRIQGNIGVQMLVDLSQCYLGKDHGFHTK
LIMLFPQKLRPRLLSSILEEQLDEETPKVCQFGALCSLQGRLQLLLSSEQFITGLIRIMK
HENDNAFLANEEKAIRLCKALREGLKVSCFEKLQTTLRVKGFNPIPHSRSETFAFLKRFG
NAVILLYIQHSDSKDINFLLALAMTLKSATDNLISDTSYLIAMLGCNDIYRIGEKLDSLG
VKYDSSEPSKLELPMPGTPIPAEIHYTLLMDPMNVFYPGEYVGYLVDAEGGDIYGSYQPT
YTYAIIVQEVEREDADNSSFLGKIYQIDIGYSEYKIVSSLDLYKFSRPEESSQSRDSAPS
TPTSPTEFLTPGLRSIPPLFSGRESHKTSSKHQSPKKLKVNSLPEILKEVTSVVEQAWKL
PESERKKIIRRLYLKWHPDKNPENHDIANEVFKHLQNEINRLEKQAFLDQNADRASRRTF
STSASRFQSDKYSFQRFYTSWNQEATSHKSERQQQNKEKCPPSAGQTYSQRFFVPPTFKS
VGNPVEARRWLRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDKDV
KPTALAQKIEEYSQQLEGLTNDVHTLEAYGVDSLKTRYPDLLPFPQIPNDRFTSEVAMRV
MECTACIIIKLENFMQQKV
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
TTD ID
T13176
Uniprot ID
Q9NZJ5
DrugMap ID
TT5OU0D
Ensemble ID
ENST00000303236.9
HGNC ID
HGNC:3255
ChEMBL ID
CHEMBL6030

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K406(1.69)  LDD0274  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C813(0.84)  LDD0547  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
TFBX
 Probe Info  		C833(0.00); C904(0.00); C598(0.00)  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C617(0.96); C598(0.94); C833(1.07)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C617(0.99); C598(0.89); C833(0.96); C336(0.86)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C617(1.00); C598(1.27); C833(1.11); C336(0.94)  LDD1509  [6]
 LDCM0230  AC113 HCT 116 C813(0.84)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C813(0.73)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C813(0.86)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C813(1.11)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C813(1.10)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C813(0.74)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C813(0.85)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C617(0.91); C598(0.60)  LDD1510  [6]
 LDCM0238  AC120 HCT 116 C813(0.82)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C813(0.98)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C813(0.78)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C813(0.69)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C813(0.99)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C813(0.87)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C813(0.87)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C813(0.73)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C617(0.95); C598(1.19); C833(0.91)  LDD1512  [6]
 LDCM0263  AC143 HCT 116 C813(1.35)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C813(1.26)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C813(1.12)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C813(1.51)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C813(1.50)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C813(1.58)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C813(1.64)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C617(1.02); C598(1.14); C833(0.93)  LDD1513  [6]
 LDCM0271  AC150 HCT 116 C813(1.08)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C813(1.20)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C813(1.58)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C813(2.11)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C813(1.52)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C813(1.12)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C813(1.28)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C813(1.20)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C617(0.84); C598(0.97); C833(1.08)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C617(0.94); C598(0.85); C833(1.03); C336(1.18)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C617(1.18); C598(0.90); C833(1.53); C336(1.05)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C617(0.88); C598(1.08); C833(0.93); C336(0.95)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C617(1.00); C598(0.65)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C617(0.96); C598(1.11); C833(0.97)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C617(0.95); C598(0.97); C833(1.02)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C617(1.07); C598(0.84); C833(0.99)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C617(1.06); C598(1.26); C833(1.00)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C617(0.72); C598(1.02); C833(1.08)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C617(0.97); C598(1.33); C833(0.99); C336(0.93)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C617(0.89); C598(1.04); C833(0.98); C336(0.90)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C617(1.01); C598(0.68)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C617(1.04); C598(0.99); C833(0.97)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C617(0.85); C598(0.95); C833(1.04); C336(1.00)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C617(1.07); C598(1.10); C833(1.02)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C617(1.09); C598(0.98); C833(0.89)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C617(1.00); C598(1.14); C833(0.99)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C617(0.92); C598(1.14); C833(1.16)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C617(0.99); C598(1.14); C833(0.94); C336(1.08)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C617(0.89); C598(1.02); C833(0.99); C336(1.15)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C617(0.93); C598(0.79)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C617(0.98); C598(0.89); C833(0.96)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C617(1.01); C598(1.02); C833(0.94)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C617(1.01); C598(1.03); C833(0.94)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C617(0.99); C598(0.74)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C617(1.03); C598(1.16); C833(0.94)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C617(0.71); C598(1.04); C833(1.03)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C617(0.88); C598(1.16); C833(1.02); C336(0.95)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C617(1.00); C598(1.46); C833(0.96); C336(1.02)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C617(0.94); C598(0.78)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C617(0.99); C598(0.90); C833(1.00)  LDD1546  [6]
 LDCM0308  AC46 HCT 116 C813(1.06)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C813(1.03)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C813(1.16)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C813(1.43)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C617(0.95); C598(0.95); C833(0.95)  LDD1551  [6]
 LDCM0313  AC50 HCT 116 C813(1.54)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C813(1.27)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C813(1.41)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C813(1.85)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C813(1.53)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C813(1.73)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C813(2.01)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C617(0.76); C598(1.02); C833(1.08)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C617(0.96); C598(1.01); C833(0.94); C336(1.26)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C617(0.89); C598(1.05); C833(0.98); C336(0.99)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C617(1.00); C598(0.84); C833(1.14)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C617(0.82); C598(1.13)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C617(0.97); C598(1.03); C833(0.98)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C617(1.07); C598(0.93); C833(0.99)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C617(1.08); C598(0.96); C833(0.93)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C617(1.05); C598(1.19); C833(0.93)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C617(0.95); C598(1.12); C833(0.89)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C617(1.00); C598(1.19); C833(0.95)  LDD1569  [6]
 LDCM0349  AC83 HCT 116 C813(1.53)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C813(1.26)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C813(1.31)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C813(1.36)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C813(0.97)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C813(1.10)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C813(1.20)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C813(1.01)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C813(1.33)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C813(1.29)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C813(1.35)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C813(1.31)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C813(1.08)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C813(1.40)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C813(1.44)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C617(1.01); C598(0.90); C833(0.97)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C617(0.84); C598(0.95); C833(1.07)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C617(1.01); C598(1.12); C833(0.98)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C617(1.04); C598(1.17); C833(0.93)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C617(1.47); C598(1.50); C833(0.95)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C617(1.09); C336(0.99)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C617(1.00); C598(1.11); C833(1.03)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C617(0.91); C598(0.97); C833(1.04)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C617(0.94); C598(1.15)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C617(1.14); C336(0.95)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C617(0.83); C598(0.91); C833(1.02)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C617(0.95); C598(0.81); C833(0.92)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C617(0.99); C598(1.06)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C617(0.99); C336(1.08)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C617(1.15); C598(0.87); C833(0.92)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C617(1.50); C598(1.01); C833(0.86)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C617(0.95); C598(0.80); C833(1.03)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C617(0.90); C598(0.95)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C617(0.97); C336(1.05)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C617(1.08); C598(1.07); C833(0.98)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C617(0.95); C598(0.99); C833(1.10)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C617(1.08); C598(0.76)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C617(1.08); C336(1.03)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C617(1.09); C598(1.41); C833(0.98)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C617(0.92); C598(1.03); C833(1.14)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C617(0.94); C598(1.06)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C617(1.57); C598(1.20); C833(1.03)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C617(0.99); C336(1.06)  LDD1595  [6]
 LDCM0392  CL121 HCT 116 C813(1.91)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C813(1.24)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C813(2.32)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C813(1.63)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C617(0.90); C598(1.21); C833(0.95)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C617(0.93); C598(0.96); C833(1.15)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C617(1.01); C598(0.66)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C617(1.09); C336(1.04)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C617(1.08); C598(1.02); C833(1.10)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C617(1.06); C598(0.78); C833(1.06)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C617(1.08); C598(1.62)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C617(1.19); C336(0.88)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C617(0.93); C598(1.50); C833(1.14)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C617(1.03); C598(1.05); C833(0.94); C336(1.14)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C617(1.04); C598(1.38); C833(1.00); C336(1.16)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C617(1.03); C598(0.80); C833(1.04)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C617(1.09); C598(0.87)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C617(1.29); C598(1.03); C833(1.01)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C617(1.35); C598(0.98); C833(0.96)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C617(1.35); C598(1.12); C833(0.92)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C617(1.58); C598(1.31); C833(0.91)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C617(1.06); C598(1.44); C833(0.95)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C617(0.97); C598(0.94); C833(0.94)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C617(1.03); C598(0.79)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C617(0.97); C336(0.99)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C617(1.16); C598(0.95); C833(0.97)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C617(1.09); C598(0.84)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C617(1.07); C598(1.26); C833(0.97); C336(1.45)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C617(1.08); C598(1.51); C833(1.04); C336(1.03)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C617(1.06); C598(0.84)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C617(1.42); C598(1.00); C833(0.97)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C617(1.45); C598(1.11); C833(0.93)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C617(1.27); C598(0.97); C833(0.93)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C617(1.46); C598(1.22); C833(0.92)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C617(1.00); C598(1.06); C833(0.89)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C617(1.18); C598(0.81)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C617(1.09); C336(1.10)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C617(1.03); C336(1.09)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C617(0.87); C598(0.99); C833(1.09)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C617(1.07); C598(1.05); C833(0.90); C336(1.10)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C617(1.01); C598(1.16); C833(1.01); C336(0.98)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C617(1.01); C598(0.69)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C617(1.50); C598(1.14); C833(0.92)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C617(1.48); C598(0.74); C833(0.85)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C617(1.55); C598(1.01); C833(0.93)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C617(1.40); C598(1.16); C833(0.97)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C617(0.96); C598(1.43); C833(1.01)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C617(0.84); C598(1.09); C833(1.04)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C617(0.98); C598(0.79); C833(1.03)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C617(1.04); C336(1.11)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C617(0.79); C598(0.94); C833(1.18)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C617(1.08); C598(1.28); C833(0.97); C336(0.96)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C617(0.99); C598(0.84); C833(1.08); C336(1.03)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C617(1.18); C598(0.80)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C617(1.48); C598(1.00); C833(1.01)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C617(1.25); C598(1.10); C833(0.98)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C617(1.27); C598(1.05); C833(0.89)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C617(0.98); C598(1.26); C833(1.09); C336(1.22)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C617(1.53); C598(1.11); C833(0.90)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C617(1.03); C598(1.26); C833(0.97)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C617(0.99); C598(1.09); C833(1.05)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C617(1.05); C598(0.92)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C617(0.93); C336(1.18)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C617(0.80); C598(0.97); C833(1.03)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C617(1.01); C598(1.03); C833(0.89); C336(1.22)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C617(1.02); C598(1.07); C833(0.93); C336(1.08)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C617(1.19); C598(0.79)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C617(1.13); C598(0.95); C833(0.89)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C617(0.93); C598(1.14); C833(1.01); C336(0.91)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C617(1.30); C598(1.03); C833(0.92)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C617(1.23); C598(0.93); C833(0.85)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C617(1.47); C598(1.24); C833(0.95)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C617(0.99); C598(1.03); C833(1.01)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C617(0.88); C598(0.71); C833(0.98)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C617(0.90); C336(0.94)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C617(0.95); C598(1.35); C833(1.07)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C617(1.04); C598(1.05); C833(0.94); C336(0.92)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C617(0.90); C598(1.02); C833(0.98); C336(1.10)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C617(1.36); C598(1.14)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C617(1.13); C598(0.80)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C617(1.21); C598(0.98); C833(0.96)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C617(1.22); C598(1.07); C833(1.01)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C617(1.13); C598(0.99); C833(0.95)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C617(1.40); C598(1.37); C833(0.91)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C617(1.02); C598(1.10); C833(0.95)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C617(0.87); C598(0.82); C833(1.09)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C617(0.95); C598(1.20)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C617(0.95); C336(1.06)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C617(1.02); C598(1.19); C833(1.12)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C617(1.21); C598(1.08); C833(0.96)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C617(1.09); C598(1.38); C833(1.04); C336(0.91)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C617(1.02); C598(1.16); C833(1.00); C336(1.03)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C617(0.92); C598(0.65)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C617(1.16); C598(1.05); C833(0.95)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C617(1.01); C598(1.07); C833(0.91)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C617(1.06); C598(1.07); C833(0.93)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C617(1.10); C598(1.39); C833(0.91)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C617(0.93); C598(1.03); C833(0.94)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C617(0.92); C598(0.73); C833(1.01)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C617(0.91); C598(0.93)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C617(0.93); C598(1.03)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C617(1.01); C598(0.76)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C617(0.99); C598(0.78); C833(0.94)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C833(0.92); C617(0.94)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C833(1.01); C617(0.92)  LDD1497  [6]
 LDCM0024  KB05 SKMEL24 C617(3.45)  LDD3323  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum chaperone BiP (HSPA5) Heat shock protein 70 family P11021
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) Ser/Thr protein kinase family Q9NZJ5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840