Details of the Target

General Information of Target

Target ID LDTP12156
Target Name Pleckstrin homology domain-containing family A member 3 (PLEKHA3)
Gene Name PLEKHA3
Gene ID 65977
Synonyms
FAPP1; Pleckstrin homology domain-containing family A member 3; PH domain-containing family A member 3; Phosphatidylinositol-four-phosphate adapter protein 1; FAPP-1; Phosphoinositol 4-phosphate adapter protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQ
LTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMKDWVEALNQASKITVPKGG
GLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR
RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLR
TIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQAL
KCHPRETSFSRSISLTRPGSSSLSSGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPV
PQAGEKLLPPGDTSEDSLFTPRPGEGSAPGVLPSSRIRHRSEPQHPKEKPFMFNLDDENI
RTSDV
Target Bioclass
Other
Subcellular location
Golgi apparatus, trans-Golgi network membrane
Function
Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane. Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration. Binds preferentially to PtdIns(4)P. Negatively regulates APOB secretion from hepatocytes.
Uniprot ID
Q9HB20
Ensemble ID
ENST00000234453.10
HGNC ID
HGNC:14338

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.58  LDD0402  [1]
DA-P3
 Probe Info  		9.16  LDD0183  [2]
DBIA
 Probe Info  		C94(22.81)  LDD0209  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		C216(0.00); C94(0.00)  LDD0147  [6]
TFBX
 Probe Info  		C94(0.00); C216(0.00)  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C216(0.95); C37(1.12)  LDD1507  [9]
 LDCM0215  AC10 HCT 116 C94(1.08)  LDD0532  [10]
 LDCM0226  AC11 HCT 116 C94(1.27)  LDD0543  [10]
 LDCM0237  AC12 HCT 116 C94(1.04)  LDD0554  [10]
 LDCM0259  AC14 HCT 116 C94(1.06)  LDD0576  [10]
 LDCM0270  AC15 HCT 116 C94(1.12)  LDD0587  [10]
 LDCM0276  AC17 HCT 116 C94(1.12)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C94(1.63)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C94(1.33)  LDD0595  [10]
 LDCM0279  AC2 HEK-293T C216(2.16); C94(1.07)  LDD1518  [9]
 LDCM0280  AC20 HCT 116 C94(1.13)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C94(1.11)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C94(1.09)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C94(1.16)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C94(1.06)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C94(0.79)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C94(0.87)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C94(0.94)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C94(0.69)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C94(0.88)  LDD0606  [10]
 LDCM0290  AC3 HEK-293T C216(1.95)  LDD1529  [9]
 LDCM0291  AC30 HCT 116 C94(0.95)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C94(0.84)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C94(0.81)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C94(0.95)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C94(1.01)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C94(0.94)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C94(0.93)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C94(0.90)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C94(1.01)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C94(1.25)  LDD0617  [10]
 LDCM0301  AC4 HEK-293T C94(1.04)  LDD1540  [9]
 LDCM0302  AC40 HCT 116 C94(1.34)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C94(1.09)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C94(1.23)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C94(1.16)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C94(1.15)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C94(1.32)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C94(0.98)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C94(1.08)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C94(1.13)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C94(1.67)  LDD0628  [10]
 LDCM0312  AC5 HEK-293T C216(1.36)  LDD1551  [9]
 LDCM0313  AC50 HCT 116 C94(1.46)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C94(0.86)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C94(1.14)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C94(1.36)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C94(1.21)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C94(1.47)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C94(2.00)  LDD0636  [10]
 LDCM0320  AC57 HEK-293T C94(1.00)  LDD0918  [10]
 LDCM0321  AC58 HEK-293T C94(0.91)  LDD0919  [10]
 LDCM0322  AC59 HEK-293T C94(1.01)  LDD0920  [10]
 LDCM0323  AC6 HCT 116 C94(1.10)  LDD0640  [10]
 LDCM0324  AC60 HEK-293T C94(1.17)  LDD0922  [10]
 LDCM0325  AC61 HEK-293T C94(1.08)  LDD0923  [10]
 LDCM0326  AC62 HEK-293T C94(1.04)  LDD0924  [10]
 LDCM0327  AC63 HEK-293T C94(0.97)  LDD0925  [10]
 LDCM0328  AC64 HEK-293T C94(0.87)  LDD0926  [10]
 LDCM0329  AC65 HEK-293T C94(1.05)  LDD0927  [10]
 LDCM0330  AC66 HEK-293T C94(1.27)  LDD0928  [10]
 LDCM0331  AC67 HEK-293T C94(1.02)  LDD0929  [10]
 LDCM0332  AC68 HCT 116 C94(1.26)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C94(1.25)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C94(1.01)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C94(1.41)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C94(1.11)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C94(1.34)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C94(1.85)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C94(1.80)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C94(2.30)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C94(1.41)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C94(1.46)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C94(1.25)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C94(1.21)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C94(1.13)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C94(1.29)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C94(1.40)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C94(2.59)  LDD0665  [10]
 LDCM0248  AKOS034007472 HCT 116 C94(1.04)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C94(1.13)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C94(1.30)  LDD0592  [10]
 LDCM0367  CL1 HCT 116 C94(0.96)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C94(0.97)  LDD0685  [10]
 LDCM0369  CL100 HEK-293T C94(1.03)  LDD1573  [9]
 LDCM0370  CL101 HCT 116 C94(1.07)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C94(0.91)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C94(1.00)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C94(1.00)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C94(1.44)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C94(1.93)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C94(1.86)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C94(1.98)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C94(1.39)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C94(0.97)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C94(1.47)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C94(1.27)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C94(0.75)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C94(0.84)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C94(0.87)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C94(1.00)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C94(1.07)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C94(1.66)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C94(1.15)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C94(1.22)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C94(1.27)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C94(1.11)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C94(1.16)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C94(1.30)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C94(1.31)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C94(1.43)  LDD0712  [10]
 LDCM0396  CL125 HEK-293T C94(0.87)  LDD0994  [10]
 LDCM0397  CL126 HEK-293T C94(0.75)  LDD0995  [10]
 LDCM0398  CL127 HEK-293T C94(0.86)  LDD0996  [10]
 LDCM0399  CL128 HEK-293T C94(0.96)  LDD0997  [10]
 LDCM0400  CL13 HCT 116 C94(0.98)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C94(1.04)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C94(0.80)  LDD0719  [10]
 LDCM0403  CL16 HEK-293T C94(0.97)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C216(1.05); C37(1.00)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C216(1.72); C94(1.02)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C216(1.13)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C94(1.21)  LDD0724  [10]
 LDCM0408  CL20 HEK-293T C94(1.20)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C216(1.27)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C94(1.03)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C216(1.04)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C216(0.94)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C216(0.70); C94(0.90)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C216(1.29); C94(0.97)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C94(0.95)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C94(0.99)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C216(1.00); C37(0.57)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C94(0.82)  LDD0735  [10]
 LDCM0419  CL30 HEK-293T C216(1.73); C94(1.11)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C216(1.35)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C94(1.07)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C216(1.17)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C94(1.08)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C216(0.96)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C216(0.89)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C216(0.75); C94(0.88)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C94(0.93)  LDD1632  [9]
 LDCM0429  CL4 HCT 116 C94(1.04)  LDD0746  [10]
 LDCM0430  CL40 HEK-293T C94(0.95)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C216(1.12); C37(0.95)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C216(1.67); C94(1.16)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C216(1.35)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C94(1.08)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C216(1.15)  LDD1639  [9]
 LDCM0436  CL46 HCT 116 C94(1.02)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C94(1.52)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C94(0.93)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C94(0.97)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C94(1.01)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C94(1.02)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C94(1.20)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C94(1.26)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C94(0.95)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C94(1.21)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C94(0.94)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C94(0.88)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C94(1.01)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C94(1.13)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C94(0.99)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C94(1.03)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C94(1.11)  LDD0769  [10]
 LDCM0453  CL61 HEK-293T C94(1.00)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C94(1.08)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C94(0.84)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C94(1.20)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C94(0.74)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C94(0.84)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C94(0.85)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C94(1.48)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C94(1.21)  LDD1059  [10]
 LDCM0462  CL7 HCT 116 C94(1.04)  LDD0779  [10]
 LDCM0463  CL70 HEK-293T C94(1.21)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C94(1.38)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C94(2.06)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C94(1.21)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C94(1.64)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C94(1.16)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C94(0.84)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C94(1.59)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C94(1.28)  LDD1070  [10]
 LDCM0473  CL8 HCT 116 C94(0.98)  LDD0790  [10]
 LDCM0474  CL80 HEK-293T C94(1.39)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C94(1.16)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C94(1.21)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C94(0.68)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C94(0.75)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C94(0.84)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C94(1.27)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C94(1.01)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C94(0.99)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C94(0.91)  LDD1081  [10]
 LDCM0484  CL9 HCT 116 C94(1.32)  LDD0801  [10]
 LDCM0485  CL90 HEK-293T C94(0.89)  LDD1083  [10]
 LDCM0486  CL91 HEK-293T C216(0.93)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C94(1.13)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C216(1.13)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C94(1.10)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C216(1.15)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C216(0.57)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C216(0.97); C94(1.00)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C216(1.35); C94(1.01)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C94(0.98)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C94(0.99)  LDD1698  [9]
 LDCM0031  Epigallocatechin gallate HEK-293T 9.16  LDD0183  [2]
 LDCM0468  Fragment33 HEK-293T C94(1.18)  LDD1066  [10]
 LDCM0427  Fragment51 HEK-293T C216(1.59); C94(1.01)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C216(0.95)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C94(22.81)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C216(1.79)  LDD3310  [11]
 LDCM0627  NUDT7-COV-1 HEK-293T C94(0.65)  LDD2206  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA cap guanine-N7 methyltransferase (RNMT) mRNA cap 0 methyltransferase family O43148
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein mL45 (MRPL45) Mitochondrion-specific ribosomal protein mL45 family Q9BRJ2
T-cell leukemia/lymphoma protein 1B (TCL1B) TCL1 family O95988
Pleckstrin homology domain-containing family A member 3 (PLEKHA3) . Q9HB20

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840
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