Details of the Target

General Information of Target

Target ID LDTP12060
Target Name Metal transporter CNNM2 (CNNM2)
Gene Name CNNM2
Gene ID 54805
Synonyms
ACDP2; Metal transporter CNNM2; Ancient conserved domain-containing protein 2; Cyclin-M2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHER
ERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEP
PPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQ
AALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVL
ALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQ
CALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLG
DSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAE
RGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT
Target Bioclass
Transporter and channel
Family
ACDP family
Subcellular location
Cell membrane
Function Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).
Uniprot ID
Q9H8M5
Ensemble ID
ENST00000369875.3
HGNC ID
HGNC:103

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.G137AfsTer107 .
C4II SNV: p.S759Ter .
CCK81 SNV: p.V687A .
CHL1 SNV: p.T479N .
EFO27 Deletion: p.Q826SfsTer12 .
HCT15 SNV: p.T850I .
HT115 SNV: p.D426N .
NCIH1155 SNV: p.A874T .
NCIH1793 SNV: p.H862Q .
RKO SNV: p.A302V .
RL952 Deletion: p.L511Ter .
SUPT1 SNV: p.C4Y .
TOV21G SNV: p.R31C; p.R36C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y588(9.60)  LDD3495  [1]
BTD
 Probe Info  		C293(0.78)  LDD2099  [2]
DBIA
 Probe Info  		C293(1.03)  LDD0532  [3]
IA-alkyne
 Probe Info  		C508(0.00); C293(0.00)  LDD0165  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [5]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
VSF
 Probe Info  		N.A.  LDD0007  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C293(0.94)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C859(1.06); C293(0.91); C508(1.09)  LDD1507  [7]
 LDCM0215  AC10 HCT 116 C293(1.03)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C293(1.08)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C293(1.52)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C293(0.83)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C293(1.09)  LDD0587  [3]
 LDCM0276  AC17 HEK-293T C859(0.98); C293(1.10); C508(1.11)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C859(1.09); C293(0.95); C508(1.04)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C859(1.14); C293(1.20)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C859(1.16); C293(0.82); C508(1.03)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C859(0.99); C293(1.14); C508(1.04)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C293(0.91)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C859(0.98); C293(0.91); C508(1.02)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C399(1.02); C293(1.03); C508(0.91)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C859(1.18); C293(0.96); C508(1.13)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C859(0.96); C293(1.14); C508(1.01)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C859(1.05); C293(0.85); C508(1.10)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C859(1.15); C293(1.10)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C859(0.95); C293(0.94); C508(0.93)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C293(1.06)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C859(1.07); C293(0.89)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C859(0.85); C293(0.97); C508(1.09)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C399(1.08); C293(0.99); C508(0.97)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C859(1.25); C293(1.03); C508(1.01)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C859(1.07); C293(0.98); C508(1.12)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C859(1.16); C293(0.77); C508(1.13)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C859(1.18); C293(0.94)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C859(0.91); C293(0.82); C508(0.99)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C293(0.97)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C859(0.86); C293(0.95); C508(1.10)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C399(1.23); C293(0.88); C508(0.99)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C859(0.98); C293(0.90); C508(1.02)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C859(1.43); C293(0.95); C508(1.06)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C859(1.10); C293(1.07); C508(1.04)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C859(1.13); C293(0.78); C508(1.06)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C859(1.03); C293(1.00)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C859(1.02); C293(0.86); C508(1.01)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C293(1.17)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C859(1.15); C293(0.97); C508(1.07)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C399(1.06); C293(0.92); C508(1.04)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C859(1.54); C293(0.96); C508(1.16)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C859(1.01); C293(1.02); C508(0.95)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C293(1.13)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C859(0.98); C293(0.90); C508(1.00)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C859(1.10); C293(0.96)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C859(0.98); C293(1.03); C508(1.03)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C293(0.99)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C859(0.86); C293(0.92); C508(1.07)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C399(1.05); C293(0.94); C508(0.97)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C859(1.21); C293(0.95); C508(1.06)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C859(1.01); C293(0.98); C508(1.05)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C859(1.05); C293(0.86); C508(0.98)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C859(1.01); C293(0.94)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C293(0.96)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C859(0.95); C293(0.96); C508(1.03)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C293(0.99)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C859(0.81); C293(0.90); C508(0.96)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C399(1.18); C293(0.93); C508(1.03)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C859(1.29); C293(0.96); C508(1.09)  LDD1567  [7]
 LDCM0334  AC7 HCT 116 C293(1.16)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C293(1.15)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C293(2.10)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C293(2.94)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C293(1.45)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C293(1.54)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C293(1.02)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C293(1.13)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C293(1.48)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C293(1.95)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C293(1.95)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C293(1.37)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C293(1.41)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C293(1.30)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C293(0.97)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C293(1.52)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C293(2.14)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C293(1.36)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C293(0.99)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C293(1.46)  LDD0592  [3]
 LDCM0367  CL1 HEK-293T C859(0.93); C293(1.01)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C859(0.96); C293(1.13); C508(1.11)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C293(0.98); C508(1.05)  LDD1573  [7]
 LDCM0370  CL101 HCT 116 C293(1.10)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C293(0.98)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C293(1.04)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C293(1.03)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C859(0.83); C293(0.82)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C293(0.96)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C859(0.86); C293(0.93)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C293(0.96); C508(1.03)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C859(0.93); C293(1.31)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C399(1.24); C293(1.12); C508(1.01)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C293(1.08)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C859(0.97); C293(1.04)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C293(0.90); C508(1.07)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C859(1.02); C293(1.14)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C293(0.94)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C859(0.97); C293(0.82)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C293(0.92); C508(1.07)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C859(1.20); C293(0.93)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C293(1.04)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C859(1.01); C293(0.95)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C859(1.21); C293(1.07); C508(1.11)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C293(0.88); C508(1.04)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C859(1.04); C293(0.98)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C293(1.05)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C859(0.88); C293(0.94)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C293(0.92); C508(1.14)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C859(1.03); C293(0.95)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C293(1.02)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C859(0.94); C293(0.84)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C293(0.98); C508(1.11)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C859(1.00); C293(0.83)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C293(1.08)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C859(0.92); C293(0.80)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C293(0.84)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C293(1.08)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C293(1.45)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C293(1.13)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C293(0.97)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C293(1.31)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C293(1.24)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C293(1.54)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C293(0.97)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C293(1.41)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C293(0.90)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C293(0.93)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C293(1.11)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C293(1.03)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C293(0.95)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C859(0.91); C293(0.77)  LDD1622  [7]
 LDCM0419  CL30 HCT 116 C293(1.19)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C859(1.00); C293(1.01)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C859(1.02); C293(1.05); C508(0.99)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C293(1.38)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C859(0.80); C293(1.14); C508(1.10)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C399(1.08); C293(1.06); C508(0.96)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C859(1.45); C293(1.13); C508(1.02)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C859(0.89); C293(1.21)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C859(0.94); C293(0.83)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C293(0.90); C508(1.13)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C293(0.92); C508(1.05)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C859(0.96); C293(1.04); C508(1.19)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C859(1.15); C293(0.97); C508(1.03)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C859(0.97); C293(1.03)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C859(0.93); C293(1.04); C508(1.04)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C293(1.14)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C859(1.05); C293(1.12); C508(1.06)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C399(0.96); C293(1.19); C508(0.93)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C859(1.21); C293(1.22); C508(1.09)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C859(1.20); C293(1.11)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C859(1.07); C293(0.92); C508(1.05)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C293(1.09)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C293(0.87); C508(1.03)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C859(0.92); C293(0.95); C508(1.13)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C859(1.02); C293(0.70); C508(1.26)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C859(1.19); C293(0.94)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C859(0.95); C293(0.89); C508(1.05)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C293(1.18)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C859(1.00); C293(1.04); C508(1.10)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C399(0.94); C293(1.04); C508(0.91)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C859(1.00); C293(0.88); C508(1.01)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C859(1.13); C293(1.02); C508(1.26)  LDD1655  [7]
 LDCM0453  CL61 HCT 116 C293(1.14)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C293(1.48)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C293(1.50)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C293(1.40)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C293(1.30)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C293(1.71)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C293(1.22)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C293(1.05)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C293(1.67)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C859(1.07); C293(0.88)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C293(1.36)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C293(1.24)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C293(1.57)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C293(1.30)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C293(1.29)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C293(1.71)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C293(0.56)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C293(0.82)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C293(1.15)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C859(1.17); C293(1.08); C508(1.34)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C293(1.02)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C293(0.61)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C293(0.92)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C293(0.91)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C293(1.21)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C293(1.54)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C293(1.20)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C293(0.89)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C293(0.85)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C293(1.74)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C293(1.13)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C293(0.80)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C859(1.11); C293(0.93)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C859(0.91); C293(0.91); C508(1.14)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C293(1.12)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C859(1.11); C293(0.97); C508(1.11)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C399(1.00); C293(1.09); C508(1.10)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C859(1.19); C293(0.96); C508(1.15)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C859(0.93); C293(1.06)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C293(0.99)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C859(0.98); C293(0.87)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C859(0.88); C293(0.87)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C293(1.32)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C293(1.03)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C293(1.01); C859(0.93)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C293(0.92); C859(1.00)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C293(0.92); C859(1.03)  LDD1502  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C293(0.78)  LDD2099  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C293(0.86)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C293(1.02)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C293(0.87)  LDD2137  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C293(0.47)  LDD2148  [2]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402