General Information of Target

Target ID LDTP11791
Target Name Protein-serine O-palmitoleoyltransferase porcupine (PORCN)
Gene Name PORCN
Gene ID 64840
Synonyms
MG61; PORC; PPN; Protein-serine O-palmitoleoyltransferase porcupine; EC 2.3.1.250; Protein MG61
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Membrane-bound acyltransferase family, Porcupine subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
TTD ID
T79747
Uniprot ID
Q9H237
DrugMap ID
TTNFBTO
Ensemble ID
ENST00000326194.11
HGNC ID
HGNC:17652
ChEMBL ID
CHEMBL1255163

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R243Ter DBIA    Probe Info 
JURKAT SNV: p.H341Y .
OVK18 SNV: p.V180I .
RL952 SNV: p.L202M .
SKNSH SNV: p.R195L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C375(2.16)  LDD3331  [1]
IPM
 Probe Info 
N.A.  LDD0005  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C381(0.35); C385(0.84)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C381(1.03); C385(1.78)  LDD0813  [3]
 LDCM0226  AC11 HEK-293T C381(1.24); C385(1.17)  LDD0824  [3]
 LDCM0237  AC12 HEK-293T C381(0.87); C385(1.14)  LDD0835  [3]
 LDCM0246  AC128 HEK-293T C381(0.70); C385(1.01)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C381(0.59); C385(1.03)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C381(0.60); C385(1.05)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C381(0.71); C385(1.09)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C381(0.64); C385(1.09)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C381(0.59); C385(1.36)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C381(0.65); C385(1.08)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C381(0.61); C385(1.42)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C381(0.55); C385(1.49)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C381(0.51); C385(1.30)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C381(0.45); C385(1.86)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C381(0.49); C385(1.61)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C381(0.75); C385(1.78)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C381(0.42); C385(1.36)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C381(0.38); C385(1.52)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C381(0.58); C385(1.49)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C385(1.46)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C385(1.55)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C385(0.91)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C385(1.21)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C385(1.15)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C385(1.08)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C385(1.17)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C381(0.63); C385(1.36)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C385(2.03)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C385(1.16)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C385(1.43)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C385(1.14)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C385(0.78)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C385(1.19)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C385(2.20)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C385(1.45)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C375(0.92)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C375(0.92)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C375(1.01)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C381(0.65); C385(1.35)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C375(0.97)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C375(0.91)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C375(0.91); C385(0.92)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C375(0.94)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C375(1.15); C385(1.05)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C375(0.94)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C375(0.93)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C375(1.00)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C375(1.03)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C375(1.01)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C381(1.03); C385(1.10)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C375(0.99); C385(0.93)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C375(0.88)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C375(1.24); C385(0.96)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C375(0.87)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C375(0.96)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C375(0.94)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C375(0.85)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C375(0.93)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C375(0.95); C385(1.08)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C375(0.85)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C381(0.93); C385(1.16)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C375(1.08); C385(0.93)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C375(0.86)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C375(0.84)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C375(0.94)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C375(0.91)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C375(0.89)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C375(0.92); C385(0.93)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C375(0.87)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C375(1.00); C385(1.01)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C375(0.86)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C381(0.72); C385(0.87)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C375(0.91)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C375(0.97)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C375(0.93)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C375(0.92)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C375(0.94); C385(0.96)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C375(0.86)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C375(1.02); C385(1.01)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C385(0.81)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C385(0.81)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C385(0.95)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C381(1.20); C385(1.17)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C385(0.87)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C385(1.37)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C385(0.95)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C385(0.83)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C385(0.88)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C385(1.16)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C385(0.93)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C385(1.15)  LDD0929  [3]
 LDCM0334  AC7 HEK-293T C381(0.86); C385(1.67)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C381(0.52); C385(1.36)  LDD0943  [3]
 LDCM0248  AKOS034007472 HEK-293T C381(1.13); C385(1.00)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C381(0.59); C385(1.27)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C381(0.71); C385(1.22)  LDD0873  [3]
 LDCM0367  CL1 HEK-293T C381(0.79)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C381(0.35)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C381(0.57); C385(1.00)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C381(0.63); C385(2.28)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C381(0.79); C385(1.25)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C381(0.77); C385(1.49)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C381(0.59); C385(1.69)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C375(0.87)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C375(0.93)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C375(0.99)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C375(0.92)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C375(0.88)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C381(0.35)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C375(0.92)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C375(0.96)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C375(0.99)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C375(0.89)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C375(0.77)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C375(0.91)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C375(0.92)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C375(0.86)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C375(0.88)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C375(1.03)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C381(0.43)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C375(1.00)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C375(0.92)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C375(0.81)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C375(0.96)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C375(0.94)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C385(0.80)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C385(0.87)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C385(0.74)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C385(0.83)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C381(0.61)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C381(0.42)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C381(0.49)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C381(1.03)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C381(1.19)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C381(0.85)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C381(0.86)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C381(0.56)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C381(0.96)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C381(0.86)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C381(1.01)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C381(1.61)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C381(0.98)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C381(0.89)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C381(0.93)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C381(1.00)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C381(1.03)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C381(1.27)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C381(0.66)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C381(0.82)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C375(0.98)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C375(0.91)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C375(1.10)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C375(1.05); C385(1.18)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C375(1.05)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C375(1.25); C385(1.25)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C375(1.01)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C375(0.97)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C381(0.53)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C375(1.03)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C375(0.94)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C375(0.96)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C375(0.97)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C375(1.00)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C375(0.95)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C381(0.86)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C381(0.98)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C381(0.98)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C381(0.95)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C381(0.49)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C381(0.94)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C381(0.80)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C381(1.08)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C381(1.03)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C381(0.92)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C381(0.78)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C381(1.11)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C381(0.74)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C381(0.88)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C381(0.84)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C381(0.76)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C381(0.66)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C381(0.68)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C381(0.59)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C381(0.48)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C381(0.88)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C381(0.47)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C381(0.59)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C381(0.60)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C381(0.43)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C381(0.75)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C381(0.50)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C381(0.66)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C381(0.62)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C381(0.75)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C381(0.62)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C381(0.27)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C375(0.98)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C375(0.93)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C375(0.90)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C375(1.01)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C381(1.82)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C375(0.99)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C375(0.97)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C375(1.05); C385(1.30)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C375(0.90)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C375(1.10); C385(1.21)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C375(1.06)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C375(0.92)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C375(0.95)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C375(1.04)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C375(0.96)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C381(1.49)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C375(1.02)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C381(0.79); C385(0.85)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C381(0.57); C385(0.81)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C381(0.89); C385(1.03)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C381(0.53); C385(1.24)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C381(0.55); C385(1.43)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C381(0.56); C385(1.00)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C381(0.76); C385(1.16)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C381(0.95); C385(1.04)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C381(0.81); C385(1.36)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C375(0.90)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C381(0.26)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C375(0.95)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C375(0.96)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C375(0.93)  LDD1497  [4]
 LDCM0024  KB05 MKN-1 C375(2.16)  LDD3331  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-IV (APOC4) Apolipoprotein C4 family P55056

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lgk974 Small molecular drug D0J5HR
Etc-1922159 . D05FKU

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402