Details of the Target

General Information of Target

Target ID LDTP11283
Target Name Kinesin-like protein KIFC3 (KIFC3)
Gene Name KIFC3
Gene ID 3801
Synonyms
Kinesin-like protein KIFC3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEP
ALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALH
EQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGE
AFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETD
RHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLD
PGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEK
TQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFL
DYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Subcellular location
Cell junction, adherens junction
Function Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.
Uniprot ID
Q9BVG8
Ensemble ID
ENST00000379655.8
HGNC ID
HGNC:6326
ChEMBL ID
CHEMBL1075119

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C682(3.62)  LDD3346  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [3]
IPM
 Probe Info  		C84(0.00); C66(0.00)  LDD0147  [4]
TFBX
 Probe Info  		C84(0.00); C153(0.00); C435(0.00)  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C168(2.54); C171(2.54)  LDD1093  [5]
 LDCM0215  AC10 PaTu 8988t C168(1.03); C171(1.03)  LDD1094  [5]
 LDCM0216  AC100 PaTu 8988t C168(1.22); C171(1.22)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C168(0.96); C171(0.96)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C168(1.35); C171(1.35)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C168(1.08); C171(1.08)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C168(0.98); C171(0.98)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C168(1.03); C171(1.03)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C168(1.17); C171(1.17)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C168(1.15); C171(1.15)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C168(1.09); C171(1.09)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C168(0.95); C171(0.95)  LDD1104  [5]
 LDCM0226  AC11 PaTu 8988t C168(0.89); C171(0.89)  LDD1105  [5]
 LDCM0227  AC110 PaTu 8988t C168(1.28); C171(1.28)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C168(1.14); C171(1.14)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C168(1.17); C171(1.17)  LDD1108  [5]
 LDCM0230  AC113 PaTu 8988t C168(0.98); C171(0.98)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C168(0.96); C171(0.96)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C168(1.28); C171(1.28)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C168(0.81); C171(0.81)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C168(1.11); C171(1.11)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C168(0.87); C171(0.87)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C168(0.81); C171(0.81)  LDD1115  [5]
 LDCM0237  AC12 PaTu 8988t C168(1.10); C171(1.10)  LDD1116  [5]
 LDCM0238  AC120 PaTu 8988t C168(0.71); C171(0.71)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C168(1.09); C171(1.09)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C168(0.93); C171(0.93)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C168(0.80); C171(0.80)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C168(1.01); C171(1.01)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C168(1.06); C171(1.06)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C168(1.07); C171(1.07)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C168(0.83); C171(0.83)  LDD1124  [5]
 LDCM0246  AC128 PaTu 8988t C168(1.68); C171(1.68)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C168(1.28); C171(1.28)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C168(1.13); C171(1.13)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C168(1.21); C171(1.21)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C168(1.11); C171(1.11)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C168(1.43); C171(1.43)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C168(1.27); C171(1.27)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C168(1.15); C171(1.15)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C168(1.19); C171(1.19)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C168(1.48); C171(1.48)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C168(1.50); C171(1.50)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C168(1.29); C171(1.29)  LDD1137  [5]
 LDCM0259  AC14 PaTu 8988t C168(1.02); C171(1.02)  LDD1138  [5]
 LDCM0260  AC140 PaTu 8988t C168(1.78); C171(1.78)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C168(1.19); C171(1.19)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C168(1.29); C171(1.29)  LDD1141  [5]
 LDCM0270  AC15 PaTu 8988t C168(1.11); C171(1.11)  LDD1149  [5]
 LDCM0276  AC17 PaTu 8988t C168(1.01); C171(1.01)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C168(1.02); C171(1.02)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C168(0.91); C171(0.91)  LDD1157  [5]
 LDCM0279  AC2 PaTu 8988t C168(1.29); C171(1.29)  LDD1158  [5]
 LDCM0280  AC20 PaTu 8988t C168(0.94); C171(0.94)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C168(1.16); C171(1.16)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C168(1.04); C171(1.04)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C168(1.07); C171(1.07)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C168(1.11); C171(1.11)  LDD1163  [5]
 LDCM0285  AC25 PaTu 8988t C168(1.38); C171(1.38)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C168(1.16); C171(1.16)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C168(0.94); C171(0.94)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C168(1.11); C171(1.11)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C168(1.20); C171(1.20)  LDD1168  [5]
 LDCM0290  AC3 PaTu 8988t C168(1.20); C171(1.20)  LDD1169  [5]
 LDCM0291  AC30 PaTu 8988t C168(0.98); C171(0.98)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C168(1.06); C171(1.06)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C168(1.04); C171(1.04)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C168(1.06); C171(1.06)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C168(0.97); C171(0.97)  LDD1174  [5]
 LDCM0296  AC35 PaTu 8988t C168(0.89); C171(0.89)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C168(0.81); C171(0.81)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C168(1.11); C171(1.11)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C168(1.02); C171(1.02)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C168(0.86); C171(0.86)  LDD1179  [5]
 LDCM0301  AC4 PaTu 8988t C168(1.17); C171(1.17)  LDD1180  [5]
 LDCM0302  AC40 PaTu 8988t C168(0.83); C171(0.83)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C168(0.92); C171(0.92)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C168(1.03); C171(1.03)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C168(0.96); C171(0.96)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C168(1.00); C171(1.00)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C168(1.00); C171(1.00)  LDD1186  [5]
 LDCM0308  AC46 PaTu 8988t C168(1.02); C171(1.02)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C168(1.25); C171(1.25)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C168(1.13); C171(1.13)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C168(1.02); C171(1.02)  LDD1190  [5]
 LDCM0312  AC5 PaTu 8988t C168(1.80); C171(1.80)  LDD1191  [5]
 LDCM0313  AC50 PaTu 8988t C168(1.17); C171(1.17)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C168(0.61); C171(0.61)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C168(1.11); C171(1.11)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C168(1.00); C171(1.00)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C168(1.34); C171(1.34)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C168(1.25); C171(1.25)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C168(1.69); C171(1.69)  LDD1198  [5]
 LDCM0320  AC57 PaTu 8988t C168(0.76); C171(0.76)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C168(0.75); C171(0.75)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C168(0.70); C171(0.70)  LDD1201  [5]
 LDCM0323  AC6 PaTu 8988t C168(1.05); C171(1.05)  LDD1202  [5]
 LDCM0324  AC60 PaTu 8988t C168(0.71); C171(0.71)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C168(0.76); C171(0.76)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C168(0.87); C171(0.87)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C168(0.75); C171(0.75)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C168(0.72); C171(0.72)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C168(0.85); C171(0.85)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C168(0.85); C171(0.85)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C168(0.74); C171(0.74)  LDD1210  [5]
 LDCM0334  AC7 PaTu 8988t C168(1.01); C171(1.01)  LDD1213  [5]
 LDCM0345  AC8 PaTu 8988t C168(1.12); C171(1.12)  LDD1224  [5]
 LDCM0349  AC83 PaTu 8988t C168(0.85); C171(0.85)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C168(0.90); C171(0.90)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C168(1.04); C171(1.04)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C168(1.19); C171(1.19)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C168(0.93); C171(0.93)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C168(0.85); C171(0.85)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C168(0.93); C171(0.93)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C168(1.11); C171(1.11)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C168(1.03); C171(1.03)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C168(0.90); C171(0.90)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C168(0.86); C171(0.86)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C168(0.87); C171(0.87)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C168(0.84); C171(0.84)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C168(0.83); C171(0.83)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C168(1.07); C171(1.07)  LDD1243  [5]
 LDCM0365  AC98 PaTu 8988t C168(1.11); C171(1.11)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C168(0.94); C171(0.94)  LDD1245  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C168(1.17); C171(1.17)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C168(0.99); C171(0.99)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C168(1.09); C171(1.09)  LDD1154  [5]
 LDCM0020  ARS-1620 HCC44 C168(1.13); C171(1.13)  LDD2171  [5]
 LDCM0367  CL1 PaTu 8988t C168(1.01); C171(1.01)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C168(0.92); C171(0.92)  LDD1247  [5]
 LDCM0369  CL100 PaTu 8988t C168(1.60); C171(1.60)  LDD1248  [5]
 LDCM0370  CL101 PaTu 8988t C168(1.32); C171(1.32)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C168(0.97); C171(0.97)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C168(1.10); C171(1.10)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C168(0.94); C171(0.94)  LDD1252  [5]
 LDCM0374  CL105 PaTu 8988t C168(1.05); C171(1.05)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C168(0.90); C171(0.90)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C168(1.44); C171(1.44)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C168(1.01); C171(1.01)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C168(0.98); C171(0.98)  LDD1257  [5]
 LDCM0379  CL11 PaTu 8988t C168(0.86); C171(0.86)  LDD1258  [5]
 LDCM0380  CL110 PaTu 8988t C168(1.07); C171(1.07)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C168(1.05); C171(1.05)  LDD1260  [5]
 LDCM0382  CL112 PaTu 8988t C168(0.82); C171(0.82)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C168(0.94); C171(0.94)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C168(1.49); C171(1.49)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C168(1.04); C171(1.04)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C168(1.04); C171(1.04)  LDD1265  [5]
 LDCM0387  CL117 PaTu 8988t C168(0.93); C171(0.93)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C168(1.12); C171(1.12)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C168(0.88); C171(0.88)  LDD1268  [5]
 LDCM0390  CL12 PaTu 8988t C168(0.93); C171(0.93)  LDD1269  [5]
 LDCM0391  CL120 PaTu 8988t C168(0.85); C171(0.85)  LDD1270  [5]
 LDCM0392  CL121 PaTu 8988t C168(1.72); C171(1.72)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C168(1.25); C171(1.25)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C168(1.47); C171(1.47)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C168(1.15); C171(1.15)  LDD1274  [5]
 LDCM0396  CL125 PaTu 8988t C168(0.91); C171(0.91)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C168(0.97); C171(0.97)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C168(0.80); C171(0.80)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C168(0.81); C171(0.81)  LDD1278  [5]
 LDCM0400  CL13 PaTu 8988t C168(1.13); C171(1.13)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C168(1.10); C171(1.10)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C168(1.15); C171(1.15)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C168(0.92); C171(0.92)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C168(1.50); C171(1.50)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C168(1.03); C171(1.03)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C168(0.78); C171(0.78)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C168(0.86); C171(0.86)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C168(0.86); C171(0.86)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C168(1.33); C171(1.33)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C168(0.78); C171(0.78)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C168(0.79); C171(0.79)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C168(0.73); C171(0.73)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C168(0.96); C171(0.96)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C168(1.34); C171(1.34)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C168(0.79); C171(0.79)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C168(0.90); C171(0.90)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C168(0.82); C171(0.82)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C168(1.03); C171(1.03)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C168(0.65); C171(0.65)  LDD1298  [5]
 LDCM0420  CL31 PaTu 8988t C168(0.97); C171(0.97)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C168(0.93); C171(0.93)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C168(1.16); C171(1.16)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C168(1.23); C171(1.23)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C168(1.02); C171(1.02)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C168(1.26); C171(1.26)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C168(0.99); C171(0.99)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C168(0.99); C171(0.99)  LDD1307  [5]
 LDCM0429  CL4 PaTu 8988t C168(0.99); C171(0.99)  LDD1308  [5]
 LDCM0430  CL40 PaTu 8988t C168(0.99); C171(0.99)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C168(1.29); C171(1.29)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C168(1.32); C171(1.32)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C168(1.27); C171(1.27)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C168(1.08); C171(1.08)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C168(1.29); C171(1.29)  LDD1314  [5]
 LDCM0436  CL46 PaTu 8988t C168(0.85); C171(0.85)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C168(0.99); C171(0.99)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C168(1.14); C171(1.14)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C168(0.73); C171(0.73)  LDD1318  [5]
 LDCM0440  CL5 PaTu 8988t C168(0.71); C171(0.71)  LDD1319  [5]
 LDCM0441  CL50 PaTu 8988t C168(1.04); C171(1.04)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C168(1.04); C171(1.04)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C168(0.89); C171(0.89)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C168(1.24); C171(1.24)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C168(1.23); C171(1.23)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C168(0.96); C171(0.96)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C168(0.47); C171(0.47)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C168(1.60); C171(1.60)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C168(1.33); C171(1.33)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C168(1.20); C171(1.20)  LDD1329  [5]
 LDCM0451  CL6 PaTu 8988t C168(0.67); C171(0.67)  LDD1330  [5]
 LDCM0452  CL60 PaTu 8988t C168(1.06); C171(1.06)  LDD1331  [5]
 LDCM0453  CL61 PaTu 8988t C168(1.20); C171(1.20)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C168(1.00); C171(1.00)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C168(1.13); C171(1.13)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C168(1.17); C171(1.17)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C168(1.09); C171(1.09)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C168(1.30); C171(1.30)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C168(0.86); C171(0.86)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C168(1.07); C171(1.07)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C168(1.14); C171(1.14)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C168(0.69); C171(0.69)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C168(1.02); C171(1.02)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C168(1.19); C171(1.19)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C168(0.99); C171(0.99)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C168(1.05); C171(1.05)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C168(1.35); C171(1.35)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C168(1.10); C171(1.10)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C168(1.55); C171(1.55)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C168(1.04); C171(1.04)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C168(1.21); C171(1.21)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C168(0.73); C171(0.73)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C168(0.97); C171(0.97)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C168(1.21); C171(1.21)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C168(1.17); C171(1.17)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C168(1.17); C171(1.17)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C168(0.96); C171(0.96)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C168(1.06); C171(1.06)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C168(1.12); C171(1.12)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C168(1.06); C171(1.06)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C168(1.22); C171(1.22)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C168(1.26); C171(1.26)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C168(0.86); C171(0.86)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C168(1.27); C171(1.27)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C168(1.67); C171(1.67)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C168(1.28); C171(1.28)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C168(1.25); C171(1.25)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C168(1.46); C171(1.46)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C168(2.14); C171(2.14)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C168(1.73); C171(1.73)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C168(1.51); C171(1.51)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C168(1.65); C171(1.65)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C168(1.66); C171(1.66)  LDD1373  [5]
 LDCM0468  Fragment33 PaTu 8988t C168(0.99); C171(0.99)  LDD1347  [5]
 LDCM0427  Fragment51 PaTu 8988t C168(1.73); C171(1.73)  LDD1306  [5]
 LDCM0022  KB02 786-O C682(1.93)  LDD2247  [1]
 LDCM0023  KB03 MDA-MB-231 C84(0.10)  LDD1701  [6]
 LDCM0024  KB05 NCI-H1666 C682(3.62)  LDD3346  [1]
 LDCM0021  THZ1 HCT 116 C168(1.13); C171(1.13)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
DNA replication licensing factor MCM7 (MCM7) MCM family P33993
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
GTPase HRas (HRAS) Ras family P01112
GTP-binding protein GEM (GEM) RGK family P55040
Helicase ARIP4 (RAD54L2) SNF2/RAD54 helicase family Q9Y4B4
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Tripartite motif-containing protein 14 (TRIM14) TRIM/RBCC family Q14142
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
BRCA1-associated RING domain protein 1 (BARD1) . Q99728
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
E3 ubiquitin-protein ligase FANCL (FANCL) . Q9NW38
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
pre-mRNA splicing regulator USH1G (USH1G) . Q495M9
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Syntaxin-1A (STX1A) Syntaxin family Q16623
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Transcription factor
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fos-related antigen 1 (FOSL1) BZIP family P15407
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 180 (ZNF180) Krueppel C2H2-type zinc-finger protein family Q9UJW8
Zinc finger protein 20 (ZNF20) Krueppel C2H2-type zinc-finger protein family P17024
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 785 (ZNF785) Krueppel C2H2-type zinc-finger protein family A8K8V0
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Estrogen-related receptor gamma (ESRRG) Nuclear hormone receptor family P62508
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
B-cell lymphoma 6 protein (BCL6) . P41182
High mobility group protein 20A (HMG20A) . Q9NP66
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Transcription factor LBX1 (LBX1) . P52954
Transcription factor SOX-5 (SOX5) . P35711
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 113 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Abl interactor 2 (ABI2) ABI family Q9NYB9
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Bystin (BYSL) Bystin family Q13895
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cep170-like protein (CEP170P1) CEP170 family Q96L14
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Conserved oligomeric Golgi complex subunit 7 (COG7) COG7 family P83436
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
G1/S-specific cyclin-D3 (CCND3) Cyclin family P30281
Guanine nucleotide exchange factor MSS4 (RABIF) DSS4/MSS4 family P47224
Dynactin subunit 2 (DCTN2) Dynactin subunit 2 family Q13561
Dysbindin (DTNBP1) Dysbindin family Q96EV8
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Protein FAM124A (FAM124A) FAM124 family Q86V42
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Protein fem-1 homolog A (FEM1A) Fem-1 family Q9BSK4
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Heat shock factor-binding protein 1 (HSBP1) HSBP1 family O75506
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha2 (KRT32) Intermediate filament family Q14532
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 14 (KRT14) Intermediate filament family P02533
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type I cytoskeletal 18 (KRT18) Intermediate filament family P05783
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 26 (KRT26) Intermediate filament family Q7Z3Y9
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Keratin, type II cytoskeletal 3 (KRT3) Intermediate filament family P12035
Keratin, type II cytoskeletal 5 (KRT5) Intermediate filament family P13647
Keratin, type II cytoskeletal 6A (KRT6A) Intermediate filament family P02538
Keratin, type II cytoskeletal 6B (KRT6B) Intermediate filament family P04259
Keratin, type II cytoskeletal 6C (KRT6C) Intermediate filament family P48668
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Peripherin (PRPH) Intermediate filament family P41219
Vimentin (VIM) Intermediate filament family P08670
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Colorectal mutant cancer protein (MCC) MCC family P23508
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Prefoldin subunit 6 (PFDN6) Prefoldin subunit beta family O15212
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
Spermatogenesis-associated protein 2 (SPATA2) SPATA2 family Q9UM82
Stathmin-3 (STMN3) Stathmin family Q9NZ72
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Synaptonemal complex central element protein 2 (SYCE2) SYCE family Q6PIF2
Syntaxin-11 (STX11) Syntaxin family O75558
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Troponin I, slow skeletal muscle (TNNI1) Troponin I family P19237
Pre-rRNA-processing protein TSR2 homolog (TSR2) TSR2 family Q969E8
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Ankyrin repeat domain-containing protein 23 (ANKRD23) . Q86SG2
Axin-2 (AXIN2) . Q9Y2T1
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
CAP-Gly domain-containing linker protein 4 (CLIP4) . Q8N3C7
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Centromere protein R (ITGB3BP) . Q13352
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
Coiled-coil domain-containing protein 28A (CCDC28A) . Q8IWP9
DCC-interacting protein 13-beta (APPL2) . Q8NEU8
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
F-BAR and double SH3 domains protein 2 (FCHSD2) . O94868
FLYWCH-type zinc finger-containing protein 1 (FLYWCH1) . Q4VC44
Golgin subfamily A member 1 (GOLGA1) . Q92805
Heat shock factor 2-binding protein (HSF2BP) . O75031
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Islet cell autoantigen 1-like protein (ICA1L) . Q8NDH6
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Nebulette (NEBL) . O76041
Neuronal migration protein doublecortin (DCX) . O43602
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Protein lin-37 homolog (LIN37) . Q96GY3
Protein moonraker (KIAA0753) . Q2KHM9
RNA-binding protein 41 (RBM41) . Q96IZ5
Sciellin (SCEL) . O95171
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Transcription elongation factor A N-terminal and central domain-containing protein (TCEANC) . Q8N8B7
Vinexin (SORBS3) . O60504

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761