Details of the Target

General Information of Target

Target ID LDTP12789
Target Name Inhibitor of growth protein 3 (ING3)
Gene Name ING3
Gene ID 54556
Synonyms
Inhibitor of growth protein 3; p47ING3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHI
PYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKEL
VQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVD
FSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAF
PGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLL
LMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAK
RAKAYFKTFVPQFQEAAFANGKL
Target Bioclass
Other
Family
ING family
Subcellular location
Nucleus
Function
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
Uniprot ID
Q9NXR8
Ensemble ID
ENST00000315870.10
HGNC ID
HGNC:14587

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR37 SNV: p.Q13K .
MEWO SNV: p.S320A .
NCIH661 SNV: p.Q350H .
NCIN87 SNV: p.K303R .
OE33 SNV: p.R21P .
SW480 SNV: p.V351I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C187(1.36)  LDD0580  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HEK-293T C403(1.07)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C403(0.65)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C403(0.80)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C403(1.06)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C403(1.09)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C403(0.94)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C403(0.91)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C187(1.03)  LDD1510  [5]
 LDCM0238  AC120 HEK-293T C403(0.86)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C403(0.83)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C403(0.97)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C403(0.86)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C403(1.03)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C403(0.76)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C403(0.58)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C403(0.44)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C406(1.23)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C406(1.27)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C406(1.41)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C406(1.23)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C406(1.44)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C406(1.92)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C406(1.28)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C406(1.78)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C406(1.68)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C406(2.64)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C406(2.94)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C406(2.47)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C187(0.98)  LDD1512  [5]
 LDCM0260  AC140 HEK-293T C406(2.12)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C406(2.26)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C406(1.64)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C187(1.36)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C187(1.75)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C187(1.25)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C187(2.25)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C187(1.82)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C187(2.50)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C187(2.26)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C187(1.05)  LDD1513  [5]
 LDCM0271  AC150 HCT 116 C187(1.31)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C187(1.21)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C187(1.86)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C187(3.01)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C187(1.56)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C187(1.50)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C187(1.19)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C187(1.12)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C406(1.70)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C406(1.15)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C406(1.10)  LDD0876  [1]
 LDCM0280  AC20 HEK-293T C406(1.11)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C406(1.67)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C406(1.44)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C406(1.58)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C406(1.01)  LDD0882  [1]
 LDCM0288  AC28 HEK-293T C187(0.96)  LDD1527  [5]
 LDCM0291  AC30 HEK-293T C187(0.93)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C187(1.11)  LDD1531  [5]
 LDCM0297  AC36 HEK-293T C187(1.06)  LDD1536  [5]
 LDCM0299  AC38 HEK-293T C187(0.87)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C187(0.95)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C187(0.97)  LDD1540  [5]
 LDCM0306  AC44 HEK-293T C187(1.08)  LDD1545  [5]
 LDCM0308  AC46 HCT 116 C187(0.94)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C187(1.35)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C187(1.23)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C187(1.51)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C187(1.34)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C187(0.83)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C187(1.20)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C187(1.36)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C187(1.26)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C187(1.54)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C187(1.77)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C403(0.94)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C403(1.74)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C403(0.95)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C187(0.91)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C403(1.44)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C403(1.31)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C403(1.34)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C403(0.89)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C403(0.98)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C403(1.33)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C403(1.01)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C403(1.76)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C406(1.14)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C406(0.99)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C187(0.99)  LDD1568  [5]
 LDCM0335  AC70 HEK-293T C406(1.29)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C406(1.01)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C406(1.00)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C406(1.17)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C406(1.21)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C406(1.20)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C406(0.94)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C406(1.39)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C406(1.28)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C406(1.36)  LDD0942  [1]
 LDCM0346  AC80 HEK-293T C406(1.26)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C406(1.24)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C406(1.61)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C187(1.23)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C187(1.42)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C187(0.96)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C187(1.19)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C187(1.46)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C187(1.25)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C187(1.23)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C187(0.94)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C187(1.09)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C187(1.24)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C187(1.00)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C187(0.95)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C187(1.44)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C187(1.25)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C187(1.39)  LDD0681  [1]
 LDCM0368  CL10 HEK-293T C187(0.82)  LDD1572  [5]
 LDCM0374  CL105 HEK-293T C406(0.84)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C406(1.08)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C406(1.11)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C406(0.84)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C406(1.27)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C187(0.85)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C406(1.15)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C406(1.06)  LDD0979  [1]
 LDCM0392  CL121 HCT 116 C187(0.67)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C187(1.71)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C187(1.15)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C187(1.49)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C403(1.24)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C403(0.98)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C403(0.81)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C403(1.03)  LDD0997  [1]
 LDCM0403  CL16 HCT 116 C187(0.94)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C187(0.99)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C187(1.61)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C187(1.31)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C187(1.40)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C187(1.78)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C187(2.36)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C187(1.81)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C187(1.63)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C187(1.54)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C187(1.49)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C187(1.40)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C187(1.61)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C187(1.55)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C187(1.67)  LDD0736  [1]
 LDCM0421  CL32 HEK-293T C187(1.12)  LDD1625  [5]
 LDCM0423  CL34 HEK-293T C187(0.98)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C187(1.16)  LDD1628  [5]
 LDCM0434  CL44 HEK-293T C187(1.06)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C403(0.78)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C403(0.95)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C403(0.86)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C403(1.37)  LDD1037  [1]
 LDCM0441  CL50 HEK-293T C403(1.13)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C403(1.03)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C403(1.21)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C403(1.38)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C403(0.92)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C403(0.91)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C403(1.50)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C403(1.32)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C403(1.45)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C403(1.60)  LDD1048  [1]
 LDCM0452  CL60 HEK-293T C403(1.38)  LDD1050  [1]
 LDCM0453  CL61 HCT 116 C187(1.32)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C187(1.53)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C187(1.60)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C187(1.75)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C187(1.78)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C187(2.32)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C187(2.20)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C187(2.00)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C187(1.42)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C187(2.24)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C187(1.64)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C187(1.39)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C187(1.72)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C187(1.71)  LDD0784  [1]
 LDCM0473  CL8 HEK-293T C187(0.86)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C187(1.08)  LDD1677  [5]
 LDCM0476  CL82 HEK-293T C187(0.91)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C187(0.98)  LDD1680  [5]
 LDCM0487  CL92 HEK-293T C187(0.97)  LDD1690  [5]
 LDCM0489  CL94 HEK-293T C187(0.91)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C187(1.05)  LDD1693  [5]
 LDCM0573  Fragment11 Ramos C187(0.77)  LDD2190  [6]
 LDCM0575  Fragment13 Ramos C187(0.96)  LDD2192  [6]
 LDCM0580  Fragment21 Ramos C187(0.95)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C187(1.34)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C187(1.01)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C187(0.87)  LDD2198  [6]
 LDCM0589  Fragment31 Ramos C187(0.94)  LDD2200  [6]
 LDCM0468  Fragment33 HCT 116 C187(1.66)  LDD0785  [1]
 LDCM0596  Fragment38 Ramos C187(0.94)  LDD2203  [6]
 LDCM0610  Fragment52 Ramos C187(0.94)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C187(0.97)  LDD2205  [6]
 LDCM0022  KB02 HG-3 C187(2.68)  LDD2355  [7]
 LDCM0023  KB03 HG-3 C187(2.21)  LDD2772  [7]
 LDCM0024  KB05 OCI-Ly3 C187(2.42)  LDD3372  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840