Details of the Target

General Information of Target

Target ID LDTP11195
Target Name RNA-binding protein 42 (RBM42)
Gene Name RBM42
Gene ID 79171
Synonyms
RNA-binding protein 42; RNA-binding motif protein 42
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLPPPDRRHVCLTTLVIMGSMAVMDAYLVEQNQGPRKIGVCIIVLVGDVCFLLVLRYVA
VWVGAEVRTAKRGYAMILWFLYIFVLEIKLYFIFQNYKAARRGAADPVARKALTLLLSVC
VPGLFLLLVALDRMEYVRTFRKREDLRGRLFWVALDLLDLLDMQASLWEPPRSGLPLWAE
GLTFFYCYMLLLVLPCVALSEVSMQGEHIAPQKMMLYPVLSLATVNVVAVLARAANMALF
RDSRVSAIFVGKNVVALATKACTFLEYRRQVRDFPPPALSLELQPPPPQRNSVPPPPPPL
HGPPGRPHMSSPTRDPLDT
Target Bioclass
Other
Family
RRM RBM42 family
Subcellular location
Nucleus
Function Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA.
Uniprot ID
Q9BTD8
Ensemble ID
ENST00000262633.9
HGNC ID
HGNC:28117

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A213D .
HT115 SNV: p.E316A .
HUH7 SNV: p.G478C .
Ishikawa (Heraklio) 02 ER Deletion: p.P327LfsTer30 .
MFE296 SNV: p.A176T .
NCIH358 SNV: p.A106P .
SW1271 SNV: p.M205I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		4.30  LDD0066  [2]
TH211
 Probe Info  		Y424(17.54); Y446(7.16)  LDD0257  [3]
IPM
 Probe Info  		N.A.  LDD0241  [4]
Probe 1
 Probe Info  		Y424(13.52); Y435(14.87); Y446(71.85)  LDD3495  [5]
DBIA
 Probe Info  		C385(1.02)  LDD1094  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		C385(0.00); H132(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		H132(0.00); C385(0.00)  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C385(0.94)  LDD1507  [13]
 LDCM0215  AC10 PaTu 8988t C385(1.02)  LDD1094  [6]
 LDCM0226  AC11 PaTu 8988t C385(0.75)  LDD1105  [6]
 LDCM0237  AC12 PaTu 8988t C385(0.86)  LDD1116  [6]
 LDCM0259  AC14 PaTu 8988t C385(0.88)  LDD1138  [6]
 LDCM0270  AC15 PaTu 8988t C385(1.28)  LDD1149  [6]
 LDCM0276  AC17 HEK-293T C385(0.92)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C385(1.49)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C385(0.87)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C385(1.17)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C385(1.21)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C385(1.04)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C385(1.23)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C385(0.99)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C385(1.43)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C385(1.09)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C385(1.23)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C385(1.28)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C385(0.96)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C385(1.03)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C385(1.02)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C385(1.18)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C385(1.24)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C385(1.15)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C385(1.02)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C385(1.04)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C385(1.31)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C385(0.92)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C385(1.26)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C385(1.31)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C385(1.04)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C385(1.08)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C385(1.37)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C385(0.85)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C385(1.17)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C385(1.06)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C385(1.04)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C385(1.21)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C385(1.27)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C385(1.15)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C385(1.24)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C385(0.91)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C385(1.26)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C385(1.42)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C385(1.07)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C385(1.09)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C385(1.21)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C385(1.34)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C385(0.94)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C385(1.20)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C385(0.88)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C385(1.39)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C385(1.40)  LDD1561  [13]
 LDCM0323  AC6 PaTu 8988t C385(0.93)  LDD1202  [6]
 LDCM0324  AC60 HEK-293T C385(1.30)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C385(1.01)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C385(1.19)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C385(0.98)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C385(1.22)  LDD1567  [13]
 LDCM0334  AC7 PaTu 8988t C385(1.07)  LDD1213  [6]
 LDCM0345  AC8 PaTu 8988t C385(1.43)  LDD1224  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C385(1.04)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C385(0.93)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C385(0.98)  LDD1154  [6]
 LDCM0156  Aniline NCI-H1299 11.43  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 PaTu 8988t C385(0.86)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C385(0.78)  LDD1247  [6]
 LDCM0369  CL100 HEK-293T C385(0.91)  LDD1573  [13]
 LDCM0370  CL101 PaTu 8988t C385(1.13)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C385(1.36)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C385(1.07)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C385(0.86)  LDD1252  [6]
 LDCM0374  CL105 HEK-293T C385(0.82)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C385(0.93)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C385(0.92)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C385(1.02)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C385(0.88)  LDD1582  [13]
 LDCM0379  CL11 PaTu 8988t C385(0.68)  LDD1258  [6]
 LDCM0380  CL110 HEK-293T C385(0.83)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C385(0.95)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C385(1.11)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C385(0.93)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C385(1.13)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C385(1.09)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C385(0.91)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C385(1.06)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C385(1.15)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C385(0.97)  LDD1593  [13]
 LDCM0390  CL12 PaTu 8988t C385(0.95)  LDD1269  [6]
 LDCM0391  CL120 HEK-293T C385(1.06)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C385(1.07)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C385(1.28)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C385(0.89)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C385(0.85)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C385(0.90)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C385(0.87)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C385(1.06)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C385(0.95)  LDD1603  [13]
 LDCM0400  CL13 PaTu 8988t C385(0.72)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C385(0.86)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C385(0.66)  LDD1281  [6]
 LDCM0403  CL16 PaTu 8988t C385(0.56)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C385(0.50)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C385(0.53)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C385(0.46)  LDD1285  [6]
 LDCM0407  CL2 PaTu 8988t C385(0.84)  LDD1286  [6]
 LDCM0408  CL20 PaTu 8988t C385(0.54)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C385(0.42)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C385(0.52)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C385(0.48)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C385(0.78)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C385(0.76)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C385(0.57)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C385(0.61)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C385(0.55)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C385(0.61)  LDD1296  [6]
 LDCM0418  CL3 PaTu 8988t C385(0.89)  LDD1297  [6]
 LDCM0419  CL30 PaTu 8988t C385(0.68)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C385(0.99)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C385(0.86)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C385(0.81)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C385(0.97)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C385(1.15)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C385(0.37)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C385(1.13)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C385(1.12)  LDD1307  [6]
 LDCM0429  CL4 PaTu 8988t C385(0.84)  LDD1308  [6]
 LDCM0430  CL40 PaTu 8988t C385(1.15)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C385(1.15)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C385(1.12)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C385(0.97)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C385(1.23)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C385(1.10)  LDD1314  [6]
 LDCM0436  CL46 HEK-293T C385(1.29)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C385(0.83)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C385(0.91)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C385(0.96)  LDD1643  [13]
 LDCM0440  CL5 PaTu 8988t C385(1.03)  LDD1319  [6]
 LDCM0441  CL50 HEK-293T C385(0.96)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C385(0.89)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C385(0.85)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C385(0.84)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C385(1.21)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C385(1.04)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C385(0.99)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C385(1.15)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C385(0.91)  LDD1653  [13]
 LDCM0451  CL6 PaTu 8988t C385(0.87)  LDD1330  [6]
 LDCM0452  CL60 HEK-293T C385(0.96)  LDD1655  [13]
 LDCM0453  CL61 PaTu 8988t C385(1.08)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C385(1.01)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C385(1.13)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C385(0.75)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C385(1.00)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C385(1.00)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C385(0.88)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C385(0.80)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C385(0.84)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C385(0.85)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C385(0.91)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C385(0.91)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C385(1.25)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C385(0.77)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C385(1.02)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C385(1.18)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C385(1.28)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C385(1.51)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C385(1.06)  LDD1351  [6]
 LDCM0473  CL8 PaTu 8988t C385(0.67)  LDD1352  [6]
 LDCM0474  CL80 PaTu 8988t C385(1.52)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C385(1.31)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C385(1.04)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C385(1.26)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C385(1.28)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C385(1.23)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C385(1.33)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C385(1.17)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C385(1.22)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C385(1.07)  LDD1362  [6]
 LDCM0484  CL9 PaTu 8988t C385(0.74)  LDD1363  [6]
 LDCM0485  CL90 PaTu 8988t C385(0.94)  LDD1364  [6]
 LDCM0486  CL91 HEK-293T C385(0.93)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C385(1.08)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C385(0.94)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C385(1.29)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C385(0.76)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C385(0.95)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C385(0.96)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C385(0.89)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C385(0.87)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C385(1.04)  LDD1698  [13]
 LDCM0625  F8 Ramos C385(0.99)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C385(0.75)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C385(0.82)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C385(0.83)  LDD2191  [14]
 LDCM0576  Fragment14 Ramos C385(1.17)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C385(0.70)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C385(1.02)  LDD2195  [14]
 LDCM0586  Fragment28 Ramos C385(0.93)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C385(1.08)  LDD2199  [14]
 LDCM0590  Fragment32 Ramos C385(0.73)  LDD2201  [14]
 LDCM0468  Fragment33 PaTu 8988t C385(0.85)  LDD1347  [6]
 LDCM0596  Fragment38 Ramos C385(0.41)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C385(0.22)  LDD2184  [14]
 LDCM0427  Fragment51 PaTu 8988t C385(1.07)  LDD1306  [6]
 LDCM0610  Fragment52 Ramos C385(1.05)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C385(0.43)  LDD2205  [14]
 LDCM0571  Fragment9 Ramos C385(0.68)  LDD2188  [14]
 LDCM0107  IAA HeLa C385(0.00); H132(0.00)  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C385(0.99)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C385(1.12)  LDD1497  [13]
 LDCM0024  KB05 HEK-293T C385(1.30)  LDD1502  [13]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0131  RA190 MM1.R C385(1.37)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.