Details of the Target

General Information of Target

Target ID LDTP12080
Target Name Queuine tRNA-ribosyltransferase accessory subunit 2 (QTRT2)
Gene Name QTRT2
Gene ID 79691
Synonyms
QTRTD1; Queuine tRNA-ribosyltransferase accessory subunit 2; Queuine tRNA-ribosyltransferase domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQTG
KLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYC
DFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPAVFGNRH
DAVYGPADTMVQYMELFNKIRKQQQVPVAGIR
Target Bioclass
Enzyme
Family
Queuine tRNA-ribosyltransferase family, QTRT2 subfamily
Subcellular location
Cytoplasm
Function
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). {|HAMAP-Rule:MF_03043}.
Uniprot ID
Q9H974
Ensemble ID
ENST00000281273.8
HGNC ID
HGNC:25771

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.E148Ter .
LNCaP clone FGC SNV: p.V115A DBIA    Probe Info 
MFE319 SNV: p.G55V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C324(1.84); C68(1.33)  LDD3311  [2]
BTD
 Probe Info  		C12(1.87)  LDD1700  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C263(0.00); C174(0.00); C33(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C174(0.00); C263(0.00)  LDD0032  [5]
Lodoacetamide azide
 Probe Info  		C263(0.00); C174(0.00)  LDD0037  [4]
IPM
 Probe Info  		C312(0.00); C324(0.00)  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Ox-W18
 Probe Info  		N.A.  LDD2175  [8]
Acrolein
 Probe Info  		C263(0.00); C174(0.00)  LDD0217  [9]
W1
 Probe Info  		N.A.  LDD0236  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C263(0.00); C174(0.00); C33(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C263(1.01); C324(1.18); C284(1.18); C174(0.91)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C324(1.04); C284(0.96); C174(0.92); C151(0.96)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C263(0.97); C324(1.02); C174(0.98); C151(0.87)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C324(1.02); C174(1.01); C151(0.99); C143(1.08)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C324(0.94); C174(0.98); C151(0.86); C103(1.22)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C324(0.95); C284(1.27); C174(0.97); C151(1.13)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C263(0.85); C324(1.06); C284(1.13); C174(0.98)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C324(1.06); C284(1.13); C174(0.95); C151(0.98)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C263(0.97); C324(1.54); C174(0.99); C151(0.78)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C324(1.05); C284(1.06); C174(0.92); C151(1.11)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C324(1.08); C174(0.99); C151(0.94); C143(1.16)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C33(1.05); C324(1.01); C174(1.01); C151(1.10)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C324(0.98); C174(1.02); C151(1.08); C103(1.07)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C324(0.96); C284(1.09); C174(1.00); C151(1.03)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C33(0.83); C263(1.10); C324(1.01); C174(1.04)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C263(0.95); C324(1.08); C284(0.91); C174(0.92)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C324(1.05); C284(0.89); C174(0.99); C151(1.08)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C263(1.08); C324(1.05); C174(0.99); C151(0.97)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C324(1.04); C174(0.98); C151(0.93); C143(0.95)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C33(1.12); C324(0.99); C174(1.06); C151(1.06)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C263(0.91); C324(1.09); C174(0.90); C151(1.04)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C324(1.01); C174(1.05); C151(1.12); C103(1.01)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C324(1.02); C284(1.06); C174(1.00); C151(0.87)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C33(0.84); C263(1.09); C324(0.97); C174(1.05)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C263(0.84); C324(1.11); C284(1.02); C174(0.91)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C324(1.03); C284(1.24); C174(1.00); C151(0.99)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C263(0.96); C324(1.02); C174(0.99); C151(1.00)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C324(1.06); C174(0.97); C151(0.94); C143(0.97)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C33(0.91); C324(0.99); C174(1.01); C151(1.08)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C324(0.96); C174(1.02); C151(0.89); C103(1.07)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C324(0.96); C284(1.28); C174(1.00); C151(1.03)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C324(1.12); C174(1.00); C151(1.04); C143(0.91)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C33(0.96); C263(1.07); C324(0.91); C174(1.00)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C263(1.04); C324(1.01); C284(1.05); C174(0.94)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C324(1.08); C284(1.00); C174(0.88); C151(0.95)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C263(0.99); C324(1.01); C174(0.99); C151(0.88)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C324(1.11); C174(1.03); C151(0.93); C143(1.02)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C33(1.19); C324(0.97); C174(1.01); C151(0.90)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C324(0.96); C174(1.12); C151(1.00); C103(1.18)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C324(0.96); C284(1.49); C174(1.01); C151(0.93)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C33(1.20); C263(1.21); C324(0.98); C174(1.07)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C263(1.03); C324(1.17); C284(1.09); C174(0.95)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C33(1.05); C324(0.97); C174(0.96); C151(1.01)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C324(0.97); C284(1.00); C174(0.98); C151(1.03)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C263(0.99); C324(1.00); C174(0.99); C151(0.97)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C324(1.04); C174(0.98); C151(1.03); C143(0.97)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C33(0.97); C324(1.00); C174(0.93); C151(1.03)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C324(1.01); C174(1.00); C151(1.00); C103(0.95)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C324(1.01); C284(1.19); C174(1.00); C151(0.94)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C33(0.80); C263(1.27); C324(0.97); C174(1.05)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C263(0.94); C324(1.13); C284(1.16); C174(0.92)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C324(1.06); C284(1.07); C174(1.00); C151(1.05)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C263(1.02); C324(0.96); C174(1.02); C151(0.92)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C324(1.06); C174(1.02); C151(0.90); C103(1.11)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C324(1.07); C174(0.93); C151(0.91); C143(1.31)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C33(1.06); C324(1.03); C174(1.02); C151(1.17)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C324(1.02); C174(0.97); C151(0.90); C103(0.98)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C324(1.01); C284(1.10); C174(1.01); C151(0.86)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C33(0.80); C263(0.99); C324(0.94); C174(1.05)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C324(0.93); C284(1.07); C174(0.97); C151(0.98)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C33(0.88); C263(1.14); C324(1.08); C174(0.96)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C33(1.15); C324(1.03); C174(1.05); C151(1.14)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C263(1.07); C324(1.11); C284(1.19); C174(0.98)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C33(0.85); C263(1.08); C324(0.95); C174(1.04)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 13.61  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C174(0.00); C263(0.00)  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C174(1.35)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C33(1.10); C263(1.02); C324(0.92); C284(0.96)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C324(0.97); C174(0.87); C151(0.80); C103(1.15)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C324(1.07); C174(0.90); C151(0.96); C356(1.03)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C33(1.08); C263(1.09); C324(0.95); C284(1.14)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C324(0.19); C284(0.95); C174(1.02); C151(0.95)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C324(0.96); C174(0.99); C151(0.92); C103(1.03)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C324(0.96); C174(0.92); C151(0.91); C356(0.91)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C33(1.03); C263(1.05); C324(0.98); C284(0.88)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C324(0.87); C284(0.86); C174(1.12); C151(1.06)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C324(0.97); C174(1.02); C151(0.97); C103(0.99)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C324(1.05); C174(1.00); C151(0.89); C356(0.94)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C33(1.27); C263(0.92); C324(0.95); C284(0.90)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C324(1.14); C284(1.28); C174(0.95); C151(1.09)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C324(0.84); C284(0.89); C174(1.08); C151(0.95)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C324(0.92); C174(0.92); C151(1.01); C103(1.10)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C324(1.21); C174(0.95); C151(0.87); C356(0.86)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C33(1.16); C263(1.10); C324(0.97); C284(0.86)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C324(0.81); C284(1.07); C174(1.09); C151(0.88)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C324(1.00); C174(1.00); C151(0.99); C103(1.19)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C324(1.00); C174(1.06); C151(1.00); C356(1.06)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C33(0.99); C263(1.16); C324(0.97); C284(1.02)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C324(0.84); C284(1.12); C174(1.23); C151(1.10)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C324(0.94); C174(0.93); C151(0.98); C103(1.08)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C33(1.01); C263(0.93); C324(1.04); C174(1.04)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C324(1.00); C174(0.98); C151(0.87); C356(1.08)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C33(1.01); C263(0.99); C324(0.98); C284(0.97)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C324(0.84); C284(0.93); C174(0.97); C151(0.93)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C324(0.89); C174(0.84); C151(0.85); C103(1.02)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C324(1.05); C174(0.89); C151(0.89); C356(0.89)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C33(0.98); C263(1.00); C324(1.09); C284(1.22)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C324(0.91); C284(0.92); C174(1.11); C151(1.00)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C324(1.00); C174(0.90); C151(1.00); C103(0.87)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C324(1.16); C174(0.99); C151(0.94); C356(1.05)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C33(1.12); C263(0.99); C324(1.11); C284(1.01)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C324(0.89); C284(1.21); C174(1.13); C151(0.95)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C324(0.89); C174(0.87); C151(0.92); C103(1.11)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C324(1.06); C174(1.09); C151(1.01); C356(1.02)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C263(0.87); C324(0.99); C284(1.15); C174(0.87)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C324(1.03); C284(1.02); C174(1.08); C151(1.09)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C263(0.90); C324(0.94); C174(0.98); C151(0.99)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C324(0.98); C284(0.95); C174(1.18); C151(1.21)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C324(1.03); C174(1.01); C151(1.17); C143(1.03)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C33(0.91); C324(1.00); C174(0.93); C151(1.06)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C324(0.96); C174(1.09); C151(0.96); C103(1.22)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C324(1.15); C284(2.10); C174(1.02); C151(1.19)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C33(1.12); C263(1.02); C324(1.06); C174(1.05)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C33(1.15); C263(1.06); C324(0.94); C284(0.89)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C324(0.95); C284(0.91); C174(1.07); C151(1.03)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C324(0.96); C174(0.91); C151(1.00); C103(1.05)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C324(1.01); C174(1.04); C151(0.97); C356(1.04)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C263(1.12); C324(1.04); C284(1.18); C174(0.96)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C324(0.98); C174(0.92); C151(0.98); C103(0.82)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C324(0.97); C284(1.00); C174(1.08); C151(1.15)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C263(1.03); C324(0.98); C174(1.03); C151(0.96)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C324(1.04); C174(1.01); C151(1.03); C143(0.97)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C33(1.05); C324(1.03); C174(0.78); C151(1.01)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C324(0.96); C174(1.02); C151(1.13); C103(1.10)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C324(1.16); C284(1.93); C174(1.04); C151(1.10)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C33(1.42); C263(1.07); C324(1.05); C174(1.01)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C33(0.97); C263(1.00); C324(0.95); C284(1.01)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C324(0.95); C174(0.83); C151(0.97); C103(1.04)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C324(1.06); C174(1.00); C151(0.99); C356(0.99)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C324(1.00); C174(1.09); C151(0.87); C356(0.90)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C263(0.83); C324(1.02); C284(1.04); C174(0.89)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C324(0.97); C284(0.95); C174(1.01); C151(1.05)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C263(1.06); C324(0.89); C174(0.99); C151(0.97)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C324(1.01); C174(1.08); C151(1.09); C143(1.07)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C33(1.07); C324(1.14); C174(0.90); C151(1.09)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C324(0.98); C174(0.97); C151(1.14); C103(0.95)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C324(1.21); C284(1.09); C174(1.06); C151(1.07)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C33(1.00); C263(1.07); C324(1.02); C174(1.12)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C33(1.16); C263(1.02); C324(0.96); C284(1.01)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C263(0.80); C324(1.15); C284(1.15); C174(0.96)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C324(0.95); C284(1.02); C174(1.00); C151(0.92)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C324(1.08); C174(1.06); C151(0.93); C356(0.96)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C263(0.77); C324(1.01); C284(0.91); C174(0.89)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C324(0.97); C284(1.01); C174(0.96); C151(0.98)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C263(0.98); C324(0.91); C174(1.05); C151(0.98)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C324(1.05); C174(1.05); C151(1.18); C143(1.06)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C33(0.91); C324(1.06); C174(1.07); C151(1.16)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C324(0.91); C174(1.00); C151(1.17); C103(1.13)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C324(1.10); C284(1.43); C174(1.13); C151(1.04)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C324(0.99); C284(1.00); C174(1.05); C151(0.95)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C33(1.02); C263(1.17); C324(1.00); C174(1.06)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C33(1.09); C263(1.09); C324(0.97); C284(1.11)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C324(0.86); C284(1.00); C174(1.24); C151(0.87)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C324(0.96); C174(0.96); C151(0.90); C103(0.96)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C324(0.98); C174(0.94); C151(1.00); C356(0.97)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C263(0.98); C324(1.05); C284(0.97); C174(0.97)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C324(0.98); C284(0.84); C174(0.99); C151(1.03)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C263(0.98); C324(0.98); C174(1.02); C151(0.84)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C324(0.97); C174(1.00); C151(1.11); C143(1.08)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C33(0.86); C324(1.04); C174(0.99); C151(1.11)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C263(0.98); C324(1.00); C174(0.98); C151(0.99)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C324(0.92); C174(1.04); C151(0.96); C103(1.11)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C324(1.10); C284(1.16); C174(1.05); C151(1.23)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C33(1.49); C263(1.03); C324(1.00); C174(1.08)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C33(1.05); C263(1.19); C324(0.97); C284(1.19)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C324(0.81); C284(1.07); C174(1.13); C151(0.93)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C324(1.05); C174(1.04); C151(0.91); C356(0.94)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C263(0.90); C324(1.12); C284(1.16); C174(0.86)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C324(1.01); C284(0.90); C174(1.03); C151(1.11)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C263(0.93); C324(1.02); C174(1.03); C151(0.96)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C324(0.96); C174(0.87); C151(0.89); C143(1.50)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C324(0.99); C174(1.05); C151(1.00); C143(1.11)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C33(1.08); C324(1.04); C174(1.08); C151(1.13)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C324(0.97); C174(1.02); C151(0.94); C103(1.04)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C324(1.12); C284(0.94); C174(1.09); C151(0.96)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C33(1.08); C263(1.10); C324(0.94); C174(1.00)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C33(1.08); C263(1.07); C324(1.03); C284(0.93)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C324(0.78); C284(1.07); C174(1.14); C151(1.01)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C324(1.07); C174(0.88); C151(1.08); C103(0.95)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C324(1.15); C174(1.02); C151(0.99); C356(1.23)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C263(0.96); C324(1.12); C284(1.12); C174(0.89)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C33(1.16); C324(1.08); C174(1.00); C151(1.15)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C324(0.95); C284(0.93); C174(1.00); C151(0.75)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C263(0.90); C324(1.00); C174(1.00); C151(0.94)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C324(1.03); C174(1.04); C151(0.92); C143(1.14)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C33(1.06); C324(0.92); C174(0.97); C151(1.13)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C324(0.97); C174(1.10); C151(0.84); C103(1.18)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C324(1.08); C284(0.75); C174(0.92); C151(0.90)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C33(1.08); C263(1.21); C324(0.97); C174(1.00)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C33(1.16); C263(0.97); C324(1.02); C284(1.07)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C324(0.92); C284(1.07); C174(1.06); C151(0.86)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C324(1.05); C174(0.90); C151(1.03); C103(1.15)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C324(0.98); C174(0.97); C151(1.01); C103(1.10)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C12(1.80); C263(1.56)  LDD1702  [3]
 LDCM0625  F8 Ramos C263(0.72)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C263(0.55)  LDD2189  [15]
 LDCM0574  Fragment12 Ramos C263(0.60)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C263(0.90)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C263(0.77)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C263(0.46)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C263(0.77)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C263(1.07)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C263(0.86)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C263(1.12)  LDD2198  [15]
 LDCM0589  Fragment31 Ramos C263(0.94)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C263(0.47)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C324(0.94); C174(0.89); C151(0.83); C103(1.08)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C263(0.69)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C263(0.57)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C324(0.97); C284(0.97); C174(1.16); C151(0.88)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C263(0.97)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C263(0.96)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C263(0.62)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C263(0.47)  LDD2188  [15]
 LDCM0107  IAA HeLa C174(0.00); C263(0.00)  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C33(0.95); C263(1.04); C174(1.10); C324(1.12)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C33(0.99); C263(1.06); C174(1.03); C324(0.95)  LDD1497  [14]
 LDCM0024  KB05 G361 C324(1.84); C68(1.33)  LDD3311  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C12(0.22)  LDD2096  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C12(0.98)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C263(0.96)  LDD2109  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C12(0.41)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C12(0.21)  LDD2124  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C12(1.87)  LDD1700  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C12(1.17)  LDD2143  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Queuine tRNA-ribosyltransferase catalytic subunit 1 (QTRT1) Queuine tRNA-ribosyltransferase family Q9BXR0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578