Details of the Target

General Information of Target

Target ID LDTP11935
Target Name E3 ubiquitin-protein ligase NRDP1 (RNF41)
Gene Name RNF41
Gene ID 10193
Synonyms
FLRF; NRDP1; E3 ubiquitin-protein ligase NRDP1; EC 2.3.2.27; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPM
VLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRR
PFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAE
RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSL
GKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKR
ARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQ
ELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNG
PFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTV
LGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
Target Bioclass
Enzyme
Function
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.
Uniprot ID
Q9H4P4
Ensemble ID
ENST00000345093.9
HGNC ID
HGNC:18401

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.M100I; p.E158Ter .
MOLT4 SNV: p.R279H; p.A311V .
YSCCC SNV: p.I17M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C63(1.68)  LDD3312  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_5
 Probe Info  		C120(0.00); C116(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C83(0.82); C90(0.82)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C116(1.06); C120(0.69); C90(1.20)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C116(1.02); C120(0.77); C90(1.33)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C116(1.17); C120(0.64); C90(0.99)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C116(1.30); C120(0.74); C90(1.11)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C116(1.03); C120(0.92); C90(1.38)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C116(0.95); C120(1.00); C90(1.49)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C116(1.09); C120(0.86); C90(0.70)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C116(1.06); C120(0.64); C90(1.13)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C116(1.02); C120(1.10); C90(0.88)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C116(1.22); C120(0.79); C90(0.97)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C83(1.04); C90(1.04)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C116(1.32); C120(0.69); C90(1.32)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C116(1.71); C120(0.58); C90(1.69)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C116(1.48); C120(0.62); C90(1.48)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C120(1.04); C90(1.28)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C120(0.69); C90(1.21)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C120(0.85); C90(1.30)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C120(1.19); C90(1.09)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C120(0.86); C90(1.24)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C120(0.76); C90(1.38)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C120(0.69); C90(1.59)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C83(1.05); C90(1.05)  LDD0835  [5]
 LDCM0238  AC120 HEK-293T C120(1.00); C90(1.23)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C120(0.69); C90(1.05)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C120(0.78); C90(2.53)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C120(0.69); C90(1.95)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C120(0.80); C90(1.52)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C120(0.70); C90(1.39)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C120(0.57); C90(1.95)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C120(0.45); C90(2.69)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C120(0.75); C83(1.01); C90(0.98)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C120(0.76); C83(1.08); C90(1.09)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C120(0.89); C83(0.99); C90(0.96)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C120(1.14); C83(1.25); C90(1.25)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C120(0.90); C83(1.19); C90(1.13)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C120(0.86); C83(1.25); C90(1.10)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C120(0.84); C83(1.15); C90(1.11)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C120(0.63); C83(0.95); C90(1.02)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C120(0.71); C83(0.77); C90(0.88)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C120(0.70); C83(0.94); C90(0.98)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C120(0.72); C83(0.98); C90(0.90)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C120(0.77); C83(1.00); C90(1.09)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C83(0.95); C90(0.95)  LDD0857  [5]
 LDCM0260  AC140 HEK-293T C120(0.72); C83(1.01); C90(1.06)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C120(0.69); C83(0.91); C90(0.97)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C120(0.86); C83(0.94); C90(1.00)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C116(1.11)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C116(1.40)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C116(1.38)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C116(1.33)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C116(1.45)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C116(1.28)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C116(1.10)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C83(1.02); C90(1.02)  LDD0868  [5]
 LDCM0271  AC150 HEK-293T C116(1.20)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C116(1.24)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C116(1.19)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C116(1.26)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C116(1.15)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C116(1.25)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C116(1.41)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C116(1.60)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C116(0.98)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C116(1.03)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C116(0.97)  LDD0876  [5]
 LDCM0280  AC20 HEK-293T C116(1.17)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C116(1.14)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C116(1.22)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C116(1.13)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C116(0.98)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C116(1.16)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C116(1.28)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C116(1.05)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C116(1.26)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C116(1.08)  LDD0887  [5]
 LDCM0291  AC30 HEK-293T C116(1.07)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C116(1.08)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C116(1.06)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C116(1.01)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C116(0.97)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C116(1.01); C83(1.08); C90(1.08)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C116(0.98); C83(0.77); C90(0.77)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C116(1.12); C83(0.71); C90(0.71)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C116(1.23); C83(0.97); C90(0.97)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C116(1.05); C83(0.76); C90(0.76)  LDD0898  [5]
 LDCM0302  AC40 HEK-293T C116(1.22); C83(0.94); C90(0.94)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C116(1.47); C83(0.95); C90(0.95)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C116(1.36); C83(1.00); C90(1.00)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C116(1.11); C83(1.22); C90(1.22)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C116(1.01); C83(1.03); C90(1.03)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C116(1.01); C83(0.83); C90(0.83)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C83(1.25); C90(1.04)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C83(1.00); C90(0.92)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C83(1.07); C90(0.89)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C83(0.95); C90(0.94)  LDD0909  [5]
 LDCM0313  AC50 HEK-293T C83(1.00); C90(0.91)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C83(0.93); C90(1.03)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C83(1.02); C90(1.04)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C83(0.95); C90(1.08)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C83(1.30); C90(1.17)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C83(0.73); C90(0.91)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C83(1.12); C90(1.05)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C116(1.10)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C116(0.96)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C116(1.13)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C83(0.89); C90(0.89)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C116(0.94)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C116(1.09)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C116(0.95)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C116(1.05)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C116(1.01)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C116(1.03)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C116(0.90)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C116(1.05)  LDD0929  [5]
 LDCM0334  AC7 HEK-293T C83(0.91); C90(0.91)  LDD0932  [5]
 LDCM0345  AC8 HEK-293T C83(0.93); C90(0.93)  LDD0943  [5]
 LDCM0349  AC83 HEK-293T C83(0.83); C90(0.88)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C83(0.77); C90(1.04)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C83(0.98); C90(1.09)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C83(0.91); C90(0.99)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C83(0.91); C90(1.02)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C83(0.78); C90(1.00)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C83(0.84); C90(1.05)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C83(0.88); C90(1.16)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C83(1.23); C90(1.20)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C83(1.03); C90(1.08)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C83(0.84); C90(0.97)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C83(0.98); C90(1.10)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C83(0.96); C90(1.12)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C83(0.99); C90(1.08)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C83(0.86); C90(1.71)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C116(1.14); C120(0.86); C90(0.79)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C116(0.97); C120(0.76); C90(1.18)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C83(0.97); C90(0.97)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C83(0.85); C90(0.85)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C83(0.80); C90(0.80)  LDD0873  [5]
 LDCM0020  ARS-1620 HCC44 C83(1.27); C90(1.27)  LDD2171  [5]
 LDCM0367  CL1 HEK-293T C83(1.01); C90(1.01)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C83(1.09); C90(1.09)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C134(0.93)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C83(0.92); C90(0.92)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C83(0.90); C90(0.90)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C83(0.94); C90(0.94)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C83(0.98); C90(0.98)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C116(0.96)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C116(1.10)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C116(1.06)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C116(1.10)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C116(1.00)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C83(0.78); C90(0.78)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C116(1.09)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C116(0.91)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C116(1.10)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C116(1.20)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C116(1.20)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C116(1.18)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C116(1.24)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C116(1.01); C83(1.05); C90(1.05)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C116(1.05); C83(0.99); C90(0.99)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C116(1.14); C83(0.86); C90(0.86)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C83(0.83); C90(0.83)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C116(1.10); C83(1.07); C90(1.07)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C83(0.95); C90(1.01)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C83(0.84); C90(0.96)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C83(1.24); C90(1.33)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C83(1.00); C90(0.95)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C116(1.09)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C116(1.20)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C116(0.94)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C116(1.02)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C83(0.67); C90(0.67)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C83(0.90); C90(0.90)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C83(0.94); C90(0.94)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C134(1.02)  LDD1607  [6]
 LDCM0407  CL2 HEK-293T C83(0.90); C90(0.90)  LDD1005  [5]
 LDCM0413  CL25 HEK-293T C238(0.98)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C134(1.01)  LDD1618  [6]
 LDCM0416  CL28 HEK-293T C134(1.07)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C83(0.79); C90(0.79)  LDD1016  [5]
 LDCM0426  CL37 HEK-293T C238(1.13)  LDD1630  [6]
 LDCM0429  CL4 HEK-293T C83(0.69); C90(0.69)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C134(0.93)  LDD1634  [6]
 LDCM0436  CL46 HEK-293T C116(1.06); C120(0.86); C83(1.03); C90(1.36)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C116(1.03); C120(0.70); C83(1.29); C90(1.40)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C116(1.03); C120(0.56); C83(0.88); C90(1.06)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C116(1.03); C120(0.71); C83(1.14); C90(1.12)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C83(0.94); C90(0.94)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C116(1.01); C120(0.74); C83(1.17); C90(1.33)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C116(0.98); C120(0.64); C83(0.99); C90(1.37)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C116(0.78); C120(0.78); C83(1.39); C90(1.17)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C116(0.93); C120(0.66); C83(0.91); C90(0.99)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C116(0.89); C120(0.52); C83(1.10); C90(1.23)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C116(0.92); C120(0.60); C83(0.96); C90(1.10)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C116(0.96); C120(0.56); C83(0.98); C90(1.08)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C116(1.00); C120(0.85); C83(0.87); C90(1.36)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C116(0.87); C120(0.67); C83(1.39); C90(1.11)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C116(1.11); C120(0.56); C83(1.00); C90(1.02)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C83(0.89); C90(0.89)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C116(1.13); C120(0.64); C83(0.87); C90(1.48)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C238(1.07)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C134(1.01)  LDD1657  [6]
 LDCM0456  CL64 HEK-293T C134(0.97)  LDD1659  [6]
 LDCM0462  CL7 HEK-293T C83(1.00); C90(1.00)  LDD1060  [5]
 LDCM0466  CL73 HEK-293T C238(0.97)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C134(1.01)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C134(1.09)  LDD1672  [6]
 LDCM0473  CL8 HEK-293T C83(1.00); C90(1.00)  LDD1071  [5]
 LDCM0479  CL85 HEK-293T C238(0.98)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C134(0.94)  LDD1683  [6]
 LDCM0482  CL88 HEK-293T C134(0.94)  LDD1685  [6]
 LDCM0484  CL9 HEK-293T C83(0.98); C90(0.98)  LDD1082  [5]
 LDCM0492  CL97 HEK-293T C238(1.13)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C134(0.90)  LDD1696  [6]
 LDCM0427  Fragment51 HEK-293T C134(1.04)  LDD1631  [6]
 LDCM0022  KB02 697 C63(1.11)  LDD2245  [1]
 LDCM0023  KB03 697 C63(1.26)  LDD2662  [1]
 LDCM0024  KB05 HMCB C63(1.68)  LDD3312  [1]
 LDCM0021  THZ1 HCT 116 C83(1.27); C90(1.27)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Replication factor C subunit 4 (RFC4) Activator 1 small subunits family P35249
Enolase-phosphatase E1 (ENOPH1) MasA/MtnC family Q9UHY7
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) Ribonucleoside diphosphate reductase small chain family Q7LG56
Serine racemase (SRR) Serine/threonine dehydratase family Q9GZT4
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
E3 ubiquitin-protein ligase NRDP1 (RNF41) . Q9H4P4
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 6 (ASB6) Ankyrin SOCS box (ASB) family Q9NWX5
Iron-sulfur cluster assembly 2 homolog, mitochondrial (ISCA2) HesB/IscA family Q86U28
Homer protein homolog 2 (HOMER2) Homer family Q9NSB8
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Maturin (MTURN) MTURN family Q8N3F0
NEDD4-binding protein 3 (N4BP3) N4BP3 family O15049
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Tetratricopeptide repeat protein 1 (TTC1) . Q99614

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402