Details of the Target

General Information of Target

Target ID LDTP12278
Target Name Steroid receptor RNA activator 1 (SRA1)
Gene Name SRA1
Gene ID 10011
Synonyms
Steroid receptor RNA activator 1; Steroid receptor RNA activator protein; SRAP
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPS
NCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH
Target Bioclass
Other
Family
SRA1 family
Subcellular location
Nucleus
Function
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
Uniprot ID
Q9HD15
Ensemble ID
ENST00000336283.9
HGNC ID
HGNC:11281

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		2.80  LDD0066  [2]
STPyne
 Probe Info  		K131(6.25)  LDD0277  [3]
BTD
 Probe Info  		C134(0.53)  LDD2101  [4]
HHS-475
 Probe Info  		Y35(1.02)  LDD0264  [5]
DBIA
 Probe Info  		C134(0.90)  LDD1508  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
IPM
 Probe Info  		N.A.  LDD2156  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C134(0.90)  LDD1508  [6]
 LDCM0237  AC12 HEK-293T C134(1.04)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C134(1.22)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C134(1.08)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C134(0.92)  LDD1516  [6]
 LDCM0279  AC2 HEK-293T C134(0.99)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C134(1.12)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C134(0.99)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C134(1.05)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C134(1.00)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C134(0.87)  LDD1523  [6]
 LDCM0286  AC26 HEK-293T C134(0.91)  LDD1525  [6]
 LDCM0288  AC28 HEK-293T C134(1.08)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C134(1.07)  LDD1528  [6]
 LDCM0291  AC30 HEK-293T C134(1.18)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C134(0.97)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C134(0.87)  LDD1532  [6]
 LDCM0295  AC34 HEK-293T C134(0.91)  LDD1534  [6]
 LDCM0297  AC36 HEK-293T C134(1.05)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C134(1.14)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C134(1.05)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C134(1.09)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C134(1.01)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C134(0.88)  LDD1541  [6]
 LDCM0304  AC42 HEK-293T C134(0.86)  LDD1543  [6]
 LDCM0306  AC44 HEK-293T C134(1.09)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C134(1.01)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C134(1.11)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C134(0.96)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C134(1.04)  LDD1549  [6]
 LDCM0312  AC5 HEK-293T C134(1.12)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C134(0.95)  LDD1552  [6]
 LDCM0315  AC52 HEK-293T C134(1.06)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C134(0.98)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C134(1.18)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C134(1.00)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C134(0.96)  LDD1558  [6]
 LDCM0321  AC58 HEK-293T C134(1.16)  LDD1560  [6]
 LDCM0323  AC6 HEK-293T C134(1.02)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C134(1.28)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C134(1.09)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C134(1.05)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C134(1.10)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C134(1.26)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C134(1.07)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C134(0.88)  LDD1569  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C134(0.55)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C134(1.08)  LDD1511  [6]
 LDCM0275  AKOS034007705 HEK-293T C134(1.14)  LDD1514  [6]
 LDCM0108  Chloroacetamide HeLa H171(0.00); C134(0.00)  LDD0222  [13]
 LDCM0368  CL10 HEK-293T C134(1.03)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C134(0.89)  LDD1573  [6]
 LDCM0371  CL102 HEK-293T C134(1.01)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C134(1.01)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C134(0.93)  LDD1577  [6]
 LDCM0375  CL106 HEK-293T C134(1.05)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C134(1.16)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C134(0.87)  LDD1581  [6]
 LDCM0379  CL11 HEK-293T C134(1.04)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C134(0.80)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C134(1.13)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C134(0.89)  LDD1586  [6]
 LDCM0384  CL114 HEK-293T C134(0.83)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C134(1.00)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C134(0.83)  LDD1590  [6]
 LDCM0388  CL118 HEK-293T C134(0.94)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C134(0.98)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C134(0.77)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C134(0.96)  LDD1595  [6]
 LDCM0393  CL122 HEK-293T C134(1.00)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C134(1.05)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C134(0.79)  LDD1599  [6]
 LDCM0397  CL126 HEK-293T C134(1.10)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C134(0.97)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C134(0.93)  LDD1603  [6]
 LDCM0401  CL14 HEK-293T C134(1.07)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C134(0.94)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C134(0.89)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C134(0.97)  LDD1609  [6]
 LDCM0407  CL2 HEK-293T C134(1.14)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C134(1.00)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C134(0.92)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C134(1.16)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C134(1.15)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C134(0.98)  LDD1616  [6]
 LDCM0414  CL26 HEK-293T C134(0.97)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C134(1.04)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C134(0.88)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C134(1.20)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C134(1.02)  LDD1623  [6]
 LDCM0421  CL32 HEK-293T C134(1.00)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C134(0.96)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C134(1.11)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C134(1.13)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C134(1.03)  LDD1629  [6]
 LDCM0428  CL39 HEK-293T C134(1.06)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C134(0.96)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C134(0.96)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C134(1.15)  LDD1636  [6]
 LDCM0434  CL44 HEK-293T C134(1.04)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C134(1.01)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C134(1.08)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C134(1.10)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C134(0.95)  LDD1642  [6]
 LDCM0441  CL50 HEK-293T C134(0.86)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C134(0.97)  LDD1646  [6]
 LDCM0445  CL54 HEK-293T C134(0.86)  LDD1648  [6]
 LDCM0447  CL56 HEK-293T C134(1.22)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C134(1.06)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C134(1.09)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C134(1.22)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C134(0.96)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C134(0.88)  LDD1655  [6]
 LDCM0454  CL62 HEK-293T C134(1.09)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C134(1.00)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C134(0.82)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C134(1.14)  LDD1661  [6]
 LDCM0460  CL68 HEK-293T C134(1.11)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C134(1.16)  LDD1664  [6]
 LDCM0463  CL70 HEK-293T C134(1.19)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C134(1.03)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C134(0.97)  LDD1668  [6]
 LDCM0467  CL74 HEK-293T C134(0.93)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C134(0.93)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C134(1.05)  LDD1674  [6]
 LDCM0473  CL8 HEK-293T C134(0.84)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C134(1.32)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C134(0.99)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C134(1.17)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C134(1.02)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C134(1.16)  LDD1681  [6]
 LDCM0480  CL86 HEK-293T C134(1.07)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C134(1.07)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C134(0.88)  LDD1685  [6]
 LDCM0484  CL9 HEK-293T C134(1.05)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C134(0.86)  LDD1688  [6]
 LDCM0487  CL92 HEK-293T C134(1.03)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C134(1.00)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C134(1.13)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C134(0.88)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C134(1.05)  LDD1694  [6]
 LDCM0493  CL98 HEK-293T C134(0.93)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C134(1.05)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C134(0.97)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C134(1.26)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C134(0.95)  LDD1631  [6]
 LDCM0116  HHS-0101 DM93 Y35(1.02)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y35(1.14)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y35(1.34)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y35(1.35)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y35(0.80)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C134(0.53)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C134(0.44)  LDD2104  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C134(0.35)  LDD2115  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C134(1.16)  LDD2128  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C134(0.51)  LDD2134  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C134(1.02)  LDD2143  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C134(1.04)  LDD2148  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 2 (HDAC2) Histone deacetylase family Q92769

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.