Details of the Target

General Information of Target

Target ID LDTP11955
Target Name Very long chain fatty acid elongase 6 (ELOVL6)
Gene Name ELOVL6
Gene ID 79071
Synonyms
FACE; LCE; Very long chain fatty acid elongase 6; EC 2.3.1.199; 3-keto acyl-CoA synthase ELOVL6; ELOVL fatty acid elongase 6; ELOVL FA elongase 6; Elongation of very long chain fatty acids protein 6; Fatty acid elongase 2; hELO2; Fatty acyl-CoA elongase; Long-chain fatty-acyl elongase; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASEVVCGLIFRLLLPICLAVACAFRYNGLSFVYLIYLLLIPLFSEPTKTTMQGHTGRLL
KSLCFISLSFLLLHIIFHITLVSLEAQHRIAPGYNCSTWEKTFRQIGFESLKGADAGNGI
RVFVPDIGMFIASLTIWLLCRNIVQKPVTDEAAQSNPEFENEELAEGEKIDSEEALIYEE
DFNGGDGVEGELEESTKLKMFRRLASVASKLKEFIGNMITTAGKVVVTILLGSSGMMLPS
LTSSVYFFVFLGLCTWWSWCRTFDPLLFSCLCVLLAIFTAGHLIGLYLYQFQFFQEAVPP
NDYYARLFGIKSVIQTDCSSTWKIIVNPDLSWYHHANPILLLVMYYTLATLIRIWLQEPL
VQDEGTKEEDKALACSPIQITAGRRRSLWYATHYPTDERKLLSMTQDDYKPSDGLLVTVN
GNPVDYHTIHPSLPMENGPGKADLYSTPQYRWEPSDESSEKREEEEEEKEEFEEERSREE
KRSIKVHAMVSVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYA
MISSPFMVVYGNLLLILQYIWSFELPEIKKVPGFLEKKEPGELASKILFTITFWLLLRQH
LTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQ
EEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVA
LYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLK
QFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDLKSIPSKEDNTIYRLAHPEGSLP
DLTMMHLTASLEKPEVRKLAEPGEEKLEGYSEKAQKGDLGKDSEESEEDGEEEEESEEEE
ETSDLRNKWHLVIDRLTVLFLKFLEYFHKLQVFMWWILELHIIKIVSSYIIWVSVKEVSL
FNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNEN
QTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVYLRNNLLMLAILAFEVTIYRHQEYY
RGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMD
FYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFK
GASFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVE
ICMNLDAASFSQHNPVPDFIHCRSYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGY
LVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNSCW
LIQAFSLACTVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVAD
IKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLS
LTQEPGEGQDMQKLSEEDDEREADKQKAKGKKKQWWRPWVDHASMVRSGDYYLFETDSEE
EEEEELKKEDEEPPRRSAFQFVYQAWITDPKTALRQRHKEKKRSAREERKRRRKGSKEGP
VEWEDREDEPIKKKSDGPDNIIKRIFNILKFTWVLFLATVDSFTTWLNSISREHIDISTV
LRIERCMLTREIKKGNVPTRESIHMYYQNHIMNLSRESGLDTIDEHPGAASGAQTAHRMD
SLDSHDSISSEPTQCTMLYSRQGTTETIEEVEAEQEEEAGSTAPEPREAKEYEATGYDVG
AMGAEEASLTPEEELTQFSTLDGDVEAPPSYSKAVSFEHLSFGSQDDSAGKNRMAVSPDD
SRTDKLGSSILPPLTHELTASELLLKKMFHDDELEESEKFYVGQPRFLLLFYAMYNTLVA
RSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKY
FFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWD
EDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVRRKRSG
SSSEPSQRSSFSSNRSQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFT
IKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADI
TSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPG
VTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRL
VPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVV
KYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQ
LKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHE
LLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTP
VTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKYNSEWWVLNLTGNRI
YNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEE
LPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREKTN
Target Bioclass
Enzyme
Family
ELO family, ELOVL6 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {|HAMAP-Rule:MF_03206}.
Uniprot ID
Q9H5J4
Ensemble ID
ENST00000302274.8
HGNC ID
HGNC:15829
ChEMBL ID
CHEMBL5704

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K53(1.08)  LDD0277  [1]
DBIA
 Probe Info  		C99(1.32)  LDD0532  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C99(0.95)  LDD1093  [2]
 LDCM0215  AC10 HCT 116 C99(1.32)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C99(0.57)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C99(0.59)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C99(0.59)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C99(0.61)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C99(0.58)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C99(0.56)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C99(0.61)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C99(0.55)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C99(0.58)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C99(0.65)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C99(0.91)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C99(0.68)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C99(0.65)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C99(0.61)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C99(1.07)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C99(0.75)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C99(0.68)  LDD0587  [2]
 LDCM0276  AC17 PaTu 8988t C99(0.81)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C99(0.65)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C99(0.76)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C99(0.97)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C99(0.65)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C99(0.67)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C99(0.65)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C99(0.69)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C99(0.69)  LDD1163  [2]
 LDCM0285  AC25 HCT 116 C99(1.04)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C99(0.95)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C99(0.83)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C99(0.94)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C99(0.94)  LDD0606  [2]
 LDCM0290  AC3 PaTu 8988t C99(0.91)  LDD1169  [2]
 LDCM0291  AC30 HCT 116 C99(0.92)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C99(0.81)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C99(0.88)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C99(0.82)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C99(0.78)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C99(1.24)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C99(1.14)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C99(1.05)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C99(1.08)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C99(0.99)  LDD0617  [2]
 LDCM0301  AC4 PaTu 8988t C99(0.99)  LDD1180  [2]
 LDCM0302  AC40 HCT 116 C99(1.02)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C99(1.08)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C99(1.08)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C99(1.06)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C99(1.05)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C99(1.10)  LDD0624  [2]
 LDCM0308  AC46 PaTu 8988t C99(0.88)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C99(0.80)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C99(0.80)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C99(0.67)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C99(0.82)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C99(0.73)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C99(0.23)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C99(0.71)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C99(0.67)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C99(0.69)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C99(0.78)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C99(0.55)  LDD1198  [2]
 LDCM0320  AC57 HCT 116 C99(1.10)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C99(1.12)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C99(0.91)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C99(1.28)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C99(1.04)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C99(1.19)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C99(1.12)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C99(1.10)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C99(1.01)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C99(1.45)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C99(1.45)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C99(1.33)  LDD0648  [2]
 LDCM0334  AC7 HCT 116 C99(1.12)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C99(1.12)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C99(0.88)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C99(0.84)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C99(1.16)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C99(1.08)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C99(0.97)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C99(0.80)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C99(1.05)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C99(1.03)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C99(1.14)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C99(1.14)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C99(0.87)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C99(1.93)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C99(0.85)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C99(1.27)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C99(1.10)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C99(0.64)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C99(0.63)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C99(1.27)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C99(1.02)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C99(0.92)  LDD0592  [2]
 LDCM0368  CL10 HEK-293T C99(2.31)  LDD1572  [4]
 LDCM0369  CL100 PaTu 8988t C99(0.86)  LDD1248  [2]
 LDCM0370  CL101 HCT 116 C99(0.78)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C99(0.88)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C99(0.66)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C99(0.81)  LDD0690  [2]
 LDCM0374  CL105 PaTu 8988t C99(0.79)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C99(0.73)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C99(0.91)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C99(0.73)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C99(0.68)  LDD1257  [2]
 LDCM0379  CL11 HEK-293T C99(1.45)  LDD1583  [4]
 LDCM0380  CL110 PaTu 8988t C99(0.75)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C99(0.70)  LDD1260  [2]
 LDCM0382  CL112 HCT 116 C99(1.24)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C99(0.97)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C99(0.95)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C99(0.93)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C99(0.92)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C99(1.10)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C99(1.06)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C99(1.02)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C99(1.33)  LDD1594  [4]
 LDCM0391  CL120 HCT 116 C99(1.03)  LDD0708  [2]
 LDCM0392  CL121 PaTu 8988t C99(0.85)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C99(0.77)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C99(0.74)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C99(0.81)  LDD1274  [2]
 LDCM0396  CL125 HCT 116 C99(1.26)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C99(1.30)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C99(1.31)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C99(1.14)  LDD0716  [2]
 LDCM0401  CL14 HEK-293T C99(1.07)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C99(1.65)  LDD1606  [4]
 LDCM0403  CL16 HCT 116 C99(0.90)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C99(1.64)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C99(1.07)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C99(0.75)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C99(1.31)  LDD1611  [4]
 LDCM0408  CL20 HCT 116 C99(0.85)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C99(1.26)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C99(1.14)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C99(0.95)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C99(1.13)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C99(1.05)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C99(0.97)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C99(1.05)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C99(1.06)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C99(1.02)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C99(1.08)  LDD1622  [4]
 LDCM0419  CL30 HCT 116 C99(1.04)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C99(0.83)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C99(0.72)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C99(0.59)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C99(0.68)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C99(0.59)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C99(0.70)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C99(0.76)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C99(0.67)  LDD1307  [2]
 LDCM0429  CL4 HEK-293T C99(1.23)  LDD1633  [4]
 LDCM0430  CL40 PaTu 8988t C99(0.59)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C99(0.59)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C99(0.61)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C99(0.72)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C99(0.77)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C99(0.77)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C99(0.77)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C99(0.68)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C99(0.75)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C99(0.71)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C99(1.34)  LDD1644  [4]
 LDCM0441  CL50 PaTu 8988t C99(0.78)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C99(0.79)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C99(0.67)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C99(0.66)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C99(0.69)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C99(0.82)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C99(0.16)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C99(0.62)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C99(0.66)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C99(0.66)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C99(1.66)  LDD1654  [4]
 LDCM0452  CL60 PaTu 8988t C99(0.60)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C99(1.08)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C99(0.92)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C99(0.89)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C99(0.89)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C99(0.84)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C99(0.83)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C99(0.94)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C99(0.94)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C99(0.81)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C99(1.13)  LDD1665  [4]
 LDCM0463  CL70 PaTu 8988t C99(0.80)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C99(0.90)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C99(1.20)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C99(0.97)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C99(0.97)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C99(0.89)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C99(0.81)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C99(0.76)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C99(0.85)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C99(4.44)  LDD1676  [4]
 LDCM0474  CL80 PaTu 8988t C99(0.74)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C99(0.75)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C99(0.83)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C99(0.69)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C99(0.81)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C99(0.74)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C99(0.79)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C99(0.79)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C99(0.74)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C99(0.74)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C99(1.39)  LDD1687  [4]
 LDCM0485  CL90 PaTu 8988t C99(0.74)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C99(0.94)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C99(0.95)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C99(0.85)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C99(0.83)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C99(0.82)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C99(0.93)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C99(0.91)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C99(0.83)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C99(0.93)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C99(0.89)  LDD1698  [4]
 LDCM0468  Fragment33 PaTu 8988t C99(0.84)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C99(0.55)  LDD1306  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Lymphocyte cytosolic protein 2 (LCP2) . Q13094

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402