Details of the Target

General Information of Target

Target ID LDTP11078
Target Name Sentrin-specific protease 7 (SENP7)
Gene Name SENP7
Gene ID 57337
Synonyms
KIAA1707; SSP2; SUSP2; Sentrin-specific protease 7; EC 3.4.22.-; SUMO-1-specific protease 2; Sentrin/SUMO-specific protease SENP7
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKS
KSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSES
LSPAHTSDFRTDDSQPPTLGQEILEEPSLPSSEVADEPPTLTKEEPVPLETQVVEEEEDS
GAPPLKRFCVDQPTVPQTASES
Target Bioclass
Enzyme
Family
Peptidase C48 family
Subcellular location
Cytoplasm
Function
Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation. Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
Uniprot ID
Q9BQF6
Ensemble ID
ENST00000314261.11
HGNC ID
HGNC:30402
ChEMBL ID
CHEMBL1741213

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL62 SNV: p.E395G .
DU145 SNV: p.S92L .
HEL SNV: p.M511V .
HEL9217 SNV: p.M511V .
IGR37 SNV: p.S29L DBIA    Probe Info 
IGR39 SNV: p.S29L DBIA    Probe Info 
LS180 SNV: p.S907L .
NCIH2291 SNV: p.E187D DBIA    Probe Info 
REH SNV: p.R841H .
TE4 SNV: p.Q241K DBIA    Probe Info 
TOV21G SNV: p.L555M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C221(1.05)  LDD0533  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C274(0.00); C992(0.00); C934(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		C934(0.00); C980(0.00); C274(0.00); C992(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C934(0.00); C221(0.00); C980(0.00); C274(0.00)  LDD0037  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C221(1.05)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C221(0.99)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C221(0.90)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C221(0.99)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C221(0.86)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C221(1.11)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C221(0.84)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C221(0.92)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C221(1.11)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C221(0.99)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C221(0.96)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C221(1.01)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C221(0.94)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C221(0.53)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C221(0.53)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C221(0.75)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C221(1.02)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C221(0.77)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C221(0.52)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C221(0.83)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C221(0.60)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C221(1.27)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C221(0.46)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C221(0.63)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C221(1.07)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C221(0.66)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C221(0.39)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C221(0.49)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C221(1.78)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C221(0.70)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C221(0.85)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C221(0.93)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C221(1.34)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C221(0.99)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C221(1.23)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C221(1.46)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C221(0.71)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C221(0.61)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C221(1.07)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C221(1.19)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C539(0.84)  LDD1512  [4]
 LDCM0260  AC140 HCT 116 C221(1.24)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C221(1.31)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C221(1.30)  LDD0579  [1]
 LDCM0282  AC22 HEK-293T C539(0.88)  LDD1521  [4]
 LDCM0291  AC30 HEK-293T C539(0.92)  LDD1530  [4]
 LDCM0299  AC38 HEK-293T C539(0.95)  LDD1538  [4]
 LDCM0308  AC46 HEK-293T C539(1.11)  LDD1547  [4]
 LDCM0317  AC54 HEK-293T C539(1.03)  LDD1556  [4]
 LDCM0323  AC6 HEK-293T C539(1.00)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C539(0.87)  LDD1565  [4]
 LDCM0365  AC98 HCT 116 C221(1.08)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C221(0.96)  LDD0683  [1]
 LDCM0367  CL1 HEK-293T C221(1.21)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C539(1.58)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C221(1.17)  LDD1574  [4]
 LDCM0374  CL105 HEK-293T C221(1.13)  LDD1578  [4]
 LDCM0378  CL109 HEK-293T C221(1.13)  LDD1582  [4]
 LDCM0383  CL113 HEK-293T C221(1.16)  LDD1587  [4]
 LDCM0387  CL117 HEK-293T C221(1.27)  LDD1591  [4]
 LDCM0392  CL121 HEK-293T C221(1.26)  LDD1596  [4]
 LDCM0396  CL125 HEK-293T C221(1.08)  LDD1600  [4]
 LDCM0400  CL13 HEK-293T C221(0.95)  LDD1604  [4]
 LDCM0403  CL16 HCT 116 C221(1.33)  LDD0720  [1]
 LDCM0410  CL22 HEK-293T C539(1.45)  LDD1614  [4]
 LDCM0413  CL25 HEK-293T C221(1.22)  LDD1617  [4]
 LDCM0421  CL32 HCT 116 C221(2.24)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C221(0.94)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C221(1.62)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C221(2.31)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C221(1.61)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C221(1.27)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C221(1.03)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C221(1.43)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C221(1.47)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C221(2.31)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C221(0.89)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C221(1.92)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C221(1.66)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C539(1.09)  LDD1640  [4]
 LDCM0439  CL49 HEK-293T C221(0.97)  LDD1643  [4]
 LDCM0449  CL58 HEK-293T C539(1.26)  LDD1652  [4]
 LDCM0453  CL61 HEK-293T C221(1.06)  LDD1656  [4]
 LDCM0463  CL70 HEK-293T C539(1.02)  LDD1666  [4]
 LDCM0466  CL73 HEK-293T C221(1.06)  LDD1669  [4]
 LDCM0476  CL82 HEK-293T C539(1.15)  LDD1679  [4]
 LDCM0479  CL85 HEK-293T C221(1.00)  LDD1682  [4]
 LDCM0489  CL94 HEK-293T C539(1.00)  LDD1692  [4]
 LDCM0492  CL97 HEK-293T C221(1.05)  LDD1695  [4]
 LDCM0427  Fragment51 HCT 116 C221(1.57)  LDD0744  [1]
 LDCM0022  KB02 T cell C221(5.26); C85(5.77)  LDD1703  [5]
 LDCM0023  KB03 A101D C274(2.81)  LDD2667  [6]
 LDCM0024  KB05 SKMEL24 C221(1.51)  LDD3323  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription intermediary factor 1-beta (TRIM28) TRIM/RBCC family Q13263
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromobox protein homolog 5 (CBX5) . P45973

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840