Details of the Target

General Information of Target

Target ID LDTP12099
Target Name Ubiquitin carboxyl-terminal hydrolase 42 (USP42)
Gene Name USP42
Gene ID 84132
Synonyms
Ubiquitin carboxyl-terminal hydrolase 42; EC 3.4.19.12; Deubiquitinating enzyme 42; Ubiquitin thioesterase 42; Ubiquitin-specific-processing protease 42
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGLVRLLQQGHRCLLAPVAPKLVPPVRGVKKGFRAAFRFQKELERQRLLRCPPPPVRR
SEKPNWDYHAEIQAFGHRLQENFSLDLLKTAFVNSCYIKSEEAKRQQLGIEKEAVLLNLK
SNQELSEQGTSFSQTCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTL
SEEFPVPPAVLQQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIINPMGL
LVEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVA
LRKLYGFTENRRPWNYSKPKETLRAEKSITAS
Target Bioclass
Enzyme
Family
Peptidase C19 family
Function Deubiquitinating enzyme which may play an important role during spermatogenesis.
Uniprot ID
Q9H9J4
Ensemble ID
ENST00000306177.10
HGNC ID
HGNC:20068

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C231(1.07)  LDD0531  [2]
IA-alkyne
 Probe Info  		C588(0.00); C1103(0.00)  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C231(1.07)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C1103(0.99); C1225(1.08); C588(0.94); C1145(1.00)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C231(0.85)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C231(0.75)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C231(0.80)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C231(0.80)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C231(0.83)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C231(0.85)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C231(0.83)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C231(0.92)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C231(0.77)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C231(0.74)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C1103(1.04); C1225(0.96); C588(0.79); C1145(1.05)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C231(0.77)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C231(0.98)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C231(0.82)  LDD0546  [2]
 LDCM0237  AC12 HEK-293T C1103(0.99); C1225(0.93); C588(1.13); C1145(0.90)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C1103(0.99); C1225(1.33); C1145(1.09); C681(1.12)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C1225(0.86); C1145(1.07); C681(0.99)  LDD1513  [8]
 LDCM0276  AC17 HCT 116 C231(0.99)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C231(0.94)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C231(1.16)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C231(1.23)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C231(0.93)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C231(1.03)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C231(0.99)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C231(0.78)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C231(0.99)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C231(0.91)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C231(0.82)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C231(1.02)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C231(0.96)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C231(0.80)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C231(1.30)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C231(0.81)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C231(0.87)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C231(0.79)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C231(0.89)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C231(0.76)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C1103(0.97); C1225(0.97); C588(1.17); C1145(1.08)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C1103(1.01); C1225(1.06); C588(1.24); C1145(0.98)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C1103(0.93); C1225(1.49); C588(0.98); C1145(1.12)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C1103(1.08); C1225(0.88); C1145(1.07); C681(1.03)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C1225(0.98); C1145(1.08); C681(1.03)  LDD1539  [8]
 LDCM0301  AC4 HCT 116 C231(1.46)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C1103(1.02); C1225(0.79); C867(1.00); C588(1.07)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C1103(0.97); C1225(0.91); C588(0.94); C1145(1.04)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C1103(1.03); C1225(1.04); C588(1.01); C1145(1.08)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C1103(1.05); C1225(1.00); C588(0.98); C1145(1.08)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C1103(0.99); C1225(0.94); C588(1.19); C1145(0.93)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C1103(0.97); C1225(0.84); C588(1.11); C1145(1.07)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C1103(1.03); C1225(1.06); C1145(1.03); C681(0.99)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C1225(0.84); C1145(0.96); C681(0.98)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C1103(1.09); C1225(1.03); C867(1.18); C588(1.05)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C1103(0.98); C1225(0.99); C588(1.07); C1145(0.99)  LDD1550  [8]
 LDCM0312  AC5 HCT 116 C231(1.36)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C1103(1.02); C1225(0.97); C588(1.06); C1145(1.00)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C1103(0.99); C1225(1.04); C588(0.80); C1145(1.14)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C1103(0.99); C1225(0.82); C588(0.98); C1145(0.97)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C1103(0.94); C1225(1.11); C588(1.02); C1145(1.14)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C1103(1.02); C1225(0.90); C1145(1.12); C681(1.02)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C1225(0.83); C1145(1.06); C681(1.09)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C1103(1.07); C1225(0.96); C867(1.05); C588(1.06)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C1103(0.98); C1225(0.87); C588(0.95); C1145(1.21)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C1103(1.06); C1225(0.94); C588(1.04); C1145(0.98)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C1103(1.10); C1225(1.04); C588(0.75); C1145(0.98)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C1103(1.16); C1225(0.83); C1145(1.09); C681(0.98)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C1103(1.06); C1225(0.80); C588(1.12); C1145(0.88)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C1103(0.97); C1225(1.06); C588(1.03); C1145(1.07)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C1103(1.10); C1225(1.00); C1145(1.08); C681(1.10)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C1225(0.82); C1145(1.05); C681(1.01)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C1103(1.10); C1225(0.91); C867(0.99); C588(1.09)  LDD1567  [8]
 LDCM0332  AC68 HCT 116 C231(1.12)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C231(1.13)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C1225(0.87); C1145(1.00); C681(0.98)  LDD1568  [8]
 LDCM0335  AC70 HCT 116 C231(1.01)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C231(0.92)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C231(1.09)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C231(0.97)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C231(1.14)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C231(0.96)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C231(0.95)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C231(1.11)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C231(0.94)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C231(1.08)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C1103(1.03); C1225(1.02); C867(1.07); C588(1.00)  LDD1569  [8]
 LDCM0346  AC80 HCT 116 C231(1.29)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C231(1.12)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C231(1.13)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C231(1.10)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C231(0.97)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C231(1.04)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C231(0.96)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C231(1.02)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C231(1.07)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C231(1.16)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C231(1.10)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C231(0.97)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C231(0.92)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C231(0.97)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C231(1.11)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C231(0.91)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C231(0.92)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C231(0.99)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C231(0.79)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C231(0.89)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C1103(0.94); C1225(0.93); C588(1.11); C1145(1.05)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C1103(0.97); C1225(1.36); C588(1.02); C1145(0.87)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C1103(1.03); C1225(0.85); C867(1.11); C588(0.95)  LDD1514  [8]
 LDCM0020  ARS-1620 HCC44 C1145(1.25)  LDD2171  [2]
 LDCM0367  CL1 HEK-293T C1103(0.80); C1225(1.05); C867(0.88); C588(1.00)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C1103(0.93); C1225(0.92); C1145(1.30); C681(1.00)  LDD1572  [8]
 LDCM0369  CL100 HCT 116 C231(1.23)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C1103(0.88); C1225(1.12); C867(1.11); C588(1.09)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C1225(1.19); C1145(0.92); C213(0.96)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C1103(0.88); C1225(0.94); C588(1.10); C1145(1.26)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C1225(1.13); C588(1.22); C1145(1.07); C213(0.95)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C231(0.95)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C231(1.00)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C231(0.99)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C231(1.06)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C231(1.11)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C1225(0.95); C1145(1.14); C681(1.19)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C231(0.94)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C231(1.08)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C231(0.91)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C231(0.80)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C231(0.56)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C231(0.68)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C231(0.85)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C1103(0.92); C1225(1.09); C867(1.13); C588(1.07)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C1225(1.26); C1145(1.09); C213(0.96)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C1103(1.01); C1225(1.20); C588(1.10); C1145(1.24)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C1103(1.03); C1225(0.76); C867(1.17); C588(0.97)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C1225(0.87); C588(1.00); C1145(1.02); C213(1.00)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C1103(0.92); C1225(1.21); C867(1.07); C588(1.09)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C1225(0.96); C1145(1.08); C213(1.05)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C1103(0.87); C1225(1.27); C588(1.12); C1145(0.96)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C1225(0.84); C588(1.12); C1145(0.96); C213(0.96)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C1103(1.29); C1225(0.81); C867(1.00); C588(1.02)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C1225(1.11); C1145(1.03); C213(1.02)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C1103(0.95); C1225(0.88); C588(1.10); C1145(0.87)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C1225(1.34); C588(0.94); C1145(0.93); C213(1.01)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C1103(0.90); C1225(1.01); C867(0.97); C588(1.03)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C1225(1.05); C1145(1.03); C213(1.03)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C1103(0.88); C1225(0.75); C588(1.14); C1145(1.18)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C1225(0.90); C588(0.75); C1145(0.99); C213(1.02)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C1103(0.80); C1225(1.15); C588(0.91); C1145(0.87)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C1103(0.97); C1225(0.97); C588(0.94); C1145(1.00)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C1103(0.94); C1225(0.94); C588(1.07); C1145(1.28)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C1225(1.14); C1145(1.09); C213(1.03)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C1103(0.91); C1225(0.82); C588(1.10); C1145(1.06)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C1103(0.88); C1225(1.20); C588(0.90); C1145(1.06)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C1103(0.90); C1225(1.00); C1145(1.21); C681(1.08)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C1225(1.09); C1145(1.24); C681(1.20)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C1103(0.97); C1225(0.89); C867(0.96); C588(0.95)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C1103(0.92); C1225(1.03); C867(0.97); C588(0.95)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C1225(1.04); C1145(1.18); C213(1.01)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C1103(0.93); C1225(0.88); C588(1.09); C1145(1.12)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C1225(1.32); C588(1.07); C1145(1.02); C213(1.01)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C1103(1.00); C1225(0.95); C588(0.96); C1145(1.11)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C1103(0.95); C1225(1.20); C588(1.06); C1145(1.29)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C1103(1.04); C1225(1.03); C588(0.97); C1145(1.11)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C1103(0.93); C1225(0.84); C588(0.69); C1145(1.05)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C1103(0.92); C1225(0.84); C588(0.89); C1145(1.20)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C1103(0.81); C1225(1.18); C588(0.85); C1145(1.05)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C1103(0.84); C1225(0.96); C1145(1.08); C681(1.08)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C1225(0.93); C1145(1.28); C681(1.20)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C1103(0.95); C1225(0.97); C867(0.93); C588(0.91)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C1103(1.02); C1225(0.86); C867(0.90); C588(0.99)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C1103(0.91); C1225(1.00); C588(1.00); C1145(1.05)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C1225(1.02); C588(1.40); C1145(0.95); C213(0.98)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C1225(0.94); C588(0.78); C1145(0.98); C213(0.94)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C1103(0.96); C1225(1.22); C588(0.88); C1145(1.03)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C1103(1.08); C1225(1.00); C588(0.97); C1145(1.08)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C1103(0.90); C1225(0.99); C588(0.81); C1145(1.15)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C1103(1.02); C1225(0.72); C588(0.99); C1145(1.10)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C1103(0.89); C1225(1.07); C588(0.86); C1145(1.15)  LDD1639  [8]
 LDCM0436  CL46 HCT 116 C231(0.78)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C231(0.80)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C231(0.89)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C231(1.16)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C1103(0.94); C1225(0.93); C588(1.06); C1145(0.79)  LDD1644  [8]
 LDCM0441  CL50 HCT 116 C231(0.85)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C231(0.90)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C231(0.83)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C231(0.91)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C231(0.85)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C231(0.83)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C231(0.81)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C231(0.86)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C231(1.04)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C231(0.88)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C1103(0.93); C1225(1.09); C588(0.96); C1145(1.08)  LDD1654  [8]
 LDCM0452  CL60 HCT 116 C231(0.91)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C231(1.13)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C231(1.15)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C231(1.04)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C231(1.04)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C231(0.98)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C231(1.08)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C231(1.01)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C231(1.05)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C231(1.12)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C1103(0.99); C1225(1.01); C588(0.89); C1145(1.23)  LDD1665  [8]
 LDCM0463  CL70 HCT 116 C231(1.16)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C231(0.91)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C231(1.06)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C231(1.17)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C231(1.13)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C1225(0.95); C588(1.03); C1145(0.97); C213(1.07)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C1103(0.93); C1225(1.02); C588(1.01); C1145(0.84)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C1103(1.04); C1225(0.92); C588(0.99); C1145(1.04)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C1103(1.06); C1225(0.92); C588(1.02); C1145(1.13)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C1103(0.87); C1225(0.60); C588(0.76); C1145(0.99)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C1103(1.00); C1225(0.67); C588(1.08); C1145(0.98)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C1103(0.92); C1225(1.05); C588(0.96); C1145(1.19)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C1103(0.87); C1225(0.83); C1145(1.09); C681(1.03)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C1225(0.77); C1145(1.20); C681(1.07)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C1103(0.97); C1225(0.75); C867(0.91); C588(0.98)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C1103(1.19); C1225(0.87); C867(0.98); C588(1.11)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C1225(1.15); C1145(1.11); C213(1.09)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C1103(1.02); C1225(1.47); C588(1.20); C1145(1.22)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C1225(0.88); C588(0.86); C1145(1.04); C213(1.06)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C1103(1.01); C1225(0.99); C588(1.03); C1145(0.96)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C1103(0.91); C1225(1.10); C588(0.87); C1145(1.24)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C1103(0.98); C1225(0.81); C588(0.87); C1145(0.82)  LDD1688  [8]
 LDCM0486  CL91 HCT 116 C231(1.09)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C231(1.03)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C231(1.16)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C231(1.27)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C231(1.06)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C231(1.20)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C231(1.52)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C231(1.02)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C231(1.11)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C1103(0.95); C1225(1.63); C588(1.21); C1145(1.10)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C231(0.95)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C1225(1.06); C1145(1.09); C213(0.88)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C1225(1.07); C588(1.12); C1145(1.02); C681(0.89)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C1225(0.89); C588(1.03); C1145(1.04); C681(0.98)  LDD1497  [8]
 LDCM0024  KB05 RVH421 C1145(1.83)  LDD3320  [9]
 LDCM0021  THZ1 HCT 116 C1145(1.25)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840